Article
Oncology
Meltem Guzin Altinel, Ayse Yagmur Kanra, Ozgun Melike Gedar Totuk, Aylin Ardagil, Kerem Kabadayi
Summary: Half-dose, half-fluence, and standard PDTs are all effective and safe treatment options for chronic central serous chorioretinopathy, with similar improvements in visual acuity and reductions in central retinal thickness. Higher central retinal thickness values during follow-up were associated with treatment failure, while eyes with intact ellipsoid zone did not experience failure.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Haidong Li, Lifeng Chen, Meng'ai Wu, Bin Zheng
Summary: This study evaluated the retinal sensitivity of macular region in patients with acute and recurrent central serous chorioretinopathy (CSCR) using microperimetry. The results showed that recurrent CSCR had worse retinal function in the affected macular areas compared to acute CSCR. Therefore, microperimetry may be a promising method for distinguishing between acute and recurrent CSCR.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Dong-Geun Park, Seongyong Jeong, Donghyoun Noh, Min Sagong
Summary: The study found that for treating chronic central serous chorioretinopathy (CSC), a 50% standard-fluence rate of PDT appears to be the most effective option, with a lower recurrence rate and higher rate of complete subretinal fluid (SRF) resolution.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Gang Seok Jeon, In Boem Chang, Dae Joong Ma, In Hwan Cho, In Hwan Hong
Summary: A prospective observational study was conducted to evaluate the changes in retinal function after anatomical resolution of central serous chorioretinopathy using multifocal electroretinography. The results showed that retinal responses increased mostly after resolution, but the amplitudes remained statistically reduced 12 months after anatomical resolution, indicating residual functional deficits detected by multifocal electroretinography.
OPHTHALMIC RESEARCH
(2023)
Article
Oncology
Susana Penas, Joao Beato, Patricia Rosinha, Joana Araujo, Ana Costa, Angela Carneiro, Fernando Falcao-Reis, Amandio Rocha-Sousa
Summary: This study on CSC patients after HD-PDT treatment shows that while there is a sustained improvement in BCVA and CMT in the first 12 to 24 months, macular sensitivity or electrical response do not show the same sustained improvement. Long-term functional deterioration might be related to the disease itself.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Ophthalmology
Susana Penas, Teresa Araujo, Ana Maria Mendonca, Simao Faria, Jorge Silva, Aurelio Campilho, Maria Lurdes Martins, Vania Sousa, Amandio Rocha-Sousa, Angela Carneiro, Fernando Falcao-Reis
Summary: This study investigates the retinal and choroidal vascular reactivity to carbogen in patients with central serous chorioretinopathy (CSC). The results suggest that the vascular reactivity in the choroidal vessels of CSC patients is significantly higher compared to controls.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Chemistry, Medicinal
Aya Chubachi, Akiko Miki, Mayuka Hayashida, Mari Sakamoto, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: This study found that low-contrast visual acuity is significantly affected after reduced-fluence photodynamic therapy in patients with resolved central serous chorioretinopathy and good baseline visual acuity. Affected eyes had significantly worse low-contrast visual acuity compared to fellow eyes, and symptom duration may play a role in affecting low-contrast visual acuity post-treatment.
Article
Multidisciplinary Sciences
Joon Seo Lim, Cheolwon Moon, Junyeop Lee
Summary: The presence of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC) is associated with disturbances in retinal blood flow, including reduced venous blood flow velocity and rate, as well as changes in venous diameter. SRF thickness is correlated with a decrease in venous blood flow rate, suggesting that SRF plays a role in altering retinal blood flow dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Bingjie Wang, Richard Brown, Jay Chhablani, Shaohua Pi
Summary: In this study, an algorithm was developed to register OCT scans of patients with CSCR without the need for prior layer segmentation, and to calculate three-dimensional structural change maps. This tool can aid in monitoring disease progression and treatment efficacy.
