Article
Biochemistry & Molecular Biology
Ana Rita Fernandes, Aleksandra Zielinska, Elena Sanchez-Lopez, Tiago dos Santos, Maria Luisa Garcia, Amelia M. Silva, Jacek Karczewski, Eliana B. Souto
Summary: This review discusses the latest developments in treatment options for age-related macular degeneration (AMD), including pharmacologic therapies and laser treatments for exudative AMD. However, there are still no successful treatments for nonexudative AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Burak Mergen, David J. Ramsey
Summary: The study found a significantly lower rate of diagnosed glaucoma or its suspicion in patients with exudative AMD compared to non-exudative AMD. There was a significant difference in the rates of suspected glaucoma between the two groups. The retrospective application of clinical criteria may help identify potential underdiagnosis of glaucoma in AMD patients.
Review
Chemistry, Multidisciplinary
Aira Sarkar, Sathish Dyawanapelly
Summary: AMD, the third leading cause of worldwide blindness that causes permanent central vision impairment in older people, has seen significant progress in diagnosis and therapy in recent years. Current diagnostic and therapeutic strategies are clinically limited, and intravitreal injection therapy has its shortcomings, leading to the investigation of engineered nanoformulations for managing AMD.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Ophthalmology
Liangbo L. Shen, Mengyuan Sun, Aneesha Ahluwalia, Michael M. Park, Benjamin K. Young, Eleonora M. Lad, Cynthia Toth, Lucian Del Priore
Summary: This study tracked the progression of eyes with geographic atrophy (GA) involving the central 1 mm diameter zone and found that the central residual effective radius (CRER) declined linearly over approximately 13 years. This finding suggests that CRER could serve as an anatomical endpoint in future clinical trials aiming to preserve the central zone.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Tommaso Bacci, Juliet O. Essilfie, Belinda C. S. Leong, K. Bailey Freund
Summary: The study describes a new clinical phenotype of exudative non-neovascular AMD characterized by intraretinal exudation causing macular edema. It emphasizes the importance of multimodal imaging in differentiating this condition from other manifestations of AMD. Further research is needed to assess the clinical impact and optimal management of exudative non-neovascular AMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Marco Rispoli, Gilda Cennamo, Luca Di Antonio, Marco Lupidi, Mariacristina Parravano, Marco Pellegrini, Daniele Veritti, Stela Vujosevic, Maria Cristina Savastano
Summary: This article provides an overview of current macular imaging techniques and describes the biomarkers that may be useful in the routine management of macular diseases, particularly exudative age-related macular degeneration (AMD). The authors discuss the use of optical coherence tomography (OCT) and OCT angiography (OCTA) in macular imaging, classification of exudative AMD, and biomarkers in structural OCT and OCTA. The integration of technologically-advanced imaging equipment with AI software is expected to enhance patient care in the future.
SURVEY OF OPHTHALMOLOGY
(2023)
Review
Medicine, Research & Experimental
Alexandre Vallee
Summary: This review article describes the different mechanisms of curcumin in exudative AMD, focusing on its effects on oxidative stress, inflammation, and angiogenesis, by interacting with Wnt/beta-catenin signaling.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Christin Henein, David H. W. Steel
Summary: There is uncertainty regarding the effectiveness of PBM treatment in slowing the progression of non-exudative macular degeneration. Well-designed controlled trials with appropriate dosimetry, powered for effectiveness and safety outcomes are needed. Adoption of agreed clinical outcome measures and patient-based outcome measures for AMD should be considered.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Engineering, Environmental
Meixin Ran, Yaxin Deng, Jiaqi Yan, Anan Zhang, Ying Wei, Xiaowen Li, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Jun Kong, Han Zhang, Hongbo Zhang, Yu Zhang
Summary: In this study, a bionic nano-eye-drop with enhanced ocular penetrability and lesion recognizability was developed for the photodynamic therapy (PDT) of wet age-related macular degeneration (wAMD), inspired by the neovascular targeting ability of endogenous low-density lipoproteins (LDL). The nano-eye-drop effectively delivered the laser-induced PDT agent, verteporfin (VP), into neovascular that overexpress LDL receptors, leading to neovascular inhibition and inflammation alleviation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Kyungseon Choi, Sang Jun Park, Sola Han, Yongseok Mun, Da Yun Lee, Dong-Jin Chang, Seok Kim, Sooyoung Yoo, Se Joon Woo, Kyu Hyung Park, Hae Sun Suh
Summary: This study evaluated the patient-centered economic burden of exudative AMD for two years, demonstrating a significant impact on reimbursement, nonreimbursement, and out-of-pocket costs. This highlights the need for expanded reimbursement strategies for patients with this condition.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Biochemistry & Molecular Biology
Marco Rispoli, Chiara M. Eandi, Luca Di Antonio, Raphael Kilian, Andrea Montesel, Maria C. Savastano
Summary: The study revealed that a single injection of Brolucizumab significantly reduced the maximum height of PED in the short term, without impacting the horizontal maximum diameter of PED and the flow area of macular neovascularization. No signs of ocular inflammation were observed during the follow-up period.
