Article
Ophthalmology
Julia Polido, Maria Emilia Xavier dos Santos Araujo, Tais H. Wakamatsu, Bernardo T. Lopes, Joao G. Alexander, Thiago Cabral, Renato Ambrosio, Denise Freitas
Summary: This study evaluated the correlation between Placido-disc and rotating Scheimpflug keratometric findings in children with progressive keratoconus before and after corneal crosslinking. The results showed that the two methods were closely correlated after surgery and in mild keratoconus.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2022)
Article
Multidisciplinary Sciences
Parisa Abdi, Mehrnaz Atighehchian, Amir Reza Farsiani
Summary: The aim of this study was to compare measurements of anterior segment biometry parameters using two Scheimpflug tomographies, Pentacam and Sirius, and assess the agreement between them. The results showed that both devices had good agreement and correlation in most parameters, although there were statistically significant differences in some parameters.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Piotr Kanclerz, Kenneth J. Hoffer, Natasza Bazylczyk, Xiaogang Wang, Giacomo Savini
Summary: This study evaluated ocular measurements and intraocular lens calculation using an anterior/posterior segment OCT device and compared the results with a validated biometer. The study showed a strong correlation between OCT biometry and Pentacam AXL for IOL calculation, but axial length measurements and calculated IOL power cannot be considered interchangeable.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ingemar Gustafsson, Dimitrios Bizios, Anders Ivarsen, Jesper O. Hjortdal
Summary: The repeatability of measurements with the Pentacam HR in patients with keratoconus is not improved by gaining more experience of the measurement situation. This improvement could enhance the accuracy in detecting progressive keratoconus.
Article
Ophthalmology
Soner Guven
Summary: This study aimed to determine the repeatability of corneal topography measurements in severe dry eye disease (DED) and compare the corneal topography parameters between severe DED and healthy subjects. The results showed that corneal topography measurements with Pentacam were highly repeatable in severe DED patients. However, further studies with different topography devices are needed for validation.
Article
Ophthalmology
Bulent Kose
Summary: This study aimed to evaluate the agreement of posterior corneal curvature parameters between two devices in healthy, myopic eyes. The results showed significant differences between the two devices, indicating that they cannot be used interchangeably for measuring posterior corneal curvature.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2022)
Article
Ophthalmology
Veronika Roeggla, Christina Leydolt, Daniel Schartmueller, Luca Schwarzenbacher, Elias Meyer, Claudette Abela-Formanek, Rupert Menapace
Summary: The study aimed to assess the impact of artificial tears with different viscosity on K-readings before cataract surgery, with results showing significant changes in K-readings in dry eye patients after instillation of high-viscosity artificial tears.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Weicong Lu, Wenzhi Ding, Rongyuan Ji, Yuyin Tian, Chenpei Zhao, Honglei Li, Mengjun Jiao, Zhen Guo, Lin Leng
Summary: The study aims to evaluate the repeatability of corneal biomechanical measurements obtained by Corvis ST in post-orthokeratology patients and analyze the correlation between biomechanical and ocular parameters. The results showed that all parameters measured by Corvis ST, except for A1L and A2L, had good intraobserver repeatability after a 3-month follow-up period. The corneal biomechanical parameters were correlated with age, refraction, AL, steep and flat keratometry, and CCT. Thus, Corvis ST is a suitable device for investigating biomechanical parameters.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Yijia Xu, Yuhao Ye, Yiyong Xian, Lingling Niu, Xingtao Zhou, Jing Zhao
Summary: The study investigated the agreement between Pentacam and CASIA2 in the evaluation of corneal and lens densities in myopes. The results showed that CASIA2 demonstrated good consistency with Pentacam in the measurement of corneal and lens densities, except for the measurement of corneal density in the central cornea and in high myopia. Despite the numerical differences, CASIA2 provides a reliable alternative densitometric measurement method.
Article
Ophthalmology
Hassan Hashemi, Soheila Asgari, Ashraf M. Mahmoud, Shiva Mehravaran, Cynthia J. Roberts
Summary: This study compared the repeatability of Cone Location and Magnitude Index expanded (CLMI.X) parameters of 2 mm diameter zone of greatest corneal curvature (Cspot-Axi) and 1 mm diameter zone of thinnest pachmymetry (Spot-Pach) with the maximum single point keratometry (Kmax), 3 mm Zonal Kmax (Z-Kmax3), and thinnest single point pachymetry (TP) in keratoconus (KC). The results showed that in the diagnosis and follow up of KC, the zonal averages of Cspot-Axi and Z-Kmax3 are more reliable than the single point Kmax, and the repeatability of Spot-Pach is similar to TP.
