Article
Neurosciences
Danielle L. Wilson, Alison M. Fung, Hannah Skrzypek, Gabrielle Pell, Maree Barnes, Mark E. Howard, Susan P. Walker
Summary: A significant number of unexplained stillbirths in Australia have led to research on the potential role of nocturnal maternal behaviors in contributing to stillbirth. This study investigated the impact of sleep-related behaviors, such as sleep position and sleep-disordered breathing, on fetuses overnight in uncomplicated pregnancies and those at increased risk due to hypertensive disorders or fetal growth restriction. The findings suggest that changes in body position during sleep may be associated with fetal heart rate events, particularly in hypertensive pregnancies, but there was no causal relationship between maternal sleeping position, snoring, or respiratory events and abnormal fetal heart rate.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Pona Park, Jeong-Whun Kim
Summary: Obstructive sleep apnea can be predicted in a large Korean population by measuring heart rate variability, body mass index, and demographic characteristics. The best performing model is a logistic regression model with an apnea-hypopnea index criterion of 30, achieving an accuracy of 70.3%.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Obstetrics & Gynecology
Janet A. DiPietro, Heather Watson, Radhika S. Raghunathan, Janice L. Henderson, Francis P. Sgambati, Grace W. Pien
Summary: Maternal sleep disorders and disruptions have negative impacts on fetal neurodevelopment, with higher sleep disordered breathing associated with delayed fetal neuromaturation and increased motor activity. Conversely, less disrupted maternal sleep is linked to higher fetal heart rate variability and coupling-based neuromaturation. The influence of maternal sleep on fetal nervous system development warrants further study and may have lasting effects beyond pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Clinical Neurology
Feihong Ding, Andrew Cotton-Clay, Laura Fava, Venkat Easwar, Arthur Kinsolving, Philippe Kahn, Anil Rama, Clete Kushida
Summary: This study evaluated the validity of an under-mattress monitoring device (Fullpower Technologies) in estimating sleep continuity and architecture, as well as obstructive sleep apnea in adults. The results showed that the device provided similar sleep continuity measures compared to standard polysomnography (PSG) and had high accuracy in distinguishing sleep stages and estimating apnea events.
Article
Clinical Neurology
Pi-Hung Tung, Meng-Jer Hsieh, Li-Pang Chuang, Shih-Wei Lin, Kuo-Chun Hung, Cheng-Hui Lu, Wen-Chen Lee, Han-Chung Hu, Ming-Shien Wen, Ning-Hung Chen
Summary: This study examined the diagnostic value of portable monitoring (PM) devices in detecting central sleep apnea (CSA) among patients with heart failure (HF). The results showed that the measurements obtained from PM devices were well-correlated with the standard polysomnography (PSG) results, and manual scoring was preferable to automated scoring.
FRONTIERS IN NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Janet A. DiPietro, Jiawei Bai, Francis P. Sgambati, Janice L. Henderson, Heather Watson, Radhika S. Raghunathan, Grace W. Pien
Summary: This study aimed to investigate the relationship between maternal sleep-disordered breathing events and fetal well-being. The results showed that episodes of maternal sleep apnea and hypopnea did not cause decelerations in fetal heart rate, despite the presence of risk factors such as maternal obesity. However, fetal heart rate variability increased during these events and returned to baseline levels soon after. There was no evidence that maternal sleep-disordered breathing posed an immediate threat to the near-term fetus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Gwanghui Ryu, Yoo-Min Kim, Kyung Eun Lee, Suk-Joo Choi, Sang Duk Hong, Yong Gi Jung, Soo-Young Oh, Hyo Yeol Kim
Summary: Obstructive sleep apnea (OSA) is significantly associated with maternal obesity during pregnancy, and it increases the risks of pregnancy-related complications such as gestational hypertension and gestational diabetes mellitus. This study aimed to determine the prevalence of OSA in overweight pregnant women and assess its impact on pregnancy-related disorders. The results showed that OSA is an important risk factor for preeclampsia, leading to an increased risk of preterm delivery.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Elie Gottlieb, Mohamed S. Khlif, Laura Bird, Emilio Werden, Thomas Churchward, Matthew P. Pase, Natalia Egorova, Mark E. Howard, Amy Brodtmann
Summary: In chronic stroke patients, 57% had undiagnosed moderate-severe obstructive sleep apnea and exhibited reduced slow-wave sleep with potentially compensatory increases in NREM 1-2 sleep compared to controls. Formal sleep studies are necessary after stroke, even in the absence of self-reported history of sleep-wake pathology.