Review
Medicine, General & Internal
Rajendra S. Apte
Summary: Age-related macular degeneration is the leading cause of vision loss in older persons in industrialized nations. Micronutrient supplementation and anti-vascular endothelial growth factor pharmacotherapy can reduce the risk of progression. Baseline examination by eye care providers and ancillary testing are essential for diagnosis and treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cell Biology
Alvita Vilkeviciute, Dzastina Cebatoriene, Loresa Kriauciuniene, Rasa Liutkeviciene
Summary: Our study revealed a protective role of VEGFA rs3025033 and the haplotype rs1570360A-rs699947A-rs3025033G-rs2146323A in exudative AMD in the Caucasian population. Additionally, we found an association between rs699947 and elevated VEGF-A serum concentrations in exudative AMD.
Article
Ophthalmology
Michael N. Cohen, Denis O'Shaughnessy, Kate Fisher, Jennifer Cerami, Carl C. Awh, Daniel E. Salazar, Philip Rosenfeld, Jeffrey S. Heier
Summary: The X-82 oral therapy combined with pro re nata anti-VEGF injections showed non-inferiority in visual acuity outcomes compared with placebo, and there was a dose-dependent decrease in the number of anti-VEGF injections over the 52-week period. However, due to limited tolerability and safety issues observed, X-82 does not have a sufficient benefit to risk profile in the treatment of AMD patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mihyun Choi, Somin Ahn, Cheolmin Yun, Seong-Woo Kim
Summary: In type 1 neovascular age-related macular degeneration (NVAMD), neovascularization patterns with fine branching vessels (C + F + group) were found to be associated with exudative activity. Quantitative analysis revealed that the number of endpoints was related to exudation in the C + F + group.
Article
Ophthalmology
Hyun Goo Kang, Tae Young Kim, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study evaluated the clinical features and OCTA findings of MEWDS patients and found that some patients may develop overlapping MFC in the same or fellow eyes, with dynamic changes in choroidal thickness.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Hyeong Ju Byeon, Ji Hwan Lee, Junwon Lee, Eun Young Choi, Yong Joon Kim, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study compared the therapeutic effect of standard-dose photodynamic therapy (PDT) with modified double-dose PDT in patients with circumscribed choroidal haemangioma (CCH). The results showed that the modified double-dose group achieved greater tumor regression and potentially better resolution of subretinal fluid compared to the standard PDT group.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jay Jiyong Kwak, Dong Hyun Lee, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study investigated the association between visual field defects and blood vessel network (BVN) formation in optic disc melanocytomas (ODMs) using optical coherence tomography angiography (OCTA). The results showed that the location of BVN absence within ODMs corresponded to the location of visual field defect and the location of fluorescein angiography (FA) hypofluorescence. Visual field defect was more severe in the incomplete BVN group than in the complete BVN group, and it was more significantly associated with the area of BVN absence than the tumor area.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Hyo Song Park, Yong Joon Kim, Eun Young Choi, Sung Chul Lee, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Summary: This study examined the origins and natural course of focal scleral nodules using multimodal imaging. The majority of lesions were solitary and confined to the sclera. Most lesions showed outer retinal abnormalities and choroidal thinning or absence. The study found that these lesions are relatively stable over time.