BIOMEDICAL OPTICS EXPRESS
(2023)
Review
Ophthalmology
Sumit Randhir Singh, John Thomas Gote, Jay Chhablani
Summary: Central serous chorioretinopathy (CSCR) is a common chorioretinal disease with various manifestations. Acute CSCR presents with localized neurosensory detachment, while chronic CSCR may show widespread changes in the retinal pigment epithelium (RPE), chronic shallow subretinal fluid, and choroidal neovascularization (CNV). Despite multiple treatment options, there is a lack of standardized treatment protocol or gold standard treatment modality.
Article
Ophthalmology
Hoang Mai Le, Sarah Mrejen, Lise Sibilia, Salomon Y. Cohen
Summary: Quantitative analysis using SD-OCTA found no significant change in choriocapillaris flow deficits before and after half-fluence PDT in patients with chronic CSC.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Junyeop Lee, Eoi Jong Seo, Young Hee Yoon
Summary: Hemodynamic changes in macula-off RRD were investigated and compared with CSC using OCTA. Lower density in macular DCP was observed in both macula-off RRD and CSC eyes. Macula-off RRD eyes showed a reduction in DCP vascular density and an increase in foveal avascular zone area compared to CSC. Less density of DCP was strongly correlated with longer duration of detachment, greater ellipsoid zone disruption, and poor visual recovery in macula-off RRD. Early reattachment and reperfusion are required for minimizing macular vasculature and photoreceptor damage in macula-off RRD.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H. Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani
Summary: This study analyzed the longitudinal changes in visual acuity and risk factors for recurrence or development of choroidal neovascularisation (CNV) in eyes with acute or chronic central serous chorioretinopathy (CSCR). The results showed that the recurrence rate of CNV was approximately 30%, and higher age and a higher number of recurrences were associated with a higher risk of early de novo CNV formation.
Article
Medicine, General & Internal
Shuhei Hosoda, Yoichi Sakurada, Taiyo Shijo, Kenji Kashiwagi
Summary: This case report describes a 58-year-old man with persistent subretinal fluid in both eyes due to cuticular drusen presenting with central serous chorioretinopathy (CSC). Despite the rarity of CSC in eyes with cuticular drusen, the patient's left eye showed improvement in visual acuity after photodynamic therapy. Physicians should be aware of the possibility of CSC development in eyes with cuticular drusen.
Article
Ophthalmology
Claudio Furino, Valeria Albano, Michela Mangione, Roberta Galati, Maria D'Addario, Michele Reibaldi, Francesco Boscia, Giovanni Alessio
Summary: This pilot study explores the use of optical coherence tomography angiography (OCT-A) in evaluating the dry macula of neovascular age-related macular degeneration (nAMD) treated with a treat-and-extend (T&E) aflibercept regimen. The study suggests that OCT-A may be useful in determining the optimal approach for adjusting injection intervals based on changes in CNV size.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Engineering, Biomedical
Pietro Palmisano, Federico Guerra, Vittorio Aspromonte, Gabriele Dell'Era, Pier Luigi Pellegrino, Mattia Laffi, Carlo Uran, Silvana De Bonis, Michele Accogli, Antonio Dello Russo, Giuseppe Patti, Francesco Santoro, Antonella Torriglia, Gerardo Nigro, Antonio Bisignani, Giovanni Coluccia, Giulia Stronati, Vincenzo Russo, Ernesto Ammendola
