Article
Obstetrics & Gynecology
Homeira Vafaei, Fahimeh Kaveh Baghbahadorani, Nasrin Asadi, Maryam Kasraeian, Azam Faraji, Shohreh Roozmeh, Marjan Zare, Khadije Bazrafshan
Summary: Maternal administration of betamethasone resulted in significant changes in fetal blood velocity waveforms and affected blood flow in the pulmonary artery, leading to increased pulmonary artery AT and AT/ET. Among fetuses with RDS, there was a significant decrease in pulmonary artery AT, but no differences were observed in pulmonary artery AT/ET.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Demetrios J. Kutsogiannis, Abdulrahman Alharthy, Abdullah Balhamar, Fahad Faqihi, John Papanikolaou, Saleh A. Alqahtani, Ziad A. Memish, Peter G. Brindley, Laurent Brochard, Dimitrios Karakitsos
Summary: This study compared the respiratory mechanics, inflammatory markers, and incidence of pulmonary embolism in COVID-19 associated ARDS patients and non-COVID-19 ARDS patients. The results showed that COVID-19 patients were slightly less recruitable and had a higher incidence of pulmonary embolism.
FRONTIERS IN MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Dong Liu, Mengmeng Long, Leilei Gao, Yanjun Chen, Fang Li, Yang Shi, Ning Gu
Summary: The respiratory system is crucial in vertebrate biology, but viral infections can cause severe damage. Currently, there are no effective treatments, but nanomedicine shows potential. This review provides a summary of the pathology and clinical treatments of respiratory injuries, focusing on nanomedicine formulations tested in preclinical models.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Critical Care Medicine
Joseph R. R. Riddell, Benjamin J. J. Jones, Bruno M. M. Fernandes, Daniel J. J. Law, Jackie A. A. Cooper, Matt P. P. Wise
Summary: Post hoc analysis of the FACTT trial showed associations between mechanical ventilation indices and pulmonary artery pressure in ARDS patients, suggesting possible clinical targets for right ventricular protective mechanical ventilation strategies.
Article
Agriculture, Dairy & Animal Science
Federica Riva, Joel Filipe, Radmila Pavlovic, Alberto Maria Luciano, Paola Dall'Ara, Francesco Arioli, Alessandro Pecile, Debora Groppetti
Summary: In canine clinical practice, it is crucial to find new reliable markers for evaluating neonatal maturity. Concerns about the safety of amniotic sampling in pregnant dogs have hindered its collection for diagnostic purposes. However, recent studies have shown that amniocentesis is a reliable and safe procedure in dogs. This study analyzed amniotic fluid samples collected from ten dogs undergoing elective Caesarean sections at term to identify potential indices of canine neonatal maturity.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Multidisciplinary Sciences
Saba Muneer Zahid, Gun Lisbet Opheim, Tore Henriksen, Trond Melbye Michelsen, Guttorm Haugen
Summary: This study evaluated the Doppler blood flow velocity in different meal states in healthy pregnant women. The results showed possible diurnal variations in MCA-PI and UA-PI, which seemed to be unaffected by maternal meal intake in healthy pregnancies.
Article
Pediatrics
Qiong Huang, Wen Ling, Qiumei Wu, Shan Guo, Tingting Dang, Hong Ma, Biying Huang, Chunxia Chen, Min Liu, Xiuqing Qiu, Zongjie Weng
Summary: This study investigates the effectiveness of prenatal ultrasonography in diagnosing the anomalous origin of the fetal pulmonary artery (AOFPA). The features of AOFPA were identified by comparing prenatal ultrasound data with anatomical casting or postnatal imaging and surgical intervention. Prenatal ultrasonography is found to accurately diagnose AOFPA and the absence of either the left or right pulmonary artery in the image may indicate origin abnormalities.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Qiaoyi Xu, Shuya Mei, Fang Nie, Zhiyun Zhang, Junqi Feng, Jinyuan Zhang, Xiaoqing Qian, Yuan Gao, Zhengyu He, Shunpeng Xing
Summary: The study demonstrates that lipopolysaccharide induces activation of the JNK signaling pathway and TNF-alpha secretion in pulmonary macrophages, leading to interaction between inflammation and metabolism that promotes lung fibroblast glycolysis. This interaction plays a crucial role in lipopolysaccharide-induced pulmonary fibrosis.
LABORATORY INVESTIGATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hend Galal Eldeen Mohamed Ali Hassan, Mona Ali Mohamed Ali Nagi, Asmaa Magdy Mohamed Salama, Mohamed Omar Abd El Aal Dawoud, Ghalia Galal Elgendy, Ahmed S. Abdelrahman
Summary: The aim of this study is to highlight the predictive role of perinatal fetal main pulmonary artery (MPA) Doppler measurements in neonatal respiratory distress syndrome (RDS) development. The study showed that fetal MPA Doppler measurements play a major role in anticipating the development of neonatal RDS in preterm and early term neonates.
