Review
Pharmacology & Pharmacy
Yang Zhang, Yanqi Zhong, Li Zou, Xiaoxia Liu
Summary: Well-developed placenta plays a fundamental role in successful pregnancy, while defective placental development is the underlying cause of preeclampsia. Placenta-derived mesenchymal stem cells (PMSCs) have the ability to differentiate into vessel wall cells and improve placental vasculature, artery remodeling, and immunoregulation. Recent studies have shown that preeclamptic PMSCs disrupt the balance and development in the placenta. However, transplantation or exosome therapies of PMSCs tend to improve placental vascular network and trophoblastic functions, suggesting a potential therapeutic strategy for preeclampsia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Developmental Biology
C. Perera, S. Zheng, M. I. Kokkinos, H. M. Georgiou, M. Schoppet, P. F. James, S. P. Brennecke, B. Kalionis
Summary: In preeclampsia, the presence of PE-DMSCs in the vascular niche contributes to endothelial cell dysfunction due to increased release of ENG. Conversely, in normotensive pregnancies, DMSC secretion of ENG likely has a beneficial effect on endothelial cells.
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nidaa A. Ababneh, Ban Al-Kurdi, Fatima Jamali, Abdalla Awidi
Summary: This study compared the differentiation abilities of MSCs isolated from different human tissue sources, and found that WJ-MSCs had a higher potential to differentiate into NSC and dopaminergic-like cells. This could provide an additional or alternative source of cells for neurological cell-based therapies.
Article
Developmental Biology
Fiona Brownfoot, Natalie Binder, Roxanne Hastie, Alesia Harper, Sally Beard, Laura Tuohey, Emerson Keenan, Stephen Tong, Natalie Hannan
Summary: The study found that nicotinamide (vitamin B3) did not show an effect on reducing markers of preeclampsia in primary human placental tissues and vascular cells.
Article
Materials Science, Multidisciplinary
Zhichao Feng, Qilu Liu, Wenhan Wang, Shengmin Zhang, Mengwei Dong, Shuang Hu, Ailing Yin, Ling Meng, Aizhu Wang, Xin Yu, Jingang Wang, Na Ren, Chunhui Sun, Hong Liu
Summary: Wireless electrical signals generated on a reduced graphene oxide membrane driven by a rotating magnetic field can induce neural differentiation of mesenchymal stem cells without the aid of biological or chemical factors. In vitro and in vivo experiments have shown the potential of this method in stem cell therapy for neurodegenerative diseases.
SCIENCE CHINA-MATERIALS
(2023)
Article
Cell & Tissue Engineering
Jie Su, Ling Guo, Chuanyue Wu
Summary: The PINCH-1 and Notch2 signaling axis is critically involved in mediating the effect of ECM stiffness on smooth muscle differentiation of human placental MSCs. Notch2 interacts directly with PINCH-1 to respond to ECM stiffness and promote smooth muscle cell differentiation.
Article
Chemistry, Multidisciplinary
Xue-Han Xu, Tie-Jun Yuan, Haseeb Anwar Dad, Mu-Yang Shi, Yi-Yu Huang, Zhi-Hong Jiang, Li-Hua Peng
Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.
Article
Engineering, Biomedical
Zahra Sadat Ghazali, Mahnaz Eskandari, Shahin Bonakdar, Philippe Renaud, Omid Mashinchian, Shahriar Shalileh, Fabien Bonini, Ilker Uckay, Olivier Preynat-Seauve, Thomas Braschler
Summary: Cell-imprinting technology is a novel method that directs stem cell fate by using substrates molded from target cells. The study demonstrated that cell-imprinted substrates can accelerate neural differentiation and induce morphological changes in stem cells, leading to upregulation of neural stem cell and early neuronal markers.
Article
Cell Biology
Huey-Shan Hung, Yi-Chin Yang, Chih-Hsuan Chang, Kai-Bo Chang, Chiung-Chyi Shen, Chien-Lun Tang, Szu-Yuan Liu, Chung-Hsin Lee, Chun-Ming Yen, Meng-Yin Yang
Summary: The study demonstrates that the composite material of chitosan and gold nanoparticles can enhance the neural differentiation of mesenchymal stem cells and has the potential as a biosafe nanomaterial for neural tissue engineering.
