Article
Medicine, General & Internal
Pritha Pramanick, Mallika Sengupta, Madhumita Banerjee, Sougata Ghosh, Anita Nandi Mitra, Mandira Chakraborty, Manideepa Sengupta
Summary: Corneal ulcer or keratitis is a significant public health problem worldwide, and infectious keratitis is one of the main preventable causes of blindness. The objective of this study was to identify the etiological organisms causing infectious corneal ulcers and determine their prevalence and antimicrobial sensitivity pattern.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Ophthalmology
Rakhi Kusumesh, Anita Ambastha, Lalan K. Arya, Anita Kumari, Neha Kumari, Bibhuti P. Sinha, Nilesh Mohan, Namrata Kumari
Summary: This retrospective study analyzed the clinical and microbiological data of 2303 non-viral MK patients in Bihar, India from 2019 to 2022. The study revealed that MK is a significant cause of ocular morbidity in Bihar, with male predominance, corneal injury being the major risk factor, and fungal infection being the most common causative organism.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Maylander Menard, Yesha S. Shah, Inna G. Stroh, Sidra Zafar, Manjari Sriparna, Nancy Zhang, Ank A. Agarwal, Nakul Shekhawat, Divya Srikumaran, Fasika Woreta
Summary: This study evaluated the characteristics, microbiological spectrum, management, and outcomes of patients with culture-proven fungal keratitis. The results showed that infection with filamentous organisms was more common than with yeast, and the most common filamentous organisms were Fusarium and Aspergillus, while the most common yeast was Candida. Contact lens use was the main predisposing factor for filamentous keratitis, while yeast keratitis was most associated with an immunocompromised host and ocular surface disease. Visual outcomes were poor, with nearly half of the eyes remaining at 20/200 or worse upon resolution of infection. Antifungal susceptibility testing influenced treatment in 80% of cases in which it was performed.
CLINICAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Anubha Rathi, Khuraman Ramazanova, Somasheila. I. I. Murthy, Ashik Mohamed, Joveeta Joseph, Mariya Bashir, Suchita Pandey, Varsha. M. M. Rathi
Summary: The aim of this study was to evaluate the risk factors, microbiology, and treatment outcomes of polymicrobial keratitis (PMK). 65 patients diagnosed with PMK between 2016 and 2019 were retrospectively analyzed. The study found that PMK responds poorly to medical therapy and early surgical intervention is advocated for better treatment outcomes.
Article
Ophthalmology
George Moussa, James Hodson, Nick Gooch, Jasvir Virdee, Cristina Penaloza, Jesse Kigozi, Saaeha Rauz
Summary: This study retrospectively collected clinical, demographic, and economic data of 101 patients admitted with microbial keratitis (MK), revealing that length of stay is the key driver for care cost. Shorter stays resulted in income surplus, while greater socioeconomic deprivation was associated with higher cost deficits.
Article
Ophthalmology
Shelley Mo, Asad F. Durrani, Zaid Safiullah, Regis P. Kowalski, Vishal Jhanji
Summary: Proteus mirabilis keratitis is an uncommon microbial infection, with poor ocular surface and contact lens use being common risk factors. Empiric treatment with fortified antibiotics or fluoroquinolones appeared to provide effective coverage for Proteus mirabilis.
Article
Ophthalmology
Shelley Mo, Asad F. Durrani, Zaid Safiullah, Regis P. Kowalski, Vishal Jhanji
Summary: Proteus mirabilis keratitis is an uncommon microbial keratitis. Patients with poor ocular surface and those who use contact lens are at increased risk for this condition. Empiric treatment with fortified antibiotics or fluoroquinolones seems to provide effective coverage for Proteus mirabilis.
Article
Microbiology
Jason Richard Daley, Matthew Kyu Lee, Xingdi Wang, Matin Ly, Chameen Samarawickrama
Summary: Microbial keratitis, the most common cause of infective vision loss, requires intensive antimicrobial therapy and varies in causative organisms by region. A retrospective review of 160 cases at an Australian tertiary referral hospital found that the most common pathogens were Herpes Simplex, Staphylococcus aureus, and Pseudomonas aeruginosa. The study showed that microbial keratitis imposes a significant economic burden, with a median cost of AUD 8013 (USD 5447) and a total annual cost of AUD 13.58 million (USD 9.23 million) in Australia.