Article
Peripheral Vascular Disease
Min Ru Chee, Jesse Hoo, Renata Libianto, Stella M. Gwini, Garun Hamilton, Om Narayan, Morag J. Young, Peter J. Fuller, Jun Yang
Summary: This study found a high prevalence of possible or likely primary aldosteronism among patients with both obstructive sleep apnea and hypertension, suggesting that they should be routinely screened for PA. No correlation was found between aldosterone, renin, or aldosterone:renin ratio and the apnea-hypopnea index, indicating the need for further research on the relationship between these conditions.
Article
Clinical Neurology
Iulia Ioan, Diane Weick, Francois Sevin, Damien Sanlaville, Benedicte De Freminville, Cyril Schweitzer, Mohamed Akkari, Laurianne Coutier, Benjamin Putois, Sabine Plancoulaine, Marine Thieux, Patricia Franco
Summary: This study aimed to assess the cognitive function of children with DS, with and without OSAS, and determine the impact of therapeutic intervention on the cognitive function of children with OSAS. The findings suggest that OSAS may have a negative impact on children's cognitive function, but treatment can improve this impact. Children with DS have low intellectual abilities and a higher risk of developing OSAS, emphasizing the importance of early screening and management to prevent further cognitive delay.
Review
Health Care Sciences & Services
Daniela Ferreira-Santos, Pedro Amorim, Tiago Silva Martins, Matilde Monteiro-Soares, Pedro Pereira Rodrigues
Summary: This study aimed to evaluate the effectiveness of using machine learning approaches for disease screening in adult patients with suspected obstructive sleep apnea (OSA). The results showed that various machine learning techniques were widely used, but there were still issues of lack of external validation and inconsistent OSA criteria definition.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Obstetrics & Gynecology
Bani Maheshwari Ratan, Abigail Hook Garbarino, Allison Archer Sellner, Di Miao, Lisa Marie Hollier
AMERICAN JOURNAL OF PERINATOLOGY
(2020)
Review
Genetics & Heredity
Ignatia B. Van den Veyver
PRENATAL DIAGNOSIS
(2019)
Article
Genetics & Heredity
Ingrid Paine, Jennifer E. Posey, Christopher M. Grochowski, Shalini N. Jhangiani, Sarah Rosenheck, Robert Kleyner, Taylor Marmorale, Margaret Yoon, Kai Wang, Reid Robison, Gerarda Cappuccio, Michele Pinelli, Adriano Magli, Zeynep Coban Akdemir, Joannie Hui, Wai Lan Yeung, Bibiana K. Y. Wong, Lucia Ortega, Mir Reza Bekheirnia, Tatjana Bierhals, Maja Hempel, Jessika Johannsen, Rene Santer, Dilek Aktas, Mehmet Alikasifoglu, Sevcan Bozdogan, Hatip Aydin, Ender Karaca, Yavuz Bayram, Hadas Ityel, Michael Dorschner, Janson J. White, Ekkehard Wilichowski, Saskia B. Wortmann, Erasmo B. Casella, Joao Paulo Kitajima, Fernando Kok, Fabiola Monteiro, Donna M. Muzny, Michael Bamshad, Richard A. Gibbs, V. Reid Sutton, Hilde Van Esch, Nicola Brunetti-Pierri, Friedhelm Hildebrandt, Ariel Brautbar, Ignatia B. Van den Veyver, Ian Glass, Davor Lessel, Gholson J. Lyon, James R. Lupski
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Review
Genetics & Heredity
Riwa Sabbagh, Ignatia B. Van den Veyver
Meeting Abstract
Obstetrics & Gynecology
Bani Ratan, Grace Johnson, Amanda Williams, Jocelyn Greely, Emily Rutledge, Charles Kilpatrick
