Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan
Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xinwen Chang, Qizhi He, Mengtian Wei, Linyan Jia, Yingying Wei, Yiding Bian, Tao Duan, Kai Wang
Summary: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) have beneficial effects on adverse birth outcomes in a preeclampsia mouse model induced by sFlt-1. They can decrease blood pressure, improve fetal birth weight, and restore placental vascular networks. In addition, HUCMSC-exos partially rescue sFlt-1-induced dysfunction of human umbilical vein endothelial cells.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Fabienne Trottmann, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Araceli Jarquin Campos, Franz H. Messerli, Lorenz Risch, Marc U. Baumann
Summary: In this study, pregnant women with AFLP had significantly higher sFlt-1 levels compared to those with HELLP syndrome. PlGF levels were also higher in AFLP patients. The sFlt-1 cutoff value of 31,100 pg/mL showed a sensitivity and specificity of 100% in distinguishing between AFLP and HELLP syndrome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Julia Binder, Erkan Kalafat, Pilar Palmrich, Petra Pateisky, Asma Khalil
Summary: Maternal serum angiogenic markers, specifically soluble fms-like tyrosine kinase 1 and placental growth factor, show high predictive accuracy in determining adverse maternal and perinatal outcomes for women with chronic hypertension. Repeated measurements of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio provide better predictive accuracy compared to a single measurement alone. Implementing angiogenic markers in clinical management guidelines for pregnant women with chronic hypertension is recommended based on the study findings.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Megan E. Smithmyer, Chileshe M. Mabula-Bwalya, Humphrey Mwape, Gabriel Chipili, Bridget M. Spelke, Margaret P. Kasaro, Kristina De Paris, Bellington Vwalika, Yuri V. Sebastiao, Jeffrey S. A. Stringer, Joan T. Price
Summary: Maternal HIV infection may lead to adverse birth outcomes through an imbalance in angiogenic factors like PlGF and sFLT-1 in the VEGF signaling pathway. Lower concentrations of these biomarkers were associated with adverse birth outcomes, particularly preterm birth and stillbirth, but larger studies are needed for further confirmation of these findings.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biochemistry & Molecular Biology
Annika Schulz, Carolin C. Drost, Bettina Hesse, Katrin Beul, Goeran R. Boeckel, Alexander Lukasz, Hermann Pavenstaedt, Marcus Brand, Giovana S. Di Marco
Summary: In this study, it was found that excess sFlt-1 led to conformational changes in the endothelial glycocalyx (eGC), resulting in increased monocyte adhesion and vascular dysfunction. The eGC became flat and stiff under excess sFlt-1, while its structural components remained unchanged. Functionally, this conformation increased endothelial adhesiveness to THP-1 monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Jakub Kornacki, Przemyslaw Wirstlein, Ewa Wender-Ozegowska
Summary: Evaluation of serum concentrations of HA in patients with PE was found to be more useful in the assessment of endothelial injury, compared to the assessment of SDC-1. The degree of EG damage was comparable in patients with early- and late-onset PE. The pathomechanism of the damage seems to be more sFlt-1 dependent in patients with early- onset PE than in the case of late-onset disease.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jessica R. Zolton, Lindsey A. Sjaarda, Sunni L. Mumford, Elizabeth A. DeVilbiss, Keewan Kim, Kerry S. Flannagan, Jeannie G. Radoc, Neil J. Perkins, Robert M. Silver, Jean Wactawski-Wende, Micah J. Hill, Alan H. DeCherney, Enrique F. Schisterman
Summary: Circulating VEGF and sFLT-1 did not vary significantly across the menstrual cycle in normal ovulating women, and may not be useful as peripheral biomarkers of endometrial changes during the menstrual cycle. Plasma may be the preferred medium for measuring circulating VEGF in reproductive-age women, regardless of menstrual cycle phase.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Wanying Cheng, Lingling Wang, Xin Gao, Guangli Yin, Jujuan Wang, Yongqian Shu, Hongxia Qiu, Limin Duan
Summary: sFLt-1 is a reliable immune biomarker for predicting the inflammatory status and prognosis of secondary hemophagocytic lymphohistiocytosis (sHLH).
