Article
Endocrinology & Metabolism
Anastasia Gant Kanegusuku, Katherine A. Araque, Hung Nguyen, Bin Wei, Saman Hosseini, Steven J. Soldin
Summary: The study evaluated the impact of abnormal concentrations of specific binding proteins (BPs) on immunoassay (IA) measurements of thyroid hormones. Results showed significant differences between IA and LC-MS/MS measurements of T3, FT3, and cortisol when TBG or CBG concentrations were low or high, indicating potential inaccuracies in diagnosis and treatment due to the influence of BP concentrations.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Valerie Anne Galton, Arturo Hernandez
Summary: This article explores the importance of thyroid hormone metabolism and its role in maintaining hormone balance, emphasizing that thyroid hormone metabolism is not solely for degradation and elimination but plays a crucial role in regulating various organs and tissues.
Article
Medical Laboratory Technology
Heleen I. Jansen, Antonius E. van Herwaarden, Henk J. Huijgen, Marc G. Vervloet, Jacquelien J. Hillebrand, Anita Boelen, Annemieke C. Heijboer
Summary: The study aimed to investigate the accuracy of testosterone, cortisol, and FT4 measurements in samples of HDp and to gain more insight into interfering factors. The results revealed that the average bias from LC-MS/MS was higher in HDp samples for testosterone, cortisol, and FT4 immunoassays compared to HC samples. FT4 IA results were falsely decreased in HDp samples, while cortisol and testosterone concentrations in females were predominantly falsely increased. These findings indicate that several IAs for testosterone, cortisol, and FT4 are less reliable in the altered serum matrix of HDp samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Heleen Jansen, Antonius E. van Herwaarden, Henk J. Huijgen, Rebecca C. Painter, Jacquelien J. Hillebrand, Anita Boelen, Annemieke C. Heijboer
Summary: This study evaluated the accuracy of several immunoassay methods for measuring fT4 in the serum of pregnant women. The results showed that the immunoassays overestimated fT4 levels in pregnant women, potentially leading to an overestimation of thyroid function.
EUROPEAN THYROID JOURNAL
(2022)
Article
Environmental Sciences
Klara Gustin, Malin Barman, Helena Skroder, Bo Jacobsson, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Marie Vahter, Maria Kippler
Summary: The study found that exposure to cadmium and mercury during pregnancy may affect thyroid function independently of iodine and selenium levels. Bayesian kernel machine regression did not indicate any mixture effect of toxic metals or interactions between metals and iodine or selenium.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Joris A. J. Osinga, Arash Derakhshan, Ulla Feldt-Rasmussen, Kun Huang, Tanja G. M. Vrijkotte, Tuija Mannisto, Judit Bassols, Abel Lopez-Bermejo, Ashraf Aminorroaya, Marina Vafeiadi, Maarten A. C. Broeren, Glenn E. Palomaki, Ghalia Ashoor, Liangmiao Chen, Xuemian Lu, Peter N. Taylor, Fang-Biao Tao, Suzanne J. Brown, Georgiana Sitoris, Lida Chatzi, Bijay Vaidya, Polina Popova, Elena A. Vasukova, Maryam Kianpour, Eila Suvanto, Elena N. Grineva, Andrew Hattersley, Victor J. M. Pop, Scott M. Nelson, John P. Walsh, Kypros H. Nicolaides, Mary E. D'Alton, Kris G. Poppe, Layal Chaker, Sofie Bliddal, Tim I. M. Korevaar
Summary: The study found that using alternative methods to define reference intervals for thyroid hormones in pregnant women can result in overdiagnosis and underdiagnosis compared to population- and trimester-specific reference intervals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Zheng Ding, Fei Guo, Yulai Zhou, Xiaoyi Huang, Zhiwei Liu, Jianxia Fan
Summary: In pregnant women after thyroidectomy for thyroid cancer, supplementation with a sufficient dose of thyroxine in early pregnancy is significantly associated with reduced neonatal birth weight, especially in male newborns, and may need close monitoring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye, Jeppe Buur Madsen, Niels Bilenberg, Philippe Grandjean, Tina Kold Jensen, Marianne S. Andersen
Summary: This study investigated the association between serum-PFAS concentrations and thyroid hormone status in early pregnancy. The results showed that higher concentrations of PFOS, PFOA, and PFNA were associated with increased FT4 levels, while no association was found with TSH levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Balsam Bohlega, Afshan Zahedi, George Tomlinson, Denice S. Feig
Summary: The study found that using a weight-based dosing method of starting thyroxine for women newly diagnosed with subclinical hypothyroidism during pregnancy increased the odds of reaching the target TSH range within 4-8 weeks. This approach should be considered by clinicians when initiating treatment during pregnancy.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
K. Aaron Geno, Matthew S. Reed, Mark A. Cervinski, Robert D. Nerenz
Summary: Automated FT4 immunoassays are not recommended for pregnant women due to potential inaccuracies, with guidelines suggesting the use of TT4 or FTI instead. This study found that FT4 levels decrease and TSH levels change throughout pregnancy, highlighting the importance of trimester-specific reference intervals for proper interpretation of thyroid status in pregnant individuals.
CLINICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Klara Gustin, Marie Vahter, Malin Barman, Bo Jacobsson, Helena Skroder, Helena Filipsson Nystrom, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Maria Kippler
Summary: This study assessed the associations between thyroid hormones and the combined status of iodine, selenium, and zinc in pregnant women. The results showed a positive correlation between the joint status of these micronutrients and plasma TSH concentrations, with zinc and selenium having a greater influence on hormone concentrations compared to iodine. This study highlights the importance of considering multiple micronutrients in studies of thyroid hormone status.
