Article
Medical Laboratory Technology
Yu Zhu, Ling Li, Ping Li
Summary: Vitamin D deficiency during pregnancy is common among women and can potentially affect the development and outcomes of gestational diabetes mellitus, but research results vary. Understanding the mechanisms of vitamin D deficiency on glucose metabolism and implementing vitamin D intervention are crucial for preventing and treating GDM.
CLINICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Waleed M. Aldahmash, Saleh H. Alwasel, Khaldoon Aljerian
Summary: Gestational diabetes mellitus poses significant risks to both the developing fetus and the mother, increasing the risk of maternal complications during pregnancy and later development of type 2 diabetes mellitus and cardiovascular disease. The study found that placental vasculopathies on both the maternal and fetal sides were significantly increased in the GDM group, indicating histopathological changes induced by GDM in the full-term placenta.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Health Care Sciences & Services
Arrigo Fruscalzo, Luigi Viola, Maria Orsaria, Stefania Marzinotto, Michela Bulfoni, Lorenza Driul, Ambrogio P. Londero, Laura Mariuzzi
Summary: This study found altered placental expression and staining pattern of STRA6 in pregnancies complicated by GDM compared to controls. These changes were associated with an altered expression pattern of several other genes involved in retinoid metabolism.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Huifeng Shi, Xiaoli Gong, Qing Sheng, Xiang Li, Ying Wang, Tianchen Wu, Yangyu Zhao, Yuan Wei
Summary: This study found an association between vitamin E (VE) levels and gestational diabetes mellitus (GDM) in pregnant women. Low first-trimester VE levels and subsequent decrease in VE during pregnancy were related to increased risk of GDM. These findings suggest the importance of consuming VE-rich foods and appropriate VE supplementation to prevent GDM in pregnant women with low baseline VE levels.
Article
Pharmacology & Pharmacy
Miaojuan Fan, Tongtong Pan, Wei Jin, Jian Sun, Shujun Zhang, Yali Du, Xinwei Chen, Qiong Chen, Wenxin Xu, Siew Woh Choo, Guanghui Zhu, Yongping Chen, Jie Zhou
Summary: The study revealed elevated expression of FGF4 in GDM patients, with rFGF4 treatment effectively normalizing adverse metabolic phenotypes and reducing neural tube defects in GDM mice. The findings suggest FGF4 as a potential diagnostic factor and therapeutic target for GDM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Thu T. M. Pham, Ya-Li Huang, Jane C. -J. Chao, Jung-Su Chang, Yi-Chun Chen, Fan-Fen Wang, Chyi-Huey Bai
Summary: The study found no significant association between 25(OH)D concentration and GDM risk, but individuals with vitamin D deficiency had a higher risk of developing GDM. Additionally, there was a nonlinear relationship between 25(OH)D and GDM risk.
Article
Nutrition & Dietetics
Minjia Mo, Bule Shao, Xing Xin, Wenliang Luo, Shuting Si, Wen Jiang, Shuojia Wang, Yu Shen, Jinhua Wu, Yunxian Yu
Summary: This study found that gene variants in the vitamin D metabolic and glucose pathways interact with vitamin D levels during pregnancy, potentially affecting the risk of gestational diabetes mellitus and its subtypes.
Article
Biochemistry & Molecular Biology
Maria Molina-Vega, Maria Jose Picon-Cesar, Fuensanta Lima-Rubio, Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Maria Suarez-Arana, Ana Maria Fernandez-Ramos, Francisco J. Tinahones, Sonsoles Morcillo
Summary: Vitamin D deficiency is common in pregnant women and is associated with a higher risk of gestational diabetes mellitus (GDM). In this study, it was found that pregnant women who required insulin for GDM had higher levels of vitamin D compared to those who did not require insulin and healthy controls at postpartum and 1 year after birth.