JOURNAL OF ULTRASOUND
(2023)
Article
Biochemistry & Molecular Biology
Peng Zhang, Baoyi Liu, Weihao Zheng, Yantang Chen, Zhentao Wu, Yuting Lu, Jie Ma, Wenjie Lu, Mingzhu Zheng, Wanting Wu, Zijie Meng, Jinhua Wu, Yan Zheng, Xin Zhang, Shuang Zhang, Yanming Huang
Summary: This study investigates the role of the lung microbiome in disease progression and potential therapeutic targets in patients with sepsis-induced acute respiratory distress syndrome (ARDS). The results show that different sites of infection and prognoses can affect the composition and diversity of the pulmonary microbiome in ARDS patients, providing insights into disease development and potential therapeutic targets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mandy Laube, Ulrich H. Thome
Summary: This article discusses sex-specific differences in alveolar epithelial functions, with a focus on preterm infants and respiratory disorders associated with premature birth. It provides an overview of fetal lung development and the challenges faced during the transition to air breathing. The article also explores potential sex-specific causes of pulmonary complications and highlights the importance of understanding steroidogenic enzymes' expression during fetal lung development. Additionally, it reviews the knowledge about sex-specific aspects of lung growth and maturation, with a special emphasis on alveolar epithelial Na+ transport and the observed sex differences in this process.
Article
Biochemistry & Molecular Biology
Eleonore Froehlich
Summary: This review discusses pulmonary changes and treatment options for ARDS induced by viruses, focusing on the potential role of pulmonary lymphatics in the pathology. Although hyaluronan may play a role in ARDS, promising pharmacological treatments are unlikely due to the limited role of drugs in lymphedema therapy.
Article
Medicine, General & Internal
Qing Qing, Ping Zha, Li-Ying Dai, Yang Wang
Summary: This study investigated the clinical efficacy of different ventilation strategies combined with pulmonary surfactant (PS) therapy in the treatment of neonatal respiratory distress syndrome (NRDS). The findings showed that the integration of high-frequency oscillatory ventilation (HFOV) with PS effectively expedited the treatment duration, decreased the occurrence of complications, and secured therapeutic efficacy in managing NRDS.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Biology
Adeel Nasrullah, Shiza Virk, Aaisha Shah, Max Jacobs, Amina Hamza, Abu Baker Sheikh, Anam Javed, Muhammad Ali Butt, Swathi Sangli
Summary: COVID-19 pandemic has caused significant morbidity and mortality, especially from severe acute respiratory distress syndrome (ARDS). The management of COVID-19-associated ARDS (CARDS) involves lung-protective ventilation, prone ventilation, neuromuscular blockade, and possibly a trial of pulmonary vasodilators for refractory hypoxemia.
Letter
Medicine, General & Internal
Katherine H. Campbell, Jean M. Tornatore, Kirsten E. Lawrence, Jessica L. Illuzzi, L. Scott Sussman, Heather S. Lipkind, Christian M. Pettker
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Review
Obstetrics & Gynecology
Katherine H. Campbell, Christian M. Pettker, Dena Goffman
SEMINARS IN PERINATOLOGY
(2020)
Article
Obstetrics & Gynecology
Justin R. Lappen, Christian M. Pettker, Judette M. Louis
Summary: Comprehensive assessment of pregnancy-related risks in the United States is crucial in reducing maternal morbidity and mortality, with identification of high-risk women and early interventions being key. Healthcare practitioners need to be educated on factors contributing to high-risk pregnancies and the importance of risk assessment in reducing maternal morbidity and mortality across the reproductive spectrum.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Scott C. Roberts, David R. Peaper, Craig D. Thorne, L. Scott Sussman, Thomas S. Murray, Steven J. Choi, Christian M. Pettker, Mark B. Russi, Richard A. Martinello
Summary: Mass asymptomatic SARS-CoV-2 testing of healthcare personnel at a large health system revealed a low prevalence of positive cases, with half of those testing positive having mild symptoms in hindsight. It is recommended that HCP with even mild symptoms should be isolated and tested.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Richard H. Lee, Mara Greenberg, Torri D. Metz, Christian M. Pettker
Summary: Intrahepatic cholestasis of pregnancy can cause maternal itching symptoms and pose potential risks for the fetus. Regular monitoring of bile acid and liver enzyme levels, medication treatment, and timely antenatal fetal surveillance are recommended.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Scott C. Roberts, Michael J. Aniskiewicz, Steven J. Choi, Christian M. Pettker, Richard A. Martinello
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Letter
Medicine, General & Internal
Scott C. Roberts, David R. Peaper, L. Scott Sussman, Richard A. Martinello, Christian M. Pettker
Summary: This quality improvement study reports the outcomes of a mass preprocedure SARS-CoV-2 testing strategy during a period of high community transmission in Connecticut.
