Article
Ophthalmology
Yun Hsia, Yi-Ting Hsieh
Summary: The morphology of macular retinal vasculature was found to be associated with the severity of idiopathic epiretinal membrane (ERM). Increased average vessel diameter, decreased skeleton density, decreased fractal dimension, and decreased vessel tortuosity were all indicators of more severe ERM and associated visual impairment. These parameters can serve as good indicators for assessing the severity of ERM and its impact on visual function.
Article
Ophthalmology
Roberto dell'Omo, Mariaelena Filippelli, Serena De Turris, Luca Cimino, David H. Steel, Carlos E. Pavesio, Andrea Govetto, Ismael Chehaibou, Francesco Parmeggiani, Mario R. Romano, Lucia Ziccardi, Enza Pirozzi, Ciro Costagliola
Summary: The study aimed to investigate FA findings in eyes with LMH and ERM foveoschisis, revealing that central and peripheral leakage are common in these conditions while perivascular leak and disc hyperfluorescence are less frequently observed. These findings suggest that breakdown of the retinal blood barrier is often associated with these vitreoretinal disorders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Qinying Huang, Jinying Li
Summary: This study aimed to compare the effects of Idiopathic epiretinal membrane (iERM) removal with or without internal limiting membrane (ILM) peeling on visual acuity and central macular thickness. The short-term benefits of ILM peeling for BCVA improvement and reduction of ERM recurrence were observed, but long-term changes in BCVA and CMT were similar with or without ILM peeling. Further large scale randomized trials with functional measures are needed to confirm these findings.
Article
Medicine, General & Internal
Zhengxi Zhang, Jianbo Mao, Jimeng Lao, Nuo Chen, Xinyi Deng, Yijing Chen, Jiwei Tao, Yiqi Chen, Lijun Shen
Summary: This study examined the foveal stereo deviations in different stages of idiopathic epiretinal membrane and assessed its predictive utility for visual acuity. The foveal stereotaxic displacement was estimated through OCT images, and the correlations between structural parameters and visual acuity were evaluated. The results showed that certain parameters were significantly correlated with baseline and postoperative visual acuity, with total distance being the strongest predictor.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Mary Romano, Fiammetta Catania, Jose Luis Vallejo-Garcia, Tania Sorrentino, Emanuele Crincoli, Paolo Vinciguerra
Summary: This study correlates postoperative optical coherence tomography (OCT) thickness changes of each retinal layer with different patterns of visual recovery after idiopathic epiretinal membrane (ERM) surgery. It finds specific layer thickness changes associated with different patterns of visual acuity recovery, which could help identify cases with poor or delayed visual recovery despite the absence of other known risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Jun Sik Kim, Min Kim, Sun Woong Kim
Summary: This study aimed to determine the prevalence and risk factors of epiretinal membrane (ERM) using spectral-domain optical coherence tomography (SD-OCT). Data from the Korea National Health and Nutrition Examination Survey were analyzed, and the adjusted prevalence of ERM was found to be 7.0%. Age, history of cataract surgery, well-controlled hypertension, and diabetic retinopathy were identified as risk factors for ERM.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Raoul Kanav Khanna, Marta Dorvault, Jeremy Pasco, Ann-Rose Cook, Tiphanie Pichard, Marie-Therese Marotte, Pierre-Jean Pisella, Sophie Arsene
Summary: The removal of unilateral idiopathic epiretinal membrane (uiERM) significantly improves monocular and binocular visual function, as well as vision-related quality of life (VR-QoL). Postoperatively at 6 months and 2 years, various visual parameters and questionnaire scores showed significant improvements.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Andrea M. Coppe, Giuliana Lapucci, Guido Ripandelli, Francesca R. Pesci, Luca Buzzonetti, Giancarlo Iarossi
