Letter
Medicine, General & Internal
Iain Beehuat Tan, Clive Tan, Li Yang Hsu, Yock Young Dan, Andrew Aw, Alex R. Cook, Vernon J. Lee
Summary: This study focuses on the prevalence and outcomes of SARS-CoV-2 infection among migrant workers in Singapore.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Mijie Li, Chuen-Seng Tan, Lingqian Xu, Li-Lian Foo, Fabian Yap, Chen-Hsin Sun, Elaine K. H. Tham, Shirong Cai, Marcus Ang, Seang-Mei Saw, Charumathi Sabanayagam
Summary: In this study of elementary school-aged children in Singapore, various sleep factors such as quality, duration, timing, and consistency were not independently associated with myopia, spherical equivalent, and axial length. Large longitudinal studies are needed to verify these results.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Studies
Joe Greener, Laura Naegler
Summary: This article discusses how urban policing, surveillance, and crime control in Geylang, Singapore contribute to the marginalization of excluded groups. By examining the intersection of political discourses, crime, and social control practices, it highlights the co-construction of class- and race-based inequalities in Singapore. The study identifies three key processes through which state power is manifested in Geylang, demonstrating how crime control policies legitimize urban political economy reliant on low-cost migrant labor.
Article
Environmental Studies
Daniel P. S. Goh, Andrew Lee
Summary: This article examines the issue of recreational spaces for temporary, low-wage male migrant workers in Singapore and explores the politics of integration/segregation and inclusion/exclusion. The study reveals that state-provisioned recreation centers have unintentionally become contact zones that foster diverse urban encounters between migrants, locals, and state-linked agents. This phenomenon has been intensified during the COVID-19 pandemic.
Article
Infectious Diseases
Li Wei Ang, Qi Gao, Lin Cui, Aysha Farwin, Matthias Paul Han Sim Toh, Irving Charles Boudville, Mark I-Cheng Chen, Angela Chow, Raymond Tzer-Pin Lin, Vernon Jian Ming Lee, Yee Sin Leo
Summary: The susceptibility to measles among migrant workers in Singapore was found to be below the herd immunity threshold, indicating the possibility of sporadic outbreaks in susceptible individuals. Seroprevalence surveys can help identify susceptible subgroups for vaccination.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Chay Junxing, Vinh Anh Huynh, Ecosse Lamoureux, Kwang Wei Tham, Eric Andrew Finkelstein
Summary: Excess weight imposes a significant health and economic burden among older adults in Singapore. Indians and Malays have a higher likelihood of obesity compared to Chinese. Overweight individuals have more work absenteeism and higher medical expenditures. Successful efforts to prevent and reduce obesity prevalence may lead to health and economic improvements.
Article
Multidisciplinary Sciences
Li Wei Ang, Oon Tek Ng, Irving Charles Boudville, Yee Sin Leo, Chen Seong Wong
Summary: Metabolic syndrome (MetS) is common in people living with HIV (PLHIV) in Singapore, with a prevalence of 23.6%. The most common metabolic abnormality is HDL hypocholesterolemia and hypertriglyceridemia. Regular monitoring, surveillance of drug effects, and behavioral interventions are needed for optimal management and prevention of metabolic disorders in PLHIV due to the long-term use of cART.
Article
Chemistry, Analytical
Xueqian Ren, Qingwen Zhang, Jinglei Yang, Xinjuan Zhang, Xueming Zhang, Yating Zhang, Liping Huang, Changshun Xu, Yuancai Ge, Hao Chen, Xiaohu Liu, Yi Wang
Summary: Retinal dopamine is crucial in the development of myopia, and the visualization of dopamine with high spatial precision is essential for understanding the biochemical mechanism. The surface-enhanced Raman scattering (SERS) technique provides a new way to detect dopamine in cells and retinal tissues, contributing to the research of myopia.
ANALYTICAL CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Sallie Yea
Summary: This article examines the factors that contribute to the high incidence of workplace injuries and fatalities among migrant workers in Singapore, focusing on the organization of migration and contract fraud. The concept of the 'produced injured' is introduced to describe those who are vulnerable to injury due to the political economy of migrant labor.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Genetics & Heredity
Hong Wang, Liansheng Li, Wencan Wang, Hao Wang, Youyuan Zhuang, Xiaoyan Lu, Guosi Zhang, Siyu Wang, Peng Lin, Chong Chen, Yu Bai, Qi Chen, Hao Chen, Jia Qu, Liangde Xu
Summary: The study found that maintaining incorrect posture is the main risk factor for myopia onset, while the age of myopia onset is the primary factor affecting high myopia progression. The ages between 8 and 12 are crucial stages for clinical interventions, especially for children with a family history of myopia.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Marek C. Allen, Michael Clinchy, Liana Y. Zanette
Summary: This study demonstrates that fear itself can significantly impact prey population growth rates in free-living wildlife, potentially constituting a considerable part of the total impact of predators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Ophthalmology
Feihui Zheng, Chee-Wai Wong, Charumathi Sabanayagam, Yin-Bun Cheung, Saiko Matsumura, Jacqueline Chua, Ryan Eyn Kidd Man, Kyoko Ohno-Matsui, Tien-Yin Wong, Ching-Yu Cheng, E. Shyong Tai, Ecosse Luc Edouard Denis Lamoureux, Leopold Schmetterer, Anthony Kuo, Quan V. Hoang, Seang-Mei Saw
Summary: In Singapore, approximately one in three adults with high myopia had posterior staphyloma, which was associated with increased odds of developing myopic maculopathy and having a detrimental impact on vision-related quality of life.
