Article
Neurosciences
Sarah Treit, Nashwan Naji, Peter Seres, Julia Rickard, Emily Stolz, Alan H. Wilman, Christian Beaulieu
Summary: The study found that QSM and R2* values in the caudate, putamen, and globus pallidus of healthy individuals increased most rapidly during childhood and continued to increase gradually throughout adulthood, with caudate susceptibility reaching a plateau in the late 30s. The thalamus showed a unique profile with R2* changes peaking in childhood and both R2* and QSM reaching a plateau in the mid-30s to early 40s.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Hiroki Masuda, Masahiro Mori, Shigeki Hirano, Akiyuki Uzawa, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Reiji Aoki, Yoshiyuki Hirano, Satoshi Kuwabara
Summary: This study aimed to compare the longitudinal brain atrophy in patients with NMOSD with healthy controls. The results showed a higher atrophy rate in patients with AQP4 + NMOSD compared to the controls. The study also found negative correlations between the normalized white matter volume (NWV) atrophy rate and the spinal cord lesion length, as well as the time between prednisolone usage and baseline MRI in patients with AQP4 + NMOSD.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Al-Radaideh, Imad Athamneh, Hadeel Alabadi, Majed Hbahbih
Summary: In patients with relapsing-remitting multiple sclerosis, deep gray matter (dGM) volumetric metrics and MTR values are significantly lower than in healthy controls, and have moderate associations with lesion load and iron concentration. T1 changes in dGM regions weakly correlate with T2 lesions, while iron concentration does not show any association with lesion metrics. Most dGM metrics do not correlate with disease severity, while most lesion metrics show weak associations with disease severity.
EUROPEAN RADIOLOGY
(2021)
Review
Clinical Neurology
Amy D. De Lury, Joseph A. Bisulca, Jimmy S. Lee, Muhammad D. Altaf, Patricia K. Coyle, Tim Q. Duong
Summary: This systematic review examines the role of deep gray matter (DGM) iron deposition detected by MRI techniques in relation to inflammatory processes in multiple sclerosis (MS). The review finds that DGM iron deposits are independent yet concurrent with demyelination and contribute to cognitive impairment and disability in MS. The variability in iron distribution appears to be influenced by a positive feedback loop between inflammation and iron release by oligodendrocytes. DGM iron shows promise as a prognostic biomarker for MS pathophysiology.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Yan Li, Sean K. Sethi, Chunyan Zhang, Yanwei Miao, Kiran Kumar Yerramsetty, Vinay Kumar Palutla, Sara Gharabaghi, Chengyan Wang, Naying He, Jingliang Cheng, Fuhua Yan, Ewart Mark Haacke
Summary: The study aimed to evaluate the impact of resolution on iron content and verify the consistency of QSM in assessing iron content of deep gray matter structures. Results showed that the susceptibility and iron content of different nuclei are related to age, and accurate estimates of age-related iron behaviors can be obtained at high resolutions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Charidimos Tsagkas, Emanuel Geiter, Laura Gaetano, Yvonne Naegelin, Michael Amann, Katrin Parmar, Athina Papadopoulou, Jens Wuerfel, Ludwig Kappos, Till Sprenger, Cristina Granziera, M. Mallar Chakravarty, Stefano Magon
Summary: This study investigates the longitudinal changes in deep gray matter (DGM) shape in relapse-onset multiple sclerosis (MS) and their relationship with clinical disability and white matter lesion-load. The study finds specific shape changes in DGM structures over time, but these changes are not associated with disease progression. However, there is a link between DGM shape and average disease severity as well as white matter lesion-load.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Gaiying Li, Rui Tong, Miao Zhang, Kelly M. Gillen, Wenqing Jiang, Yasong Du, Yi Wang, Jianqi Li
Summary: This study used quantitative susceptibility mapping to simultaneously investigate age-dependent trajectories of mean susceptibility, adjusted volume, and total iron content in deep gray matter nuclei. The study found that the mean susceptibility and total iron content of all six nuclei increased with age, while the adjusted volume showed linear or quadratic relationships with age in different nuclei. It also revealed sex-related differences in magnetic susceptibility, volume, and iron content of the nuclei. Additionally, combining mean susceptibility and volume of certain nuclei showed the strongest associations with brain age prediction.
