Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 207, Issue 3, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2012.06.009
Keywords
delivery; gestational hypertension; maternal and neonatal outcomes
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health [HHSN267200603425C]
- Center for Clinical and Translational Science, University of Illinois at Chicago from the National Center for Research Resources [UL1RR029879]
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OBJECTIVE: To assess the optimal timing of delivery for women with gestational hypertension. STUDY DESIGN: A multicenter database that contained 228,668 deliveries was used to extract data on gravidas with gestational hypertension. The week-specific rates of maternal and neonatal morbidity/mortality were calculated after induction of labor. Point wise 95% confidence intervals were calculated around each of these gestational age-specific rates. RESULTS: After induction of labor, the rate of maternal morbidity/mortality reached a nadir of 89.9 per 1000 live births (95% confidence interval, 68.1-111.8) at 38-38 6/7 weeks' gestation, although the rate of neonatal morbidity/mortality fell to 10.5 per 1000 live births (95% confidence interval, 2.8-18.2) at 39-39 6/7 weeks. There were only 3 total stillbirths in our study cohort. CONCLUSION: In women with gestational hypertension, induction of labor between 38- and 39-weeks' balances the lowest maternal and neonatal morbidity/mortality.
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