Article
Endocrinology & Metabolism
Emily Robertson, Caroline Thew, Natalie Thomas, Leila Karimi, Jayashri Kulkarni
Summary: The findings of a clinical follow-up feasibility study suggest that treatment with nomegestrol acetate/17-beta estradiol is acceptable and effective in improving mood symptoms in PMDD patients. The majority of women reported a positive mood response, high adherence to the medication, and minimal side effects. Further research, such as a randomized controlled trial, is needed to confirm these results and explore the impact of this treatment on mood in PMDD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Ajna Hamidovic, Fatimata Soumare, Aamina Naveed, John Davis
Summary: This study investigated the association between progesterone, estradiol, and premenstrual food cravings. The results showed a protective effect of progesterone on premenstrual food cravings, based on prior research suggesting neurobiological overlaps between food and drug cravings. The study enrolled 37 non-illicit drug- or medication-using women and classified them as either premenstrual dysphoric disorder (PMDD) or control participants, based on daily ratings of symptoms. Blood samples were collected at eight clinic visits and analyzed using ultraperformance liquid chromatography tandem mass spectrometry. Hierarchical modeling revealed a significant inverse effect of progesterone on premenstrual food cravings, regardless of PMDD or control status.
Article
Computer Science, Cybernetics
Soyoung Ahn, Yongsoon Choi
Summary: This study developed a smart mirror called Smiley, which can only be seen when users smile, and evaluated its effects on women suffering from PMS. The results showed that smiling can change negative emotions caused by PMS and positively influence users' psychological stability and daily life.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Obstetrics & Gynecology
Joseph V. Turner, Lucas A. McLindon, Damien V. Turner, Yolaine Alefsen, Rene Ecochard
Summary: This study aims to investigate the relationship between luteal-phase hormonal profile and PMS. It found that symptomatic women had lower serum progesterone levels, especially after nine days of PMS symptoms.
REPRODUCTIVE SCIENCES
(2023)
Review
Psychiatry
Bethany Sander, Jennifer L. Gordon
Summary: Recent findings suggest that early menopause transition may exacerbate existing MRMDs due to hormonal changes, leading to depressive mood in some women. There is also evidence that some women with MRMD may have increased mood sensitivity to ovarian hormone withdrawal during late menopause transition and early postmenopausal phase. Further research is needed to clarify the trajectory of premenstrual dysphoria in the menopause transition and to be vigilant for potential worsening of symptoms in perimenopause for women with past or current premenstrual dysphoric disorder.
CURRENT PSYCHIATRY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jacques Donnez, Marie-Madeleine Dolmans
Summary: Oral gonadotropin-releasing hormone (GnRH) antagonists have shown effectiveness in managing endometriosis-associated symptoms, especially in patients who do not respond well to traditional treatments. Research needs to take into account the different phenotypes of the disease and propose novel treatment algorithms in order to improve management strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sibel Nayman, Isabelle Florence Schricker, Iris Reinhard, Christine Kuehner
Summary: This study investigated the impact of childhood adversity on mood and stress appraisal in women with Premenstrual Dysphoric Disorder (PMDD), finding that childhood adversity may have independent deteriorating effects on mood worsening and stress appraisal in PMDD patients. The observed cortisol cyclicity in women with higher childhood adversity may suggest different neuroendocrine subtypes of PMDD related to childhood trauma and warrants further research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Psychiatry
Anastasiya Slyepchenko, Luciano Minuzzi, Benicio N. Frey
Summary: Bipolar disorder presents differently in females compared to males, with characteristics such as more depressive episodes and rapid cycling. Comorbid PMDD with BD in females may lead to a more complex illness course and unique neurobiological correlates, posing challenges in treatment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Birgit Alsbjerg, Ulrik S. Kesmodel, Helle Elbaek, Rita Laursen, Steen B. Laursen, Dorthe Andreasen, Betina B. Povlsen, Peter Humaidan
Summary: The study did not find a significant reduction in total pregnancy loss or biochemical pregnancy loss with GnRHa supplementation in HRT-FET cycles. However, participants who had a live birth had higher progesterone concentrations. Additionally, there was a trend for higher live birth rates correlated with the highest estradiol concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Donghao Lu, Jurate Aleknaviciute, Ragnar Bjarnason, Rulla M. Tamimi, Unnur A. Valdimarsdottir, Elizabeth R. Bertone-Johnson
Summary: Rodents are omnivorous animals that primarily feed on plants, including various species such as rabbits, hamsters, and mice. They usually live on the ground, but there are also species that live in trees. Their characteristics include sharp incisors and lateral movement of the jaw.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
India I. Pappas, Wendy Y. Craig, Lindsey Spratt, Daniel Spratt
Summary: Testosterone and estradiol therapy are generally effective in suppressing gonadal function in transgender patients, without the need for progestin or GnRH agonist therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Clinical Neurology
Haohao Yan, Yudan Ding, Wenbin Guo
Summary: The study found that PMDD patients have a higher risk of suicidal ideation, suicide attempt, and suicide plan. Clinicians treating PMDD patients should be vigilant about signs of suicide ideation and behavior to implement better treatment and preventive measures.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Mingzhou Gao, Hao Zhang, Zhan Gao, Xunshu Cheng, Ya Sun, Mingqi Qiao, Dongmei Gao
Summary: This study aims to estimate the prevalence and risk factors of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) globally and regionally, with the goal of providing scientific basis for prevention and management of these disorders.