Summary: The study found that in patients with unilateral idiopathic epiretinal membrane, fellow eyes showed significantly reduced ganglion cell layer thickness and vessel density in the superficial capillary plexus. These results suggest that a vascular defect in the superficial capillary plexus may lead to cellular loss in the inner retina, contributing to the proliferation of epiretinal membrane.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
I-Hsin Ma, Chung-May Yang, Yi-Ting Hsieh
Summary: The study reported on anatomical characteristics of wide-based foveal pit and its possible associations with macular diseases. Eyes with wide-based foveal pits demonstrated larger FAZ and wider RAT, indicating a predisposition to idiopathic epiretinal membrane formation. Fellow eyes of these cases also showed a tendency towards epiretinal membrane and macular hole formation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Annegret Hetzel, Jonas Neubauer, Faik Gelisken
Summary: The purpose of this study was to investigate the clinical and morphological characteristics of epiretinal membrane (ERM)-Foveoschisis. They studied 175 eyes with ERM-Foveoschisis and analyzed their OCT features and best corrected visual acuity (BCVA). They identified different types of ERM-Foveoschisis based on the OCT examination and found that closed ERM-Foveoschisis had higher central foveal thickness (CFT) and lower BCVA than the open type.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Rossella D'Aloisio, Paolo Carpineto, Agbeanda Aharrh-Gnama, Carla Iafigliola, Luca Cerino, Marta Di Nicola, Annamaria Porreca, Lisa Toto, Rodolfo Mastropasqua
Summary: This observational comparative study using WSS-OCTA examined early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for iERM or MH. The study found significant increases in PD of SCP and DCP postoperatively in both groups, indicating potential for monitoring and predicting surgery outcomes.
Article
Ophthalmology
Yu-Chieh Ko, Yen-Cheng Chen, Yi-Ming Huang, Yu-Fan Chang, Yu-Bai Chou, Catherine Jui-ling Liu, Shih-Jen Chen
Summary: This study aimed to evaluate the visual outcomes after idiopathic epiretinal membrane surgery in glaucomatous and nonglaucomatous eyes. The study found that glaucoma patients had smaller improvements in visual acuity compared to nonglaucoma patients. Preoperative visual field defects in glaucoma patients were correlated with changes in visual acuity postoperatively.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Jee Hyun Jeong, Kyung Tae Kang, You Hyun Lee, Yu Cheol Kim
Summary: Patients with preoperative idiopathic epiretinal membrane (ERM) may have a higher risk of pseudophakic cystoid macular edema (PCME) after cataract surgery, and the likelihood of PCME development increases with higher ERM grades. Therefore, careful attention should be given to patients with preexisting ERM and ectopic inner foveal layer before cataract surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Seong Joon Ahn, Se Joon Woo, Kyu Hyung Park
Summary: This study aimed to evaluate the incidence and clinical course of recurrent epiretinal membrane (ERM) after ERM surgery, and identified predisposing OCT findings for the recurrence, such as neighboring remnant membrane, hyperreflective dots on the retinal surface, and postoperative inner retinal wrinkling. Optical coherence tomography examination may be useful for the prediction and sensitive detection of recurrent ERM.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Thibaud Mathis, Batoul El Ameen, Cristina Vartin, Yasmine Serrar, Frederic Matonti, Aditya Sudhalkar, Alper Bilgic, Amina Rezkallah, Laurent Kodjikian
Summary: This study examined the validity of using anatomical criteria alone to make retreatment decisions in patients with DME, compared to the gold standard that incorporates visual acuity. The OCT-guided strategy yielded equivalent results to the gold standard in 82.7% of cases, with variations in sensitivity and specificity based on the patient's treatment regimen.