Summary: The clinical use of implantable loop recorder (ILR) in elderly patients with recurrent, traumatic, unexplained syncope is still limited. In this specific patient population, there is a lack of data on the actual risk of traumatic syncope recurrence during ILR monitoring. This prospective registry study aimed to assess the risk of traumatic and non-traumatic syncopal recurrences during ILR observation. The findings demonstrate that ILR monitoring is effective and safe in patients with unexplained, recurrent, traumatic syncope. Remote monitoring significantly reduces the time to diagnosis and significantly reduces the risk of syncope recurrence, including both traumatic and non-traumatic syncope.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Correction
Cardiac & Cardiovascular Systems
Vincenzo Russo, Alfredo Caturano, Federico Guerra, Federico Migliore, Giuseppe Mascia, Andrea Rossi, Martina Nesti, Vincenzo Ezio Santobuono, Emilio Attena, Gianfranco Tola, Luigi Sciarra, Giulio Conte, Alessandro Paoletti Perini, Pietro Francia, Gregory Dendramis, Zefferino Palama, Stefano Albani, Andrea Ottonelli Ghidini, Leonardo Calo, Antonio D'Onofrio, Enrico Baldi
Article
Cardiac & Cardiovascular Systems
Vincenzo Russo, Alfredo Caturano, Federico Guerra, Federico Migliore, Giuseppe Mascia, Andrea Rossi, Martina Nesti, Vincenzo Ezio Santobuono, Emilio Attena, Gianfranco Tola, Luigi Sciarra, Giulio Conte, Alessandro Paoletti Perini, Pietro Francia, Gregory Dendramis, Zefferino Palama, Stefano Albani, Andrea Ottonelli Ghidini, Leonardo Calo, Antonio D'Onofrio, Enrico Baldi
Summary: This study compares device-related complications, infections, and inappropriate therapies between drug-induced type 1 Brugada Syndrome patients with transvenous-ICD (TV-ICD) and subcutaneous-ICD (S-ICD). The results show that there were no significant differences between S-ICD and TV-ICD in terms of inappropriate ICD therapies, device-related complications, and infections. However, the S-ICD group had a trend towards reduced lead-related complications.
Article
Biochemistry & Molecular Biology
Simona Daniele, Simona Saporiti, Stefano Capaldi, Deborah Pietrobono, Lara Russo, Uliano Guerrini, Tommaso Laurenzi, Elham Ataie Kachoie, Luca Palazzolo, Vincenzo Russo, Maria Pia Abbracchio, Ivano Eberini, Maria Letizia Trincavelli
Summary: GPR17, a key regulator of myelination, is activated by endogenous ligands and pro-inflammatory molecules. This study investigates the structural and functional interactions between GPR17 and chemokine receptors CXCR2 and CXCR4. The results show that these receptors can form heterodimers and modulate intracellular cAMP levels. This cross-talk between receptors could impact the neuroinflammatory environment associated with demyelinating events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Anna Lombardi, Mariarosaria De Luca, Dario Fabiani, Francesco Sabatella, Carmen Del Giudice, Adriano Caputo, Luigi Cante, Michele Gambardella, Stefano Palermi, Rita Tavarozzi, Vincenzo Russo, Antonello D'Andrea
Summary: SARS-CoV-2 rapidly spread globally, causing the costly and deadly COVID-19 pandemic. Pulmonary manifestations are common in this syndrome, along with frequent cardiovascular complications. Ultrasound evaluations, particularly POCUS protocols, are crucial in diagnosing, monitoring, and predicting the prognosis of COVID-19 patients, especially in intensive care units.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andreina Carbone, Roberta Bottino, Antonello D'Andrea, Vincenzo Russo
Summary: Currently, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy for non-valvular atrial fibrillation (NVAF) patients, showing equal efficacy and greater safety compared to warfarin. However, the results of DOAC trials cannot be extrapolated to specific populations such as obese, elderly, frail, and cancer patients, which are common in clinical practice. Additionally, the evidence for DOAC use in patients with bioprosthetic heart valves is limited and controversial. This review aims to clarify the best anticoagulant strategy for these special and understudied subpopulations.
