Article
Ophthalmology
Michael Simmons, Jingyun Wang, Joel N. Leffler, Shanshan Li, Sarah E. Morale, Angie de la Cruz, Eileen E. Birch
Summary: In this study comparing the effects of different treatments on the visual development of children with ROP, it was found that children treated with IVB had a slower rate of myopic refractive error development in the first year compared to those treated with laser. The IVB group also had less anisometropia. The final visual acuity in both groups was similar, with a mean of 0.47 logMAR (equivalent to 20/60).
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Amir Sternfeld, Safa Rahmani, Jennifer L. Rossen, David L. Zhang, Yuping D. Li, Victor L. Quan, Russell Huang, Hawke H. Yoon
Summary: Long-term FA findings in consecutive patients with type 1 ROP treated with IVB showed persistent vascular pathologies, suggesting potential long-term progression in retinal vascularization in some cases.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sadik Etka Bayramoglu, Nihat Sayin
Summary: This study investigated the relationship between refractive outcomes and the extent of retinal vascularization and severity of disease in infants treated with intravitreal bevacizumab. The results showed that there was a linear and low positive correlation between the extent of retinal vascularization and refractive outcomes, and a low negative correlation between the severity of disease and refractive outcomes. Additionally, the retinal zone and the extent of retinal vascularization were found to be related to the development of myopia.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Tomoya Murakami, Yoshimi Sugiura, Fumiki Okamoto, Yoshifumi Okamoto, Atsuko Kato, Sujin Hoshi, Motomichi Nagafuji, Yayoi Miyazono, Tetsuro Oshika
Summary: Compared to laser treatment for ROP, IVB showed no inferiority in neurodevelopment or visual outcome and was superior in refractive error. Cases in the IVB group exhibited retinal holes, suggesting long-term follow-up and fundus examination after IVB treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Danny A. Mammo, Shaina M. Rubino, Polly A. Quiram
Summary: This study aimed to evaluate the safety and efficacy of less dense panretinal photocoagulation in aggressive posterior retinopathy of prematurity infants. The results suggest that this treatment approach may be safe and effective after intravitreal bevacizumab, with no observed complications.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Ophthalmology
Marko M. Popovic, Prem Nichani, Rajeev H. Muni, Kamiar Mireskandari, Nasrin N. Tehrani, Peter J. Kertes
Summary: In the treatment of retinopathy of prematurity, intravitreal injection (IVI) of antivascular endothelial growth factor agents and laser photocoagulation (LPC) have similar regression rates, but eyes receiving IVI are more likely to require additional treatment and longer time. Eyes receiving IVI required surgical intervention less often compared to LPC, and had lower levels of astigmatism.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Critical Care Medicine
Cho-Yi Huang, Hsin-Chung Huang, Mei-Huei Chen, Tso-Ting Lai, Hung-Chieh Chou, Chien-Yi Chen, Ting -An Yen, Wellington Cardoso, Po-Nien Tsao
Summary: This study retrospectively evaluated the respiratory outcomes of preterm infants with bronchopulmonary dysplasia who received intravitreal bevacizumab (IVB) treatment. The results showed that IVB was significantly associated with prolonged ventilatory support and a lower likelihood of being ventilator free.
Article
Ophthalmology
Esay Kiran Yenice, Ikbal Seza Petricli, Caner Kara
Summary: The study investigates the effects of laser photocoagulation (LPC) and intravitreal bevacizumab (IVB) therapy on the first age refraction values in the treatment of retinopathy of prematurity (ROP). The results suggest that IVB therapy causes less myopia compared to LPC, and the stage and zone of ROP also have a significant effect on the development of myopia.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Nada O. Taher, Abdullah A. Ghaddaf, Sarah A. Al-Ghamdi, Jumanah J. Homsi, Bandar J. Al-Harbi, Lugean K. Alomari, Hashem S. Almarzouki
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of anti-VEGF monotherapy for retinopathy of prematurity (ROP). The results showed that anti-VEGF monotherapy had fewer adverse events compared to laser therapy, with no significant differences in other outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Sharon F. Freedman, Amra Hercinovic, David K. Wallace, Raymond T. Kraker, Zhuokai Li, Amit R. Bhatt, Charline S. Boente, Eric R. Crouch, G. Baker Hubbard, David L. Rogers, Deborah VanderVeen, Michael B. Yang, Nathan L. Cheung, Susan A. Cotter, Jonathan M. Holmes
Summary: For type 1 retinopathy of prematurity (ROP), low-dose and very low-dose intravitreal bevacizumab (IVB) as initial treatment resulted in excellent retinal outcomes. Additional treatment was required in many cases, but the risk of reactivation of severe ROP was not associated with the initial IVB dose. However, a data-driven analysis suggested that reactivation occurred sooner with very low doses.
Article
Engineering, Biomedical
Manavi D. Sindal, C. K. Nagesha, Divya Yadav, Romana Fazal
Summary: This study retrospectively analyzed the data of babies with posterior retinopathy of prematurity (ROP) receiving intravitreal bevacizumab (IVB) treatment, and found that IVB monotherapy can promote retinal vascular development. However, approximately 21% of patients still require laser treatment. Selective laser treatment can be performed for cases without recurrence or failure to mature.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Pediatrics
Ameay V. Naravane, Peter J. Belin, Shaina Rubino, Polly A. Quiram
Summary: This study reviewed the course of children treated with intravitreal bevacizumab for APROP and identified long term limitations they face years after treatment. The results showed regression without detachment in most eyes, with functional vision in verbal children. However, a significant proportion of these children developed chronic neurological disorders and other complications.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ophthalmology
Sadik Etka Bayramoglu, Nihat Sayin
Summary: The study aimed to evaluate the factors associated with refractive outcome in eyes treated with intravitreal bevacizumab injection for retinopathy of prematurity. The extent of pretreatment and prelaser retinal vascularization was found to be the most important factors affecting the refractive outcome.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Caifeng Gao, Ge Mu, Huanhuan Zhao, Jiao Zheng, Qingyang Feng, Yining Wu, Yinan Li, Xuelin Huang, Wei Sun
Summary: This study assessed the intraocular pressure (IOP) effect of intravitreal injection of conbercept (IVC) for retinopathy of prematurity (ROP). The results showed that infants with ROP experienced a sharp increase in IOP immediately after injection, which decreased to below 30 mmHg after 1 hour and remained stable for 1 week or longer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Ophthalmology
Tatsuya Inoue, Ryo Asaoka, Yohei Hashimoto, Kohdai Kitamoto, Marie Kitano, Asahi Fujita, Keiko Azuma, Kazuhiro Yamamoto, Miyuki Nagahara, Kazuaki Kadonosono, Ryo Obata
Summary: The study found a significant association between the number of laser shots applied during laser photocoagulation treatment and the degree of myopia in children. Eyes with high myopia received a significantly higher number of laser shots, and this number was positively correlated with the degree of myopia.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)