Article
Dermatology
Yasmin Chia Chia Liew, Karen Jui Lin Choo, Choon Chiat Oh, Shiu Ming Pang, Yi Wei Yeo, Haur Yueh Lee
Summary: This study evaluated the differences between Mycoplasma-related and drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. The results showed no significant differences in baseline characteristics and extent of involvement, but significant differences in mortality rates between the two groups.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Tsung-Yu Tsai, I-Hsin Huang, Yuan-Chen Chao, Hua Li, Tyng-Shiuan Hsieh, Hsiao-Han Wang, Yu-Ting Huang, Chun-Yuan Chen, Ying-Chih Cheng, Po-Hsiu Kuo, Yu-Chen Huang, Yu-Kang Tu
Summary: Systematic review and network meta-analysis indicated that combination therapy with corticosteroids and intravenous immunoglobulin was the only treatment showing significant survival benefits for patients with TEN and SJS/TEN overlap. However, limitations such as heterogeneity and a lack of eligible randomized controlled trials need to be considered. Further studies are required to provide clearer evidence on promising therapies like cyclosporine and etanercept.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Ophthalmology
Gabor Toth, Andrea Lukacs, Frank Schirra, Gabor L. Sandor, Petra Killik, Otto A. Maneschg, Zoltan Z. Nagy, Nora Szentmary
Summary: The aim of the review article was to summarize the current literature on Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN). SJS/TEN is a serious multi-system, immune-mediated, mucocutaneous disease with a high mortality rate and potential for ocular complications. Early diagnosis, timely amniotic membrane transplantation, and aggressive topical management are important for preventing long-term eye problems. Ophthalmologists should regularly examine patients in both the acute and chronic phases for comprehensive ophthalmic care.
OPHTHALMOLOGY AND THERAPY
(2023)
Review
Pharmacology & Pharmacy
Lin Cheng
Summary: Adverse drug reactions, particularly SJS and TEN, are a significant public health concern with high mortality rates and ineffective treatment options. Factors such as infections, mutations in drug metabolic enzymes, and immune responses contribute to SJS/TEN development. Future research directions include epigenetics, metabolites, and regulatory T cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hua-Ching Chang, Tsung-Jen Wang, Ming-Hsiu Lin, Ting-Jui Chen
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases caused by drugs. The effectiveness of systemic immunomodulating treatments for SJS/TEN is still controversial, but cyclosporine and biologic anti-TNF-alpha have shown promising results. Combination treatments are also being explored. Large-scale randomized controlled trials are needed for more definitive evidence. Advances in understanding the pathogenesis of SJS/TEN may inspire the discovery of potential therapeutic targets.
Article
Dermatology
Rentao Yu, Shuang Chen, Yun Pan, Chunrong Ma, Li Hu, Aijun Chen, Bin Wei
Summary: This study compared the effectiveness and side-effects of combined use of cyclosporine with glucocorticoids/IVIG in the treatment of SJS/TEN. The results showed that the combined use of cyclosporine could reduce the occurrence of systemic infection, accelerate re-epithelialization, and shorten the length of stay.
JOURNAL OF DERMATOLOGY
(2022)
Review
Dermatology
I Torres-Navarro, A. Briz-Redon, R. Botella-Estrada
Summary: Some treatments for SJS/TEN demonstrate better performance, such as cyclosporine and the combination of immunoglobulins with corticosteroids. However, there is still insufficient evidence to recommend widespread use in all patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, General & Internal
Ekaterina A. Nikitina, Daria S. Fomina, Ulyana A. Markina, Sergey S. Andreev, Yuri V. Streltsov, Tatiana S. Kruglova, Marina S. Lebedkina, Alexander V. Karaulov, Maryana A. Lysenko
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare syndromes characterized by necrotic skin and mucosal lesions. Drug-induced mechanisms are the most common cause, with certain drugs posing a higher risk. There is no gold standard treatment, but TNF-α inhibitors have shown promise in SJS/TEN cases.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Ting-Jung Hsu, Hsu-Hang Yeh, Chih-Hung Lee, Kwei-Lan Liu
Summary: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal adverse drug reactions. The most common culprit drug is carbamazepine, which has a strong association with HLA-B*15:02. There is no statistically significant correlation between in-hospital stay and the average daily dose of corticosteroids.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Nicolas Glasson, Cecile De Sandre, Olivier Pantet, Antoine Reinhard, Karma Lambercy, Kishore Sandu, Francois Gorostidi
Summary: This study evaluated ENT mucosal lesions in severe toxic epidermal necrolysis patients and proposed a management algorithm to prevent long-term debilitating sequalae of these lesions.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Kathleen F. O'Brien, Sarah E. Bradley, Caroline M. Mitchell, Michael A. Cardis, Melissa M. Mauskar, Helena B. Pasieka
Summary: This study examined the acute and chronic vulvovaginal involvement in toxic epidermal necrolysis, providing comprehensive care recommendations for both adult and pediatric patients. Treatment strategies, including medication use, menstrual suppression, physical therapy, and surgical referrals, should be individualized based on each patient's specific needs.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Pan Lv, Jiangxia Huang, Qianru Yang, Ting Yang, Xianwei Cao, Ougen Liu, Zhibin Zhang
Summary: This study analyzed the expression profiles of circRNAs in peripheral blood mononuclear cells of SJS/TEN patients and found a correlation between circRNA expression and disease severity. Specifically, hsa_circ_0083619 was identified as a potential indicator for SJS/TEN severity and a circRNA-miRNA-mRNA network was constructed. The study suggests that the hsa_circ_0083619/miR-18a-5p/BCL2L10 axis may play a role in the pathogenesis of SJS/TEN.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Huinan Suo, Biling Jiang, Xiaoyan Sun, Jing Dong, Mahin Alamgir, Xin Guan, Hua Su, Yan Liu, Yuting Xia, Nuoya Zhou, Aiping Feng, Juan Tao
Summary: The accuracy of ABCD-10 and SCORTEN in predicting in-hospital mortality in central China's cohort was compared. ABCD-10 performed well overall but underestimated mortality, showing inferior performance to SCORTEN, with slightly better results on day 3 of hospitalization.
Review
Medicine, General & Internal
Eri Tsukagoshi, Yoichi Tanaka, Yoshiro Saito
Summary: Drug-related Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse drug reactions, with predicting their onset remaining challenging. Pharmacogenomic information on drug labels may differ among countries, but CPIC guidelines provide a scientifically sound goal for future pharmacogenomic implementation.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
E. J. Roberts, V. Melchionda, G. Saldanha, S. Shaffu, J. Royle, K. E. Harman
Summary: Toxic epidermal necrosis (TEN)-like lupus is a rare condition that occurs in patients with acute severe flares of systemic lupus erythematosus, characterized by epidermal loss and mucosal ulceration. This condition may resemble drug-induced Stevens-Johnson syndrome/TEN, but differs in the absence of a suitable culprit drug and the context of acute lupus, requiring early input from Rheumatologists for appropriate management.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)