Article
Medicine, General & Internal
Jung Sub Kim, Chang Rae Rho, Yeon Woo Cho, Jeongah Shin
Summary: Retrospective comparison of central corneal thickness measurements obtained by four instruments showed good correlation, with the largest discrepancy observed between Pentacam HR and the other instruments, while the best agreement was found between USP and RTVue.
Article
Multidisciplinary Sciences
Sung Uk Han, Soyoung Ryu, Hyunjean Jung, Hyunmin Ahn, Sangyeop Kim, Ikhyun Jun, Kyoung Yul Seo, Tae-im Kim
Summary: This study investigated keratometric measurements according to axial length in an aged population. It found a negative correlation between mean corneal curvature and axial length, but no significant differences in corneal astigmatism based on axial length. The study also showed good inter-device reliability for mean corneal curvature but not corneal astigmatism among the four ophthalmic devices.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Robert Edward T. Ang, Edward Kenneth F. Reyes, Fernando Amado J. Ayuyao, Maria Isabel N. Umali, Emerson M. Cruz
Summary: The measurements obtained from Orbscan II, IOLMaster 700, and Pentacam AXL cannot be used interchangeably when calculating ICL sizing. Combining the WTW from caliper measurement with the ACD of IOLMaster 700 or Pentacam AXL improves the accuracy of ICL sizing and increases the percentage of eyes with the desired vault.
Review
Medicine, General & Internal
Piotr Kanclerz, Ramin Khoramnia, Xiaogang Wang
Summary: Accurate assessment of corneal shape is crucial in cataract and refractive surgery, with corneal topography focusing on surface shape and tomography providing a three-dimensional section. Different technologies are used for these purposes, emphasizing the importance of thorough understanding for doctors involved in corneal surgery.
Article
Ophthalmology
Ugur Tunc, Yusuf Berk Akbas, Yusuf Yildirim, Burcin Kepez Yildiz, Ahmet Kirgiz, Ahmet Demirok
Summary: This study evaluated the repeatability and reliability of corneal parameters in keratoconus patients using a combined Scheimpflug-Placido disc analysis system. The study found that corneal curvature parameters were less repeatable as keratoconus severity increased, while corneal aberrations showed repeatability in all keratoconus subgroups.
Article
Ophthalmology
Jie Zhang, Amatul M. Ahmad, Hannah Ng, Jane Shi, Charles N. J. McGhee, Dipika V. Patel
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Mohammed Ziaei, Akilesh Gokul, Hans Vellara, Dipika Patel, Charles N. J. McGhee
Summary: This study found that in eyes with keratoconus, epithelial debridement increased the anterior corneal prolateness and tended to increase astigmatism while shifting its axis towards the against-the-rule orientation.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Ophthalmology
Helen Danesh-Meyer, Charles N. J. McGhee
Summary: Ophthalmologists are at high risk of COVID-19 infection due to their close contact with patients and equipment-intensive clinics. Measures such as social distancing and wearing masks are recommended to prevent transmission. Further studies are needed to explore the role of the conjunctiva in disease transmission.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Jina V. Han, Charles N. J. McGhee
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jessica C. Trollip, Jay J. Meyer, Charles N. J. McGhee, Kevin Liu, Helen Danesh-Meyer, Rachael L. Niederer
Summary: Band keratopathy is a rare complication of herpes zoster ophthalmicus. Older age, high intraocular pressure, and number of recurrences are associated with an increased risk for band keratopathy. Corneal melt is a serious complication, with uveitis and disodium EDTA chelation treatment being associated with increased risk. Treatment with EDTA chelation should be approached with caution due to the significant risk of severe complications.
Article
Ophthalmology
Akilesh Gokul, Mohammed Ziaei, Jeremy J. Mathan, Jina Han, Stuti L. Misra, Dipika Patel, Charles N. J. McGhee
Summary: This study investigated the epidemiologic, demographic, and clinical characteristics of keratoconus patients managed by optometrists in New Zealand. The results showed that keratoconus is relatively common in New Zealand, with most patients having mild to moderate disease. However, Maori and Pacific Peoples may have greater disease severity.
