Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Kelly K. Ferguson, Sara Sammallahti, Emma Rosen, Michiel van den Dries, Anjoeka Pronk, Suzanne Spaan, Monica Guxens, Henning Tiemeier, Romy Gaillard, Vincent W. V. Jaddoe
Summary: This study identified three distinct fetal growth trajectories for weight among babies born small for gestational age (SGA). Children who were consistently small from mid-pregnancy had the worst neurodevelopmental outcomes at age 6, showing lower IQ and slightly more ADHD symptoms compared to non-SGA babies. The findings suggest that fetal growth trajectories may help identify SGA babies who are at risk for poor neurodevelopmental outcomes.
Article
Pediatrics
Dan Wu, Jianzheng Zhu, Xiulian Wang, Huiqing Shi, Yanyan Huo, Meiyan Liu, Fanfan Sun, Hongyan Lan, Chong Guo, Honghua Liu, Tingting Li, Lian Jiang, Xiangying Hu, Tianshu Li, Jing Xu, Guoying Yao, Guowei Zhu, Guangjun Yu, Jinjin Chen
Summary: This study found that rapid increase in BMI during early infancy in former SGA newborns leads to a persistent risk of obesity, highlighting the importance of controlling energy intake and closely monitoring BMI changes for optimal management.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Shangzhi Xu, Weiming Wang, Qian Li, Li Huang, Xi Chen, Xu Zhang, Xiaoyi Wang, Weizhen Han, Xingwen Hu, Xuefeng Yang, Liping Hao, Guoping Xiong, Nianhong Yang
Summary: This study found that higher Hb concentrations in late pregnancy and less reduction in Hb during pregnancy were associated with an increased risk of SGA in women at low risk of iron deficiency.
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Korede K. Yusuf, Deepa Dongarwar, Dania E. Alagili, Sitratullah O. Maiyegun, Hamisu M. Salihu
Summary: This study examined the temporal trends and risk of small for gestational age (SGA) phenotypes among Asian American ethnic groups using population-based retrospective data. The findings showed that NH-Whites had the lowest SGA rates, while all Asian ethnic groups had consistently higher rates. Among the Asian subgroups, Asian Indians had the highest odds of any SGA compared to NH-Whites. The study highlights the importance of recognizing the diversity within the Asian American population for effective health research and interventions.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Allen J. Wilcox, Marianna Cortese, D. Robert McConnaughey, Dag Moster, Olga Basso
Summary: The study found that birthweight percentiles performed poorly in identifying high-risk infants, while gestational age was effective. The results in Norway and the United States were virtually identical, suggesting this trend is robust across populations.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Chaelin Lee, Seung Mi Lee, Dong Jun Byun, So Yeon Kim, Hugh Kim, Do Yup Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Man Ho Choi
Summary: Increased levels of tetrahydrocortisol and decreased levels of 21-deoxycortisol were observed in pregnant women carrying small-for-gestational-age (SGA) fetuses. The combination of 21-deoxycortisol concentration and two metabolic ratios of cortisol/21-deoxycortisol and tetrahydrocortisol/cortisol can serve as potential biomarkers for predicting SGA in the first trimester.
REPRODUCTIVE SCIENCES
(2022)
Review
Endocrinology & Metabolism
Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, Veronica Mericq, Robert Rapaport, Abdullah Alherbish, Debora Braslavsky, Evangelia Charmandari, Steven D. Chernausek, Wayne S. Cutfield, Andrew Dauber, Asma Deeb, Wesley J. Goedegebuure, Paul L. Hofman, Elvira Isganatis, Alexander A. Jorge, Christina Kanaka-Gantenbein, Kenichi Kashimada, Vaman Khadilkar, Xiao-Ping Luo, Sarah Mathai, Yuya Nakano, Mabel Yau
Summary: This International Consensus Guideline, developed by experts from 10 pediatric endocrine societies worldwide, provides new insights into the causes and consequences of short stature after SGA birth. It also offers recommendations for accurate diagnosis, early follow-up, and appropriate treatment options. The guideline emphasizes the importance of genetic testing and counseling, as well as promoting a healthy lifestyle for young adults born SGA.
