☆ 4.6 Editorial Material

Angiogenic imbalances: the obstetric perspective

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2010)

Journal

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Volume 203, Issue 1, Pages -

Publisher

MOSBY-ELSEVIER

DOI: 10.1016/j.ajog.2009.10.891

Keywords

angiogenic imbalance; endoglin; Mirror syndrome; molar; ovarian hyperstimulation syndrome; preeclampsia; sFlt-1; vascular endothelial growth factor (VEGF)

Categories

Obstetrics & Gynecology

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Abstract

Clinical and experimental evidence indicates that angiogenic imbalances may participate in the mechanisms of disease of several pregnancy complications, some of which may be life threatening. This article reviews current evidence in support of this view and the possibility that the fetus may play a central role in these imbalances; it also reviews recent experimental observations that modulation of angiogenic imbalances during pregnancy may have prophylactic and/or therapeutic value.

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