Article
Surgery
Francesca Maria Russo, Marina Gabriela Monteiro Carvalho Mori Da Cunha, Julio Jimenez, Flore Lesage, Mary Patrice Eastwood, Jaan Toelen, Jan Deprest
Summary: The study aimed to evaluate the effect of combining antenatal sildenafil with fetal tracheal occlusion (TO) in fetal rabbits with surgically induced congenital diaphragmatic hernia (CDH) and found that the combination had a complementary effect on lung development.
Article
Acoustics
F. M. Russo, A-G Cordier, D. Basurto, L. Salazar, E. Litwinska, O. Gomez, A. Debeer, J. Nevoux, S. Patel, L. Lewi, A. Pertierra, M. Aertsen, E. Gratacos, K. H. Nicolaides, A. Benachi, J. Deprest
Summary: The antenatal measurement of lung size can predict the survival of fetuses with isolated right-sided congenital diaphragmatic hernia (iRCDH). In cases with severe lung hypoplasia, fetal endoscopic tracheal occlusion (FETO) is associated with a significant increase in survival without an associated increase in neonatal morbidity.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Ben Van Calster, Alexandra Benachi, Kypros H. Nicolaides, Eduard Gratacos, Christoph Berg, Nicola Persico, Glenn J. Gardener, Michael Belfort, Yves Ville, Greg Ryan, Anthony Johnson, Haruhiko Sago, Przemyslaw Kosinski, Pietro Bagolan, Tim Van Mieghem, Philip L. J. DeKoninck, Francesca M. Russo, Stuart B. Hooper, Jan A. Deprest
Summary: This analysis suggests that fetoscopic endoluminal tracheal occlusion improves survival in cases of moderate and severe lung hypoplasia. The timing of balloon insertion may impact the treatment effect, but further research is needed to determine its precise influence due to the limited sample size and confounding factors. In particular, early insertion of the balloon greatly increases the risk of preterm delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pediatrics
Shelby R. Sferra, Melanie K. Nies, Jena L. Miller, Alejandro V. Garcia, Erica I. Hodgman, Annalise B. Penikis, Abigail J. Engwall-Gill, Vera Joanna Burton, Jessica L. Rice, Peter J. Mogayzel, Ahmet A. Baschat, Shaun M. Kunisaki
Summary: This study aimed to evaluate the long-term outcomes of children with severe congenital diaphragmatic hernia (CDH) who underwent fetoscopic endoluminal tracheal occlusion (FETO). The results showed that the survival rates and morbidity rates of FETO patients were comparable to those of non-FETO patients, but during the follow-up period, FETO patients still required treatment and feeding support.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Review
Acoustics
Y. Chen, R. Xu, X. Xie, T. Wang, Z. Yang, J. Chen
Summary: This study conducted a systematic review and meta-analysis to evaluate the overall effects of fetal endoscopic tracheal occlusion (FETO) on clinical outcomes of fetuses with congenital diaphragmatic hernia (CDH). The results showed that FETO can reduce mortality, rates of pulmonary hypertension, and the usage of extracorporeal membrane oxygenation (ECMO) in severe CDH, while it only reduces the risk of mortality in moderate CDH. Furthermore, FETO increases the risk of preterm birth but not extreme prematurity.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Pediatrics
Jiyoon Jeong, Byong Sop Lee, Teahyen Cha, Euiseok Jung, Ellen Ai-Rhan Kim, Ki-Soo Kim, Dae Yeon Kim, Jung-Man Namgoong, Seong Chul Kim, Mi-Young Lee, Hye-Sung Won
Summary: This study presented treatment outcomes of patients with antenatally diagnosed RCDH and found that O/E LHR could be a useful predictor for perinatal outcomes in isolated RCDH cases. Further large cohort studies are needed to confirm the association between O/E LHR values and the severity of RCDH.
