Article
Ophthalmology
Erfan Noury, Suria S. Mannil, Robert T. Chang, An Ran Ran, Carol Y. Cheung, Suman S. Thapa, Harsha L. Rao, Srilakshmi Dasari, Mohammed Riyazuddin, Dolly Chang, Sriharsha Nagaraj, Clement C. Tham, Reza Zadeh
Summary: The study developed a 3D deep learning algorithm for glaucoma detection using SD-OCT ONH cube scans and validated its performance on diverse datasets from different countries and on cropped images. The results showed that the model can accurately distinguish glaucoma from normal cases, with the lamina cribrosa playing an important role in glaucoma detection.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Christopher A. Girkin, Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Robert N. Weinreb, Jeffrey M. Liebmann, James A. Proudfoot, Linda M. Zangwill, Massimo A. Fazio
Summary: The study aimed to determine if the rate of change in the depth of the surface of the lamina cribrosa due to glaucomatous remodeling differs between glaucoma patients of African descent (AD) and European descent (ED). After adjusting for baseline characteristics, it was found that the ED group had significantly greater ALCSD posterior migration compared to the AD group.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Palaiologos Alexopoulos, Yoav Glidai, Zeinab Ghassabi, Bo Wang, Behnam Tayebi, Anse Vellappally, Mengfei Wu, Mengling Liu, Katie Lucy-Jones, Ronald Zambrano, Hiroshi Ishikawa, Joel S. Schuman, Gadi Wollstein
Summary: The purpose of this study was to investigate the deformation of pore paths in the lamina cribrosa (LC) under different intraocular pressure (IOP) and intracranial pressure (ICP) conditions. The results showed that the tortuosity of pore paths varied among different eyes and changed when manipulating IOP or ICP. These findings suggest that the tortuosity of pore paths may be associated with glaucoma susceptibility.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Review
Computer Science, Interdisciplinary Applications
Rita Marques, Danilo Andrade De Jesus, Joao Barbosa-Breda, Jan Van Eijgen, Ingeborg Stalmans, Theo van Walsum, Stefan Klein, Pedro G. Vaz, Luisa Sanchez Brea
Summary: This review summarizes the latest technology applications of automatic segmentation of the optic nerve head (ONH) in optical coherence tomography (OCT), pointing out the lack of consensus on segmented regions, extracted parameters, and validation methods, highlighting the importance of establishing standardized methods. Only with a concrete set of guidelines, these automatic segmentation algorithms can enter clinical practice.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Ophthalmology
Yong Woo Kim, Jin Ju Choi, Michael J. A. Girard, Jean Martial Mari, Dong Gyu Choi, Ki Ho Park
Summary: During axial elongation in childhood, changes in temporal border tissue configuration, BMO enlargement, and nasal peripapillary tissue elevation show a significant correlation with changes in AXL.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Ophthalmology
Alice Paulo, Pedro G. Vaz, Danilo Andrade De Jesus, Luisa Sanchez Brea, Jan Van Eijgen, Joao Cardoso, Theo van Walsum, Stefan Klein, Ingeborg Stalmans, Joao Barbosa Breda
Summary: The lamina cribrosa (LC) is an active structure that can respond to strain by altering its morphology, with abnormal changes often associated with certain pathologies such as glaucoma. Recent advances in optical coherence tomography (OCT) have allowed for detailed in vivo studies on LC characteristics, particularly in the field of glaucoma management. While LC depth and thickness are the most studied features, further research is needed to fully understand the potential diagnostic and prognostic value of LC features in various diseases.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Soo-Ji Jeon, Hae-Young Lopilly Park, Chan-Kee Park
Summary: The study aimed to investigate the association of decreased vessel density in the deep peripapillary region with structural features of the lamina cribrosa. Results showed that eyes with deep vessel density defects in the peripapillary region had thinner lamina cribrosa, and the area with deep vessel density defects had thinner and deeper lamina cribrosa compared to other areas.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Yoav Glidai, Katie A. Lucy, Joel S. Schuman, Palaiologos Alexopoulos, Bo Wang, Mengfei Wu, Mengling Liu, Jonathan P. Vande Geest, Hirut G. Kollech, TingFang Lee, Hiroshi Ishikawa, Gadi Wollstein
Summary: This study investigated the in vivo microstructural deformation within the lamina cribrosa volume in response to acute intraocular pressure (IOP) modulation while maintaining fixed intracranial pressure (ICP). Results showed that only half of the eyes exhibited deformation in the lamina cribrosa, and the location of maximum deformation varied between eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Chemistry, Analytical
Md Habibur Rahman, Hyeon Woo Jeong, Na Rae Kim, Dae Yu Kim
Summary: This study proposes a new intelligent system that automatically quantifies the morphological parameters of the lamina cribrosa in optical coherence tomography images using a deep learning model. The system includes detection, segmentation, and post-processing stages to accurately obtain key information and achieve quantification.