Article
Genetics & Heredity
Hwal Rim Jeong, Jae-A Han, Heeji Kim, Hye Jin Lee, Young Suk Shim, Min Jae Kang, Jong Seo Yoon, Seongho Ryu, Il Tae Hwang
Summary: This study investigated the exosomal miRNA signature associated with catch-up growth in small-for-gestational-age (SGA) children. The results showed that SGA children without catch-up growth have a distinct exosomal miRNA expression profile compared with SGA children with catch-up growth and appropriate-for-gestational-age (AGA) children. The study also identified certain miRNAs that may be associated with growth failure in SGA children.
Article
Environmental Sciences
Zhenghong Zhu, Huanqing Hu, Tarik Benmarhnia, Zhoupeng Ren, Jiajun Luo, Wei Zhao, Sidi Chen, Kaipu Wu, Xiaoxin Zhang, Liyun Wang, Jiangli Di, Cunrui Huang, Qiong Wang
Summary: This study aimed to explore the roles of maternal blood pressure and hemoglobin in the relationship between PM2.5 exposure and small for gestational age (SGA). The results showed that increases in maternal blood pressure and hemoglobin in the second and third trimesters independently and jointly mediated the effects of gestational PM2.5 exposure on SGA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Gabriel Bernardino, Alvaro Sepulveda-Martinez, Merida Rodriguez-Lopez, Susanna Prat-Gonzalez, Carolina Pajuelo, Rosario J. Perea, Maria T. Caralt, Francesca Crovetto, Miguel A. Gonzalez Ballester, Marta Sitges, Bart Bijnens, Fatima Crispi
Summary: Being born small for gestational age (SGA) is associated with increased risk of cardiovascular mortality and lower exercise tolerance. This study aimed to assess the impact of central obesity on cardiac remodeling and dysfunction in young adults born SGA.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Aurelie Pham, Delphine Mitanchez, Anne Forhan, Laurence Perin, Yves Le Bouc, Frederic Brioude, Marie-Laure Sobrier, Barbara Heude, Irene Netchine
Summary: Research suggests that lower levels of DLK1 in maternal blood during the second trimester of pregnancy may indicate a higher risk of SGA. However, DLK1 alone is not a reliable predictor of SGA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
George A. Macones
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Editorial Material
Obstetrics & Gynecology
George A. Macones, Alison Cahill, Katherine Goetzinger, Amanda Trudell
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Editorial Material
Obstetrics & Gynecology
Lorie M. Harper, George A. Macones
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Editorial Material
Obstetrics & Gynecology
Lorie M. Harper, Mary B. Keegan, Jessica A. McPherson, Amanda S. Trudell
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Editorial Material
Obstetrics & Gynecology
George A. Macones, Amanda Trudell, Jourdie Stuart Triebwasser, Rachel Zigler
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Editorial Material
Obstetrics & Gynecology
George A. Macones, Amanda Trudell, Jourdie Stuart Triebwasser, Rachel Zigler
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Editorial Material
Obstetrics & Gynecology
Molly J. Stout, George A. Macones
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Editorial Material
Obstetrics & Gynecology
Molly J. Stout, Kristina Epplin, Amber Wood, Amanda Trudell
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Amanda S. Trudell, Methodius G. Tuuli, Alison G. Cahill, George A. Macones, Anthony O. Odibo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Amanda S. Trudell, Judette M. Louis, Methodius G. Tuuli, Aaron B. Caughey, Anthony O. Odibo, Alison G. Cahill
AMERICAN JOURNAL OF PERINATOLOGY
(2015)
Article
Obstetrics & Gynecology
Amanda S. Trude, Anthony O. Odibo
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2014)