Article
Nutrition & Dietetics
Nuria Agueero-Domenech, Silvia Jover, Ana Sarrion, Javier Baranda, Jose A. Quesada-Rico, Avelino Pereira-Exposito, Vicente Gil-Guillen, Ernesto Cortes-Castell, Maria J. Garcia-Teruel
Summary: A relationship between vitamin D deficiency and gestational diabetes mellitus has been found, independent of body mass index.
Article
Endocrinology & Metabolism
Anna Papadopoulou, Eirini Thymara, Eirini Maratou, George Kanellopoulos, Vasiliki Papaevangelou, Sophia Kalantaridou, Spyridon Kanellakis, Pinelopi Triantafyllidou, George Valsamakis, George Mastorakos
Summary: This study evaluated the expression of placental LRP5 and sclerostin in pregnancies with gestational diabetes mellitus (GDM) and investigated their associations with umbilical sclerostin concentrations and clinical outcomes. The results showed that placental sclerostin and LRP5 were significantly higher in GDM mothers compared with non-GDM mothers, and placental sclerostin expression was positively correlated with maternal pregestational body mass index and fasting glucose concentrations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Alireza Milajerdi, Fatemeh Abbasi, Seyed Mohammad Mousavi, Ahmad Esmaillzadeh
Summary: The study revealed a significant association between vitamin D deficiency and an increased risk of GDM, with the lowest risk found among individuals with serum vitamin D levels within the range of 40-90 nmol/L.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Aleksandra S. Tkachuk, Elena A. Vasukova, Anna D. Anopova, Tatiana L. Karonova, Evgenii A. Pustozerov, Yana A. Teplova, Angelina Eriskovskaya, Artem O. Isakov, Elena Y. Vasilieva, Maria A. Kokina, Irina Y. Zazerskaya, Tatiana M. Pervunina, Elena N. Grineva, Polina Popova
Summary: Several meta-analyses have found that low maternal serum 25-hydroxyvitamin D (25(OH)D) levels are associated with gestational diabetes mellitus (GDM). However, this study examined the association between serum 25(OH)D concentration and GDM in Russian women and found no significant correlation. Additionally, the increased intake of vitamin D supplements during pregnancy did not result in higher levels of 25(OH)D.
Article
Cardiac & Cardiovascular Systems
Ishai Heusler, Tal Biron-Shental, Sivan Farladansky-Gershnabel, Yael Pasternak, Debora Kidron, Inna Vulih-Shuitsman, Yael Einbinder, Keren Cohen-Hagai, Sydney Benchetrit, Tali Zitman-Gal
Summary: The study evaluated the expression of Gal-3 in maternal blood and placental tissue of women with GDM, and found that Gal-3 expression was higher in GDM patients but lower in cord blood. This highlights the important role of the placenta in protecting the fetus from potential Gal-3 damage.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Kristof Y. Neven, Bianca Cox, Charlotte Cosemans, Wilfried Gyselaers, Joris Penders, Michelle Plusquin, Harry A. Roels, Karen Vrijens, Ann Ruttens, Tim S. Nawrot
Summary: The study found that higher placental iodine concentrations are associated with a lower risk of GDM, and lower placental iodine load is linked with altered plasma insulin concentration, HOMA-IR index, and beta-cell activity. These findings suggest that mild-to-moderate iodine deficiency may be associated with subclinical and early-onset changes in normal insulin homeostasis in healthy pregnant women, indicating a need for further research on the functional link between gestational iodine status and GDM.
Article
Nutrition & Dietetics
Eleonora Salakos, Tioka Rabeony, Marie Courbebaisse, Joelle Taieb, Vassilis Tsatsaris, Jean Guibourdenche, Marie-Victoire Senat, Hazar Haidar, Jacques C. Jani, Dragos Barglazan, Emeline Maisonneuve, Marie-Clotilde Haguet, Norbert Winer, Damien Masson, Caroline Elie, Jean-Claude Souberbielle, Alexandra Benachi
Summary: This study aimed to assess the relationship between vitamin D levels in the first trimester of pregnancy and the risk of GDM. The findings indicated that patients with 25OHD levels <20 ng/mL had a significantly increased risk of GDM, while there was no significant relationship with other thresholds. The study also showed a non-linear relationship between 25OHD levels and GDM risk, suggesting that the risk does not continuously decrease as 25OHD concentrations increase.
