Article
Health Care Sciences & Services
Luis D'Marco, Ana Checa-Ros, Dionilux Gamero, Carlos Soto, Juan Salazar, Manuel Nava, Valmore Bermudez, Fabiola Dapena
Summary: This study investigates the benefits of current SHP treatment options, mainly paricalcitol and/or etelcalcetide, in improving the inflammatory state of hemodialysis patients. The results show that combined treatment with paricalcitol and etelcalcetide significantly reduces CRP levels and safely lowers PTH levels.
Article
Environmental Sciences
Bin Wang, Heng Wan, Jing Cheng, Yingchao Chen, Yuying Wang, Yi Chen, Chi Chen, Wen Zhang, Fangzhen Xia, Ningjian Wang, Li Wang, Yingli Lu
Summary: Higher blood lead levels were associated with increased urinary albumin excretion in diabetic patients with vitamin D deficiency. However, this association was attenuated or non-significant in patients with sufficient vitamin D levels. The combination of high blood lead and low vitamin D levels corresponded to significantly higher urinary albumin-to-creatinine ratio. It was also found that the impact of blood lead levels on urinary albumin excretion was more pronounced in patients with reduced estimated glomerular filtration rate in the group with vitamin D deficiency.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Review
Nutrition & Dietetics
Marta Zieminska, Beata Sieklucka, Krystyna Pawlak
Summary: Vitamin K and vitamin D deficiency in chronic kidney disease can lead to impaired bone health and increased risk of fractures. Currently, there is no consensus on the optimal supplementation approach for these vitamins in CKD patients.
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Thi Thuy Uyen Nguyen, Hyeongwan Kim, Yoon Jung Chae, Jong Hwan Jung, Won Kim
Summary: This study indicates that serum VEGF-D may be an important biomarker in patients with diabetic CKD, associated with renal dysfunction and proteinuria.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Public, Environmental & Occupational Health
Ye Seul Jang, Yu Shin Park, Hyunkyu Kim, Kyungduk Hurh, Eun-Cheol Park, Suk-Yong Jang
Summary: This study aimed to explore the association between sedentary time and chronic kidney disease (CKD) in the South Korean population. The results showed that women who sat for more than 12 hours per day had a significantly higher risk of CKD, regardless of their physical activity levels. Furthermore, among women who sat for over 12 hours, those with low levels of physical activity had a higher risk of CKD.
Article
Medical Laboratory Technology
G. Priyadarshini, Sreejith Parameswaran, Jayaprakash Sahoo, Sandhiya Selvarajan, Medha Rajappa
Summary: The study found that 75% of CKD patients in South India had normal levels of vitamin D, with 15% being deficient and 10% severely deficient. Most patients had a history of taking vitamin D and calcium supplements before coming to the institute, which may explain this paradoxical finding.
CLINICA CHIMICA ACTA
(2021)
Review
Nutrition & Dietetics
Giuseppe Cianciolo, Maria Cappuccilli, Francesco Tondolo, Lorenzo Gasperoni, Fulvia Zappulo, Simona Barbuto, Francesca Iacovella, Diletta Conte, Irene Capelli, Gaetano La Manna
Summary: The text highlights the common issue of poor vitamin D status in patients with chronic kidney disease, attributing it to various factors such as uremic malnutrition, dietary restrictions, and proteinuria. Furthermore, it points out the lack of large-scale interventional studies on the non-calcemic activities of vitamin D in the literature.
Article
Transplantation
Dion Groothof, Adrian Post, Camilo G. Sotomayor, Charlotte A. Keyzer, Jose L. Flores-Guerero, Eelko Hak, Jens H. J. Bos, Leon J. Schurgers, Gerjan J. Navis, Reinold O. B. Gans, Coby Eelderink, Martin H. de Borst, Stephan J. L. Bakker, Ineke J. Riphagen
Summary: The study found that plasma desphospho-uncarboxylated matrix gamma-carboxyglutamate protein is associated with the risk of chronic kidney disease and microalbuminuria, but these associations lost significance after adjusting for factors such as renal function and age.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Nutrition & Dietetics
Wen-Fang Chiang, Po-Jen Hsiao, Jenq-Shyong Chan
Summary: This article reviews the immune system alterations and risks of COVID-19 infections in chronic kidney disease (CKD) patients, as well as the role of vitamin D in the pathogenesis of COVID-19. Previous studies have shown that vitamin D deficiency can affect the outcomes of COVID-19, and supplementing vitamin D during treatment may be protective against COVID-19.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Mengyi Liu, Yanjun Zhang, Sisi Yang, Qimeng Wu, Ziliang Ye, Chun Zhou, Panpan He, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin
Summary: This study investigates the bidirectional associations between renal function and depression in a cohort of young and middle-aged adults. The results show that depression is associated with CKD development, and CKD is associated with an increased risk of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Urology & Nephrology
Marc G. Vervloet, Simon Hsu, Ian H. de Boer
Summary: The efficacy of vitamin D supplements in patients with chronic kidney disease is controversial. Observational studies have shown that higher circulating concentrations of 25hydroxyvitamin D are associated with improved health outcomes. However, recent large clinical trials have contradicted these findings.