Article
Biology
Andrzej Sliwerski, Karolina Koszalkowska
Summary: The study found that fatigue, depressed mood, feeling overwhelmed, anxiety/tension, and decreased interest in everyday activities were the best predictors of PMS. However, PSST over-diagnosed PMS/PMDD in the depressed group but not in the group of women without PMS/PMDD. Clinicians should be aware that a retrospective diagnosis with PSST can be more sensitive to mood disorders and cycle phases than a prospective diagnosis with a daily symptoms calendar.
Review
Psychiatry
Jingyi Long, Yuejie Wang, Lianzhong Liu, Juan Zhang
Summary: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are related to the menstrual cycle and can affect patients' psychological, physical, and behavioral well-being. The detailed pathogenesis of these conditions is still unclear, and research on brain structure and function may provide insights into disease development.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Torbjorn Backstrom, Roshni Das, Marie Bixo
Summary: GABA is the main inhibitory neurotransmitter in the brain, and Allopregnanolone (Allo) is a steroid that modulates the GABA(A) receptor, affecting mood, memory, and food intake. While Allo is generally considered to be anxiolytic and anti-depressant, studies have shown that it may have paradoxical effects in certain individuals. A new substance, Isoallopregnanolone (Isoallo), has been discovered to function as a GABA(A) receptor modulating steroid antagonist (GAMSA).
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Johanna Molin, Eszter Vanky, Tone S. Lovvik, Eva Dehlin, Marie Bixo
Summary: Excessive gestational weight gain (GWG) is associated with enhanced leptin resistance and attenuated physiological increase in serum allopregnanolone levels during pregnancy. Metformin reduces the risk of excessive GWG in pregnant women with PCOS and improves leptin sensitivity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Anna Wikman, Julia Sacher, Marie Bixo, Angelica L. Hirschberg, Helena Kopp Kallner, C. Neill Epperson, Erika Comasco, Inger Sundstrom Poromaa
Summary: Current suicidal ideation was reported by nearly 40% of women with confirmed PMDD in the late luteal phase. Previous psychological treatment for PMDD and higher depressive symptoms in the late luteal phase were positively associated with current suicidal ideation, while higher self-rated health ratings were associated with lower odds ratios for current suicidal ideation.
Article
Obstetrics & Gynecology
Emil Nussler, Gabriel Granasen, Marie Bixo, Mats Lofgren
Summary: This study investigated the re-operation rates up to 10 years and patient-reported outcomes (PROMs) 5 years after POP surgery. The results showed low re-operation rates and a high response rate in the web-based PROM survey after 5 years. The subjective cure rate after primary POP operations was high, with reduced symptoms and satisfied patients.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
M. Makenzius, C. Obern, T. Tyden, M. Larsson, K. Gemzell-Danielsson, I Sundstrom-Poromaa, M. Ekstrand Ragnar
Summary: This study investigates women's decision-making on induced abortion in Sweden. The results show that half of the women find the decision relatively easy, while the other half finds it difficult. Reasons for choosing abortion include economic difficulties, early stage in the relationship, desire to work or study first, uncertainty about the relationship, and being too young. Factors predicting difficulty in decision-making include partner's hesitance, being born outside the Nordic countries, discussing the decision with someone, age over 30, the Covid-19 pandemic, and the desire to have children in the future.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Obstetrics & Gynecology
Anton Sandstrom, Marie Bixo, Torbjoern Backstrom, Anna Moller, Sahruh Turkmen
Summary: A study found that women with painful endometriosis have lower sensitivity to GABA(A) receptor stimulation compared to healthy controls. This indicates altered GABA(A) receptor function in the context of endometriosis-related pain.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Inger Sundstrom-Poromaa, Erika Comasco
Summary: Premenstrual symptoms are common among women of reproductive age, with 5% experiencing premenstrual dysphoric disorder (PMDD) during the luteal phase. Selective serotonin reuptake inhibitors are effective for many patients, but not all. Recent research shows that treatment with a selective progesterone receptor modulator (SPRM) significantly reduces the severity of PMDD symptoms, with minimal side effects.