CLINICAL NUTRITION
(2021)
Article
Nanoscience & Nanotechnology
D. Tuvshin, T. Ochirkhuyag, S. C. Hong, D. Odkhuu
Summary: Ab initio electronic structure calculations show that interstitial 2p elements significantly affect the structural stability and intrinsic magnetic properties of L1(0)-phase FeNi. Among them, only B improves the stability of FeNi and increases its uniaxial magnetic anisotropy. The mechanism involves changes in Fe and Ni 3d levels due to charge rearrangement and 2p-3d hybridization.
Article
Engineering, Electrical & Electronic
Tumentsereg Ochirkhuyag, Soon Cheol Hong, Dorj Odkhuu
Summary: The intrinsic magnetic properties and uniaxial magnetic anisotropy of alpha ''-phase Fe16N2-xBx and Fe16N2-xCx alloys were investigated through first-principles calculations. The addition of B or C dopant atoms enhances tetragonal distortion, magnetic properties, and the K-u values of the alloys, while simultaneously reducing the magnetic moments of Fe atoms due to less electron transfer compared to N. The enhancement in K-u is attributed to Jahn Teller lattice distortion, atom-decomposed magnetocrystalline anisotropy, and orbital magnetism.
IEEE TRANSACTIONS ON MAGNETICS
(2021)
Article
Obstetrics & Gynecology
Hee-Sun Kim, Kyu-Min Lee, Sung Won Han, Geum Joon Cho, Han-Sung Hwang
Summary: This study found an association between pre-pregnancy body mass index and sensorineural hearing loss during pregnancy. However, SSNHL during pregnancy did not increase the risk during delivery or cause adverse perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yoonjee Park, Geum Joon Cho, Seung-Young Roh, Jin Oh Na, Min-Jeong Oh
Summary: Pregnancy-induced hypertension is significantly associated with the development of arrhythmia within 1 year after delivery, particularly atrial fibrillation. However, it does not increase the incidence of lethal arrhythmias. Arrhythmia, especially atrial fibrillation, may contribute significantly to future cardiovascular risk in women with a history of pregnancy-induced hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Materials Science, Multidisciplinary
T. Thuy Hoang, S. H. Rhim, S. C. Hong
Summary: This paper presents a systematic density functional study on alkali-metal-based half-Heusler compounds, revealing that most ACrZ compounds have a wide band gap and stable half-metallicity. The compounds LiCrZ and NaCrZ (Z = As, Sb) are proposed as promising candidates for spintronics applications, due to their stability, surface and strain tolerance, and good lattice mismatch with zinc-blende semiconductors.
PHYSICAL REVIEW MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Thi H. Ho, D. Odkhuu, S. H. Rhim, S. C. Hong
Summary: In this study, density functional calculations were used to investigate the magnetocrystalline anisotropy (MCA) of hcp and fcc Co films. The results reveal that symmetry, thickness, and surface have significant effects on the MCA of the films. The MCA energy of Co films is greatly enhanced compared to bulk, and thickness-dependent oscillations in MCA were observed.
CURRENT APPLIED PHYSICS
(2022)
Article
Chemistry, Physical
Tumentsereg Ochirkhuyag, Soon Cheol Hong, Dorj Odkhuu
Summary: In this study, it was theoretically demonstrated that simple metal substitutional atoms not only stabilized certain phases but also improved their magnetic properties. Furthermore, these atoms also improved the single-domain size of the particles. The results were explained by the strong spin-orbit coupling and orbital angular momentum of the Sm 4f-electron orbitals.