ACTA OPHTHALMOLOGICA
(2021)
Article
Health Care Sciences & Services
Mark D. Chatfield, Daniel M. Farewell
Summary: This study highlights the importance of understanding between-cluster variation in clustered binary data research and suggests visualizing the distribution of true cluster prevalences or calculating their standard deviation for improved understanding. Additionally, quantities defined on the log odds scale are found to be more transportable between studies with different outcomes and prevalences compared to intra-cluster correlation and coefficient of variation.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Si Ying Tan, Luting Poh, Jeremy Lim
Summary: The global trend of aging populations has led to a pressing need for adequate long-term care for older people worldwide. In Singapore, there is a public discourse on expanding assisted living to create age-friendly environments for long-term care. Despite being in the early stages of development, assisted living is seen as a viable care model that should be expanded to meet the increasing demand for care among older populations.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Ophthalmology
Bariah Mohd-Ali, Yu Chen Low, Mizhanim Mohamad Shahimin, Norlaili Arif, Hamzaini Abdul-Hamid, Wan Haslina Wan Abdul-Halim, Norhani Mohidin
Summary: This study evaluated the impact of wearing Orthokeratology (ortho-K) lenses on the quality of life of myopic children in Kuala Lumpur. The results showed that myopic children wearing ortho-K lenses had higher vision-related quality of life scores compared to those wearing single-vision spectacles (SVSs).
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Nathan Congdon, Augusto Azuara-Blanco, Yoram Solberg, Carlo E. Traverso, Michele Iester, Carlo Alberto Cutolo, Alessandro Bagnis, Tin Aung, Scott J. Fudemberg, Richard Lindstrom, Thomas Samuelson, Kuldev Singh, Eytan Z. Blumenthal, Gus Gazzard
Summary: This study aims to compare the efficacy and non-inferiority of Eagle direct selective laser trabeculoplasty (DSLT) and selective laser trabeculoplasty (SLT) in reducing intraocular pressure (IOP) in patients with open angle glaucoma (OAG). The study is a randomized controlled trial with the primary outcome being the mean change in IOP at 6 months.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Eleni Nikita, Gus Gazzard, Dawn A. Sim, Sandro Fasolo, Karsten Kortum, Hari Jayaram
Summary: This study evaluates the feasibility of using expanded eligibility criteria for glaucoma care in virtual glaucoma clinics (VGCs) and finds that it is a safe and effective approach with high levels of patient satisfaction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Anna C. S. Tan, Miao Li Chee, Beau J. Fenner, Paul Mitchell, Yih Chung Tham, Tyler Rim, Kelvin Teo, Shaun S. Sim, Ching Yu Cheng, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Summary: This study aimed to report the incidence of age-related changes in drusen volume detected by optical coherence tomography (OCT) over a span of 6 years and their systemic and ocular associations. The results showed that the incidence of age-related macular degeneration (AMD) detected at 6 years was low. Drusen volume in the macular region either decreased, remained stable, or increased over the 6-year period. Older age, smoking, and chronic kidney disease were associated with decreased drusen volume, while older age and hypertension were associated with increased drusen volume.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Bingyao Tan, Nicole-Ann Lim, Rose Tan, Alfred Tau Liang Gan, Jacqueline Chua, Simon Nusinovici, Chui Ming Gemmy Cheung, Usha Chakravarthy, Tien Yin Wong, Leopold Schmetterer, Gavin Tan
Summary: Optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature can be used to detect the presence and severity of diabetic retinopathy (DR). Choriocapillaris parameters show better discrimination between non-diabetic and diabetic without DR groups. Evaluating both retinal and choroidal microvasculature significantly improves the detection of diabetic retinopathy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Zhenzhen Liu, Shan Huang, Yingfeng Zheng, Tian Zhou, Leyi Hu, Lang Xiong, David Wan-cheng Li, Yizhi Liu
Summary: The crystalline lens is a transparent and refractive biconvex structure formed by lens epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading cause of blindness in the world. LECs are the principal cells of lens throughout human life, exhibiting different physiological properties and functions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Jiexuan Lv, Ruxin Gao, Yao Wang, Changquan Huang, Renyi Wu
Summary: Glaucoma is a leading cause of irreversible blindness worldwide. Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, has been shown to have neuroprotective effects in acute ocular hypertension (AOH). The present study found that LIF treatment inhibited retinal damage induced by AOH and reduced RGC loss and apoptosis. This effect was associated with the activation of STAT3 and mTOR/p70S6K signaling pathways. These findings suggest that LIF may serve as a potential neuroprotective agent in the treatment of glaucoma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Ophthalmology
