Article
Clinical Neurology
David D. M. Nicholl, Patrick J. Hanly, Ann A. Zalucky, George B. Handley, Darlene Y. Sola, Sofia B. Ahmed
Summary: Severe NH in OSA patients was associated with impaired renal function, which improved after CPAP therapy, while moderate NH did not show significant changes in renal hemodynamics.
Article
Clinical Neurology
Eunhye Bae, Nakwon Kwak, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Jaeyoung Cho
Summary: This study assessed mortality in patients with chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and overlap syndrome, and found that patients with overlap syndrome had increased mortality, although not higher than those with COPD alone. In predicting mortality, measurement of hypoxemic load was found to be more accurate than the apnea-hypopnea index.
Article
Endocrinology & Metabolism
Mahmoud I. Mahmoud, Raed K. Alotaibi, Rayyan Almusally, Hanaa Shafiek, Yasir Elamin, Ziad Alhaj, Waleed AlBaker, Alaeldin Elfaki, Hatem Qutub, Suha J. Albahrani, Fatima M. Alabdrabalnabi, Zahra A. Al Saeed, Reem Al Argan, Fatima Al Rubaish, Yousef D. Alqurashi, Noor-Ahmed Jatoi, Abdullah H. Alharmaly, Zainab Z. Almubarak, Abir H. Al Said, Nada Albahrani
Summary: This study investigated the association between glycosylated hemoglobin (HbA1c) levels and nocturnal hypoxemia and apnea-hypopnea index (AHI) in Saudi patients with obstructive sleep apnea (OSA) and diabetes mellitus (DM). The findings suggest that nocturnal hypoxemia may be an important factor affecting glycemic control in patients with OSA and DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alberto R. Ramos, Noam Alperin, Sang Lee, Kevin A. Gonzalez, Wassim Tarraf, Rene Hernandez-Cardenache
Summary: This study aimed to determine the sleep correlates of age-related brain loss in middle-aged to older males with obstructive sleep apnea (OSA). Findings indicated that the insomnia severity index score and average oxygen levels during sleep had the strongest correlations with brain volumes and cognition, suggesting potential strategies to improve age-related brain loss in OSA patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Lirong Yan, Hea Ree Park, Eric J. Kezirian, Soonhyun Yook, Jae-Hun Kim, Eun Yeon Joo, Hosung Kim
Summary: Altered cerebral perfusion patterns were observed in OSA patients compared to healthy reference subjects. This impaired perfusion, mainly affecting the parietal and prefrontal cortices, may contribute to neurocognitive deficits in OSA. Correlation analysis showed distinctive associations between regional hypoperfusion and parameters of intermittent hypoxia and sleep fragmentation, suggesting a potential pathomechanism for neurocognitive deficits in OSA.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, General & Internal
Guo-hui Zeng, Guo Xu, Hong-yu Liu, Zhong Gao
Summary: This study evaluated the correlation between mean platelet volume (MPV) and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children, and found that MPV can be used as an auxiliary diagnostic index to judge the severity of OSAHS and the degree of hypoxia in children.
Review
Microbiology
Andras Bikov, Silvano Dragonieri, Balazs Csoma, Carmen Mazzuca, Panaiotis Finamore, Giulia Rocchi, Lorenza Putignani, Michele Guarino, Simone Scarlata
Summary: The bacteria in the human body, especially the gut microbiome, play an important role in respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. This article summarizes the evidence and discusses the impact of altered gut microbiome on these diseases and their comorbidities, as well as the potential of manipulating the gut microbiome for therapeutic purposes.
Article
Clinical Neurology
Clara Gregori-Pla, Peyman Zirak, Gianluca Cotta, Pau Bramon, Igor Blanco, Isabel Serra, Anna Mola, Ana Fortuna, Jordi Sola-Soler, Beatriz F. Giraldo Giraldo, Turgut Durduran, Mercedes Mayos
Summary: This study aimed to investigate the impact of obstructive sleep apnea/hypopnea events on cerebral hemodynamics and their association with polysomnographic parameters. The results showed that these events cause profound and periodic changes in cerebral hemodynamics, including changes in cerebral blood flow, total hemoglobin concentration, and cerebral blood oxygen saturation. The duration of the events was found to be a strong determinant of the cerebral hemodynamic response, with apnea events showing a more pronounced response compared to hypopnea events.
