Article
Biochemistry & Molecular Biology
Adrian C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. Spradley, Patricia Dauer, Joey P. Granger, Sarosh Rana
Summary: Preeclampsia is a dangerous complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to find new compounds to reduce placental sFlt-1 and discovered that luteolin showed the most potent inhibition of sFlt-1 release, with over 95% reduction. Luteolin was found to reduce sFlt-1 through inhibition of HIF-1 alpha, possibly via the Akt pathway.
Article
Biochemistry & Molecular Biology
Xiaojie Huang, Linyan Jia, Yuanhui Jia, Xianghong Xu, Ruixue Wang, Mengtian Wei, Han Li, Hao Peng, Yingying Wei, Qizhi He, Kai Wang
Summary: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. Exosomes derived from PE patients contain higher levels of soluble FMS-like tyrosine kinase-1 (sFlt-1) and induce endothelial dysfunction and PE development. The treatment with trophoblast-derived sFlt-1-enriched exosomes (sFlt-1-Exo) inhibits human umbilical vein endothelial cell (HUVEC) migration and tube formation, and increases sFlt-1 secretion through enhanced transcription in HUVECs. In pregnant mice, sFlt-1-Exo or recombinant mouse sFlt-1 treatment induces a preeclampsia-like phenotype.
Article
Medicine, General & Internal
Hiroaki Tanaka, Kayo Tanaka, Sho Takakura, Naosuke Enomoto, Tomoaki Ikeda
Summary: This study suggests that sFlt-1 may be useful in predicting the timing of pregnancy termination in patients with preeclampsia. However, further research is needed to confirm these findings and determine the optimal timing for pregnancy termination in order to reduce severe maternal complications.
FRONTIERS IN MEDICINE
(2022)
Article
Developmental Biology
S. Rowson, M. Reddy, D. L. De Guingand, A. Langston-Cox, S. A. Marshall, F. da Silva Costa, K. R. Palmer
Summary: This study found that using placental-specific sFLT-1 e15a performs comparably to total sFLT-1 in diagnosing preeclampsia, which is particularly helpful in diagnosing early-onset preeclampsia.
Article
Pediatrics
Kalie F. Beckers, Viviane C. L. Gomes, Kassandra J. Raven Crissman, Daniella M. Adams, Chin-Chi Liu, Fabio Del Piero, Scott D. Butler, Jenny L. Sones
Summary: Preeclampsia is a common hypertensive disorder during pregnancy, posing risks to both mother and baby, with links to obesity and long-term effects on offspring health.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Adrian C. C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. T. Spradley, Patricia Dauer, Joey P. P. Granger, Sarosh Rana
Summary: Preeclampsia is a serious complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to identify new compounds that can reduce sFlt-1 and inhibit HIF-1a, a prohypertensive factor. The natural compound luteolin showed the strongest inhibition of sFlt-1 release, with over 95% reduction compared to the control group. Luteolin also reduced HIF-1a expression through the Akt pathway. This makes luteolin a potential novel treatment for preeclampsia.
Article
Medicine, General & Internal
Anne Karge, Linus Desing, Bernhard Haller, Javier U. Ortiz, Silvia M. Lobmaier, Bettina Kuschel, Oliver Graupner
Summary: Obese women with pre-eclampsia have a higher risk of adverse perinatal outcome. The measurement of sFlt-1/PIGF ratio in maternal serum can be helpful for both diagnosis of pre-eclampsia and prediction of adverse perinatal outcome. However, obese women show lower levels of sFlt-1, resulting in poorer performance of sFlt-1/PIGF as a predictor for adverse perinatal outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Karla Cecilia Marrufo-Gallegos, Jose Rafael Villafan-Bernal, Salvador Espino-y-Sosa, Guadalupe Estrada-Gutierrez, Iris Paola Guzman-Guzman, Raigam Jafet Martinez-Portilla, Johnatan Torres-Torres
Summary: The early identification of women at risk of preeclampsia is important, and this study aimed to determine relevant biomarkers for predicting preeclampsia. Serum creatine kinase, soluble tyrosine protein kinase receptor (sTIE2), and anti-angiogenic factor soluble c-Met (sMet) were found to be significantly different between women with and without preeclampsia, indicating their potential as biomarkers. However, other kinases and phosphatases were not found to be different between the two groups. Rating: 7
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Developmental Biology
Qing Zuo, Yanfeng Zou, Shiyun Huang, Tianjun Wang, Yetao Xu, Tingting Zhang, Min Zhang, Zhiping Ge, Ziyan Jiang
Summary: Aspirin reduces trophoblast apoptosis in preeclampsia by inactivating the NF-kappa B signaling pathway and reversing endothelial dysfunction and oxidative stress caused by sFlt-1. This treatment significantly improves the condition of patients with preeclampsia.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Ross McNally, Abdelrahim Alqudah, Emma M. McErlean, Claire Rennie, Nabila Morshed, Amy Short, Kristine McGrath, Olga Shimoni, Tracy Robson, Helen O. McCarthy, Lana McClements
Summary: This study developed a new model of preeclampsia by modulating the circulating protein sFlt-1 associated with the pregnancy complication using a safe and effective approach. The new model shows promise for testing and developing treatments for preeclampsia.
