Article
Urology & Nephrology
Jarcy Zee, Qian Liu, Abigail R. Smith, Jeffrey B. Hodgin, Avi Rosenberg, Brenda W. Gillespie, Lawrence B. Holzman, Laura Barisoni, Laura H. Mariani
Summary: This study aimed to identify histologic and ultrastructural descriptors that can predict clinical outcomes in patients with MCD/FSGS. The results showed that both conventional and novel features were highly predictive of clinical outcomes. Standardized reporting of these descriptors is crucial for guiding prognostication of proteinuric glomerular diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Larissa Lebedev, Marina Sapojnikov, Alexander Wechsler, Ronen Varadi-Levi, Doron Zamir, Ana Tobar, Nomy Levin-Iaina, Shlomo Fytlovich, Yoram Yagil
Summary: A 50-year-old man developed minimal change disease (MCD) with nephrotic syndrome and acute kidney injury (AKI) shortly after receiving his first dose of the Pfizer-BioNTech COVID-19 vaccine. Treatment with prednisone was initiated and kidney function gradually improved, eventually returning to normal. While the association between the vaccine and MCD is temporal and by exclusion, further reports are needed to evaluate the true incidence of this potential vaccine side effect.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Urology & Nephrology
Ho Jun Chin, Dong-Wan Chae, Yong Chul Kim, Won Suk An, ChunGyoo Ihm, Dong-Chan Jin, Sung Gyun Kim, Yong-Lim Kim, Yong-Soo Kim, Yoon-Goo Kim, Ho Seok Koo, Jung Eun Lee, Kang Wook Lee, Jieun Oh, Jung Hwan Park, Hongsi Jiang, Hyuncheol Lee, Sang Koo Lee
Summary: This study showed that combined therapy with tacrolimus and low-dose steroid was noninferior to high-dose steroid for inducing complete remission in adults with minimal change nephrotic syndrome. Additionally, relapse rates were significantly lower in patients maintained on tacrolimus and steroid compared to those on steroid alone, with no clinically-relevant safety differences observed.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Zeki Aydin, Murvet Yilmaz, Murat Sipahioglu, Erkan Dervisoglu, Nihal Aydemir, Sami Uzun, Zulal Istemihan, Oktay Unsal, Erhan Tatar, Haci Bayram Berktas, Arzu Ozdemir, Abdullah Sumnu, Gizem Kumru, Hakki Cetinkaya, Sinan Kazan, Ismail Kocyigit, Cenk Gokalp, Baris Hasbal, Ayse Serra Artan, Ruya Ozelsancak, Dilek Taymez, Serap Yadigar, Selma Alagoz, Bilal Burcak Aslan, Selcuk Yaylaci, Jabrayil Jabrayilov, Kenan Turgutalp, Belda Dursun, Garip Sahin
Summary: The purpose of this study was to investigate the diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) in our country, as well as their clinical and laboratory findings. The results showed that histopathological changes were more common in patients aged 40 years and older compared to younger patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Anna Kolb, Peter J. Gallacher, Jacqueline Campbell, Martin O'Neill, James R. Smith, Samira Bell, Bryan R. Conway, Wendy Metcalfe, Nicola Joss, Vishal Dey, Annette Alfonzo, Michael Kelly, Shahzad Shah, Emily McQuarrie, Colin Geddes, Jamie Traynor, Robert W. Hunter
Summary: This study found that adults with nephrotic syndrome have high rates of mortality and end-stage kidney disease. Cardiovascular causes were the main reason for excess mortality in primary nephrotic syndrome. Early remission of proteinuria and absence of early acute kidney injury were associated with lower rates of death and end-stage kidney disease.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Medicine, General & Internal
Sophia Lionaki, Evangelos Mantios, Ioanna Tsoumbou, Smaragdi Marinaki, George Makris, George Liapis, Chrysovalantis Vergandis, Ioannis Boletis
Summary: The study found that nearly 46% of adult MCD patients experienced at least one relapse, although renal progression was rare. Younger age of onset was identified as an independent risk factor for relapse in adult MCD patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ryohei Yamamoto, Enyu Imai, Shoichi Maruyama, Hitoshi Yokoyama, Hitoshi Sugiyama, Asami Takeda, Shunya Uchida, Tatsuo Tsukamoto, Kazuhiko Tsuruya, Yasuhiro Akai, Kosaku Nitta, Megumu Fukunaga, Hiroki Hayashi, Kosuke Masutani, Takashi Wada, Tsuneo Konta, Ritsuko Katafuchi, Saori Nishio, Shunsuke Goto, Hirofumi Tamai, Arimasa Shirasaki, Tatsuya Shoji, Kojiro Nagai, Tomoya Nishino, Kunihiro Yamagata, Junichiro J. Kazama, Keiju Hiromura, Hideo Yasuda, Makoto Mizutani, Tomohiko Naruse, Takeyuki Hiramatsu, Kunio Morozumi, Hiroshi Sobajima, Yosuke Saka, Eiji Ishimura, Daisuke Ichikawa, Takashi Shigematsu, Tadashi Sofue, Shouichi Fujimoto, Takafumi Ito, Hiroshi Sato, Ichiei Narita, Yoshitaka Isaka