Article
Health Care Sciences & Services
Feiyue Yin, Zichun Yan, Yongmei Li, Shuang Ding, Xiaohua Wang, Zhuowei Shi, Jinzhou Feng, Silin Du, Zeyun Tan, Chun Zeng
Summary: This study used machine learning to explore microstructural alterations in the deep gray matter nucleus of multiple sclerosis (MS) patients. The results showed that these alterations were strongly associated with clinical symptoms and primarily affected cognitive function and clinical disability.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cell & Tissue Engineering
Foteini Tsouki, Anna Williams
Summary: The review highlights the significant role of microglia in gray matter changes in MS, particularly in neuronal loss and cortical atrophy. Microglia exhibit regional heterogeneity within the central nervous system, showing their ability to provide context-dependent responses tailored to the demands of their microenvironment.
Article
Endocrinology & Metabolism
Juho R. H. Raiko, Jetro J. Tuulari, Teemu Saari, Riitta Parkkola, Nina Savisto, Pirjo Nuutila, Kirsi Virtanen
Summary: The study suggests a potential correlation between brown adipose tissue activity and gray matter volume, with implications for protection against cognitive degeneration associated with cardiometabolic risk factors like obesity and insulin resistance. Further research is needed to examine the causal relationships between BAT activity and GM volumes.
Article
Soil Science
Mackenzie E. Patrick, Catie T. Young, Andrew R. Zimmerman, Susan E. Ziegler
Summary: Boreal forests in Newfoundland and Labrador have a significant impact on global forest soil organic carbon (SOC) stock and its vulnerability to climate change. However, regional studies on the climate's relevant controls for this area are lacking. This study examines the relationship between mineral soil characteristics and other ecosystem parameters with SOC and N content, highlighting the potential role of seasonal hydrology on metal-stabilized C and N sequestration in boreal forests.
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, Research & Experimental
VyVy N. Young, Joseph Kidane, Grant E. Gochman, David J. Bracken, Yue Ma, Clark A. Rosen
Summary: This study is the first to objectively assess laryngopharyngeal sensation in AdLD. The findings demonstrate increased laryngopharyngeal sensation in AdLD patients compared to controls. The identification of increased laryngeal hypersensitivity in these patients may improve understanding of AdLD pathophysiology and identify future targets for intervention.
Article
Health Care Sciences & Services
Yoko Shigemoto, Noriko Sato, Norihide Maikusa, Daichi Sone, Miho Ota, Yukio Kimura, Emiko Chiba, Kyoji Okita, Tensho Yamao, Moto Nakaya, Hiroyuki Maki, Elly Arizono, Hiroshi Matsuda
Summary: Recent developments in image analysis have allowed for the evaluation of brain networks and prediction of brain age from gray matter images. This study examined the effects of age and sex on gray matter networks in a large sample of healthy individuals. The findings revealed that while the brain network retained its small-world properties regardless of age, reduced small-world properties were observed with advancing age. Women showed higher network properties than men, but had faster age-related network declines, leading to no sex differences in participants aged >= 70 years. The study provides new insights into network alterations that occur with aging.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
David J. Madden, Jenna L. Merenstein
Summary: Quantitative susceptibility mapping (QSM) is an MRI technique that assesses the magnetic properties of cerebral iron. This integrative review of 47 QSM studies on healthy aging reveals the age-related increases in iron accumulation in deep gray matter nuclei and cortical regions, and the behavioral relevance and interaction of iron with brain function and pathology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin Kraemer, Benedikt Herzau, Juergen R. Reichenbach
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2020)
Review
Biophysics
Martin Meyerspeer, Chris Boesch, Donnie Cameron, Monika Dezortova, Sean C. Forbes, Arend Heerschap, Jeroen A. L. Jeneson, Hermien E. Kan, Jane Kent, Gwenael Layec, Jeanine J. Prompers, Harmen Reyngoudt, Alison Sleigh, Ladislav Valkovic, Graham J. Kemp, Celine Baligand, Pierre G. Carlier, Benjamin Chatel, Bruce Damon, Linda Heskamp, Milan Hajek, Melissa Jooijmans, Martin Krssak, Juergen Reichenbach, Albrecht Schmid, Jill Slade, Krista Vandenborne, Glenn A. Walter, David Willis
Summary: This article provides a detailed overview of the skeletal muscle phosphorus-31 P-31 MRS methodology for in vivo metabolic research, covering signal acquisition parameters, quantitative assessment of metabolic information, interpretation of potential issues, and requirements for research data, aiming to offer a reliable and comprehensive description of muscle physiology and pathophysiology.