Article
Ophthalmology
Satish K. Panda, Haris Cheong, Tin A. Tun, Sripad K. Devella, Vijayalakshmi Senthil, Ramaswami Krishnadas, Martin L. Buist, Shamira Perera, Ching-Yu Cheng, Tin Aung, Alexandre H. Thiery, Michael J. A. Girard
Summary: This study develops a novel deep-learning approach for describing the structural phenotype of the glaucomatous optic nerve head (ONH) and serving as a robust glaucoma diagnosis tool. By analyzing the latent parameters, it reveals the changes in ONH morphology during the transition from a non-glaucoma to a glaucoma condition.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Do-Young Park, Hoon Noh, Changwon Kee, Jong-Chul Han
Summary: This study aimed to investigate the topographic relationships among the deep optic nerve head (ONH) parameters representing myopic axial elongation or changes in the lamina cribrosa (LC) in patients with primary open-angle glaucoma (POAG). The study found that the AL-related parameters showed a strong spatial correspondence with glaucomatous ONH damage, whereas the LC-related parameter had less correlation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Anoop Sainulabdeen, Yoav Glidai, Mengfei Wu, Mengling Liu, Palaiologos Alexopoulos, Hiroshi Ishikawa, Joel S. Schuman, Gadi Wollstein
Summary: This study characterized the structure of the lamina cribrosa (LC) in healthy non-human primates (NHPs) using spectral-domain optical coherence tomography (OCT). The results showed regional differences in the thickness of the LC in the central and peripheral regions, as well as in the superior and inferior quadrants. The anterior LC had smaller beams and pores compared to the middle and posterior lamina.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Fatih Aslan, Nedime Sahinoglu-Keskek, Emin Utku Altindal
Summary: The study evaluated the behavior of the lamina cribrosa following successful phacoemulsification surgery in patients with non-glaucomatous pseudoexfoliation syndrome (PXS). It was found that the PXS group had significantly thinner LCt values compared to the non-PXS group, and there was a significant increase in anterior laminar depth in the non-PXS group during follow-up.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Giedre Pakuliene, Loreta Kuzmiene, Brent Siesky, Alon Harris, Ingrida Januleviciene
Summary: The study found that OAG patients had a greater absolute IOP reduction pre- and postoperatively compared to the control group; ACD and ACA increased in both groups postoperatively; axial length shortened in the control group postoperatively.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Zhenhe Ma, Ning Ding, Zhen Li, Keliang Zhu, Ang Li, Zhanhong Lin, Yi Wang, Yuqian Zhao, Yao Yu, Jingmin Luan, Xin Zhu, Jian Liu
Summary: This article introduces a method to extract the photoacoustic (PA) signal from the contrast reduction in the interference spectrum obtained from spectral domain optical coherence tomography (SDOCT). The method utilizes the specular reflection on the water surface to achieve all-optical detection in a non-contact manner. By analyzing the phase changes in the interference spectrum induced by water surface vibration, the method enables quantification of the interference contrast reduction for PA imaging.