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Annika Schulz, Carolin Christina Drost, Bettina Hesse, Katrin Beul, Marcus Brand, Giovana Seno Di Marco
Summary: sFlt-1 has damaging effects on endothelial cell structure and function. Its levels are correlated with endothelial cell cortex stiffening, which is accompanied by cytoskeleton reorganization and changes in endothelial barrier function, mediated by p38 MAPK activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Ana G. Nolasco-Leanos, Karla L. Ramirez-Valenzuela, Reyes Carrillo-Juarez, Carlos J. Molina-Perez, Irma Isordia-Salas, Alfredo Leanos-Miranda
Summary: In women with gestational hypertension, imbalance of angiogenic factors is associated with adverse maternal and perinatal outcomes as well as progression to preeclampsia. Circulating concentrations of sEng and the soluble fms-like tyrosine kinase-1/placental growth factor ratio can be used as suitable markers to assess the risk of adverse outcomes.
JOURNAL OF HYPERTENSION
(2021)
Review
Peripheral Vascular Disease
Juilee S. Deshpande, Deepali P. Sundrani, Akriti S. Sahay, Sanjay A. Gupte, Sadhana R. Joshi
Summary: Preeclampsia is a dangerous disorder for pregnant women and neonates that requires specific and reliable biomarkers for early prediction. The imbalance of angiogenic factors contributes to the pathophysiology. Applying a multivariable model from the start of pregnancy throughout gestation is essential for early and specific prediction of preeclampsia.
HYPERTENSION RESEARCH
(2021)
Article
Acoustics
A. C. M. Kluivers, A. Biesbroek, W. Visser, L. Saleh, H. Russcher, A. H. J. Danser, R. I. Neuman
Summary: This study aims to evaluate the levels of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and free PlGF in women with pre-eclampsia (PE) with or without a small-for-gestational-age (SGA) neonate. The findings suggest that diminished PlGF production is an important cause of low free PlGF levels, particularly in pregnancies with early-onset PE and SGA. The upregulation of sFlt-1 occurs synergistically in women with both PE and SGA.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana
Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Laura A. Magee, Mark A. Brown, David R. Hall, Sanjay Gupte, Annemarie Hennessy, S. Ananth Karumanchi, Louise C. Kenny, Fergus McCarthy, Jenny Myers, Liona C. Poon, Sarosh Rana, Shigeru Saito, Anne Cathrine Staff, Eleni Tsigas, Peter von Dadelszen
Summary: Uniform departmental management protocols should be maintained for managing hypertensive pregnant women, and regular audits of maternal and fetal outcomes should be conducted. The cause and optimal clinical management of pre-eclampsia and hypertensive disorders of pregnancy remain uncertain, therefore, it is recommended that every hypertensive pregnant woman be given the opportunity to participate in research, clinical trials, and follow-up studies.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Zolt Arany, Denise Hilfiker-Kleiner, S. Ananth Karumanchi
Summary: Cardiovascular complications during pregnancy, such as preeclampsia and peripartum cardiomyopathy, have become a major cause of maternal mortality and have long-term effects on maternal cardiovascular health. However, the causes and mechanisms underlying these complications are not well understood, and treatment options are limited. Preclinical models have played an important role in advancing our understanding of these diseases.
CIRCULATION RESEARCH
(2022)
Editorial Material
Medical Laboratory Technology
Kathryn J. Gray, Martin Hemberg, S. Ananth Karumanchi
CLINICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Summary: Preeclampsia is a potentially lethal pregnancy complication driven by overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1). Researchers have found that injecting specific siRNA can reduce placental sFLT1 and improve symptoms. They also discovered that modifying siRNA chemically can enhance its effectiveness and safety, providing a framework for further development of this therapeutic approach.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Endocrinology & Metabolism
Mengyao Tang, Anders Berg, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Sahir Kalim
Summary: The impact of glycated hemoglobin (HbA(1c)) on renal outcomes in patients with diabetes and chronic kidney disease (CKD) is modified by carbamylation and anemia.
