Article
Clinical Neurology
Shivaprakash B. Hiremath, Karine Massicotte-Tisluck, Santanu Chakraborty
Summary: This study assessed factors associated with intensive care unit (ICU) admissions, mechanical ventilation, and length of stay (LoS) in patients with posterior reversible encephalopathy syndrome (PRES). The results showed that hypertension and elevated INR were associated with ICU admissions, while hematopoietic stem cell transplantation (HSCT), mean arterial pressure (MAP), intraparenchymal hematoma, and sepsis were correlated with LoS. The severity of imaging based on vasogenic edema extent may be a better predictor due to its association with restricted diffusion.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Xiaoqian Chen, Weixue Zhu, Suhua Jiang
Summary: This study analyzed the clinical diagnosis and treatment of children with PRES combined with ICH, emphasizing the importance of early diagnosis and timely adjustment of medication regimen to prevent irreversible brain damage.
Article
Clinical Neurology
Abbas Alshami, Asseel Al-Bayati, Steven Douedi, Mohammad A. Hossain, Swapnil Patel, Arif Asif
Summary: Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder primarily affecting white matter, presenting with various symptoms. While it is generally reversible, it can also lead to severe complications and even death.
Article
Medicine, General & Internal
Peng An, Junyan Zhang, Yang Li, Peng Duan, Yan Hu, Xiumei Li, Zhongqiu Wang
Summary: This study investigated the risk factors of reversible posterior leukoencephalopathy syndrome (RPLS) in pregnant women with severe preeclampsia or eclampsia, and found that hypertensive emergency, headache, blood routine, and biochemical indicators are important risk factors for RPLS. The combined model was found to be more effective in predicting RPLS.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Medicine, General & Internal
Jing Xu, Ying Ding, Zhen Qu, Feng Yu
Summary: This case study reports a 14-year-old girl with MPA who developed seizures and CNS complications, including intracerebral hemorrhage and PRES. Treatment with methylprednisolone, plasma exchange, hemodialysis, antiseizure medications, and antihypertensives led to remission. It is important to consider and manage potential adverse effects of medications such as corticosteroids and biological therapy when treating MPA patients with CNS involvement. Analyses of similar cases can help understand the clinical characteristics of this complication.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Yi Zhang, Bing Liang, Cuiping Zhao, Yi Zhou, Chuanzhu Yan
Summary: This case report describes a pregnant woman who developed posterior reversible encephalopathy syndrome (PRES) without pre-eclampsia, eclampsia, or any other known causes. The MRI showed diffuse high-signal intensity lesions in the white matter and medulla oblongata. After termination of pregnancy, the patient's symptoms improved and complete recovery was observed at the 6-month follow-up.
Article
Immunology
Yang Li, Junmin Song, Ahm M. Huq, Suraj Timilsina, M. Eric Gershwin
Summary: Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome characterized by acute or subacute neurological symptoms and impaired endothelial barrier function, resulting in reversible bilateral subcortical vasogenic edema. Various predisposing or precipitating conditions, such as hypertension, autoimmune diseases, and certain therapeutic agents, have been identified. The immune activation hypothesis, especially the presence of autoimmunity, plays a significant role in PRES.
AUTOIMMUNITY REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Ava L. Liberman, Cenai Zhang, Neal S. Parikh, Setareh Salehi Omran, Babak B. Navi, Richard I. Lappin, Alexander E. Merkler, Jed H. Kaiser, Hooman Kamel
Summary: This study aimed to estimate the misdiagnosis rate of PRES/RCVS in the emergency department and its associated factors. The study found that approximately one in twenty patients with PRES/RCVS in a large, multistate cohort may experience misdiagnosis in the emergency department. Misdiagnosed patients were typically younger, more often female, and had comorbidities such as headache and substance use disorder.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Emergency Medicine
Saki Hieda, Naoto Ishimaru, Jun Ohnishi, Shimpei Mizuki, Yohei Kanzawa, Kei Kawano, Takahiro Nakajima, Saori Kinami
Summary: Hyperosmolar hyperglycemic syndrome is a life-threatening diabetic emergency that can lead to altered mental status. This case report highlights a rare concurrent occurrence of posterior reversible encephalopathy syndrome with hyperosmolar hyperglycemic syndrome, emphasizing the importance of prompt diagnosis and management.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Clinical Neurology
Charlene Pringle, Katherin Portwood, Manuel A. Viamonte, Dhanashree Rajderkar
Summary: Based on a retrospective review of pediatric patients diagnosed with PRES, this study found that the MRI findings in children were more often atypical at the time of diagnosis. Although the vasogenic edema related to the acute phases of PRES typically resolved, follow-up imaging showed new volume loss in the affected areas.
PEDIATRIC NEUROLOGY
(2022)
Article
Developmental Biology
Ting Deng, Xinyu Zhang, Xiaoling Peng, Hailun Peng, Ling He, Yue Hu
Summary: This study investigated the clinical features and prognosis of posterior reversible encephalopathy syndrome (PRES) in children. It found that PRES has multiple causes, but most patients have a good prognosis. Severity on MRI and length of in-hospital stay are independent risk factors for PRES.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Emergency Medicine
Ross Miller, Samuel Wagner, Jordan Hammond, Nathan Roberts, Ken Marshall, Bradley Barth
Summary: This article discusses the clinical presentation, diagnosis challenges, and risk factors of Posterior Reversible Encephalopathy Syndrome (PRES), and provides a brief summary of a retrospective observational study on PRES.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Christopher Nelke, Andreas Schulte-Mecklenbeck, Marc Pawlitzki, Leoni Rolfes, Saskia Rauber, Catharina C. Gross, Jens Minnerup, Sven G. Meuth, Heinz Wiendl, Tobias Ruck
Summary: The study found that total protein levels in the cerebrospinal fluid (CSF) of posterior reversible encephalopathy syndrome (PRES) patients are elevated, indicating an innate immune response rather than adaptive immunity in the pathophysiology of PRES. Analysis of monocyte subsets showed an increase in CD14(++)/CD16(+) monocytes in the peripheral blood (PB) and CSF of PRES patients, serving as a marker for disease severity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Alexander Balcerac, Kevin Bihan, Dimitri Psimaras, Benedicte Lebrun-Vignes, Joe-Elie Salem, Nicolas Weiss
Summary: In this study, a disproportionality analysis was performed using the VigiBase database to identify drugs associated with PRES. A total of 73 drugs were found to be statistically associated with PRES. These results can assist clinicians in identifying potential drugs associated with PRES and making decisions regarding their discontinuation.
JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Martin Valdez-Lopez, Eduardo Aguirre-Aguilar, Sergio Ivan Valdes-Ferrer, Francisco M. Martinez-Carrillo, Antonio Arauz, Ana Barrera-Vargas, Javier Merayo-Chalico
Summary: Posterior Reversible Encephalopathy Syndrome (PRES) is an acute neurological syndrome characterized by seizures, altered mental status, headache, and visual disturbances. It is often associated with Systemic Lupus Erythematosus (SLE), with SLE causing alterations in pathways implicated in the development of PRES. This suggests that PRES in the setting of SLE may be considered a distinct neuropsychiatric syndrome.
AUTOIMMUNITY REVIEWS
(2021)