Article
Ophthalmology
Un Chul Park, In Hwan Cho, Sang Woong Moon, Hyeong Gon Yu
OCULAR IMMUNOLOGY AND INFLAMMATION
(2018)
Article
Ophthalmology
Baek-Lok Oh, Jeong Seok Lee, Hee Young Lee, Hyeong Gon Yu
OCULAR IMMUNOLOGY AND INFLAMMATION
(2019)
Article
Multidisciplinary Sciences
Dae Joong Ma, Un Chul Park, Ei Tae Kim, Hyeong Gon Yu
Article
Multidisciplinary Sciences
Sung Wook Park, Woonhyung Ghim, Sanghyeon Oh, Yejin Kim, Un Chul Park, Jaeseung Kang, Hyeong Gon Yu
Article
Ophthalmology
Ashish Sharma, Baruch D. Kuppermann, Francesco Bandello, Paolo Lanzetta, Dinah Zur, Sung Wook Park, Hyeong Gon Yu, V. R. Saravanan, Leandro Cabral Zacharias, Alan K. Barreira, Matias Iglicki, Fernando Miassi, Daniele Veritti, Sean Tsao, Deepika Makam, Nidhee Jain, Anat Loewenstein
Article
Ophthalmology
Un Chul Park, Hyeong Gon Yu
Summary: This study evaluated changes in ocular inflammation and SCT after PPV in VKH patients, finding that PPV improved vision but an increase in SCT in the early postoperative period may lead to uveitis recurrence.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Un Chul Park, Dae Joong Ma, Woon Hyung Ghim, Hyeong Gon Yu
SCIENTIFIC REPORTS
(2019)
Article
Medical Laboratory Technology
Eun Kyoung Lee, Young Joo Kim, Won-Jun Shon, Hyeong Gon Yu
TRANSLATIONAL RESEARCH
(2020)
Article
Ophthalmology
Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee, Hyeong Gon Yu
Summary: The study investigated the incidence and risk factors of blindness in uveitis patients. It found that the incidence of unilateral and bilateral blindness was 2.93 and 0.42 per 1,000 person-years, with risk factors including age, low household income, and Behcet's disease. These findings can help in understanding and planning healthcare strategies for uveitis patients.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Sanghyeon Oh, Young Joo Kim, Eun Kyoung Lee, Sung Wook Park, Hyeong Gon Yu
Article
Ophthalmology
Un Chul Park, Bo Hee Kim, Hye Rim Choe, Dong Yun Yeon, Hyeong Gon Yu
Summary: The study demonstrates that reduced-fluence PDT is an effective and safe rescue treatment for patients with type 1 neovascularization refractory to anti-VEGF. Although therapeutic efficacy wore off during long-term follow-up, rescue PDT may be repeated safely.
ACTA OPHTHALMOLOGICA
(2021)
Article
Genetics & Heredity
Dae Joong Ma, Hyun-Seob Lee, Kwangsoo Kim, Seongmin Choi, Insoon Jang, Seo-Ho Cho, Chang Ki Yoon, Eun Kyoung Lee, Hyeong Gon Yu
Summary: This study conducted genetic analysis of IRD patients in Korea using WES, identifying various causative genes and providing important reference for future genetic screening and treatment development.
BMC MEDICAL GENOMICS
(2021)
Article
Ophthalmology
Bo Hee Kim, Un Chul Park, Sung Wook Park, Hyeong Gon Yu
Summary: The study found that UWFA scores significantly improved in Behcet's uveitis patients treated with adalimumab, and further improvement of UWFA scores was observed even in patients with clinically quiescent inflammation.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Chang Ki Yoon, Kunho Bae, Hyeong Gon Yu
Summary: This study investigates the longitudinal changes in the retinal and choroidal microstructure in patients with retinitis pigmentosa. The results show that the thickness of the ganglion cell inner plexiform layer, outer nuclear layer, and inner segment ellipsoid decreases at the moderate stage, while the retinal nerve fiber layer and ganglion cell inner plexiform layer thickness decrease at the advanced stage. Choroidal thickness also decreases continuously. Additionally, retinal pigment epithelium atrophy and choroidal vascular index reduction are prominent at the advanced stage.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Chang Ki Yoon, Jaeryung Oh, Kunho G. Bae, Un Chul G. Park, Kyung-Sang G. Yu, Hyeong Gon G. Yu
Summary: This study demonstrates the efficacy, safety, and immunogenicity equivalence of the proposed biosimilar CKD-701 with the reference ranibizumab in treatment-naive patients with neovascular age-related macular degeneration (nAMD). Individualized treatment regimen of PRN dosing achieves improvement and maintenance of visual outcome.
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)