Article
Pediatrics
Olga Caporale, Silvia Consolo, Francesca S. Grassi, Maria R. Grassi, Giuseppe Puccio, Giovanni Montini, Fabio Paglialonga
Summary: This study compares the effects of low and standard dialysate sodium concentrations on interdialytic weight gain and blood pressure in children and young adults on hemodialysis. The results show that a lower dialysate sodium concentration is associated with a significant reduction in interdialytic weight gain. Further long-term studies are needed to investigate the effect of lowering dialysate sodium concentration on blood pressure.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Soraiya Manji, Jasmit Shah, Ahmed Twahir, Ahmed Sokwala
Summary: Using a lower dialysate sodium concentration during dialysis did not show significant differences in interdialytic weight gain or blood pressure, indicating the need for further studies with larger sample size to confirm these findings.
Article
Urology & Nephrology
Francisco Maduell, Jose J. Broseta, Diana Rodriguez-Espinosa, Joaquim Casals, Victor Escudero, Miquel Gomez, Lida M. Rodas, Marta Arias-Guillen, Manel Vera, Nestor Fontsere
Summary: A new automated dialysate Na control biosensor was implemented in this study to optimize dialysis treatment and reduce discomfort symptoms by reducing the diffusive load of Na. The module showed significant differences in serum Na values and changes in pre- to postdialysis plasma Na levels.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Engineering, Biomedical
Roohi Chhabra, Andrew Davenport
Summary: In this study on dialysis patients, subjective thirst was found to be more common in younger individuals and those reporting higher levels of distress, but had no direct association with interdialytic weight gains (IDWGs), dietary sodium intake, or dialysate sodium.
Article
Urology & Nephrology
Maurizio Bossola, Laura Angioletti, Enrico Di Stasio, Tania Monteburini, Stefano Santarelli, Emanuele Luigi Parodi, Michela Balconi
Summary: This study investigates the relationship between interdialytic weight gain (IDWG) and symptoms of depression and apathy in hemodialysis patients. The results show that there is no significant correlation between IDWG and symptoms of depression or apathy, suggesting that behavioral interventions to reduce IDWG may not be necessary in this population.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Health Care Sciences & Services
Li-Yu Yang, Bih-O Lee, Kai-Ni Lee, Chien-An Chen
Summary: This study confirms that transcutaneous electrical acupoint stimulation (TEAS) has a significant improvement on xerostomia symptoms and interdialytic weight gain (IDWG) in hemodialysis patients. A TEAS program can be used to manage symptoms for xerostomia patients who undergo hemodialysis.
Review
Urology & Nephrology
Lale A. Ertuglu, Atalay Demiray, Carlo Basile, Baris Afsar, Adrian Covic, Mehmet Kanbay
Summary: Sodium and ultrafiltration profiling are methods used to adjust dialysate sodium concentration and ultrafiltration rate to improve hemodynamic stability during hemodialysis. However, complications such as increased interdialytic weight gain and thirst due to sodium excess have limited the widespread use of sodium profiling. Further clinical investigation is needed to determine the optimal method of sodium profiling and the utility of sodium/ultrafiltration profiling in routine practice.
HEMODIALYSIS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
David A. Jaques, Andrew Davenport
Summary: The study found that blood pressure trends in haemodialysis patients are influenced by volume status and small solutes variation. Peridialytic systolic blood pressure decline is mainly driven by changes in serum sodium concentration, with volume status having minimal impact. Middle-aged and overweight patients are particularly susceptible to blood pressure decline.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Jule Pinter, Brendan Smyth, Stefano Stuard, Meg Jardine, Christoph Wanner, Patrick Rossignol, David C. Wheeler, Mark R. Marshall, Bernard Canaud, Bernd Genser
Summary: Excess mortality in hemodialysis patients is associated with abnormal fluid status and plasma sodium concentrations. The choice of dialysate sodium affects sodium removal and tonicity adjustment. Lower dialysate sodium may increase sodium removal but comes with certain risks, while higher dialysate sodium can preserve blood volume and hemodynamic stability.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Takashi Hara, Miho Kimachi, Tadao Akizawa, Shunichi Fukuhara, Yosuke Yamamoto
Summary: The study analyzed data from multiple phases of the J-DOPPS and found that hemoglobin concentration interacts with interdialytic weight gain in affecting major adverse cardiovascular events, suggesting a potential need to limit hemoglobin concentration in patients with high weight gain between dialysis sessions.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Hematology
Sadia Anjum Ashrafi, Madhura Phansikar, Kenneth R. R. Wilund
Summary: This study aimed to explore the association between hemodialysis (HD) patients' subjective thirst and interdialytic weight gain (IDWG). The findings suggest a positive association between patients' subjective thirst and IDWG. However, caution should be exercised in interpreting the results due to variability in thirst and IDWG measurement techniques.