Article
Obstetrics & Gynecology
C. Andrew Combs, Dena Goffman, Christian M. Pettker
Summary: Hospital readmission is considered a core measure of quality in healthcare, but the maternal readmission rate after childbirth currently has limited utility as a metric for quality or performance improvement.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Joseph B. Lillegard, Stephanie A. Eyerly-Webb, David A. Watson, Mert Ozan Bahtiyar, Kelly A. Bennett, Stephen P. Emery, Allan J. Fisher, Ruth B. Goldstein, William H. Goodnight, Foong-Yen Lim, Laurence B. McCullough, Ueli Moehrlen, Julie S. Moldenhauer, Anita J. Moon-Grady, Rodrigo Ruano, Daniel W. Skupski, Marjorie C. Treadwell, KuoJen Tsao, Amy J. Wagner, Michael V. Zaretsky
Summary: This study investigated whether an anterior placenta was associated with increased rates of complications in mothers and babies who underwent open maternal-fetal surgery for fetal myelomeningocele closure. The results showed that an anterior placenta was associated with a higher risk of intraoperative fetal resuscitation and thinning at the hysterotomy closure site, but did not significantly impact gestational age at delivery or maternal or fetal clinical outcomes.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Obstetrics & Gynecology
Linda L. Fan, Sangini S. Sheth, Christian M. Pettker
Summary: This study aims to establish a sustainable and trackable process to understand the role of social determinants of health, bias, and racism in adverse gynecologic events. The study used a standardized health equity checklist and evaluated multiple gynecologic adverse events. The results showed that social determinants of health and implicit bias played a significant role in some adverse events.
OBSTETRICS AND GYNECOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Linda L. L. Fan, Sangini S. S. Sheth, Christian M. M. Pettker
Summary: When evaluating unexpected medical adverse events after pharmaceutical, medical, or surgical treatment, it is important to investigate the roles of bias, systemic racism, and social determinants of health. Social determinants of health, including living environments, have a significant impact on clinical outcomes. Racial health disparities exist in various gynecologic procedures and outcomes, and investigating social determinants of health affecting patient outcomes is crucial. This study established a systematic and trackable process to determine the role of social determinants of health, bias, and racism in adverse gynecologic events.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Obstetrics & Gynecology
Abigail Wilpers, Erica Goldblatt Hyatt, Mert Ozan Bahtiyar, Yunzhe Hu, Daisy Leon-Martinez, Frank Chervenak, Judith L. M. Mccoyd
Summary: The study aims to develop a deeper understanding of the methods clinicians currently use to train for and provide counseling about maternal-fetal surgery. Findings indicate a lack of evidence-based communication practices and guidance, as well as systemic limitations affecting pregnant people's decision-making options related to maternal-fetal surgery.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Abigail Wilpers, Anna Y. Lynn, Barbara Eichhorn, Amy B. Powne, Megan Lagueux, Janene Batten, Mert Ozan Bahtiyar, Cary P. Gross
Summary: The quality of sociodemographic reporting in maternal-fetal surgery studies is poor and fails to adequately represent the racial and ethnic diversity of different disease populations.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Chrispin Chaguza, Andreas Coppi, Rebecca Earnest, David Ferguson, Nicholas Kerantzas, Frederick Warner, H. Patrick Young, Mallery Breban, Kendall Billig, Robert Tobias Koch, Kien Pham, Chaney C. Kalinich, Isabel M. Ott, Joseph R. Fauver, Anne M. Hahn, Irina R. Tikhonova, Christopher Castaldi, Bony De Kumar, Christian M. Pettker, Joshua L. Warren, Daniel M. Weinberger, Marie L. Landry, David R. Peaper, Wade Schulz, Chantal B. F. Vogels, Nathan D. Grubaugh
Summary: This study found that the odds of being infected with the Omicron variant were higher among vaccinated individuals compared to the Delta variant, and these odds increased with the number of vaccine doses. The positivity rates for the Delta variant were significantly reduced after two and three vaccine doses compared to unvaccinated individuals, while the positivity rate for the Omicron variant only significantly decreased after three doses.
Letter
Obstetrics & Gynecology
Christopher M. Zahn, Marc Jackson, Hyagriv N. Simhan, Christian M. Pettker
OBSTETRICS AND GYNECOLOGY
(2021)