Review
Cardiac & Cardiovascular Systems
Michele Iavarone, Anna Rago, Riccardo Molinari, Antonello D'Andrea, Martina Nesti, Saverio Muscoli, Giuseppe Mascia, Vincenzo Russo
Summary: Sudden cardiac death (SCD) is a leading cause of cardiovascular death, and identifying high-risk patients for primary prevention is crucial. Noninvasive arrhythmic risk indexes are available but their effectiveness is debated. Programmed ventricular stimulation (PVS) is an invasive approach historically used for SCD risk stratification and is included in international guidelines. This review aims to summarize available data regarding the role of PVS for SCD risk stratification in different clinical settings.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Vincenzo Russo, Michele Ciabatti, Michele Brunacci, Gregory Dendramis, Vincenzo Santobuono, Gianfranco Tola, Giuseppe Picciolo, Lucciola Maria Teresa, Antonello D'Andrea, Martina Nesti
Summary: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a well-established therapy for preventing sudden cardiac death and serves as an alternative to transvenous implantable cardioverter-defibrillator systems for selected patients. Numerous observational studies have examined the clinical performance of S-ICD in different patient subgroups. This review aims to outline the advantages and disadvantages of S-ICD, particularly in special populations and various clinical settings.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Review
Biology
Vincenzo Russo, Luigi Falco, Viviana Tessitore, Alfredo Mauriello, Dario Catapano, Nicola Napolitano, Moiz Tariq, Alfredo Caturano, Giovanni Ciccarelli, Antonello D'Andrea, Antonio Giordano
Summary: Optimizing anticoagulation therapy is crucial for patients with malignant tumors due to the high incidence of venous thromboembolism (VTE), which is the second leading cause of death in this population. Cancer significantly increases the risk of thrombosis and bleeding, making the management of cancer-associated VTE complex. This review highlights the anti-inflammatory and anticancer effects of DOACs and LWMHs.
Article
Psychology, Multidisciplinary
Vincenzo Russo, Marco Bilucaglia, Chiara Casiraghi, Simone Chiarelli, Martina Columbano, Alessandro Fici, Fiamma Rivetti, Cristina Rossi, Riccardo Valesi, Margherita Zito
Summary: This paper presents an innovative research project that explores the emotional factors influencing decision-making in response to infomercials using cutting-edge consumer neuroscience techniques. The study identifies various variables, including seller characteristics and neurophysiological responses, that significantly impact the effectiveness of infomercials in generating Call-to-Action, Purchase Intention, and likability. The findings emphasize the importance of considering both seller attributes and consumers' neurophysiological responses in understanding and predicting their behaviors towards marketing stimuli.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alfredo Caturano, Margherita D'Angelo, Andrea Mormone, Vincenzo Russo, Maria Pina Mollica, Teresa Salvatore, Raffaele Galiero, Luca Rinaldi, Erica Vetrano, Raffaele Marfella, Marcellino Monda, Antonio Giordano, Ferdinando Carlo Sasso
Summary: Oxidative stress plays a critical role in the development and progression of diabetes and its associated complications. The imbalance between reactive oxygen species (ROS) production and the body's antioxidant defense mechanisms leads to cellular damage and dysfunction. By understanding and addressing oxidative stress, it may be possible to alleviate the burden of diabetes and improve patient outcomes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Anna Rago, Ciro Pirozzi, Antonello D'Andrea, Pierpaolo Di Micco, Andrea Antonio Papa, Antonio D'Onofrio, Paolo Golino, Gerardo Nigro, Vincenzo Russo
Summary: This review evaluates the gender-related differences in cardioembolic risk and response to anticoagulants in atrial fibrillation patients. Non-vitamin K oral anticoagulants (NOACs) are the gold standard for thromboembolic risk prevention in non-valvular atrial fibrillation patients. In comparison to men, the use of NOACs in women with atrial fibrillation is associated with a lower risk of intracranial bleeding, major bleeding, and all-cause mortality.
MEDICINA-LITHUANIA
(2023)
Review
Genetics & Heredity
Alfredo Mauriello, Antonia Ascrizzi, Riccardo Molinari, Luigi Falco, Alfredo Caturano, Antonello D'Andrea, Vincenzo Russo
Summary: Pharmacogenomics plays an important role in personalized medicine, especially in the field of cardiovascular drug therapy. Genotype-guided approach improves the effectiveness of antiplatelet therapy, while various genetic polymorphisms affect the efficacy of anticoagulants and statin drugs. Pharmacogenomics has the potential to guide new drug therapies for cardiovascular diseases.
Meeting Abstract
Surgery
D. Khan, K. Tariq, K. Lee, E. Dyson, V. Russo, L. Watkins, A. Russo
BRITISH JOURNAL OF SURGERY
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