Summary: This study investigated the association between serum albumin concentration and the cumulative incidence of remission and relapse in adult patients with Minimal Change Disease (MCD). The results showed that lower serum albumin concentration and higher estimated glomerular filtration rate (eGFR) were associated with earlier remission but not with relapse.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Andrew J. B. Watts, Keith H. Keller, Gabriel Lerner, Ivy Rosales, A. Bernard Collins, Miroslav Sekulic, Sushrut S. Waikar, Anil Chandraker, Leonardo V. Riella, Mariam P. Alexander, Jonathan P. Troost, Junbo Chen, Damian Fermin, Jennifer L. Yee, Matthew G. Sampson, Laurence H. H. Beck Jr, Joel M. Henderson, Anna Greka, Helmut G. Rennke, Astrid Weins
Summary: In a subset of patients with minimal change disease, circulating nephrin autoantibodies were detected during active disease but significantly reduced or absent during treatment response. These autoantibodies were correlated with podocyte-associated punctate IgG in renal biopsies. A steroid-dependent patient with childhood minimal change disease developed end stage kidney disease, with high pretransplant circulating nephrin autoantibodies associated with massive post-transplant recurrence of proteinuria.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Colin Bauer, Federica Piani, Mindy Banks, Flor A. Ordonez, Carmen de Lucas-Collantes, Kaori Oshima, Eric P. Schmidt, Igor Zakharevich, Alfons Segarra, Cristina Martinez, Carlos Roncal-Jimenez, Simon C. Satchell, Petter Bjornstad, Marshall Scott Lucia, Judith Blaine, Joshua M. Thurman, Richard J. Johnson, Gabriel Cara-Fuentes
Summary: Our study suggests that alterations in the systemic and glomerular endothelium are present in almost all patients with MCD and SSNS, and circulating factors in the sera of patients during relapse can directly activate glomerular endothelial cells.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Immunology
Maximilian Webendoerfer, Linda Reinhard, Rolf A. K. Stahl, Thorsten Wiech, Hans-Willi Mittruecker, Sigrid Harendza, Elion Hoxha
Summary: This study found that rituximab can induce remission of proteinuria in patients with MCD even if circulating B cells are absent. CD20(+) T cells may play a role in the pathogenesis of MCD and might be a promising treatment target in patients with MCD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Ai-bo Qin, Xiao-juan Yu, Su-xia Wang, Fu-de Zhou, Ming-hui Zhao
Summary: Patients with mercury-associated minimal change disease (M-MCD) have similar clinicopathological features with primary minimal change disease (P-MCD), but with less severe foot process effacement. Mercury detoxification therapy is highly effective for M-MCD patients and can be considered as a primary choice in clinical practice, showing a lower relapse rate compared to patients with P-MCD.
Article
Medicine, General & Internal
Shu-Peng Lin, Feng-Ge Zhu, Jin-Ling Meng, Xiao-Wei Sun, Jing Cui, Shuang Liang, Zhong Yin, Xue-Feng Sun, Guang-Yan Cai
Summary: This study found that the percentage of AKI in patients with minimal change nephropathy is significantly higher than that in patients with membranous nephropathy, and patients over 50 years old are more likely to develop AKI. Renal tubular epithelial cell injury and renal interstitial edema may be the main pathological lesions associated with elevated serum creatinine in patients with minimal change nephropathy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Urology & Nephrology
Chih-Yang Hsu, Chung Chang, Hsin-Yu Chen, Shih-Hsiang Ou, Kang-Ju Chou, Hua-Chang Fang, Chien-Liang Chen, Chien-Wei Huang, Tzung-Yo Ho, Po-Tsang Lee
Summary: Patients with idiopathic minimal change nephrotic syndrome (MCNS) undergoing immunosuppressive therapy are at risk for infectious complications. Advanced acute kidney injury and non-remission by treatment are independent risk factors for developing infectious complications. Prophylactic antibiotic treatment for Pneumocystis jirovecii pneumonia or other bacterial infections appears unnecessary, while screening and prophylactic therapy for hepatitis B and latent tuberculosis are critical, especially in prevalent areas.
Review
Medicine, General & Internal
Shrey Purohit, Federica Piani, Flor A. Ordonez, Carmen de Lucas-Collantes, Colin Bauer, Gabriel Cara-Fuentes
Summary: Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood, characterized by massive proteinuria, edema, and podocyte foot process effacement. Studies suggest an association between MCD and immune dysregulation, possibly mediated by unknown factors released by T cells. The pathogenesis of the disease remains unknown, with recent focus on the role of B cells and endothelial cells in MCD.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Urology & Nephrology
John D. Mahan, Mahmoud Kallash, William E. Smoyer
Summary: The study demonstrates the non-inferiority of a short taper for relapse of childhood NS compared to long-term treatment. It highlights the need for more well-designed studies and the use of personalized treatment for each child with idiopathic NS.
KIDNEY INTERNATIONAL
(2021)