Article
Respiratory System
Andrew E. Beaudin, Jill K. Raneri, Najib T. Ayas, Robert P. Skomro, Nurit Fox, A. J. Marcus Hirsch Allen, Matthew W. Bowen, Andrhea Nocon, Emma J. Lynch, Meng Wang, Eric E. Smith, Patrick J. Hanly
Summary: The prevalence of mild cognitive impairment (MCI) is high in patients referred to sleep clinics for obstructive sleep apnea (OSA), especially among older males with moderate to severe OSA and vascular comorbidities. Moderate to severe OSA is an independent risk factor for MCI, with higher odds for cognitive impairment compared to patients with no OSA.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Engineering, Biomedical
Marika Rissanen, Henri Korkalainen, Brett Duce, Saara Sillanmaki, Henna Pitkanen, Aaron Suni, Sami Nikkonen, Antti Kulkas, Juha Toyras, Timo Leppanen, Samu Kainulainen
Summary: This study aimed to examine the effects of atrial arrhythmias on the severity and characteristics of desaturation in patients with obstructive sleep apnea. Retrospective analysis was conducted on 520 suspected patients, and various parameters were calculated from polysomnographic recordings. The results showed that patients with a previous atrial arrhythmia diagnosis had greater desaturation recovery area and more gradual recovery slopes compared to those without a diagnosis. Patients with atrial fibrillation also exhibited more gradual oxygen saturation fall and recovery slopes than patients with sinus rhythm. These findings suggest that considering the desaturation recovery section could provide valuable information about OSA severity.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Clinical Neurology
Aye-Thandar Aung, William Kristanto, Megan Jia-Ing Tan, Chieh-Yang Koo, Pei-Qing Xu, Calvin W. Chin, Glenn Roldan, As Tar Thant, Siew-Pang Chan, Ai-Ping Chua, Ferran Barbe, Pipin Kojodjojo, Chi-Hang Lee
Summary: Patients who underwent percutaneous coronary intervention often experience obstructive sleep apnea during REM sleep, with diabetes mellitus being identified as an independent predictor of this condition.
SLEEP AND BREATHING
(2021)
Article
Clinical Neurology
Carlos Alberto Nigro, Ignacio Bledel, Eduardo Borsini
Summary: This study assessed the relationship between hypoxemia during polysomnography (PSG) and patient-reported night sweats (NS). The study found that night sweats were significantly and independently associated with a higher hypoxic burden in patients with obstructive sleep apnea (OSA).
SLEEP AND BREATHING
(2023)
Article
Anesthesiology
Frances Chung, Rida Waseem, Chew Yin Wang, Edwin Seet, Colin Suen, Matthew T. Chan
Summary: The study aims to determine whether preoperative oximetry-derived hypoxemia can predict postoperative cardiovascular events in surgical patients with unrecognized obstructive sleep apnea.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Clinical Neurology
Nicole Kye Wen Tan, Dominic Wei Ting Yap, Benjamin Kye Jyn Tan, Yao Hao Teo, Elisabeth Ker Hsuen Tan, Jason Yongsheng Chan, Haur Yueh Lee, Anna See, Song Tar Toh
Summary: Meta-analysis of the association between obstructive sleep apnea (OSA) and melanoma suggests a higher risk of melanoma in patients with OSA. Future studies should focus on exploring the differential risk of melanoma for varying severity of OSA.
Article
Biology
Yung-Lung Chen, Yung-Che Chen, Hui-Ting Wang, Ya-Ting Chang, Yen-Nan Fang, Shukai Hsueh, Wen-Hao Liu, Pei-Ting Lin, Po-Yuan Hsu, Mao-Chang Su, Kuo-Tung Huang, Meng-Chih Lin
Summary: Obstructive sleep apnea syndrome (OSAS) is a significant risk factor for left atrial (LA) remodeling. Intermittent hypoxemia plays a crucial role in cardiovascular pathologies by affecting the viability, oxidative stress, apoptosis, and inflammation-associated cytokine expression in cells. The study also found a correlation between OSAS severity and LA size. Exosomes from patients with significant OSAS were found to increase the expression of HIF-1 alpha, IL-1 beta, and IL-6 in HL-1 cells.