Xue-Li Chen, Yan-Jing Fu, Bo Qu, Ye-Wei Wang, Xin Tang, Yu-Hong Wang, Guo-Yi Zhou, Ming-Kai Lin, Jing-Yuan Shen, Jin Yao, Su-Yan Li, Miao-Qin Wu, Hua-Zong Peng, Ming-Ying Lai, Ren-Yi Wu, Yi-Nong Zhang, Yan Li, Xiao-Jun Wu, Ming-Chang Zhang, Su-Ping Guo, Xing-Huai Sun
Summary: This study investigated the treatment pattern and safety of tafluprost for glaucoma and ocular hypertension in clinical practice in China. The results showed that tafluprost is safe and tolerable when used alone or in combination with other eye drops.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhuo-Xing Shi, Zhi-Chao Chen, Jia-Yong Zhong, Kun-Hua Hu, Ying-Feng Zheng, Ying Chen, Shang-Qian Xie, Xiao-Chen Bo, Feng Luo, Chong Tang, Chuan-Le Xiao, Yi-Zhi Liu
Summary: Long-read single-cell RNA isoform sequencing can reveal the complex landscape of alternative RNA splicing in individual cells, but it has a low read throughput. The authors developed circular consensus sequencing methods to achieve high-throughput and high-accuracy single-cell RNA isoform sequencing.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Xiuxing Liu, Yuhan Su, Zhaohao Huang, Jianjie Lv, Chenyang Gu, Zhuang Li, Tianyu Tao, Yidan Liu, Qi Jiang, Runping Duan, Binyao Chen, Rong Ju, Xianggui Wang, Yingfeng Zheng, Wenru Su
Summary: Sleep loss is associated with the higher risk of autoimmune and inflammatory disorders. The study found that sleep deprivation led to compositional and functional changes in immune cells, especially in effector CD4(+) T and myeloid cells. Sleep loss aggravated autoimmune uveitis development by promoting Th17 differentiation and activation.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Ophthalmology
Zitian Liu, Wenyong Huang, Zhenyu Wang, Ling Jin, Nathan Congdon, Yingfeng Zheng, Shida Chen, Yizhi Liu
Summary: This study demonstrates that the portable, self-imaging OCT is highly consistent with clinic-based SD-OCT in measuring CST and identifying most retinal lesions.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ruxin Gao, Jinkun Liu, Xiaojie Zhou, Luping Huang, Weiyi Huang, Yingying Xue, Fei Wang, Songjian Gong, Renyi Wu, Yuhong Wang
Summary: This study evaluated the influence of pilocarpine eyedrops on ocular biometric parameters and its effect on intraocular lens (IOL) power calculation in patients with primary angle-closure glaucoma (PACG). The results showed that pilocarpine eyedrops induced slight changes in ocular biometric parameters including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and lens position (LP). However, these parameter changes did not result in significant differences in IOL power estimation.
JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biology
Wen Shi, Jinguo Ye, Zhuoxing Shi, Caineng Pan, Qikai Zhang, Yuheng Lin, Dan Liang, Yizhi Liu, Xianchai Lin, Yingfeng Zheng
Summary: This study presents a multi-omic single-cell analysis of Behcet's disease (BD), revealing the epigenetic and transcriptional characteristics of BD peripheral blood. It uncovers cell-type-specific active and pro-inflammatory immunity in BD, and identifies potential TF regulators that contribute to chromatin accessibility and gene expression. The study expands our understanding of potential epigenomic immunopathology in BD.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Fei Yu, Yao Wang, Chang-Quan Huang, Si-Jie Lin, Ru-Xin Gao, Ren-Yi Wu
Summary: Mesenchymal stem cell-derived extracellular vesicles have neuroprotective effects in reducing retinal damage and increasing retinal ganglion cells, potentially through inhibiting cell apoptosis. In a rat model of chronic ocular hypertension mimicking glaucoma-induced optic nerve injury, we injected extracellular vesicles derived from umbilical cord mesenchymal stem cells into the vitreous cavity one week after injury, finding significant improvements in retinal damage and caspase-3 activation inhibition. These findings suggest the potential of mesenchymal stem cell-derived extracellular vesicles as a therapeutic approach for optic nerve injury caused by chronic ocular hypertension.
NEURAL REGENERATION RESEARCH
(2023)
Article
Ophthalmology
Kai Xiong Cheong, Hengtong Li, Yih Chung Tham, Kelvin Yi Chong Teo, Anna Cheng Sim Tan, Leopold Schmetterer, Tien Yin Wong, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Qiao Fan
Summary: This study evaluated the relationship between genetic susceptibility to AMD and retinal thickness, finding that certain genetic variants were associated with thinner retinal layers, particularly the photoreceptor layers. These findings suggest that retinal thickness could serve as a potential risk marker for prodromal AMD, highlighting the importance of considering topographic variation.
OPHTHALMOLOGY SCIENCE
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