BLOOD PURIFICATION
(2023)
Article
Nursing
Melyza Perdana, Miaofen Yen
Summary: The study found that most participants did not adhere adequately to fluid intake restrictions. Factors such as self-efficacy, gender, educational background, and urine output were strongly correlated with intradialytic weight gain.
JOURNAL OF NURSING RESEARCH
(2021)
Article
Medicine, General & Internal
Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Zhonghua Liu, Bo Shen, Jie Teng, Jianzhou Zou, Xiaoqiang Ding
Summary: This study investigated the relationship between absolute intradialytic blood pressure changes and mortality with different interdialytic weight gain (IDWG) levels. It was found that in patients with lower IDWG, greater intradialytic blood pressure changes were associated with worse prognosis, while in patients with higher IDWG, lesser changes were associated with higher mortality. Both blood pressure stability and volume balance are crucial to patients' prognosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Urology & Nephrology
Maurizio Bossola, Gilda Pepe, Manuela Antocicco, Altea Severino, Enrico Di Stasio
Summary: This study aimed to investigate the impact of educational/cognitive/behavioral or psychological interventions on interdialytic weight gain in patients on chronic hemodialysis. The results showed that these interventions significantly reduced interdialytic weight gain, but the clinical relevance of this reduction was limited.
JOURNAL OF NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Chen Chen, Jing Zheng, Martha Driessnack, Xu Liu, Jiali Liu, Ke Liu, Junsheng Peng, Liming You
Summary: This study explored the impact of health literacy on perceived benefits of fluid restriction, self-reported fluid restriction, and relative-interdialytic weight gain in people receiving hemodialysis. The results indicated that improving patients' health literacy could increase their understanding of the benefits of fluid restriction and lead to better adherence to fluid restrictions, ultimately reducing relative-interdialytic weight gain.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Medicine, Research & Experimental
Michael Poppe, Christian Clodi, Christoph Schriefl, Matthias Mueller, Raute Sunder-Plassmann, Birgit Reiter, Maximilian Rechenmacher, Wisse van Os, J. G. Coen van Hasselt, Michael Holzer, Harald Herkner, Michael Schwameis, Bernd Jilma, Christian Schoergenhofer, Christoph Weiser
Summary: This study compared the pharmacokinetics of pantoprazole at different stages of targeted temperature management following cardiac arrest. Results showed that CYP2C19-dependent drug metabolism is downregulated during targeted temperature management, which may impact drug choice and dosing of similarly metabolized drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Critical Care Medicine
Nikolai Ramadanov, Jasmin Arrich, Roman Klein, Harald Herkner, Wilhelm Behringer
Summary: This study compared the effects of different cooling methods on neurologic outcome and survival in patients resuscitated from cardiac arrest (CA). The results showed that intravascular cooling (IC) was significantly associated with better neurologic outcome and survival compared to surface cooling without temperature feedback (SCnoF). There were no significant differences in neurologic outcome and survival between IC and surface cooling with temperature feedback (SCF), and between SCF and SCnoF.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Amila Kahrovic, Philipp Angleitner, Harald Herkner, Alfred Kocher, Marek Ehrlich, Guenther Laufer, Martin Andreas
Summary: In patients with left-sided infective endocarditis <55 years of age, implantation of a mechanical valve prosthesis is associated with superior outcomes, including lower risks of all-cause mortality and combined events.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Emergency Medicine
Calvin Lukas Kienbacher, Juergen Grafeneder, Katharina Tscherny, Mario Krammel, Verena Fuhrmann, Maximilian Niederer, Sabine Neudorfsky, Klaus Herbich, Wolfgang Schreiber, Harald Herkner, Dominik Roth
Summary: This study aimed to evaluate the influence of PPE with different types of FFP masks on attention and dexterity of EMS personnel during BLS. The results showed that attention and dexterity were not impaired when wearing PPE, including FFP2 masks. Therefore, appropriate PPE should be used during BLS.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2022)
Article
Virology
Daniela Gerges, Sebastian Kapps, Esperanza Hernandez-Carralero, Raimundo Freire, Monika Aiad, Sophie Schmidt, Wolfgang Winnicki, Thomas Reiter, Sahra Pajenda, Alice Schmidt, Gere Sunder-Plassmann, Ludwig Wagner
Summary: SARS-CoV-2 Omicron variant has caused a significant increase in infections worldwide. This study found that the anti-RBD IgG level against Omicron was lower compared to the Alpha variant, but the presence of cross-reactive antibodies may contribute to a milder course of COVID-19.