Article
Ophthalmology
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
Article
Multidisciplinary Sciences
Seung Hyen Lee, Tae-Woo Kim, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari, Robert Ritch
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Tae Wan Kim, Euncheol Choi, Jeonghoon Park, Dong-ho Shin, Su Kyung Jung, Susie Seok, Kwan Ho Cho, Joo-Young Kim, Dae Yong Kim, Tae Hyun Kim, Yang Kwon Suh, Yeon Joo Kim, Sung Ho Moon
CANCER RESEARCH AND TREATMENT
(2018)
Article
Multidisciplinary Sciences
Jeong-Ah Kim, Tae-Woo Kim, Robert N. Weinreb, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari
SCIENTIFIC REPORTS
(2018)
Article
Ophthalmology
Ji-Ah Kim, Tae-Woo Kim, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari
Article
Multidisciplinary Sciences
Seung Hyen Lee, Tae-Woo Kim, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari
SCIENTIFIC REPORTS
(2019)
Article
Ophthalmology
Gyu-Nam Kim, Eun Ji Lee, Tae-Woo Kim
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Eun Ji Lee, Ji-Ah Kim, Tae-Woo Kim, Hyunjoong Kim, Hee Kyung Yang, Jeong-Min Hwang
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim
Summary: This study aimed to investigate the influence of peripapillary retinoschisis (PRS) on visual field (VF) test results in patients with primary open angle glaucoma (POAG). The results showed that PRS had no short-term effect on VF sensitivity, and VF testing can still be used for evaluating glaucomatous damage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Orthopedics
Hyung Jun Park, Moon Jong Chang, Tae Woo Kim, Chong Bum Chang, Seung-Baik Kang
Summary: The study aimed to determine the recovery of orthopedic surgery volumes over time during the ongoing COVID-19 pandemic. The impact of COVID-19 on orthopedic surgery volumes weakened as the pandemic continued. While the total volumes of orthopedic surgery decreased by 8.5%-10.1% in the first wave, they recovered to a 2.2%-2.8% decrease from the expected volumes during the second and third waves. The resumption of surgery differed based on the surgical characteristics, with open reduction and internal fixation and cruciate ligament reconstruction decreasing, while total knee arthroplasty showed recovery. Hemiarthroplasty of the hip did not see a decrease throughout the year.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Ophthalmology
Jeong-Ah Kim, Dong Hwan Son, Eun Ji Lee, Hyunjoong Kim, Tae-Woo Kim
Summary: The characteristics of the peripapillary choroid (PPC) were compared between the eyes of patients with unilateral treatment-naive normal-tension glaucoma (NTG). Eyes with NTG showed higher intraocular pressure, thinner PPC, larger area and maximum radial width of beta-zone parapapillary atrophy (PPA), and more frequent microvasculature dropout (MvD) compared to contralateral healthy eyes. Factors such as higher IOP, thinner PPC, larger maximum radial width of beta-zone PPA, and the presence of MvD were independently associated with the risk of NTG.
OPHTHALMOLOGY GLAUCOMA
(2021)
Article
Ophthalmology
Eun Ji Lee, Ji-Ah Kim, Tae-Woo Kim
OPHTHALMOLOGY GLAUCOMA
(2020)
Article
Medicine, General & Internal
Sang Jun Park, Kyu Hyung Park, Tae Woo Kim, Byung Joo Park
JOURNAL OF KOREAN MEDICAL SCIENCE
(2019)
Article
Ophthalmology
Ji-Ah Kim, Tae-Woo Kim, Eun Ji Lee, Michael J. A. Girard, Jean Martial Mari
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Ophthalmology
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
BRITISH JOURNAL OF OPHTHALMOLOGY
(2018)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)