Review
Pediatrics
Oluyinka O. Olutoye, Walker D. Short, Jamie Gilley, J. D. Hammond, Michael A. Belfort, Timothy C. Lee, Alice King, Jimmy Espinoza, Luc Joyeux, Krithika Lingappan, Jason P. Gleghorn, Sundeep G. Keswani
Summary: Congenital diaphragmatic hernia (CDH) is a complex disease associated with pulmonary hypoplasia and pulmonary hypertension. Fetoscopic endoluminal tracheal occlusion (FETO) has shown potential in improving lung volume and morphology in CDH patients, but its cellular and molecular effects are still an emerging field of research.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Vincent Serapiglia, Chad A. Stephens, Rashika Joshi, Emrah Aydin, Marc Oria, Mario Marotta, Jose L. Peiro, Brian M. Varisco
Summary: Fetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). This study found that tracheal occlusion (TO) leads to an increase in basal cells and a decrease in ciliated cells in the lung epithelial cell populations. The increased nuclear Yap, a known regulator of basal cell fate, contributes to the expansion of basal cells.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Romain Corroenne, Katherine H. Zhu, Rebecca Johnson, Amy R. Mehollin-Ray, Alireza A. Shamshirsaz, Ahmed A. Nassr, Michael A. Belfort, Magdalena Sanz Cortes, Anil Shetty, Wesley Lee, Jimmy Espinoza
Summary: The study found that lung volume measurements using free 3DSlicer software in infants with severe CDH who underwent FETO are reproducible and reliable, with comparable predictive capability for survival as those measured using conventional software.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Pediatrics
Yuichiro Miyake, Wai Hei Tse, Jia Qi Wang, Nolan De Leon, Muntahi Mourin, Daywin Patel, Arzu Ozturk Aptekmann, Atsuyuki Yamataka, Richard Keijzer
Summary: We established a new rat lung explant model to mimic nitrofen-induced pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) by tying the trachea. The effects of tracheal occlusion (TO) on lung weight, morphology, and abundance of Ki-67, Active caspase-3, and Prosurfactant Protein C (proSP-C) were evaluated. The results showed that TO increased lung weight and abundance of Ki-67 and Active caspase-3, while decreasing proSP-C abundance. The TO model in lung explants mimics the outcomes of current surgical models of TO and further studies can reveal the cellular and molecular effects of TO in CDH lungs.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Genetics & Heredity
Rogelio Cruz-Martinez, Sherif Shazly, Miguel Martinez-Rodriguez, Alma Gamez-Varela, Jonahtan Luna-Garcia, Israel Juarez-Martinez, Hugo Lopez-Briones, Fausto Coronel-Cruz, Rosa Villalobos-Gomez, Daniel Ibarra-Rios, Ricardo Ordorica-Flores, Jaime Nieto-Zermeno
Summary: In CDH fetuses with moderate lung hypoplasia, FETO is associated with lower gestational age at delivery, higher survival rate, lower respiratory morbidity, shorter ventilatory support, and shorter NICU stay.
PRENATAL DIAGNOSIS
(2022)
Article
Pediatrics
R. Gregorio-Hernandez, C. Ramos-Navarro, S. Vigil-Vazquez, E. Rodriguez-Corrales, A. Perez-Perez, M. Arriaga-Redondo, M. Sanchez-Luna
Summary: Lung ultrasound is a valuable tool for assessing pulmonary aeration in neonates, including those with congenital diaphragmatic hernia (CDH). In this study, lung ultrasound examinations were performed on 8 CDH patients before and after surgical correction, and compared between two groups based on mechanical ventilation duration. Lung ultrasound showed potential for diagnosing postoperative complications without radiation exposure and offered quick and serial assessments. These findings highlight the importance of lung ultrasound as an effective alternative to conventional imaging methods in managing CDH.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Roopali Donepudi, Michael A. Belfort, Alireza A. Shamshirsaz, Timothy C. Lee, Sundeep G. Keswani, Alice King, Nancy A. Ayres, Caraciolo J. Fernandes, Magdalena Sanz-Cortes, Ahmed A. Nassr, Andres F. Espinoza, Candace C. Style, Jimmy Espinoza
Summary: This study found that FETO is associated with resolution of PH by hospital discharge in fetuses with moderate left-sided CDH according to O/E-LHR criteria, with no significant differences in other outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pediatrics
Erin E. Perrone, Jan A. Deprest
Summary: The manuscript summarizes the history and current status of fetal intervention for congenital diaphragmatic hernia, highlighting that the FETO technique is still in the investigational stage. The studies discussed emphasize that there is still insufficient evidence to recommend FETO as the standard treatment for CDH.