Letter
Urology & Nephrology
Sophie H. Schmidt, Alice Schmidt, Christof Aigner, Renate Kain, Gere Sunder-Plassmann
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biology
Sahra Pajenda, Ludwig Wagner, Daniela Gerges, Harald Herkner, Tamar Tevdoradze, Karl Mechtler, Alice Schmidt, Wolfgang Winnicki
Summary: Acute kidney injury (AKI) is a leading complication in hospitalized patients, and urinary collectrin may serve as a biomarker for early detection of AKI.
Article
Engineering, Biomedical
Daniel Schneditz, Sebastian Mussnig, Simon Krenn, Manfred Hecking
Summary: The current estimation of body fluid volumes in hemodialysis patients using bioimpedance analysis assumes constant specific electrical characteristics of biological tissues despite a large variation in plasma Na+ concentrations [Na+]. This study examined the potential effect of variable [Na+] on bioimpedance-derived volume overload and found that the increase in volume overload was abolished when the same bioimpedance data were analyzed under revised conditions that account for differences in tissue electrical properties using individual [Na+]. The overestimation in extracellular volume overload caused by the variation in [Na+] may become important when comparing data of larger patient groups.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Article
Biochemistry & Molecular Biology
Wolfgang Winnicki, Andreas Fichtenbaum, Harald Herkner, Florina Regele, Michael Baier, Sieglinde Zelzer, Ludwig Wagner, Guerkan Sengoelge
Summary: This study aimed to investigate individualized approaches to mycophenolic acid (MPA) therapy to improve clinical outcomes in renal transplant patients. The results showed that pharmacodynamic monitoring of IMPDH activity in peripheral blood cells may be an effective method for drug dose adjustment.
Article
Nutrition & Dietetics
Sebastian Mussnig, Michael Schmiedecker, Maximilian Waller, Janosch Niknam, Christopher Paschen, Daniel Schneditz, Manfred Hecking, Simon Krenn
Summary: This study aimed to compare the differences between two versions (3.2.5 and 3.3.3) of the Body Composition Monitor (BCM) in measuring body impedance, fat and lean tissue mass, fluid compartments, and overhydration. The results showed significant differences between the two versions of the BCM in terms of overhydration, with the newer version 3.3.3 tending to measure less overhydration. Therefore, it is important to check the version of the BCM device and use devices of the same version for each patient to ensure better within-patient consistency.
Article
Biology
Constantin Gatterer, Dietrich Beitzke, Senta Graf, Max Lenz, Gere Sunder-Plassmann, Christopher Mann, Markus Ponleitner, Robert Manka, Daniel Fritschi, Pierre-Alexandre Krayenbuehl, Philipp Kamm, Olivier Dormond, Frederic Barbey, Pierre Monney, Albina Nowak
Summary: This study aimed to provide long-term cardiac magnetic resonance (CMR) data for the treatment with migalastat. It was found that migalastat treatment can stabilize myocardial structure and reduce left ventricular hypertrophy. However, disease progression may be faster for patients who already have myocardial fibrosis at the time of therapy initiation.
Article
Urology & Nephrology
Patrizia Natale, Manfred Hecking, Amelie Kurnikowski, Nicole Scholes-Robertson, Juan Jesus Carrero, Germaine Wong, Giovanni Strippoli, Allison Jaure
Summary: There is a gender disparity in access to kidney transplantation, with women being 20% less likely to receive a transplant compared to men across different backgrounds and socioeconomics. Nephrologists perceive that this disparity is exacerbated by gender norms, stigma, prejudice, and educational and financial disadvantages faced by women.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Transplantation
Maximilian Waller, Simon Krenn, Sebastian Mussnig, Michael Schmiedecker, Janosch Niknam-Saeidi, Christopher C. Mayer, Peter Wabel, Daniel Schneditz, Charles Chazot, Manfred Hecking
Summary: This article provides a video link to watch the related content.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Nicholas C. Chesnaye, Juan Jesus Carrero, Manfred Hecking, Kitty J. Jager
Summary: Improved understanding of gender differences in kidney disease epidemiology, management, and outcomes is crucial to provide better care to patients. Women have a higher prevalence of early-stage chronic kidney disease, while men have a higher risk of kidney function decline, kidney failure, and cardiovascular disease. However, the protective effect of female sex diminishes with disease progression. Women are less likely to be diagnosed and treated for kidney disease and have lower health-related quality of life. They face more barriers to access the transplant waiting list but have better survival after transplantation.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Daniel Schneditz, Peter Hofmann, Simon Krenn, Maximilian Waller, Sebastian Mussnig, Manfred Hecking
Summary: Short-term variability in body mass is common but data on this variability is limited. For individuals with impaired volume homeostasis, such as kidney failure patients, body mass variability should be taken into consideration during therapy. The study found that body mass relative differences remained constant over time.