Article
Sociology
Jessica Naidu, Elizabeth Oddone Paolucci, Tanvir Chowdhury Turin
Summary: This study focuses on the impact of racism as a social determinant of health for racialized immigrant population in developed countries such as the United States, Canada, New Zealand, and European countries. Racism is defined as an organized system that disadvantages a specific racial group. The research argues that racism affects immigrants in their acculturation process and suggests that these acculturation pathways are strategies used by refugees to cope with post-displacement stress and trauma. Health policymakers and practitioners are encouraged to recognize racism as a social determinant of health and work towards reducing its impact.
Article
Cardiac & Cardiovascular Systems
Danica H. Chang, Sandra M. Dumanski, Sofia B. Ahmed
Summary: Cardiovascular disease is the leading cause of death in women, yet females are underrepresented in cardiovascular research, leading to poorer health outcomes. A framework is proposed to address this issue by including female models, considering sex as a biological variable, and increasing female participation in clinical trials. It is essential to collect sex-specific data and stratify data by sex to ensure reproducibility and relevance of findings. Increasing female representation and considering female-specific cardiovascular risk factors will improve cardiovascular health for all.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Health Care Sciences & Services
Tanvir C. Turin, Mashrur Kazi, Nahid Rumana, Mohammad A. A. Lasker, Nashit Chowdhury
Summary: Meaningful community engagement involves addressing community needs, enhancing community capacity, and using culturally tailored strategies. Currently, community engagement in health and wellness research typically begins and ends with a specific research project, limiting the transfer of outcomes to future projects. This article proposes a philosophical approach that views community engagement as an infinite game, emphasizing long-term research programs and the community's active involvement.
HEALTH EXPECTATIONS
(2023)
Editorial Material
Urology & Nephrology
Sofia B. Ahmed, Lauren B. Beach, Joshua D. Safer, Jaimie F. Veale, Cameron T. Whitley
Summary: Transgender persons face barriers in accessing equitable, inclusive and appropriate care. Five researchers with expertise across various disciplines provide their perspectives on key considerations for achieving optimal care for transgender individuals, including barriers and strategies to ensure inclusive and safe care provision.
NATURE REVIEWS NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Sofia B. Ahmed
Summary: The importance of considering factors related to sex and gender in research is gaining recognition. Differences in kidney disease pathophysiology, presentation, therapy response, and outcomes exist between sexes and genders, yet they are often overlooked in basic and clinical studies. It is time for nephrology to catch up.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Physiology
David D. M. Nicholl, Patrick J. Hanly, Jennifer M. MacRae, Ann A. Zalucky, George B. Handley, Darlene Y. Sola, Sofia B. Ahmed
Summary: Obstructive sleep apnea (OSA) is more common in men than women due to the differences in body fluid composition. This study aimed to determine the impact of continuous positive airway pressure (CPAP) on body fluid composition in OSA patients. The results showed that there were no significant sex differences in the response to CPAP, indicating that CPAP does not affect body fluid composition differently between men and women with OSA.
PHYSIOLOGICAL REPORTS
(2023)
Article
Sociology
Mohammad M. H. Raihan, Nashit Chowdhury, Tanvir C. Turin
Summary: Skilled immigrants are vital to Canada's social and economic vitality. However, due to a lack of inclusive post-immigration professional integration policies and support, they often struggle to find employment aligned with their skillset. This paper examines the current state of low job market integration for skilled immigrants in Canada and the implications it has on their social integration and mental well-being. Despite possessing sufficient skills and qualifications, skilled immigrants still face disparities in obtaining desired jobs. Research suggests that this low job market integration hampers their productivity and leads to reduced social integration and deteriorated mental well-being. Therefore, collaborative efforts from various stakeholders are needed to improve the mental well-being of skilled immigrants by providing equal opportunities and eliminating social exclusion and marginalization.
