Article
Obstetrics & Gynecology
Putora Katharina, Hornung Rene, Kinkel Janis, Fischer Tina, Putora Paul Martin
Summary: This study aimed to investigate guidelines on preterm birth, analyze decision-criteria, and identify consensus and discrepancies among these guidelines. The results showed that a shortened cervix and a history of preterm birth are relevant in singleton pregnancies. Most guidelines recommend progesterone treatment for cases with no history of preterm birth and with a shortened cervix.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Corina N. Schoen, Heather Frey, Alexis C. Gimovsky, Edward Springel, Sami Backley, Vincenzo Berghella
Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Vincenzo Berghella, Moti Gulersen, Amanda Roman, Rupsa C. Boelig
Summary: After the withdrawal of 17-alpha hydroxyprogesterone caproate by the FDA, recommendations for the management of patients with singleton pregnancy and previous spontaneous preterm birth have varied among national societies. This article highlights the use of vaginal progesterone for preventing recurrent spontaneous preterm birth in singleton pregnancies, based on randomized trial data and translational evidence. It suggests offering prophylactic vaginal progesterone starting at 16 weeks and 0 days every night to patients with singletons and previous singleton spontaneous preterm birth, irrespective of cervical length. If a transvaginal ultrasound detects a cervical length = 25 mm at <24 weeks, the progesterone should be continued along with cerclage placement.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Shimrit Shor, Ariel Zimerman, Ron Maymon, Michal Kovo, Maya Wolf, Ifat Wiener, Jacob Bar, Yaakov Melcer
Summary: The study compared the outcomes of pregnant women with short cervical length managed with different treatment protocols. The combination therapy involving vaginal progesterone, cervical cerclage, and Arabin cervical pessary emerged as a promising management strategy for pregnant women at high risk for preterm delivery. Additional studies are required to confirm these findings.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jee Yoon Park, Young Mi Jung, Song-Yi Kook, Se Jeong Jeon, Kyung Joon Oh, Joon-Seok Hong
Summary: The use of postoperative vaginal progesterone was found to be associated with significantly lower rates of preterm birth and longer gestational age at delivery in women who underwent ultrasound-indicated cervical cerclage placement.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Anne -Marie Aubin, Liam McAuliffe, Kimberley Williams, Ashad Issah, Rosanna Diacci, Jack E. McAuliffe, Salma Sabdia, Jason Phung, Carol A. Wang, Craig E. Pennell
Summary: This study aimed to determine the efficacy of combining cervical cerclage and vaginal progesterone in the prevention of preterm birth. The results showed that combined therapy was associated with a lower risk of preterm birth and better outcomes compared to single therapy.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
David B. Nelson, Donald D. McIntire, Kenneth J. Leveno
Summary: This article discusses the results of a clinical trial in the US on preterm birth prevention, which failed to demonstrate the effectiveness of a drug in preventing recurrent preterm birth, leading to reflections on accelerated approval and pharmaceutical regulatory processes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Pharmacology & Pharmacy
Asad Mir, Richa V. Vartak, Ketan Patel, Steven M. Yellon, Sandra E. Reznik
Summary: Preterm birth is a major cause of infant morbidity and mortality worldwide. Advances in nanomedicine have allowed for the delivery of drugs to the female reproductive tract through vaginal administration, providing new possibilities for treating preterm birth. Studies using murine models have also provided insights into the role of the cervix in pregnancy and parturition. These recent developments indicate a paradigm shift in the field of reproductive biology for treating preterm birth.
Article
Obstetrics & Gynecology
Azin Alavi, Amene Ranjbar, Farzane Atighpoor, Shahram Zare
Summary: In this study, vaginal progesterone and 17OHP-C showed similar efficacy in preventing preterm birth and neonatal outcomes. However, the incidence of adverse events was higher in the 17-OHP-C group compared to the vaginal progesterone group.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
James J. Cummings, Arun K. Pramanik
Summary: The American Academy of Pediatrics provides updated recommendations on the use of postnatal corticosteroids to manage chronic lung disease in preterm neonates, emphasizing the importance of individualized clinical judgment and shared decision-making with parents.
Review
Medicine, General & Internal
Ulla-Britt Wennerholm, Lina Bergman, Pihla Kuusela, Elin Ljungstrom, Anna C. Moller, Cecilie Hongslo Vala, Ann-Catrin Ekelund, Ann Liljegren, Max Petzold, Petteri Sjogren, Mikael Svensson, Annika Strandell, Bo Jacobsson
Summary: This systematic review examined randomized controlled trials on the prevention of preterm birth in asymptomatic women. It found that progesterone and cerclage can reduce the risk of preterm birth in singleton pregnancies, while pessary and acetylsalicylic acid have limited effectiveness. Screening programs are necessary to identify women at risk of preterm birth.