Article
Ophthalmology
Seok Hyun Bae, Hye Kyoung Hong, Jong Young Lee, Min Seok Kim, Christopher Seungkyu Lee, Min Sagong, Sook Young Kim, Baek-lok Oh, Young Hee Yoon, Jae Pil Shin, Young Joon Jo, Kwangsic Joo, Sang Jun Park, Kyu Hyung Park, Se Joon Woo
Summary: This study evaluated the diagnostic efficacy of plasma antiretinal autoantibody (ARA) profiling for autoimmune retinopathy (AIR). The results showed that the detection rates of anticone-rod homeobox/cone-rod retinal dystrophy 2, heat shock protein 60, and aldolase C autoantibodies in AIR patients were higher compared to the RP and normal control groups.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Kirill Zaslavsky, Teresa Park, Rachel Lang Mcinnis, Mark Mandell, Jihwan Lee, Christopher Lee, Rose Gilbert, Larissa Derzko-Dzulynsky
Summary: The study systematically reviewed various treatment modalities for choroidal neovascularization (CNV) associated with punctate inner choroidopathy (PIC). Anti-VEGF agents were found to decrease the likelihood of moderate visual loss, although their effect was moderated by presenting visual acuity and patient age. Increasing the number of treatment modalities was associated with longer follow-up time, but did not improve vision.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Hae Rang Kim, Nang Kyeong Lee, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Summary: This study aimed to evaluate the association between retinal vascular occlusion and stages of hypertension. The results showed that elevated BP, stage 1 hypertension, and stage 2 hypertension were all associated with a higher risk of retinal vascular occlusion compared to normal BP. Controlling hypertension appeared to reduce the risk, but the incidence rate was still significantly higher than that in individuals with normal BP.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Seonghee Choi, Sung Chul Lee, Seok Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Summary: This study aimed to investigate the clinical characteristics and outcomes of peripheral exudative hemorrhagic chorioretinopathy (PEHCR) in Asian patients. The mean age of the patients was 70 years, with 75.9% of them being women. Vitreous hemorrhage occurred in 51.5% of eyes during follow-up, and it was associated with thicker baseline subfoveal choroid and male sex. The final visual acuity was worse than 20/200 in 29.2% of eyes, and factors predictive of poor final visual acuity included initial poor visual acuity, extensive peripheral retina involvement, subretinal hemorrhage extension to the macula, and absence of complete tumor regression.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Medicine, General & Internal
Soyoung Ryu, Hoon-Chul Kang, Sung Chul Lee, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Summary: The purpose of this study was to examine refractive errors, retinal manifestations, and genotype in tuberous sclerosis complex (TSC) patients in a Korean population. A total of 98 TSC patients were enrolled in a retrospective cohort study. The findings showed that TSC1 variant patients were more myopic, while TSC2 variant patients showed association with more extensive involvement of retinal astrocytic hamartoma.
YONSEI MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Chae Eun Lee, Nang Kyung Lee, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Summary: This study investigated the possible association between polycystic ovary syndrome (PCOS) and non-infectious uveitis. The results showed that PCOS patients had a higher incidence of non-infectious uveitis, which may be related to hormonal changes and proinflammatory factors.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Junwon Lee, Han Jeong, Hyun Goo Kang, Jinkyu Park, Eun Young Choi, Christopher Seungkyu Lee, Suk Ho Byeon, Min Kim
Summary: This study establishes a rapid and accurate diagnostic method for pathogen detection in infectious uveitis using nanopore metagenomic next-generation sequencing (NGS). Compared with conventional methods, nanopore sequencing can identify all causative pathogens with a shorter turnaround time. It is also capable of detecting pathogens even when the quantity or quality of DNA is suboptimal.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Genetics & Heredity
Dong Geun Kim, Kwangsic Joo, Jinu Han, Mihyun Choi, Seong-Woo Kim, Kyu Hyung Park, Sang Jun Park, Christopher Seungkyu Lee, Suk Ho Byeon, Se Joon Woo
Summary: The study aimed to investigate the clinical characteristics of Korean patients with retinal dystrophy associated with pathogenic variants of the CRX gene. Eleven patients with CRX-RD were included in the study, and their clinical features and genotype-phenotype correlation were analyzed. The study found that pathogenic variants within the homeodomain of the CRX gene mainly resulted in cone-rod dystrophy or macular dystrophy with bull's eye maculopathy, while variants downstream of the homeodomain caused more diverse phenotypes, including cone-rod dystrophy, Leber congenital amaurosis, and retinitis pigmentosa. Further molecular research is needed to explore this correlation.
Article
Ophthalmology
Yong Joon Kim, Hyo Song Park, Jeonghwan Youk, Jung Woo Han, Suk Ho Byeon, Sung Soo Kim, Young Seok Ju, Christopher Seungkyu Lee
Summary: This study found that some retinoblastoma patients carry germline BRCA1/2 family variants, which may be associated with the development of retinoblastoma along with RB1 mutations.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Genetics & Heredity
Young Hoon Jung, Jay Jiyong Kwak, Kwangsic Joo, Hyuk Jun Lee, Kyu Hyung Park, Min Seok Kim, Eun Kyoung Lee, Suk Ho Byeon, Christopher Seungkyu Lee, Jinu Han, Junwon Lee, Chang Ki Yoon, Se Joon Woo
Summary: This study investigated the clinical features, natural course, and genetic characteristics of Koreans with rhodopsin-associated retinitis pigmentosa (RHO-associated RP). The study found that the generalized RP group had a higher rate of visual field impairment progression to late-stage RP compared to the sector RP group. Best-corrected visual acuity deterioration was observed only in the generalized RP group. The study also identified several RHO gene mutations, including some that presented with both generalized and sector RP phenotypes.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Jae Yong Han, Yong Joon Kim, Eun Young Choi, Junwon Lee, Ji Hwan Lee, Min Kim, Suk Ho Byeon, Sung Soo Kim, Christopher Seungkyu Lee
Summary: Oral spironolactone therapy showed therapeutic benefits in improving subretinal fluid and subfoveal choroidal thickness in patients with central serous chorioretinopathy, but frequent recurrence should be noted.
YONSEI MEDICAL JOURNAL
(2022)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