Article
Public, Environmental & Occupational Health
Cerisa Obern, Maria Ekstrand Ragnar, Tanja Tyden, Margareta Larsson, Jenny Niemeyer Hultstrand, Kristina Gemzell-Danielsson, Inger Sundstrom-Poromaa, Marlene Makenzius
Summary: Multiple abortions are common in Sweden and are linked to parity, low education, tobacco use, and exposure to violence. Although Sweden offers high-quality and accessible comprehensive abortion care, counseling should be adaptable and address specific needs in vulnerable groups.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2023)
Editorial Material
Neurosciences
Nicole Petersen, Adriene M. Beltz, Kathleen V. Casto, Caitlin M. Taylor, Emily G. Jacobs, Inger Sundstroem-Poromaa, Belinda Pletzer
Summary: The neuroscience of hormonal contraceptives is a crucial yet emerging field. Although limited in size and scope, existing studies emphasize the complex effects of hormonal contraceptives on the nervous system, which can vary due to individual differences, contraceptive type and formulation, and timing of use. Neuroscientists can provide individuals with knowledge about the biopsychological effects of hormonal contraceptives through rigorous randomized controlled trials, large-scale studies examining population-level trends, and dense imaging or intensive longitudinal studies assessing individual-level effects.
NATURE NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Theodora Kunovac Kallak, Alice Zancanaro, Katja Junus, Anna-Karin Wikstroem, Inger Sundstroem Poromaa, Susanne Lager
Summary: This is a cross-sectional study aiming to investigate the associations between maternal weight, diet, exercise, pregnancy weight gain, and pregnancy outcome. Pregnant women at Uppsala University Hospital, Sweden were included in the study. Questionnaires regarding their dietary and exercise habits were collected, along with samples of maternal adipose tissues and placental tissue for analysis. The results will be published in peer-reviewed, international scientific journals.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Psychiatry
Louise Stiernman, Manon Dubol, Erika Comasco, Inger Sundstrom-Poromaa, Carl-Johan Boraxbekk, Maja Johansson, Marie Bixo
Summary: Premenstrual dysphoric disorder (PMDD) is associated with altered sensitivity to ALLO and ISO, neurosteroids that affect GABA(A) activity. ISO has been shown to alleviate PMDD symptoms. In this study, PMDD subjects exhibited increased brain activity during emotion processing in the late-luteal phase. The relationship between ISO/ALLO ratio and brain activity differed between PMDD subjects and controls in key emotion processing regions.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Esmeralda Hidalgo-Lopez, Jonas Engman, Inger Sundstrom Poromaa, Malin Gingnell, Belinda Pletzer
Summary: This study investigated the effects of hormonal contraceptives on mood side effects and found that they caused increased connectivity within the default mode network and decreased connectivity within the executive control network. Mood lability was the most consistent and prominent side effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
Jenny Niemeyer Hultstrand, Elin Tornroos, Tanja Tyden, Margareta Larsson, Marlene Makenzius, Kristina Gemzell-Danielsson, Inger Sundstrom-Poromaa, Maria Ekstrand Ragnar
Summary: Despite efforts to promote women's sexual and reproductive health in Sweden, many women seeking abortion still have unmet contraceptive needs. This study investigated the contraceptive use among these women, revealing a high rate of non-use and discontinuation of contraception. Limited fertility awareness and negative experiences with contraceptives were identified as factors contributing to the unmet need.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