FRONTIERS IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Heather A. Frey, Matthew M. Finneran, Erinn M. Hade, Colleen Waickman, Courtney D. Lynch, Jay D. Iams, Mark B. Landon
Summary: Vaginal progesterone is not inferior to 17-alpha hydroxyprogesterone caproate (17OHP-C) in preventing recurrent preterm birth (PTB). However, further randomized trials are needed to confirm these findings and consider other factors that may affect the effectiveness of the treatments.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Doron Kabiri, Yael Hamou, Gali Gordon, Yosef Ezra, Ilan Matok
Summary: A study on 1,048 pregnant women found that vaginal micronized progesterone significantly reduces the risk of preterm birth in women with a shortened cervix in the second trimester; there was no significant difference in the effectiveness of vaginal gel and vaginal capsules containing micronized progesterone for preventing preterm birth.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
David B. Nelson, Ashlyn Lafferty, Chinmayee Venkatraman, Jeffrey G. McDonald, Kaitlyn M. Eckert, Donald D. McIntire, Catherine Y. Spong
Summary: Preterm birth is a significant public health concern in obstetrics, affecting approximately 15 million births worldwide. This study aimed to evaluate the effectiveness of vaginal progesterone for preterm birth prevention. The findings showed that the recurrence rate of preterm birth was higher in the vaginal progesterone treatment group compared to the historical control group. Moreover, analysis based on treatment adherence and specific sequences of prior preterm births and term births did not show a lower recurrence rate with vaginal progesterone treatment.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Obstetrics & Gynecology
Olivet Martinez, Hannah Kang Moran, Sharon Fitzgerald Wolff, Charles Gibbs, Gene Lee, Kelly Gorman, Angela Martin
Summary: The study compared vaginal progesterone to cerclage in preventing preterm birth and adverse perinatal outcomes among singleton gestations with incidentally found short cervix (<15mm) and no history of preterm birth, and found no significant difference between the two treatments in terms of reducing preterm birth risk and prolonging gestation.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Santosh Pandipati, C. Andrew Combs, Alan Fishman, Sarah Y. Lee, Kimberly Mallory, Francesca Ianovich
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Meeting Abstract
Obstetrics & Gynecology
Jodi Lapidus, C. Andrew Combs, Michael Gravett, Thomas Garite, Jerome Lapointe
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Obstetrics & Gynecology
C. Andrew Combs, Thomas J. Garite, Kimberly Maurel, Diana Abril, Anita Das, William Clewell, Kent Heyborne, Helen How, Wilson Huang, David Lewis, George Lu, Hugh Miller, Michael Nageotte, Richard Porreco, Asad Sheikh, Lan Tran
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Obstetrics & Gynecology
C. Andrew Combs, Thomas J. Garite, Jodi A. Lapidus, Jerome P. Lapointe, Michael Gravett, Julie Rael, Erol Amon, Jason K. Baxter, Kim Brady, William Clewell, Keith A. Eddleman, Stephen Fortunato, Albert Franco, David M. Haas, Kent Heyborne, Durlin E. Hickok, Helen Y. How, David Luthy, Hugh Miller, Michael Nageotte, Leonardo Pereira, Richard Porreco, Peter A. Robilio, Hyagriv Simhan, Scott A. Sullivan, Kenneth Trofatter, Thomas Westover
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Obstetrics & Gynecology
C. Andrew Combs, Alan Fishman
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2016)
Editorial Material
Obstetrics & Gynecology
C. Andrew Combs
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Letter
Obstetrics & Gynecology
C. Andrew Combs, Michael Gravett, Thomas J. Garite
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Thomas J. Garite, C. Andrew Combs
CLINICS IN PERINATOLOGY
(2012)
Article
Obstetrics & Gynecology
C. Andrew Combs
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2012)
Editorial Material
Acoustics
Lisa Finch, C. Andrew Combs
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ming K. Zhou, C. Andrew Combs, Santosh Pandipati, Amber Del Rosario
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
C. Andrew Combs, Ramon Castillo, Carolyn Kline, Kisti Fuller, Emily L. Seet, Gilbert Webb, Amber del Rosario
Summary: This study evaluated the applicability of 5 established abdominal circumference norms for the diagnosis of abnormal fetal abdominal circumference. The World Health Organization standard had the best fit for the data.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Letter
Obstetrics & Gynecology
C. Andrew Combs, Darren L. Handler, Reese H. Clark
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Letter
Obstetrics & Gynecology
C. Andrew Combs, Ming-Kun Zhou, Santosh Pandipati, Amber Del Rosario
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