NPJ COMPUTATIONAL MATERIALS
(2022)
Article
Obstetrics & Gynecology
Hyun-Woong Cho, Sohyeon Jeong, Geum Joon Cho, Eunjin Noh, Jae Kwan Lee, Jin Hwa Hong
Summary: The study found that the risk of coronary heart disease (CHD) and cerebrovascular disease did not increase in Asian (especially Korean) gynaecologic cancer survivors compared with the general population. However, cancer patients without any comorbidities showed a higher risk of CHD compared with the non-cancer population.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Seung Yeon Pyeon, Eunjin Noh, Geum Joon Cho
Summary: Uterine artery embolization (UAE) is commonly used in obstetrical cases to manage various conditions while preserving the uterus. However, there are concerns among physicians regarding its potential effects on future fertility and ovarian function. This study aimed to evaluate the impact of UAE during the postpartum period on primary ovarian failure (POF), menstrual disorders, and infertility in women. The analysis of a large database revealed that women who underwent UAE after delivery had a higher risk of POF, menstrual disorders, and infertility compared to those who did not undergo UAE.
REPRODUCTIVE SCIENCES
(2023)
Article
Rheumatology
Young Mi Jung, Jin Kyun Park, Min-Jeong Oh, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
Summary: The aim of this study was to determine the risk of congenital malformations in offspring born to women with systemic lupus erythematosus (SLE). The study found that neonates born to SLE mothers have a slightly increased risk of congenital malformations affecting the nervous system, head and neck, cardiovascular system, and musculoskeletal system compared to the general population.
Article
Obstetrics & Gynecology
Kwang Hyun Lee, Ji Hye Bae, Jeesun Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Geum Joon Cho, Seung Mi Lee
Summary: Hypertensive disease during pregnancy increases the risk of maternal morbidity and mortality and leads to the development of multi-organ dysfunction, including kidney dysfunction. This study aimed to evaluate the risk of developing renal disorders in patients with a history of hypertensive disease during pregnancy.
OBSTETRICS & GYNECOLOGY SCIENCE
(2023)
Article
Obstetrics & Gynecology
Junghyun Jee, Su Jung Hong, Sungyeon Ha, Ho Yeon Kim, Ki Hoon Ahn, Soon-Cheol Hong, Min-Jeong Oh, Hai-Joong Kim, Geum Joon Cho
Summary: The aim of this study was to evaluate the changes in twin pregnancy outcomes between 2007 and 2016 in a Korean population. The rate of twin pregnancies increased, along with the risk of preterm birth. However, the risk of twin growth discordance decreased. The risks of cesarean section, gestational diabetes mellitus, and postpartum hemorrhage all increased from 2007 to 2016.
OBSTETRICS & GYNECOLOGY SCIENCE
(2023)
Article
Medicine, General & Internal
Ki-Jin Ryu, Won Young Wi, Seunghyun Nam, Hye Gyeong Jeong, Geum Joon Cho, Hyuntae Park, Tak Kim
Summary: This study examined the relationship between polycystic ovary syndrome (PCOS) in Korean women and the childhood growth and obesity of their offspring. The results showed that female offspring aged 66-80 months born to women with PCOS had a significantly higher body mass index (BMI) than those born to women without PCOS. However, there was no significant difference in BMI for male offspring regardless of maternal PCOS. The study suggests that maternal PCOS is independently associated with an increased incidence of childhood obesity in female offspring among Korean women.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Ho Yeon Kim, Ki Hoon Ahn, Geum Joon Cho, Soon-Cheol Hong, Min-Jeong Oh, Hai-Joong Kim
Summary: This study aimed to identify the influence of prepregnancy glucose levels on obstetric complications in subsequent pregnancy. The results showed that higher prepregnancy glucose levels within the normal range were associated with gestational diabetes and macrosomia.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Hyun-Woong Cho, Geum Joon Cho, Eunjin Noh, Jin Hwa Hong, Minjeong Kim, Jae Kwan Lee
Summary: The study revealed that women who underwent non-obstetric pelvic surgery during pregnancy had a higher risk of preterm birth, low birth weight, cesarean section, and gestational hypertension compared to pregnant women who did not undergo surgery.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)