JOURNAL OF NUTRITION
(2022)
Article
Obstetrics & Gynecology
Kelly Nijsten, Marjette H. Koot, Joris A. M. van der Post, Joke M. J. Bais, Carrie Ris-Stalpers, Christiana Naaktgeboren, Henk A. Bremer, David P. van der Ham, Wieteke M. Heidema, Anjoke Huisjes, Gunilla Kleiverda, Simone M. Kuppens, Judith O. E. H. van Laar, Josje Langenveld, Flip van der Made, Dimitri Papatsonis, Marie-Jose Pelinck, Paula J. Pernet, Leonie van Rheenen-Flach, Robbert J. Rijnders, Hubertina C. J. Scheepers, Sarah E. Siegelaar, Tatjana Vogelvang, Ben W. Mol, Tessa J. Roseboom, Iris J. Grooten, Rebecca C. Painter
Summary: This study aimed to assess the utility of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) as markers and predictors for the severity and clinical course of hyperemesis gravidarum (HG). The findings showed inconsistent role for TSH, TSH MoM, or FT4 at time of admission in guiding the severity and clinical course of HG.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Federica D'Aurizio, Alessia Biasotto, Claudia Cipri, Franco Grimaldi, Jessica Zucco, Stefania Marzinotto, Francesco Curcio, Salvatore Benvenga
Summary: This case report described incongruent thyroid function test results in both a pregnant woman and her newborn. The mother's FT4 values during pregnancy showed inconsistency without clinical symptoms, suspected to be influenced by circulating antibodies. The newborn also showed inconsistent TFT results, but without signs of congenital hyperthyroidism.
EUROPEAN THYROID JOURNAL
(2022)
Article
Endocrinology & Metabolism
Aleksandra Mikolajczak, Katarzyna Kufel, Renata Bokiniec
Summary: This study indicates the need for adjusted FT4 values in preterm infants based on gestational age, and ultrasound thyroid imaging may be helpful in evaluating suspected thyroid disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Piotr Bargiel, Malgorzata Szczuko, Laura Stachowska, Piotr Prowans, Norbert Czapla, Marta Markowska, Jan Petriczko, Jakub Kledzik, Alicja Jedrzejczyk-Kledzik, Joanna Palma, Paulina Zabielska, Dominika Maciejewska-Markiewicz
Summary: This review summarizes the differences in the composition of intestinal microbiota in patients with thyroid diseases compared to healthy individuals, discusses the impact of microbiome on the proper functioning of the thyroid gland, and describes the association between microbiome, its metabolites, and thyroid dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Elizabeth N. Pearce, Maria Alexiou, Eftychia Koukkou, Lewis E. Braverman, Xuemei He, Ioannis Ilias, Maria Alevizaki, Kostas B. Markou
CLINICAL ENDOCRINOLOGY
(2012)
Editorial Material
Endocrinology & Metabolism
Devin W. Steenkamp, Ana Junqueira, Lewis E. Braverman
ENDOCRINE PRACTICE
(2013)
Article
Endocrinology & Metabolism
Pamela M. Katz, Angela M. Leung, Lewis E. Braverman, Elizabeth N. Pearce, George Tomlinson, Xuemei He, Jaclyn Vertes, Nan Okun, Paul G. Walfish, Denice S. Feig
ENDOCRINE PRACTICE
(2013)
Editorial Material
Endocrinology & Metabolism
Lewis E. Braverman, James A. Magner
ENDOCRINE PRACTICE
(2013)
Editorial Material
Endocrinology & Metabolism
Daniel E. Shumer, Jamie E. Mehringer, Lewis E. Braverman, Andrew Dauber
ENDOCRINE PRACTICE
(2013)
Article
Endocrinology & Metabolism
Mandy B. Belfort, Elizabeth N. Pearce, Lewis E. Braverman, Xuemei He, Rosalind S. Brown
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Veterinary Sciences
Charlotte H. Edinboro, Elizabeth N. Pearce, Sam Pino, Lewis E. Braverman
JOURNAL OF FELINE MEDICINE AND SURGERY
(2013)
Article
Pediatrics
Kara J. Connelly, Bruce A. Boston, Elizabeth N. Pearce, David Sesser, David Snyder, Lewis E. Braverman, Sam Pino, Stephen H. LaFranchi
JOURNAL OF PEDIATRICS
(2012)
Article
Endocrinology & Metabolism
Angela M. Leung, Lewis E. Braverman, Xuemei He, Timothy Heeren, Elizabeth N. Pearce
Article
Endocrinology & Metabolism
Angela M. Leung, Lewis E. Braverman, Xuemei He, Kristin E. Schuller, Alexandra Roussilhes, Katherine A. Jahreis, Elizabeth N. Pearce
Letter
Endocrinology & Metabolism
Angela M. Leung, Xuemei He, Elizabeth N. Pearce, Lewis E. Braverman
Editorial Material
Endocrinology & Metabolism
Angela M. Leung, Elizabeth N. Pearce, Lewis E. Braverman
Editorial Material
Endocrinology & Metabolism
Lewis E. Braverman
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2012)
Review
Endocrinology & Metabolism
Angela M. Leung, Lewis E. Braverman
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2012)
Review
Nutrition & Dietetics
Angela M. Leung, Lewis E. Braverman, Elizabeth N. Pearce