OBSTETRICS AND GYNECOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Riwa Sabbagh, Deeksha Madala, Andrea Moon, Hadi Erfani, Ignatia Van den Veyver
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Genetics & Heredity
David J. Amor, Lyn S. Chitty, Ignatia B. Van den Veyver
PRENATAL DIAGNOSIS
(2020)
Biographical-Item
Genetics & Heredity
Ronald J. Wapner, Ignatia B. Van den Veyver, Arthur L. Beaudet
PRENATAL DIAGNOSIS
(2020)
Article
Genetics & Heredity
Tachjaree Panchalee, Liesbeth Vossaert, Qun Wang, Brielle R. Crovetti, Anne K. McCombs, Ronald J. Wapner, Ignatia B. van den Veyver, Arthur L. Beaudet
PRENATAL DIAGNOSIS
(2020)
Article
Genetics & Heredity
Sara E. Arian, Hadi Erfani, Lauren E. Westerfield, Alexandra Buffie, Salma Nassef, William E. Gibbons, Ignatia B. Van den Veyver
PRENATAL DIAGNOSIS
(2020)
Article
Obstetrics & Gynecology
Sara Arian, Jessica Rubin, Imen Chakchouk, Momal Sharif, Sangeetha K. Mahadevan, Hadi Erfani, Katharine Shelly, Lan Liao, Isabel Lorenzo, Rajesh Ramakrishnan, Ignatia B. van den Veyver
Summary: Loss of maternal Nlrp2 in mice leads to subfertility, smaller litters with birth defects, and growth abnormalities in offspring. In vitro fertilization does not further perturb or improve the development of embryos from Nlrp2-deficient females. The reproductive phenotype observed in offspring from Nlrp2-deficient females is oocyte-specific and not rescued by development in a wild-type uterus, with abnormal DNA methylation patterns persisting in surviving offspring.
REPRODUCTIVE SCIENCES
(2021)
Article
Education, Scientific Disciplines
Grace J. Johnson, Charlie C. Kilpatrick, Eve Zaritsky, Emily Woodbury, Marie Boller, Madreya Burton, Tirsit Asfaw, Bani M. Ratan
Summary: The study assessed the interest and needs of obstetrics and gynecology residents and faculty regarding leadership curriculum, finding that most participants believed residents would benefit from such a curriculum. Small group exercises and leadership case studies taught by physicians were preferred formats.
JOURNAL OF SURGICAL EDUCATION
(2021)
Article
Medicine, General & Internal
Allison Archer Sellner, Abigail Hook Garbarino, Di Miao, Lisa Marie Hollier, Bani Maheshwari Ratan
Summary: Results of the study suggest that obese women in obesity class 1 who lose weight may have a higher chance of giving birth to small-for-gestational-age infants, while those in obesity classes 2 and 3 may not have a significant increase in such risk with weight loss or inadequate weight gain. Additionally, weight loss in class 1 and 2 obese women was associated with a higher likelihood of preterm delivery and preterm labor, whereas class 3 obese patients did not show this association. Obese class 3 women who lost weight were more likely to develop gestational diabetes mellitus.
SOUTHERN MEDICAL JOURNAL
(2021)
Article
Education, Scientific Disciplines
Matthew R. Carroll, Charlie C. Kilpatrick, Grace Johnson, Neelima Sukhavasi, Bani M. Ratan
Summary: Structured worksheets can facilitate resident teaching on the OB/GYN clerkship. Students have a generally positive attitude towards the structured worksheets, believing that it helps improve their clinical reasoning skills and assist residents in effective teaching.
MEDICAL SCIENCE EDUCATOR
(2021)
Article
Education, Scientific Disciplines
Bani M. Ratan, Jocelyn T. Greely, M. Diane Jensen, Charlie C. Kilpatrick
MEDICAL SCIENCE EDUCATOR
(2020)