Article
Anatomy & Morphology
Peter W. Hadden, Dane A. Gerneke, Charles N. J. McGhee, Jie Zhang
Summary: In this study, the skeletal elements present in the penguin eye and orbit were imaged using macro photographs and micro-CT, revealing that the penguin scleral ring not only maintains the shape of the eye but also provides protection and a site of insertion for rectus muscles. The extreme variability in the os opticus suggests that it is not essential to normal function.
JOURNAL OF MORPHOLOGY
(2021)
Article
Ophthalmology
Jay J. Meyer, Charlotte A. Jordan, Dipika V. Patel, Akilesh Gokul, Simon J. Dean, Suheb Ahmed, Shanu Subbiah, Charles N. J. McGhee
Summary: This study demonstrates that CXL is effective in reducing maximum keratometry and maintaining better visual acuity for at least 5 years in patients with progressive keratoconus. However, complications may occur in some participants and require careful consideration.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Aaron P. C. Ong, Jie Zhang, Andrea L. Vincent, Charles N. J. McGhee
Summary: Megalocornea and anterior megalophthalmos disorders are characterized by a corneal diameter > 12.5 mm, often congenital and associated with syndromes. Megalocornea spectrum disorders are distinguished from keratoglobus by their typically progressive nature. Surgical management can be challenging due to specific anatomical features.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jie Zhang, Mohammed Ziaei, James McKelvie, Charles N. J. McGhee, Dipika Patel
Summary: The study investigated the in vivo biocompatibility of an acellular collagen-based scaffold for anterior lamellar keratoplasty in a rabbit model. Results showed that the scaffold supported corneal re-epithelialization without signs of rejection but further modifications are needed for better integration.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ye Li, Akilesh Gokul, Charles McGhee, Mohammed Ziaei
Summary: The study found that both devices showed good repeatability but poor agreement in biometric measurements in keratoconus patients. There was no significant difference in repeatability between eyes with or without prior crosslinking or contact lens wear, but the interchangeable use of the two devices is not recommended.
Article
Multidisciplinary Sciences
Ye Li, Akilesh Gokul, Charles McGhee, Mohammed Ziaei
Summary: This study investigated the repeatability of corneal thickness and epithelial thickness measurements in keratoconus patients using AS-OCT. The results showed that AS-OCT provides reliable measurements in both central and peripheral cornea, and a history of CXL has no significant impact on the repeatability of measurements.
Article
Multidisciplinary Sciences
Alexander Buckenham Boyle, Soobin Namkung, William Shew, Akilesh Gokul, Charles N. J. McGhee, Mohammed Ziaei
Summary: This study assessed the agreement and repeatability of horizontal visible iris diameter (HVID) or white-to-white (WTW) measurements between four imaging modalities. The results indicated significant differences in measurements among the devices, with Galilei G2 showing the highest repeatability and Orbscan IIz the lowest.
Article
Ophthalmology
Xu Chen, Jiaxin Zhao, Katja C. Iselin, Davide Borroni, Davide Romano, Akilesh Gokul, Charles N. J. McGhee, Yitian Zhao, Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Mohammed Ziaei, Stephen Kaye, Vito Romano, Yalin Zheng
Summary: The study evaluated the accuracy of convolutional neural networks technique in detecting keratoconus using colour-coded corneal maps obtained by a Scheimpflug camera. Results showed that the CNN model has excellent detection performance and can accurately differentiate between different severities of the disease, with potential for screening and management of keratoconus.
BMJ OPEN OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Ioannis N. Petropoulos, Kathryn C. Fitzgerald, Jonathan Oakley, Georgios Ponirakis, Adnan Khan, Hoda Gad, Pooja George, Dirk Deleu, Beatriz G. Canibano, Naveed Akhtar, Ashfaq Shuaib, Ahmed Own, Taimur Malik, Daniel B. Russakoff, Joseph L. Mankowski, Stuti L. Misra, Charles N. J. McGhee, Peter Calabresi, Shiv Saidha, Saadat Kamran, Rayaz A. Malik
Summary: Axonal loss is the main determinant of disease progression in multiple sclerosis, and corneal confocal microscopy was found to be useful in detecting corneal axonal loss in different courses of MS. The study confirmed significant corneal axonal loss in MS patients, including those with clinically isolated syndrome, using two independent segmentation methods. The corneal nerve parameters were comparably reduced in different courses of MS, with excellent reproducibility between the algorithms.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)