TRANSLATIONAL PEDIATRICS
(2021)
Review
Pediatrics
Shelby R. Sferra, Jena L. Miller, Sanz M. Cortes, Michael A. Belfort, Rogelio Cruz-Martinez, Shaun M. Kunisaki, Ahmet A. Baschat
Summary: This study evaluated the impact of an integrated prenatal and postnatal care setting on survival outcomes in severe congenital diaphragmatic hernia (CDH) after fetoscopic endoluminal tracheal occlusion (FETO). The results showed that institutional integration of prenatal and postnatal care is associated with the highest overall survival in children with severe CDH.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Obstetrics & Gynecology
Madushka Y. De Zoysa, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, Ramen H. Chmait
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Obstetrics & Gynecology
Margaret E. Purnell, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, Brendan H. Grubbs, Ramen H. Chmait
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Obstetrics & Gynecology
Andrew H. Chon, Stephen Y. Ma, Lisa M. Korst, Hikmat R. Chmait, Margaret E. Purnell, Ramen H. Chmait
Summary: This retrospective study investigated the antenatal course of 48 monochorionic diamniotic twins with selective intrauterine growth restriction (SIUGR) type III. The study found that approximately half of the patients progressed during the antenatal period, with the lack of progression being associated with a higher dual survivorship rate. Dual survivorship was significantly lower in the group that progressed compared to the group that did not progress.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ramen H. Chmait, Andrew H. Chon, Lisa M. Korst, Y. Stephen, Arlyn Llanes, Joseph G. Ouzounian
Summary: The study found that over one-third of patients with SIUGR type II who underwent selective laser photocoagulation of communicating vessels (SLPCV) achieved dual twin survival. Normal middle cerebral artery (MCA) peak systolic velocity (psv) and ductus venosus (DV) waveform were associated with SIUGR type II twin survival.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Lauryn C. Gabby, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, David A. Miller, Ramen H. Chmait
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Obstetrics & Gynecology
Ramen H. Chmait, Valerian Catanzarite, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, Joseph G. Ouzounian
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Obstetrics & Gynecology
Lauryn C. Gabby, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, Ramen H. Chmait
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Behavioral Sciences
Hikmat R. Chmait, Andrew H. Chon, Lisa M. Korst, Samuel P. Putnam, Arlyn Llanes, Douglas L. Vanderbilt
Summary: The study found no significant temperament differences between twins treated in utero for TTTS, despite the different in utero environments they experienced. This may provide some reassurance to parents whose pregnancies are complicated by TTTS.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Claribel Solorio, Jana S. Guenther, Andrew H. Chon, Lisa M. Korst, Gabrielle L. Glassen, Ramen H. Chmait
Summary: This study aimed to characterize patients with twin-twin transfusion syndrome who would be excluded from laser surgery according to European criteria. The results showed that restricting the definition of twin-twin transfusion syndrome to a maximum vertical pocket for the recipient of >= 10 cm may potentially exclude 14.5% of patients from laser surgery, majority of whom had advanced stage of twin-twin transfusion syndrome.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Health Care Sciences & Services
Moshe Fridman, Lisa M. Korst, David J. Reynen, Lisa A. Nicholas, Naomi Greene, Samia Saeb, Jennifer L. Troyan, Kimberly D. Gregory
Summary: This study evaluated California hospital performance based on a standardized SMM measure using maternal hospital delivery discharge data from 2016 to 2017. The results showed that 25.3% (14.9%) of hospitals were identified as underperformers in experiencing significantly more SMM events than expected across all hospital types.
JOINT COMMISSION JOURNAL ON QUALITY AND PATIENT SAFETY
(2021)
Article
Acoustics
Sami R. Chmait, Martha A. Monson, Lisa M. Korst, Arlyn Llanes, Andrew H. Chon
Summary: In a retrospective study of sFGR Type III patients, meeting more stringent parameters of the consensus definition was not associated with disease progression or dual survivorship.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Genetics & Heredity
Ariane C. Youssefzadeh, Gabrielle L. Glassen, Andrew H. Chon, Lisa M. Korst, Tania F. Esakoff, Yalda Afshar, Ciprian P. Gheorghe, Arlyn Llanes, Ramen H. Chmait
Summary: The study evaluated individual cases of dual twin demise following laser surgery for twin-twin transfusion syndrome (TTTS) from 2006 to 2019. Among 753 twins who underwent laser surgery, 6.9% experienced postoperative dual demise, with preterm birth being the most common cause. Nearly one-quarter of dual demise cases were deemed potentially preventable.
PRENATAL DIAGNOSIS
(2021)
Article
Genetics & Heredity
Nicole G. Gomez, Martha A. Monson, Andrew H. Chon, Lisa M. Korst, Arlyn Llanes, Ramen H. Chmait
Summary: This study aimed to describe outcomes following immediate laser surgery for stage I TTTS at a single fetal surgery center. The results showed favorable survival and neurological outcomes for patients who underwent laser surgery in this center.
PRENATAL DIAGNOSIS
(2022)
Article
Acoustics
R. H. Saab, G. R. Devore, M. Monson, J. Masri, L. M. Korst, R. H. Chmait
Summary: This study aimed to assess the difference in umbilical vein flow (UVF) between the recipient and donor twins with twin-twin transfusion syndrome (TTTS), and to evaluate the change in UVF following laser surgery. The results showed a significant preoperative difference in UVF between the recipient and donor twins, and a substantial increase in UVF of the donor twin postoperatively, confirming the effectiveness of laser surgery in improving perfusion.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Health Care Sciences & Services
Moshe Fridman, Lisa M. Korst, David J. Reynen, Lisa A. Nicholas, Naomi Greene, Samia Saeb, Jennifer L. Troyan, Kimberly D. Gregory
Summary: This study aims to adapt the Centers for Disease Control and Prevention (CDC) measure of severe maternal morbidity (SMM) for hospital performance measurement and evaluate it. The study found that the rate of potentially preventable SMM, as defined by pSMM, was less than half of the previously published rate of CDC SMM. Therefore, pSMM can be used for hospital performance comparison and quality improvement.
JOINT COMMISSION JOURNAL ON QUALITY AND PATIENT SAFETY
(2023)
