Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Wei Zhou, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao Wu
Summary: Dysfunction of mesangial cells and infiltration of macrophages are significant pathological features in glomerular lesions. Recent studies highlight the importance of the crosstalk between kidney resident cells and inflammatory cells in the development of DN.
Article
Biochemical Research Methods
Tingting Zhao, Fang Cheng, Dongdong Zhan, Jin'e Li, Chunxia Zheng, Yinghui Lu, Weisong Qin, Zhihong Liu
Summary: By integrating the transcriptomics and proteomics profiles of DN patients and controls, researchers identified differentially expressed genes, constructed a regulatory network of transcription factors-target genes, and discovered new DN-specific proteins. This study provides deeper insights into the pathogenesis of DN and opens the potential avenue for finding new therapeutic interventions.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Manuela Harloff, Sally Prueschenk, Roland Seifert, Jens Schlossmann
Summary: The study demonstrated the beneficial effects of sGC activator cinaciguat in treating diabetic nephropathy in a mouse model. Activation of sGC may be a potential therapy option for patients with Type 1 diabetes.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Transplantation
Michael T. Eadon, Sam Lampe, Mirza M. Baig, Kimberly S. Collins, Ricardo Melo Ferreira, Henry Mang, Ying-Hua Cheng, Daria Barwinska, Tarek M. El-Achkar, Tae-Hwi Schwantes-An, Seth Winfree, Constance J. Temm, Michael J. Ferkowicz, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Sharon M. Moe, Ranjani N. Moorthi, Carrie L. Phillips, Pierre C. Dagher
Summary: A study comparing the clinical, histopathologic, and transcriptomic features of 48 cases of idiopathic nodular glomerulosclerosis (ING) and 751 cases of nodular diabetic nephropathy (DN) found that despite similar clinical and histopathologic characteristics, ING has distinct molecular features from nodular DN, warranting further investigation into these relationships.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Xinxin Pang, Xiaotao Hou, Chengxiao Hu, Shilong Lu, Huifang Gan, Huifei Yang, Shaowei Xiang, Jun Zhou, Hongjun Gao, Shuangqin Chen
Summary: This study found that TNC is upregulated in diabetic nephropathy patients and diabetic mice, and it induces proliferation and fibrosis of renal tubular interstitial cells through the beta-catenin pathway.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Hansen Yang, Jia Wang, Zheng Zhang, Rui Peng, Dan Lv, Handeng Liu, Yan Sun
Summary: In diabetic nephropathy, Rmrp promotes proliferation and fibrosis of mesangial cells by regulating miR-1a-3p and JunD expression levels, with Sp1 playing a key regulatory role in this process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Tingting Zhao, Dongdong Zhan, Shuang Qu, Song Jiang, Wenhua Gan, Weisong Qin, Chunxia Zheng, Fang Cheng, Yinghui Lu, Mingwei Liu, Jinsong Shi, Hongwei Liang, Yi Wang, Jun Qin, Ke Zen, Zhihong Liu
Summary: It has been discovered that the lengthening of 3' UTR of APA genes contributes to the progression of diabetic nephropathy (DN) by increasing protein translation and participating in inflammation-related biological processes. The analysis of glomeruli samples revealed the significant role of APA-mediated 3' UTR lengthening in DN pathogenesis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jing Yang, Dongwei Liu, Zhangsuo Liu
Summary: This study aimed to explore the endothelial dysfunction mechanisms caused by serum exosomes from diabetic retinopathy and diabetic nephropathy patients. The results suggest that serum exosomes from these patients may cause endothelial dysfunction by upregulating the alpha subunit of fibrinogen and downregulating 1-methylhistidine. Bioinformatics analysis indicated that reduced cysteine and methionine metabolism played an important role in this process.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yu Tao, Ramesh Kasetti, Gulab Zode, Keisa W. Mathis, Rong Ma
Summary: This study demonstrates the expression of neogenin receptor in glomerular mesangial cells and its role in regulating ECM protein production. High glucose and oxidative stress can increase neogenin expression, while antioxidant treatment can attenuate this increase. The previously unrecognized neogenin-fibronectin pathway may contribute to glomerular injury responses during the course of diabetic nephropathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Physiology
Hao Liu, Jianguo Feng, Liling Tang
Summary: Diabetic nephropathy is a serious complication of diabetes mellitus, and early diagnosis is crucial. Current clinical methods for assessing renal function have limitations, necessitating the search for biomarkers that can accurately characterize structural changes in the kidneys. This review summarizes potential biomarkers and discusses research methods for diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wencheng Xu, Wanci Song, Shuhe Chen, Shanshan Jin, Xue Xue, Jinwen Min, Xiaoqin Wang, Pengtao You
Summary: This study found that tetrandrine inhibited the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via the IgA receptor/MAPK/NF-kappa B signaling pathway, indicating that tetrandrine could be an appealing therapeutic option for IgAN.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiu Du, Ying-xue Fu, An-mei Shu, Xing Lv, Yu-ping Chen, Yu-yan Gao, Jing Chen, Wei Wang, Gao-hong Lv, Jin-fu Lu, Hui-qin Xu
Summary: Loganin protects the kidney from damage in diabetic nephropathy by inhibiting macrophage infiltration and activation. It regulates the RAGE/MCP-1/CCR2 signaling pathway, affecting macrophage phenotypic transformation and expression of inflammatory factors.
Article
Physiology
Feiying Wen, Shengmiao Zhang, Liqin Sun, Manqing Qian, Haofeng Xu
Summary: The study found that SAB can alleviate kidney histopathological changes, improve function, and reduce cell apoptosis in DN rats at various doses. SAB enhances the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), while decreasing levels of reactive oxygen species (ROS) and malondialdehyde (MDA).
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lassina Barro, Jui-Ting Hsiao, Chu-Yin Chen, Yu-Lung Chang, Ming-Fa Hsieh
Summary: Puerarin, extracted from Pueraria lobata, has shown anti-hyperglycemic and anti-oxidative properties. Liposomal puerarin was successfully prepared and demonstrated protective effects on rat mesangial cells under high glucose conditions. The study highlights the potential therapeutic application of liposomal puerarin in diabetic nephropathy.