NMR IN BIOMEDICINE
(2021)
Article
Biophysics
Martin Kraemer, Matthias R. Kollert, Nicholas M. Brisson, Marta B. Maggioni, Georg N. Duda, Juergen R. Reichenbach
NMR IN BIOMEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Daniel F. B. Haeufle, Johannes Siegel, Stefan Hochstein, Alexander Gussew, Syn Schmitt, Tobias Siebert, Reinhard Rzanny, Juergen R. Reichenbach, Norman Stutzig
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Neurosciences
Silvio Schmidt, Sidra Gull, Karl-Heinz Herrmann, Marcus Boehme, Andrey Irintchev, Anja Urbach, Juergen R. Reichenbach, Carsten M. Klingner, Christian Gaser, Otto W. Witte
Summary: Volumetric magnetic resonance imaging studies have shown that intense learning can lead to grey matter volume increases in adult brains. In a study with rats, it was found that use-dependent grey matter increases were primarily associated with swelling of astrocytes rather than other mechanisms, indicating structural plasticity involving synaptic and astrocytic remodeling.
Article
Multidisciplinary Sciences
Evgeniya Kirilina, Saskia Helbling, Markus Morawski, Kerrin Pine, Katja Reimann, Steffen Jankuhn, Juliane Dinse, Andreas Deistung, Jurgen R. Reichenbach, Robert Trampel, Stefan Geyer, Larissa Mueller, Norbert Jakubowski, Thomas Arendt, Pierre-Louis Bazin, Nikolaus Weiskopf
Article
Neurosciences
Alina Lopatina, Stefan Ropele, Renat Sibgatulin, Juergen R. Reichenbach, Daniel Gullmar
FRONTIERS IN NEUROSCIENCE
(2020)
Review
Engineering, Biomedical
S. M. Seyedpour, S. Nafisi, M. Nabati, D. M. Pierce, J. R. Reichenbach, T. Ricken
Summary: MRI-based mathematical and computational modeling studies can enhance our understanding of cartilage mechanics and diseases, as well as optimize artificial cartilage production. These studies demonstrate the potential for an engineering-level approach to analyze the effects of cartilage diseases on material properties and function.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Guellmar, Nina Jacobsen, Andreas Deistung, Dagmar Timmann, Stefan Ropele, Jurgen R. Reichenbach
Summary: The application of deep neural networks for segmentation in medical imaging has gained significant interest in recent years. This study systematically investigates the sensitivity of deep learning in medical image segmentation to variations in input data. The study also explores the effectiveness of different data augmentation strategies, providing a useful tool for selecting appropriate parameters for augmentation.
ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
(2022)
Article
Neurosciences
Meng Li, Lena Vera Danyeli, Lejla Colic, Gerd Wagner, Stefan Smesny, Tara Chand, Xin Di, Bharat B. Biswal, Jorn Kaufmann, Juergen R. Reichenbach, Oliver Speck, Martin Walter, Zuemruet Duygu Sen
Summary: Reproducible resting-state functional connectivity patterns and their alterations have significant implications in neuropsychiatric research. This study utilizes multimodal imaging and magnetic resonance spectroscopy to investigate the correlation between regional neurotransmitter levels and rsFC strength, providing insights into the modulation of interaction between brain regions at a macroscopic level.
HUMAN BRAIN MAPPING
(2022)
Article
Pediatrics
Beatrice Steiniger, Ursula Lechel, Juergen R. Reichenbach, Martin Fiebich, Rene Aschenbach, Alexander Schegerer, Matthias Waginger, Anelyia Bobeva, Ulf Teichgraeber, Hans-Joachim Mentzel
Summary: This study compared the image quality and radiation exposure of three different imaging modalities, including high-class CT, mid-class CT, and cone beam CT, in infants. The results showed that high-class CT had the lowest dose but the worst image quality, while cone beam CT had the best image quality but the highest radiation exposure. Mid-class CT was in between. Based on the results, high-end CT should be used for surgical planning, while cone beam CT should be considered for cases requiring the highest image quality.
PEDIATRIC RADIOLOGY
(2022)
Article
Cell Biology
Sidra Gull, Christian Gaser, Karl-Heinz Herrmann, Anja Urbach, Marcus Boehme, Samia Afzal, Juergen R. Reichenbach, Otto W. Witte, Silvio Schmidt
Summary: By using MRI and DBM, we examined the structural changes in the brains of male RccHan:WIST rats. The study found that the overall brain volume increased with age, but there were also divergent local morphologic alterations. The visual, auditory, and somatosensory cortical areas showed shrinkage, while the higher-order brain areas such as the ectorhinal, entorhinal, retrosplenial, and cingulate cortical regions were preserved and grew with age.
Article
Neurosciences
Feliberto de la Cruz, Gerd Wagner, Andy Schumann, Stefanie Suttkus, Daniel Gullmar, Jurgen R. Reichenbach, Karl-Juergen Baer
Summary: Recent fMRI studies revealed a close functional connection between the default mode network and monoaminergic nuclei, suggesting a top-down information flow in the resting-state condition where activity in DMN areas influences the production of DA/5-HT. The findings indicate a high variability in latencies, likely due to the resting condition.
HUMAN BRAIN MAPPING
(2021)
Meeting Abstract
Clinical Neurology
A. Pigoni, L. Squarcina, D. Dwyer, S. Borgwardt, B. Crespo-Facorro, P. Dazzan, S. Smesny, F. Spaniel, G. Spalletta, R. Sanfelici, L. Antonucci, A. Reuf, O. Oeztuerk, A. Schmidt, S. Ciufolini, F. Harrisberger, K. Langbein, A. Gussew, J. Reichenbach, Y. Zaytseva, F. Piras, M. Bellani, M. Ruggeri, A. Lasalvia, D. Tordesillas-Gutierrez, V. Ortiz, N. Koutsouleris, P. Brambilla
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Psychiatry
Alessandro Pigoni, Dominic Dwyer, Letizia Squarcina, Stefan Borgwardt, Benedicto Crespo-Facorro, Paola Dazzan, Stefan Smesny, Filip Spaniel, Gianfranco Spalletta, Rachele Sanfelici, Linda A. Antonucci, Anne Reuf, Oemer Oeztuerk, Andre Schmidt, Simone Ciufolini, Fabienne Harrisberger, Kerstin Langbein, Juergen Reichenbach, Yulia Zaytseva, Marcella Bellani, Mirella Ruggeri, Antonio Lasalvia, Diana Tordesillas-Gutierrez, Nikolaos Koutsouleris, Paolo Brambilla
SCHIZOPHRENIA BULLETIN
(2020)