Review
Ophthalmology
Joveeta Joseph, Roshini Karoliya, Esther Sheba, Savitri Sharma, Bhupesh Bagga, Prashant Garg
Summary: The purpose of this study was to assess the trends in microorganisms causing infectious keratitis and their antibiotic susceptibility patterns at a tertiary eye care center in India. Retrospective review of microbiological records from 1991 to 2020 revealed a decrease in bacteria and an increase in fungal isolates. Gram-positive bacteria, particularly Streptococcus pneumoniae, showed a rising trend, while Staphylococcus epidermidis decreased over the 30-year period. Pseudomonas aeruginosa was the most prevalent gram-negative pathogen, and Fusarium spp. and Aspergillus spp. were the most common fungal isolates. Resistance to various antibiotics, including fluoroquinolones, showed an increasing trend. The changing spectrum of keratitis and the rising antibiotic resistance emphasize the importance of regular surveillance.
Article
Microbiology
Ming-Chih Ho, Eugene Yu-Chuan Kang, Lung-Kun Yeh, David H. K. Ma, Hsin-Chiung Lin, Hsin-Yuan Tan, Hung-Chi Chen, Ching-Hsi Hsiao
Summary: Burkholderia cepacia keratitis primarily affects patients with preexisting ocular disease, especially herpetic keratitis, and responds well to ceftazidime or fluoroquinolones. However, the visual outcomes are generally poor.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Biotechnology & Applied Microbiology
Jyoti Chauhan, Narinder Kaur, Harit Kumar, Rosy Bala, Richa Dhiman
Summary: This study aimed to investigate the microbiological profile, risk factors, epidemiology, and antimicrobial susceptibility pattern of bacteria isolated from patients with corneal ulcers. The results showed that Gram-positive and Gram-negative bacteria were the main causative agents of infectious keratitis. This information is crucial for effective treatment and prevention of complications associated with corneal ulcers.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Susana Lauw, Nelson Kei, Po Lam Chan, Tsz Kwan Yau, Ka Lee Ma, Carol Ying Ying Szeto, Janice Su-Chuen Lin, Sunny Hei Wong, Peter Chi Keung Cheung, Hoi Shan Kwan
Summary: Increasing dietary fiber consumption from fruits and vegetables combined with synbiotic supplementation is more effective in tackling obesity by modulation of the gut microbiota and improving metabolic syndrome traits.
Article
Ophthalmology
Anasua G. Kapoor, Vijitha S. Vempuluru, Srujana Laghimshetty, Aravind Roy, Savitri Sharma, Dilip K. Mishra, Ashik Mohamed, Swathi Kaliki
Summary: The study evaluated the incidence, clinical features, microbiology, risk factors, and treatment outcomes of ocular surface squamous neoplasia (OSSN) coexisting with microbial keratitis (MK). The results showed that the combination of MK and OSSN led to poor treatment outcomes, and risk factors for this association included male sex, human immunodeficiency virus seropositivity, large limbal pigmented OSSN lesion, noduloulcerative morphology, and scleral invasion.
Article
Allergy
Agnes S. Y. Leung, Rebecca M. Y. Li, Ann W. S. Au, Jaime Sou Rosa Duque, Po Ki Ho, Gilbert T. Chua, Chi Hang Wong, David C. K. Luk, Mike Y. W. Kwan, Yat Sun Yau, Gary W. K. Wong, Ting Fan Leung
Summary: Anaphylaxis incidence is increasing among children in Hong Kong, with food-induced anaphylaxis, particularly from peanuts and shellfish, being the most common triggers. Most episodes are severe (Grade 4) and often misdiagnosed, with adrenaline underutilized in management, indicating a need for improved awareness and management strategies.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Ophthalmology
Nada N. Alwohaibi, Malak Bamashmoos, Abdulaziz Al Somali
Summary: This study describes the predisposing factors, causative organisms, treatment modalities, and visual outcomes of childhood non-viral microbial keratitis in our region. The study found that most cases were associated with preventable risk factors, with contact lens wear being the leading cause. Early detection and management are crucial in reducing the risk of vision-threatening complications.
