Article
Medicine, General & Internal
Gaku Tachibana, Tomomi Higashide, Koji Nitta, Kazuhisa Sugiyama
Summary: This study found that disc hemorrhage (DH) is associated with glaucoma progression. However, it is unclear whether the association between DH and glaucoma progression differs between the superior and inferior hemiretinas. The results showed that the macular ganglion cell complex (GCC) thickness had a stronger relationship with DH in the inferior hemiretina, suggesting that more attention should be paid to DH in the inferior disc area as a sign of glaucoma progression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
In Ki Park, Kyoung Woo Kim, Nam Ju Moon, Jae-Ho Shin, Yeoun Sook Chun
Summary: The study compares the patterns of visual field defects in normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) with different severities. Results demonstrate that NTG exhibits significant asymmetry between the superior and inferior hemifields, while HTG shows more diffuse defects.
JOURNAL OF GLAUCOMA
(2021)
Article
Medicine, General & Internal
Urszula Lukasik, Dominika Wrobel-Dudzinska, Jaromir Jarecki, Karolina Gasinska, Tomasz Zarnowski, Anna Swiech, Ewa Kosior-Jarecka
Summary: The aim of this study was to compare the results of OCTA and OCT examinations in patients with NTG and HTG at the early stage of glaucoma. The study found that the only statistical difference between early NTG and HTG in terms of RNFL thickness was observed in the temporal sector, with thinner values in the NTG group. There were no statistical differences between early NTG and HTG in terms of OCTA results.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Yu Meng Wang, Ruyue Shen, Timothy P. H. Lin, Poemen P. Chan, Mandy O. M. Wong, Noel C. Y. Chan, Fangyao Tang, Alexander K. N. Lam, Dexter Y. L. Leung, Clement C. Y. Tham, Carol Y. Cheung
Summary: This study aimed to determine the relationship between optical coherence tomography angiography (OCTA) metrics and visual field (VF) progression in eyes with normal tension glaucoma (NTG). The findings showed that lower superotemporal cpVD measured from OCTA in the peripapillary region improves the prediction of VF deterioration in NTG.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Anna Lee, Kyung Rim Sung
Summary: The purpose of this study was to investigate the longitudinal changes in VD and structural parameters and their associations with future VF defects in the unaffected hemifields of POAG eyes with single-hemifield defects. The study found that monitoring progressive changes in VD and structural parameters effectively predicted future VF defects in the unaffected hemifields of POAG eyes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Takafumi Yoshioka, Youngseok Song, Motofumi Kawai, Tomofumi Tani, Kengo Takahashi, Satoshi Ishiko, Fabio Lavinsky, Gadi Wollstein, Hiroshi Ishikawa, Joel S. Schuman, Akitoshi Yoshida
Summary: In NTG eyes with single-hemifield damage, the RBF was significantly reduced in the damaged hemisphere compared with the normal one. The RBF decreased in the normal and damaged hemispheres of NTG eyes compared with the healthy hemisphere independent from RNFLT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Austin R. Fox, John H. Fingert
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, characterized by optic nerve damage and visual field defects. While elevated intraocular pressure (IOP) is a significant risk factor, normal tension glaucoma (NTG) can occur within the normal range of IOP. Genetic mutations in optineurin (OPTN), TANK binding kinase 1 (TBK1), and myocilin (MYOC) have been identified as the primary causes of NTG. In this review, we examine pedigree studies and clinical features of NTG associated with these mutations.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Review
Chemistry, Medicinal
Maria Letizia Salvetat, Francesco Pellegrini, Leopoldo Spadea, Carlo Salati, Marco Zeppieri
Summary: Normal tension glaucoma (NTG) is a subtype of primary open-angle glaucoma (POAG) in which the intraocular pressure (IOP) values are within the normal range without treatment. The exact cause of NTG is not fully understood and multiple factors are believed to contribute to its development. Lowering IOP is the standard treatment for NTG, but it may not be enough in all cases, suggesting the involvement of other factors. Various therapeutic approaches targeting different risk factors have been proposed, but there is no standardized or proven alternative treatment for NTG. This review aims to highlight the strategies reported in the literature and the challenges in finding appropriate and effective treatments for NTG.
Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Chun-Mei Hsueh, Jong-Shiuan Yeh, Jau-Der Ho
Summary: The purpose of this study was to identify risk factors for progression in treated normal-tension glaucoma (NTG) in highly myopic and non-highly myopic eyes. The results showed that the highly myopic group had a larger optic disc tilt ratio and thinner inferior macular thickness compared to the non-highly myopic group. Furthermore, basal pattern standard deviation and post treatment IOP were identified as risk factors for visual field progression in normal tension glaucoma patients.