KIDNEY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Jialing Zhang, Aihua Zhang
Summary: The relationship between Klotho and cognitive function in chronic kidney disease patients with albuminuria is examined in this study. The findings suggest that increased levels of Klotho are associated with improved cognitive function in CKD patients with microalbuminuria. Further research is needed to investigate if Klotho could serve as a beneficial biomarker for cognitive health and neurodegeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Janet B. B. McGill, Rajiv Agarwal, Stefan D. D. Anker, George L. L. Bakris, Gerasimos Filippatos, Bertram Pitt, Luis M. M. Ruilope, Andreas L. L. Birkenfeld, Maria L. L. Caramori, Meike Brinker, Amer Joseph, Andrea Lage, Robert Lawatscheck, Charlie Scott, Peter Rossing, FIDELIO-DKD Investigator, FIGARO-DKD Investigator
Summary: The aim of this study was to evaluate the effect of finerenone on cardiorenal outcomes and diabetes progression, and to assess its interaction with baseline HbA1c, HbA1c variability, diabetes duration and baseline insulin use. The results showed consistent risk reductions in cardiovascular and kidney outcomes with finerenone compared to placebo across subgroups. Higher HbA1c variability was associated with an increased risk of cardiorenal outcomes. The study concludes that finerenone is effective regardless of baseline characteristics. Overall, the study is rated 9 out of 10.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Peripheral Vascular Disease
Rajiv Agarwal, Luis M. Ruilope, Gema Ruiz-Hurtado, Hermann Haller, Roland E. Schmieder, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Peter Rossing, Marc Lambelet, Christina Nowack, Peter Kolkhof, Amer Joseph, George L. Bakris
Summary: Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, was found to reduce 24-hour, daytime, and nighttime systolic blood pressure in patients with chronic kidney disease and type 2 diabetes.
JOURNAL OF HYPERTENSION
(2023)
Editorial Material
Transplantation
Rajiv Agarwal, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Valentina Gracchi, Sophie M. van den Belt, Eva Corpeleijn, Dick de Zeeuw, Hiddo J. L. Heerspink, Henkjan J. Verkade
Summary: Mildly increased albuminuria is common in adults and 2-year-old children. This study aims to evaluate the longitudinal persistence of albuminuria from infancy to school age, and found that albuminuria at 2 years of age does not largely persist until the age of 12.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Endocrinology & Metabolism
J. David Smeijer, Donald E. Kohan, D. de Zeeuw, Hiddo J. L. Heerspink
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Amy Kang, Brendan Smyth, Brendon L. L. Neuen, Hiddo J. L. Heerspink, Gian Luca Di Tanna, Hong Zhang, Clare Arnott, Carinna Hockham, Rajiv Agarwal, George Bakris, David M. M. Charytan, Dick de Zeeuw, Tom Greene, Adeera Levin, Carol Pollock, David C. C. Wheeler, Kenneth W. W. Mahaffey, Vlado Perkovic, Meg J. J. Jardine
Summary: The aim of this study was to assess the risk of non-genital skin and soft tissue infections (SSTIs) associated with the sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin. A post hoc analysis of two trials was conducted, and the results showed that canagliflozin did not significantly affect the risk of non-genital SSTIs or non-genital fungal SSTIs compared with placebo. This suggests that the changes in skin microenvironment mediated by SGLT2 inhibitors may not have meaningful clinical consequences.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Robert A. Fletcher, Clare Arnott, Patrick Rockenschaub, Aletta E. Schutte, Lewis Carpenter, Muthiah Vaduganathan, Rajiv Agarwal, George Bakris, Tara I. Chang, Hiddo J. L. Heerspink, Meg J. Jardine, Kenneth W. Mahaffey, Bruce Neal, Carol Pollock, Min Jun, Anthony Rodgers, Vlado Perkovic, Brendon L. Neuen
Summary: Using data from CANVAS and CREDENCE trials, this study found that visit-to-visit blood pressure variability is independently associated with the risks of hospitalization for heart failure and all-cause mortality in patients with type 2 diabetes and high cardiovascular risk or chronic kidney disease. However, the use of canagliflozin has little to no effect on blood pressure variability.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Urology & Nephrology
Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol Pollock, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J. L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine
Summary: This study found that the effect of canagliflozin on adverse kidney and cardiovascular events in individuals with diabetic kidney disease does not vary by age and sex. Canagliflozin consistently reduces the risk of kidney events in both sexes and across different age groups.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
J. David Smeijer, Donald E. Kohan, Peter Rossing, Ricardo Correa-Rotter, Adrian Liew, Sydney C. W. Tang, Dick de Zeeuw, Ron T. Gansevoort, Wenjun Ju, Hiddo J. Lambers Heerspink
Summary: Severe insulin resistance is associated with increased risk of cardio-renal outcomes, and the endothelin receptor antagonist atrasentan can reduce insulin resistance.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Urology & Nephrology
Kam Wa Chan, J. David Smeijer, Meir Schechter, Niels Jongs, Priya Vart, Donald E. Kohan, Ron T. Gansevoort, Adrian Liew, Sydney C. W. Tang, Christoph Wanner, Dick de Zeeuw, Hiddo J. L. Heerspink
Summary: Pain is common among patients with diabetes and chronic kidney disease, and the use of commonly prescribed drugs is limited due to their nephrotoxicity. This study investigated the association between the endothelin receptor antagonist atrasentan and pain and prescription of analgesics. The findings suggest that atrasentan may reduce pain-related events and the use of analgesics in patients with type 2 diabetes and chronic kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Panagiotis Georgianos, Rajiv Agarwal
Summary: Hypertension is common and poorly controlled in patients with chronic kidney disease (CKD). Accurate BP measurement is crucial. Dietary sodium restriction and the use of renin-angiotensin system blockers are recommended. Thiazide-like diuretic chlorthalidone is effective in patients with stage 4 CKD and uncontrolled hypertension.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Caroli, Giulia Villa, Paolo Brambilla, Matias Trillini, Kanishka Sharma, Sandro Sironi, Giuseppe Remuzzi, Norberto Perico, Andrea Remuzzi
Summary: This study presents and validates a diffusion MRI (DWI)-based method for quantifying total kidney and cyst volume (TCV) and characterizing non-cystic tissue microstructure in autosomal dominant polycystic kidney disease (ADPKD). DWI shows potential in ADPKD to assess and predict disease progression, evaluate the impact of novel therapies, and identify microcysts and peritubular interstitial fibrosis in non-cystic kidney tissue.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Federica Casiraghi, Marta Todeschini, Manuel Alfredo Podesta, Marilena Mister, Barbara Ruggiero, Matias Trillini, Camillo Carrara, Olimpia Diadei, Alessandro Villa, Ariela Benigni, Giuseppe Remuzzi
Summary: Immune dysregulation plays a key role in the pathogenesis of steroid-dependent/frequently relapsing nephrotic syndrome (SDNS/FRNS). However, no major B- or T-cell alterations have been described for adults, unlike in pediatric cases. This study found that patients with SDNS/FRNS have expansion of memory B cells and reduced memory Tregs. The levels of CD45RO(+) Tregs at baseline may help predict which patients will achieve sustained remission following rituximab infusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Rajiv Agarwal, Sanjeev Anand, Kai-Uwe Eckardt, Wenli Luo, Patrick S. Parfrey, Mark J. Sarnak, Christine M. Solinsky, Dennis L. Vargo, Wolfgang C. Winkelmayer, Glenn M. Chertow
Summary: Anemia is common in chronic kidney disease (CKD) and has negative impacts on quality of life and cardiovascular outcomes. Current standard of care for anemia in CKD requires chronic injections, making it less accessible to certain patients. Safety concerns have also been raised regarding the use of erythropoiesis-stimulating agents. The orally active vadadustat may offer advantages over these agents by activating endogenous erythropoietin production.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)