Article
Sociology
Jessica Naidu, Elizabeth Oddone Paolucci, Tanvir C. Turin
Summary: Critical Discourse Analysis (CDA) is an interdisciplinary research methodology that analyzes the social construction of meaning through studying discourse as a form of social practice. It draws from critical studies and aims to challenge and change societal practices by focusing on social and political forces that produce social phenomena. This article demonstrates the relevance of CDA in population public health (PPH) research by highlighting its theoretical foundations, three crucial principles (contribution to social justice, theory-based approach, and constructivist epistemology), and its alignment with PPH goals of addressing social determinants of health and reducing health inequities.
Article
Geriatrics & Gerontology
Mohammad M. H. Raihan, Nashit Chowdhury, Mohammad Z. I. Chowdhury, Tanvir C. Turin
Summary: This study examines the relationship between various mental health indicators and involuntary delayed retirement (IDR) in working older adults (≥65 years) in the USA. The findings suggest that older adults who experience IDR are more likely to have depression, anxiety, and anger-in. However, IDR is not significantly associated with anger-out in older adults who work past the traditional retirement age.
AGING & MENTAL HEALTH
(2023)
Editorial Material
Urology & Nephrology
David Collister, Sofia B. Ahmed
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Cindy Z. Kalenga, Amy Metcalfe, Magali Robert, Kara A. Nerenberg, Jennifer M. MacRae, Sofia B. Ahmed
Summary: The route of estrogen administration and formulation of estrogen in hormone therapy for postmenopausal women are associated with the risk of hypertension. Oral estrogen is associated with a higher risk of hypertension, while transdermal, vaginal, or intramuscular estrogen is associated with a lower risk. Conjugated equine estrogen is associated with an increased risk, while estradiol or estrone is not. The duration and cumulative dose of estrogen use are positively associated with the risk of hypertension.
Article
Medicine, General & Internal
Stephana Julia Moss, Nicole Racine, Sofia Ahmed, Kathryn Birnie, Michal S. Cherak, Janet A. Curran, Donna Halperin, Scott A. Halperin, Micaela Harley, Jia Hu, Laura Leppan, Angie Nickel, Kristine Russell, May Solis, Stacie Smith, Andrea Soo, Maia Stelfox, Perri R. Tutelman, Henry Thomas Stelfox, Kirsten M. Fiest, Jeanna Parsons Leigh
Summary: This article presents a research protocol for partnering with youth and families to develop a user-centered digital tool for youth mental well-being.
Article
Urology & Nephrology
Danica H. Chang, Sandra M. Dumanski, Erin A. Brennand, Shannon M. Ruzycki, Kaylee Ramage, Taryn Gantar, Silvi Shah, Sofia B. Ahmed
Summary: Abnormal menstruation and period poverty are common among female individuals with CKD, and contraceptive use is low. Fear and lack of multidisciplinary care are the main barriers.
Article
Health Care Sciences & Services
Bishnu Bahadur Bajgain, Mohammad Z. I. Chowdhury, Rudra Dahal, Kalpana Thapa Bajgain, Kamala Adhikari, Nashit Chowdhury, Tanvir C. Turin
Summary: This study aimed to assess unmet healthcare needs among Nepalese immigrants in Calgary. Almost half of the participants reported unmet needs, primarily due to long waits for care, healthcare costs, and lack of knowledge on where to seek help. Unmet healthcare needs had a significant impact on individuals' personal health, daily life activities, and financial capacity. Strategies to improve access to primary healthcare for disadvantaged populations are crucial.
Review
Public, Environmental & Occupational Health
Nashit Chowdhury, Ayisha Khalid, Tanvir C. Turin
Summary: This rapid integrative review examines the prevalence of misinformation during large-scale infectious disease outbreaks since 2000. The study finds widespread misinformation in various aspects, with conspiracy theories regarding vaccines being particularly prevalent. The lack of scientific knowledge and trust in the government contribute to the consumption and dissemination of misinformation, especially through social media. This review provides valuable insights for addressing misinformation during the ongoing COVID-19 pandemic or any future pandemics.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