Review
Peripheral Vascular Disease
Takahiko Nakagawa, Ana Andres-Hernando, Tomoki G. Kosugi, Laura Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo R. Rodriguez-Iturbe, Dean A. Tolan, Miguel J. Lanaspa, Richard Johnson
Summary: Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placentation. Fructose, which plays a critical role in fetal growth, is produced in the placenta during early pregnancy to assist fetal survival in a hypoxic environment. Impaired placentation leads to excessive fructose production, which drives various pathological features of preeclampsia. In addition, dietary fructose intake has been identified as an independent risk factor for preeclampsia.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Sahir Kalim, Sophia Zhao, Mengyao Tang, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Anders H. Berg
Summary: Protein carbamylation, driven by elevated blood urea levels, is associated with adverse outcomes in ESKD. However, its relationship to clinical outcomes in earlier stages of CKD is not well understood.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Gena Guidry, Nicklaus A. Sparrow, Hyyat S. Marshall, Roberta De Souza Santos, Suman P. Bharath, Michael M. Gezalian, Margareta D. Pisarska, Jean-Philippe Vit, Scott A. Kelly, S. Ananth Karumanchi, Shouri Lahiri
Summary: Urinary tract infections (UTIs) can lead to delirium-like states, and postmenopausal females are more susceptible to delirium following UTIs. It has been found that 17 beta-estradiol can reduce neuronal injury and improve delirium-like behaviors caused by UTIs, possibly by suppressing the expression of interleukin-6 (IL-6).
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nicklaus A. A. Sparrow, Gena Guidry, Faizan Anwar, Sonja Darwish, Scott A. A. Kelly, S. Ananth Karumanchi, Shouri Lahiri
Summary: Prone positioning can alleviate neuronal injury and inflammation by reducing interleukin 6 (IL-6) in a model of mechanical ventilation-induced acute lung injury. Further studies are needed to investigate the relationship between prone positioning and delirium, and to develop novel diagnostic or therapeutic approaches to reduce systemic and cerebral IL-6 expression.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Qing Lu, Jaime Ibarrola, Alec Stepanian, Joshua J. Man, Brigett V. Carvajal, Nicholas D. Camarda, Zsuzsanna Zsengeller, Geraldine Skurnik, Ellen W. Seely, S. Ananth Karumanchi, Iris Z. Jaffe
Summary: Preeclampsia is associated with hypertension and end organ damage, and women exposed to preeclampsia have an increased risk of hypertension after pregnancy. This study found that exposure to sFlt1 during pregnancy leads to enhanced responsiveness of smooth muscle cell mineralocorticoid receptors (SMC-MR) to hypertensive stimuli, contributing to postpartum hypertension. These findings suggest that targeting SMC-MR could be a potential intervention to mitigate cardiovascular risk in women after preeclampsia.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Diana Pintye, Reka Eszter Sziva, Maxim Mastyugin, Marianna Torok, Sonako Jacas, Agnes Lo, Saira Salahuddin, Zsuzsanna K. Zsengeller
Summary: Preeclampsia (PE), a syndrome specific to pregnancy, affects 5-7% of patients and currently has no effective treatment. Early abnormal placental development leads to oxidative stress and release of reactive oxygen species (ROS) in the placenta, resulting in downstream signaling, stabilization of Hypoxia Inducible Factor 1A (HIF1A), and transcription of anti-angiogenic factors sFLT1 and sEng. This study found that the nitroxide-type antioxidant molecule HMP could reduce placental oxidative stress and alleviate PE symptoms in vitro.
Article
Biology
Diana Pintye, Reka E. Sziva, Maxim Mastyugin, Brett C. Young, Sonako Jacas, Marianna Toeroek, Saira Salahuddin, Prakash Jagtap, Garry J. Southan, Zsuzsanna K. Zsengeller
Summary: This study confirmed the validity of targeting redox deficiencies and angiogenic imbalances in preeclampsia for therapeutic intervention. This will have a significant impact on pregnant women affected by preeclampsia and their babies.
Article
Obstetrics & Gynecology
Eynav Accortt, James Mirocha, Dongsheng Zhang, Sarah J. Kilpatrick, Towia Libermann, S. Ananth Karumanchi
Summary: This study aimed to determine if a panel of novel third-trimester plasma protein biomarkers in pregnant women can be used to identify those who have a high predisposed risk for perinatal mood and anxiety disorders. The results showed that participants with perinatal mood and anxiety disorders had a unique and distinct plasma protein signature that regulated a variety of neuronal signaling and proinflammatory pathways. Further validation studies with larger sample sizes are needed to determine the potential use of these molecules for early detection of perinatal mood and anxiety disorders when combined with traditional risk factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