Review
Pharmacology & Pharmacy
Li Liao, Xingtao Zhao, Mengting Zhou, Ying Deng, Yunxia Li, Cheng Peng
Summary: sFlt-1 is associated with various angiogenesis-related diseases, such as pre-eclampsia, perinatal cardiomyopathy, diabetic nephropathy, hypertension, tumor, atherosclerosis, etc. Its regulatory mechanisms in these diseases are mainly related to the bioavailability of VEGF and vascular endothelial cell integrity.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Rebekka Vogtmann, Mian Bao, Monia Vanessa Dewan, Alina Riedel, Rainer Kimmig, Ursula Felderhoff-Mueser, Ivo Bendix, Torsten Ploesch, Alexandra Gellhaus
Summary: Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring's metabolism, resulting in long-term metabolic changes. In this study, researchers examined the consequences of sFLT1 overexpression in transgenic mice with PE/FGR on the offspring's metabolic phenotype. The results showed that sFLT1 overexpression led to growth-restricted fetuses with altered liver development and metabolic gene expression. The postnatal follow-up revealed increased weight gain and abnormal hormone levels in male PE offspring, suggesting adverse metabolic pre-programming specifically targeting males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Malia Su-Qin Murphy, Egle Bytautiene, George Saade, Graeme Neil Smith
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2015)
Article
Obstetrics & Gynecology
Egle Bytautiene Prewit, Talar Kechichian, Deborah Okunade, Huaizhi Yin, Alison M. Stuebe
REPRODUCTIVE SCIENCES
(2018)
Article
Public, Environmental & Occupational Health
E. Bytautiene Prewit, C. Porter, M. La Rosa, N. Bhattarai, H. Yin, P. Gamble, T. Kechichian, L. S. Sidossis
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Article
Obstetrics & Gynecology
Egle Bytautiene, Esther Tamayo, Talar Kechichian, Nathan Drever, Phyllis Gamble, Gary D. V. Hankins, George R. Saade
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Karin A. Fox, Monica Longo, Esther Tamayo, Talar Kechichian, Egle Bytautiene, Gary D. V. Hankins, George R. Saade, Maged M. Costantine
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Nathan Drever, Huaizhi Yin, Talar Kechichian, Maged Costantine, Monica Longo, George R. Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Article
Obstetrics & Gynecology
Arshag Kalanderian, Nicola Abate, Igor Patrikeev, Jingna Wei, Kathleen Listiak Vincent, Massoud Motamedi, George Robert Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Article
Obstetrics & Gynecology
Egle Bytautiene, Nataliya Bulayeva, Geeta Bhat, Li Li, Kevin P. Rosenblatt, George R. Saade
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2013)
Article
Obstetrics & Gynecology
Alexandria J. Hill, Nathan Drever, Huaizhi Yin, Esther Tamayo, George Saade, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Aaron T. Poole, Kathleen L. Vincent, Gayle L. Olson, Igor Patrikeev, George R. Saade, Alison Stuebe, Egle Bytautiene
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Article
Obstetrics & Gynecology
Giuseppe Chioss, Maged M. Costantine, Egle Bytautiene, Ancizar Betancourt, Gary D. V. Hankins, George R. Saade, Monica Longo
AMERICAN JOURNAL OF PERINATOLOGY
(2012)
Article
Obstetrics & Gynecology
Giuseppe Chiossi, Maged M. Costantine, Egle Bytautiene, Talar Kechichian, Gary D. V. Hankins, Elena Sbrana, George R. Saade, Monica Longo
AMERICAN JOURNAL OF PERINATOLOGY
(2012)
Article
Obstetrics & Gynecology
Sandra R. Herrera, Kathleen L. Vincent, Aaron Poole, Gayle Olson, Igor Patrikeev, Jamal Saada, Phyllis Gamble, Massoud Motamedi, George R. Saade, Alison M. Stuebe, Egle Bytautiene Prewit
AMERICAN JOURNAL OF PERINATOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Julio Mateus, Egle Bytautiene, Fangxian Lu, Esther H. Tamayo, Ancizar Betancourt, Gary D. V. Hankins, Monica Longo, George R. Saade
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2011)
Article
Obstetrics & Gynecology
Mauricio La Rosa, Talar Kechichian, Gayle Olson, George Saade, Egle Bytautiene Prewit
REPRODUCTIVE SCIENCES
(2020)