Article
Biochemistry & Molecular Biology
Massimo Conese, Ottavio Napolitano, Onofrio Laselva, Sante Di Gioia, Luigi Nappi, Luigia Trabace, Maria Matteo
Summary: This study found that the levels of PLAC1 in AMSCs were lower in patients with preeclampsia, and abnormal shedding of PLAC1 from AMSC plasma membranes may contribute to trophoblast proliferation and support its role in the development of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Monika Sypecka, Aleksandra Bzinkowska, Dorota Sulejczak, Filip Dabrowski, Anna Sarnowska
Summary: Wharton's jelly (WJ) from the umbilical cord (UC) is a good source of mesenchymal stem/stromal cells (MSCs) for therapy. Protocols for UC transportation, cell isolation, cultivation, and banking should be unified and optimized. WJ-MSCs showed higher levels of cytokines and chemokines secretion compared to WJ bioptats, and exhibited neural markers when exposed to cerebrospinal fluid (CSF). A protocol for manufacturing an advanced-therapy medicinal product was developed based on the findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Arseniy Lobov, Polina Kuchur, Aigul Khizhina, Anastasia Kotova, Andrei Ivashkin, Daria Kostina, Polina Klausen, Evgeniia Khokhlova, Egor Repkin, Kseniia Postnikova, Daria Perepletchikova, Evgeny Denisov, Tatiana Gerashchenko, Rashid Tikhilov, Svetlana Bozhkova, Andrey Sereda, Vitaliy Karelkin, Natella Enukashvily, Anna Malashicheva
Summary: In this study, we conducted a comparative analysis of mesenchymal cell primary cultures from various sources and found differences in their ability to undergo osteogenic differentiation and produce extracellular matrix. Based on the analysis of secretome, proteome, and transcriptome, we classified them into dental stem cells, mesenchymal stem cells, and fetal stem cells. Although they have differences, mesenchymal cells from all sources secreted core bone extracellular matrix-associated proteins. These findings shed light on the distinctive characteristics of mesenchymal stem cells and provide insights into their potential applications in regenerative medicine and the inherent diversity of mesenchymal cells in vivo.
Article
Biochemistry & Molecular Biology
Behnaz Sadat Eftekhari, Dawei Song, Paul A. Janmey
Summary: Electrical stimulation of human mesenchymal stem cells cultured on soft conductive biodegradable substrates promotes neurite outgrowth and upregulates neuronal markers while downregulating glial markers. The combination of soft conductive substrates and electrical stimulation is a promising tool for enhancing neuronal tissue engineering outcomes.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Shuichang Yu, Xinran You, Hansi Liang, Ying Li, Yi Fu, Xia Zhang, Xiaohan Hu, Jinnan An, Yunyun Xu, Fang Li
Summary: This study aimed to compare the effectiveness of first trimester placental chorion mesenchymal stem cells (FCMSCs) and third trimester placental chorion mesenchymal stem cells (TCMSCs) in the treatment of acute myocardial infarction (AMI). The results showed that FCMSCs exhibited superior in vitro endothelial cell differentiation and angiogenic potential, as well as improved cardiac function, compared to TCMSCs. Increased levels of pro-angiogenesis genes may be the mechanism behind this effect.
Article
Infectious Diseases
Anda-Petronela Radan, David Baud, Guillaume Favre, Andrea Papadia, Daniel Surbek, Marc Baumann, Luigi Raio
Summary: This study found that SARS-CoV-2 infection during pregnancy may lead to abnormal placental function, characterized by decreased placental weight, increased b/p ratio, and abnormal scaling exponent b. This has important implications for the increased stillbirth rate associated with SARS-CoV-2 infection during pregnancy.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Environmental Sciences
Eva Gerbier, Sereina M. Graber, Marlene Rauch, Carole A. Marxer, Christoph R. Meier, David Baud, Ursula Winterfeld, Eva Blozik, Daniel Surbek, Julia Spoendlin, Alice Panchaud
Summary: This study evaluated the utilization of drugs to treat chronic diseases during pregnancy in Switzerland. The results showed that some potentially teratogenic/fetotoxic drugs were still being used during pregnancy. Levothyroxine and antihypertensives were the most commonly used drugs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cell Biology
Benjamin P. Luescher, Christiane Albrecht, Bruno Stieger, Daniel V. Surbek, Marc U. Baumann
Summary: This study reveals the efficient role of the placental uric acid transport system in maintaining uric acid homeostasis, with GLUT9 playing a crucial role in this process. Further investigation on the role of the placental uric acid transport system in preeclampsia is urgently needed.
Article
Obstetrics & Gynecology
Fabienne Trottmann, Anne Elena Mollet, Sofia Amylidi-Mohr, Daniel Surbek, Luigi Raio, Beatrice Mosimann
Summary: The aim of this study was to determine the feasibility of integrating preeclampsia (PE) screening into routine practice. The results showed that this screening method was widely accepted and embraced by pregnant women and healthcare providers.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Article
Endocrinology & Metabolism
Anja Helmer, Isotta Magaton, Odile Stalder, Petra Stute, Daniel Surbek, Michael von Wolff
Summary: This study provides guidance for the optimal timing of ovulation triggering in infertility treatments based on natural menstrual cycles, which is crucial for treatment optimization.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Anda-Petronela Radan, Mihaela-Madalina Fluri, Konstantinos Nirgianakis, Beatrice Mosimann, Bettina Schlatter, Luigi Raio, Daniel Surbek
Summary: This study suggests that gestational diabetes mellitus (GDM) increases the risk of SARS-CoV-2 infection in pregnant women, while SARS-CoV-2 infection during pregnancy may increase the risk of developing GDM. Vaccination and protective measures should be recommended to pregnant women, especially those with GDM.