CLINICAL OPHTHALMOLOGY
(2022)
Article
Biochemical Research Methods
I. L. G. Law, J. F. C. Loo, H. C. Kwok, H. Y. Yeung, C. C. H. Leung, M. Hui, S. Y. Wu, H. S. Chang, Y. W. Kwan, H. P. Ho, S. K. Kong
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Microbiology
Chendi Zhu, Veranja Liyanapathirana, Carmen Li, Vasanthi Pinto, Mamie Hui, Norman Lo, Kam T. Wong, Nilanthi Dissanayake, Margaret Ip
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Shik Luk, Viola Chi Ying Chow, Kelvin Chung Ho Yu, Enoch Know Hsu, Ngai Chong Tsang, Vivien Wai Man Chuang, Christopher Koon Chi Lai, Mamie Hui, Rodney Allan Lee, Wai Man Lai, Tak Lun Que, Sau Chun Fung, Wing Kin To, Vincent Chi Chung Cheng, Andrew Tin Yau Wong
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2019)
Article
Chemistry, Organic
Mengwan Li, Yibin Ye, Lisi He, Mamie Hui, Tzi Bun Ng, Jack Ho Wong, Gavin Chit Tsui
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Yun Kit Yeoh, Zigui Chen, Mamie Hui, Martin C. S. Wong, Wendy C. S. Ho, Miu Ling Chin, Siew C. Ng, Francis K. L. Chan, Paul K. S. Chan
Article
Infectious Diseases
Nelson Leung-sang Tang, Xingyan Wang, Kwok Chiu Chang, Chiu-yeung Chan, Natalie Wing-sum Szeto, Dan Huang, Junyi Wu, Grace C. Y. Lui, Chi Chiu Leung, Mamie Hui
INFECTION GENETICS AND EVOLUTION
(2019)
Article
Gastroenterology & Hepatology
Yun Kit Yeoh, Zigui Chen, Martin C. S. Wong, Mamie Hui, Jun Yu, Siew C. Ng, Joseph J. Y. Sung, Francis K. L. Chan, Paul K. S. Chan
Article
Dentistry, Oral Surgery & Medicine
Yun Kit Yeoh, Man Hin Chan, Zigui Chen, Eddy W. H. Lam, Po Yee Wong, Chi Man Ngai, Paul K. S. Chan, Mamie Hui
Article
Multidisciplinary Sciences
Fen Zhang, Tao Zuo, Yun Kit Yeoh, Frankie W. T. Cheng, Qin Liu, Whitney Tang, Kitty C. Y. Cheung, Keli Yang, Chun Pan Cheung, Chow Chung Mo, Mamie Hui, Francis K. L. Chan, Chi-Kong Li, Paul K. S. Chan, Siew C. Ng
Summary: FMT is emerging as a potential treatment for GvHD, and this study examines the temporal dynamics of the bacteriome, mycobiome, and virome in a patient who received multiple FMTs.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Chendi Zhu, Carmen Li, Christopher K. C. Lai, Rita Ng, Ka Yee Chau, Kam Tak Wong, Norman W. S. Lo, Nilakshi Barua, Ying Yang, Veranja Liyanapathirana, Mamie Hui, Raymond W. Lai, Kitty S. C. Fung, Dominic N. Tsang, I. P. Margaret
Summary: This study describes the molecular epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in patients from Hong Kong hospitals, with increasing isolation rates and dominance of bla(NDM) and bla(IMP) genes. Enhanced containment strategies are required to mitigate the rising trend of CPE in healthcare settings.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Pharmacology & Pharmacy
Christopher K. C. Lai, Rita W. Y. Ng, Sharon S. Y. Leung, Mamie Hui, Margaret Ip
Summary: Antimicrobial resistance is a normal evolutionary process for microorganisms and has become a global crisis. Existing antimicrobials are no longer effective in treating infections caused by resistant pathogens. Novel drug delivery approaches offer new hopes in overcoming antimicrobial resistance and targeting hard-to-reach sites.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Microbiology
Man Kit Cheung, Sylvia L. Y. Tong, Martin C. S. Wong, Jason Y. K. Chan, Margaret Ip, Mamie Hui, Christopher K. C. Lai, Rita W. Y. Ng, Wendy C. S. Ho, Apple C. M. Yeung, Paul K. S. Chan, Zigui Chen
Summary: This study characterized the bacterial and fungal microbiomes in oral and stool samples from healthy Chinese adults. The results showed limited transmission of microbiota between the oral cavity and gut in healthy individuals, with only a few shared bacterial and fungal variants. The sharing of potentially transmissible fungal variants was associated with host factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Jacky C. H. Chu, Miu Ling Chin, Clarence T. T. Wong, Mamie Hui, Pui-Chi Lo, Dennis K. P. Ng
Summary: This study presents a facile synthetic approach to prepare a phthalocyanine-based photosensitizer conjugated with a cyclic bactenecin peptide, which shows selective affinity toward bacteria and synergistic cytotoxic effects against a spectrum of multidrug-resistant bacterial strains. The inhibition mechanism is believed to be based on the physical destruction of the cell membrane due to the cyclic peptide followed by photodynamic action induced by the phthalocyanine unit.
ADVANCED THERAPEUTICS
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Fen Zhang, Yun Kit Yeoh, Tao Zuo, Frankie Cheng, Whitney Tang, Kitty Cheung, Keli Yang, Qin Liu, Chun Pan Cheung, Chow Chung Mo, Mamie Hui, Francis Chan, Chi-Kong Li, Paul Chan
Article
Microbiology
A. F. C. Leonard, X. L. Yin, T. Zhang, M. Hui, W. H. Gaze
FEMS MICROBIOLOGY ECOLOGY
(2018)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