Article
Multidisciplinary Sciences
Hyun Joo Kee, Jong Chul Han, Eui Do Song, Eui Jun Choi, Dong Ook Son, Eun Jung Lee, Yoon Kyoung Jang, Changwon Kee
Summary: This study investigated the possible risk factors affecting the pattern of visual field progression in open-angle glaucoma (OAG) patients. VF deterioration was found to be associated with longer follow-up period, higher baseline intraocular pressure, lower mean ocular perfusion pressure, and smaller angular location of the longest border tissue.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Gloria Roberti, Manuele Michelessi, Lucia Tanga, Luca Belfonte, Laura Maria Del Grande, Marisa Bruno, Francesco Oddone
Summary: This study examined the agreement between clinical judgment and GPAII in evaluating visual field progression in glaucoma patients. Glaucoma experts showed better ability than general ophthalmologists in detecting progression, but the agreement between clinical judgment and GPAII ranged from fair to moderate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hideki Mizohata, Kengo Ikesugi, Mineo Kondo
Summary: Frequent self-measurements of intraocular pressure can effectively evaluate the IOP-lowering effect of medications in patients with normal tension glaucoma.
Article
Ophthalmology
Lewei Tang, Liang Chen, Cong Ye, Jingwei Zheng, Yi Zhou, Yan Tao, Qiangjie Huang, Xiaoyan Wang, Xiao Shang, Xiafei Pan, Nathan Congdon, Yuanbo Liang
Summary: This study found that Yang-deficient constitution and higher intraocular pressure are risk factors for visual field progression in normal-tension glaucoma (NTG) patients, which is consistent with prior research.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Health Care Sciences & Services
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Summary: The study found that comorbidities such as hypotension, sleep disturbances, peptic ulcers, and allergic rhinitis are more highly associated with NTG than POAG.
Article
Ophthalmology
Jae Hwan Choi, Jong Chul Han, Changwon Kee
JOURNAL OF GLAUCOMA
(2019)
Article
Ophthalmology
Do Young Park, Sung Yoon Cho, Dong-Kyu Jin, Changwon Kee
JOURNAL OF GLAUCOMA
(2019)
Article
Ophthalmology
Jong Chul Han, Jae Hwan Choi, Do Young Park, Eun Jung Lee, Changwon Kee
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Jong Chul Han, Sun Hyup Han, Do Young Park, Eun Jung Lee, Changwon Kee
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Do Young Park, Jong Chul Han, Eun Jung Lee, Changwon Kee
JOURNAL OF GLAUCOMA
(2019)
Review
Ophthalmology
Eun Jung Lee, Jong Chul Han, Do Young Park, Changwon Kee
PROGRESS IN RETINAL AND EYE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Eun Jung Lee, Jong Chul Han, Do Young Park, Junhun Cho, Changwon Kee
Summary: The study on successful CTGF suppression using the CRISPR-Cas9 system in GFS surgery shows promising results in reducing fibrotic responses, indicating a potential new approach to improve surgical outcomes.
Article
Multidisciplinary Sciences
Eun Jung Lee, Jong Chul Han, Do Young Park, Changwon Kee
SCIENTIFIC REPORTS
(2020)
Review
Ophthalmology
Eun Jung Lee, Hyun Joo Kee, Jong Chul Han, Changwon Kee
Summary: Disc hemorrhage is closely associated with glaucoma development and may be a secondary development of glaucomatous damage. It is suggested to be considered as an indicator of glaucomatous development or progression rather than a risk factor.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ki Young Son, Jong Chul Han, Changwon Kee
Summary: The study aimed to investigate the topographic relationship between deep-layer microvasculature dropout (MvD) and retinal nerve fiber layer (RNFL) defects in eyes with open-angle glaucoma (OAG). It was found that MvD is only observed at the location of the RNFL defect in one hemiretina eyes, and usually found in the location of more severe RNFL defects in eyes with defects in both hemiretinas. This suggests that MvD may be a sign accompanying glaucomatous damage in OAG eyes.
ACTA OPHTHALMOLOGICA
(2022)
Article
Multidisciplinary Sciences
Do Young Park, Jong Chul Han, Eun Jung Lee, Changwon Kee
Summary: The excessive drop in finger temperature after exposure to ice water was significantly associated with faster VF progression in patients with low-teen NTG. Older age, worse initial VF MD, and greater decrease in finger temperature after ice water exposure were significantly associated with faster VF progression rates.
Article
Multidisciplinary Sciences
Hyun Joo Kee, Eun Jung Lee, Jong Chul Han, Changwon Kee
Summary: In this study, implantation of AGV coated with PMPC significantly reduced the number of inflammatory cells and fibrosis compared to AGV without PMPC.
Article
Ophthalmology
Eun Jung Lee, Hyun Joo Kee, Kyung-Ah Park, Jong Chul Han, Changwon Kee
Summary: The study identified the presence of choroidal microvascular dropout (MvD) in both nonarteritic anterior ischemic optic neuropathy (NAION) and open-angle glaucoma (OAG) eyes, with a higher frequency in NAION eyes and larger areas of MvD and RNFL defects. The distribution of MvD showed a strong correspondence to superimposition areas of beta PPA and RNFL defects, highlighting a potential mechanistic relationship between these factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Eun Jung Lee, Hyun Joo Kee, Jong Chul Han, Changwon Kee
Summary: The study aimed to identify the temporal correlation between the increase in peripapillary retinoschisis (PPRS) and glaucoma progression. Through comparative clinical timeline analysis, it was found that the increase in PPRS temporally correlated with glaucoma progression in eyes with PPRS. The study suggested that possible glaucoma progression may be considered around the time of increase and de novo development of PPRS in glaucomatous eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Eun Jung Lee, Jong Chul Han, Do Young Park, Changwon Kee
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)