DIABETES & METABOLISM
(2022)
Review
Acoustics
H. Stepan, A. Galindo, M. Hund, D. Schlembach, J. Sillman, D. Surbek, M. Vatish
Summary: Pre-eclampsia is characterized by dysfunction in the placenta and maternal endothelium, and it is associated with various complications. The levels of angiogenic factors such as sFlt-1 and PlGF are altered in placenta-related disorders. This review summarizes the current knowledge on the use of PlGF, sFlt-1, and the sFlt-1/PlGF ratio for screening, diagnosing, predicting, and monitoring placenta-related disorders in singleton and twin pregnancy.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Correction
Cell & Tissue Engineering
Gierin Thomi, Daniel Surbek, Valerie Haesler, Marianne Joerger-Messerli, Andreina Schoeberlein
STEM CELL RESEARCH & THERAPY
(2022)
Article
Obstetrics & Gynecology
Sofia Amylidi-Mohr, Cheryl Lang, Beatrice Mosimann, Georg M. Fiedler, Christoph Stettler, Daniel Surbek, Luigi Raio
Summary: This study aimed to investigate the predictability of gestational diabetes mellitus (GDM) in the first trimester by combining glycosylated hemoglobin A1c (HbA1c) with maternal characteristics. The results showed that by combining HbA1c and random plasma glucose levels with age, body mass index, and personal and family history, women at increased risk of developing GDM in the first trimester can be identified.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Pharmacology & Pharmacy
Guillaume Favre, Eva Gerbier, Emeline Maisonneuve, Leo Pomar, Ursula Winterfeld, Karine Lepigeon, Kitty W. M. Bloemenkamp, Odette de Bruin, Eimir Hurley, Hedvig Nordeng, Satu J. Siiskonen, Miriam C. J. M. Sturkenboom, David Baud, Alice Panchaud
Summary: This study aimed to describe the use of COVID-19-related medicines during pregnancy and how it evolved between the early and late periods of the pandemic. The results showed that the proportion of pregnant women who used COVID-19-related medicines increased with disease severity. The use of antibiotics, antivirals, and hydroxychloroquine was lower during the late period of the pandemic.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Obstetrics & Gynecology
Jasmin L. Aeberhard, Anda-Petronela Radan, Ricard Delgado-Gonzalo, Karin Maya Strahm, Halla Bjorg Sigurthorsdottir, Sophie Schneider, Daniel Surbek
Summary: Artificial intelligence has gained increasing interest in the field of medicine, particularly in the context of cardiotocography (CTG) interpretation, due to its ability to learn patterns directly from data and potentially remove biases and improve observer variability. This study presents an overview of different approaches and their strengths, gaps, and limitations in AI-assisted CTG interpretation. While there are promising approaches, none of them have gained widespread acceptance in clinical practice, highlighting the need for further investigation and refinement of algorithms and features.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Surgery
Jonathan Lawaetz, Gilles Soenens, Jonas Eiberg, Isabelle Van Herzeele, Lars Konge, Craig Nesbitt, Flavia Gentile, Konstantinos Stavroulakis, Salome Weiss, Leizl Joy Nayahangan
Summary: This study explores the status of simulation-based education for learning vascular surgical procedures in Europe and identifies facilitators and barriers to its implementation. The findings suggest a need for structured and mandatory simulation-based education programs in vascular surgery.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Health Care Sciences & Services
Guillaume Favre, Emeline Maisonneuve, Leo Pomar, Charlotte Daire, Christophe Poncelet, Thibaud Quibel, Cecile Monod, Begona Martinez de Tejada, Leonhard Schaffer, Andrea Papadia, Anda Petronela Radan, Monya Todesco-Bernasconi, Yves Ville, Cora Alexandra Voekt, Beatrice Eggel-Hort, Romina Capoccia-Brugger, Silke Johann, Claudia Grawe, Sophie Defert, Nicolas Mottet, Christian R. Kahlert, Charles Garabedian, Loic Sentilhes, Brigitte Weber, Steffi Leu, Dirk Bassler, Karine Lepigeon, Ursula Winterfeld, Alice Panchaud, David Baud
Summary: Unvaccinated pregnant women infected with SARS-CoV-2 are at higher risk of adverse outcomes. This study found that the risk of severe maternal adverse outcome was higher during the Delta period and lower during the Omicron period compared to the pre-Delta era.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Medicine, General & Internal
Hon-Lai Chan, Dimitrios D. Papazoglou, Silvan Jungi, Salome Weiss, Daniel Becker, Drosos Kotelis, Vladimir Makaloski
Summary: This study found that fenestrated physician-modified endografts are safe and effective in treating patients with juxtarenal abdominal aortic aneurysms, especially when incorporating main renal arteries. However, limited success was observed when targeting accessory renal arteries, especially those with a small diameter. Long-term follow-up is needed to determine the durability of these endografts for renal artery preservation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Patricia Christoph, Julia Aebi, Lena Sutter, Kai-Uwe Schmitt, Daniel Surbek, Stephan Oelhafen
Summary: In Switzerland, one third of children are born by caesarean section, which often leads to a restricted birth experience for women. An extended gentle CS protocol, offering early skin-to-skin contact and observation of the delivery process through a transparent drape, was evaluated. Although there was no significant difference in satisfaction, most women preferred the extended gentle CS and recommended it as an option for all women undergoing CS.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
