Review
Pharmacology & Pharmacy
Rowan Sultan, Tessa O. van den Beukel, Michael O. Reumerman, Hester E. M. Daelmans, Hans Springer, Els Grijmans, Majon Muller, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar
Summary: With the aging population, the prevalence of comorbid disorders and polypharmacy is rising, calling for regular medication reviews to prevent adverse events. A study showed that an interprofessional student-run medication review program can enhance prescribing practices and medication safety in geriatric outpatient clinics.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Jamil M. Kazma, John Van den Anker, Homa K. Ahmadzia
Summary: There is a lack of evidence to support clinical decision making and counseling regarding medication use in pregnancy. The inclusion of pregnant women in clinical drug trials assessing efficacy and safety remains scarce despite efforts from legislative bodies and advocacy groups. This review presents the status of pregnant women in clinical trials and highlights the ethical stigma and potential future directions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Bin Lin, Yangmin Hu, Ping Xu, Tao Xu, Chunyan Chen, Le He, Mi Zhou, Zhangzhang Chen, Chunhong Zhang, Xuben Yu, Luo Fang, Junfeng Zhu, Yanlan Ji, Qun Lin, Hengbin Cao, Youqin Dai, Xiaoyan Lu, Changcheng Shi, Li Li, Changjiang Wang, Xumei Li, Qiongyan Fang, Jing Miao, Zhengyi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Yalan Zhu, Xinjun Cai, Yin Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yubin Xu, Pea Federico, Saiping Jiang, Haibin Dai
Summary: Through in-depth research on Linezolid, a team of experts from various disciplines has formed a consensus on the therapeutic drug monitoring and safe use of Linezolid.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Oncology
Jiaxin Zhang, Huiqiong Han, Lei Wang, Wenjia Wang, Mei Yang, Yanru Qin
Summary: Hepatocellular carcinoma is the main type of liver cancer and the third leading cause of cancer-related deaths worldwide. The constituents of the tumor microenvironment may explain the mechanisms of therapeutic resistance in HCC, but the heterogeneity of the microenvironment makes treatment more challenging. Three-dimensional organoid models also play an important role in the study of HCC therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Mathematics
Calin Itu, Polidor Bratu, Nicusor Dragan, Adrian Goanta, George Lucian Nicolae, Marilena Cristina Nitu, Paul Nicolae Borza, Sorin Vlase
Summary: This study aimed to investigate the vibrational response of the inertial platform at ELI-NP complex, based on a finite element model, in order to ensure experiments can be conducted smoothly without being disturbed by unwanted vibrations.
Review
Pharmacology & Pharmacy
Charlotte Moore-Hepburn, Michael Rieder
Summary: The development of specific drug therapy for children has transformed paediatric medical practice, but challenges still exist in drug treatment for children, with improvements in labelling for new drugs and slower progress for older drugs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xi Liu, Jimin Xu, Jia Zhou, Qiang Shen
Summary: Cancer is a major global health issue, with chemotherapy being the primary treatment option. Oridonin and its derivatives have shown promise in overcoming therapeutic resistance in cancer treatment, with potential as clinical trial drug candidates.
Article
Thermodynamics
Hajra Kaneez, M. Nawaz, Yasser Elmasry
Summary: This paper uses constitutive models with viscoelastic and micro-inertia properties, as well as vortex viscosity effects to model heat energy and dust flow. The governing models are solved using the finite element method, with guaranteed convergence and mesh-free results. Micro-rotations have a significant impact on shear stress and wall heat flux. The relaxation time for momentum shows a decrease in velocity for macro-flow. Increasing vortex viscosity increases angular motion. The Deborah number shows a decreasing trend on flow, leading to a decrease in convective heat transport. The temperature of dust particles increases with an increase in the ratio of specific heat and fluid particle interaction parameter for temperature. However, the opposite behavior is observed when increasing the relaxation time of the particle phase. The hybrid nanofluid transports more momentum than mono-nanofluid.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Health Care Sciences & Services
Konrad Michel, Daniela Lutz-Beck, Sylva Engeroff
Summary: Studies show that the quality of the doctor-patient relationship plays a significant role in the effectiveness of pharmacotherapy. To improve the therapeutic relationship in the pharmacotherapy of depression, researchers developed a concise manual and interactive materials for psychiatry residents and their patients. In a pilot study, patients treated using the manual showed a significant increase in satisfaction with the doctor-patient relationship at the three-month follow-up. Both groups showed a decrease in depression symptoms, with no significant differences between them. However, the manual group had a higher rate of continuation of antidepressant medication at six months.
Article
History
James Marchio
Summary: This article delves into a little known chapter in the history of the Intelligence Community, discussing the push for using new analytic methods in the 1970s, its implications, and whether it changed the way intelligence analysis was conducted. Ultimately, it identifies lessons from this experience half a century ago for the IC today.
INTELLIGENCE AND NATIONAL SECURITY
(2021)
Review
Pharmacology & Pharmacy
Disha Iyengar, Katyayani Tatiparti, Navnath S. Gavande, Samaresh Sau, Arun K. Iyer
Summary: Pancreatic cancer has a low 5-year survival rate due to a lack of early detection and screening options. However, the use of nanoparticle drug delivery systems can improve chemotherapy efficacy without increasing toxicity risks. This has significant implications for the survival rates and prognosis of patients with pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Article
Environmental Sciences
Filip Stanic, Ognjen Govedarica, Nenad Jacimovic, Branislava Lekic, Anja Randelovic
Summary: The constant and falling head permeability tests are two conventional methods for determining the water permeability of saturated porous medium. The constant head permeability test is suitable for more permeable materials, measuring the outflow at various constant water heads, while the falling head permeability test is more convenient for low permeable materials, measuring the continuous water head falling due to filtration. However, neither method is useful for materials of high permeability and large cross-sectional area. We propose an approach based on the measured water level change in two connected reservoirs and a new semi-analytical expression to account for the theoretical deficiencies. This approach has been tested on four pervious paver samples and shows satisfactory agreement with constant head permeability data.
WATER RESOURCES RESEARCH
(2023)
Review
Medicine, General & Internal
Ajay A. Mohite, Jennifer A. Perais, Philip McCullough, Noemi Lois
Summary: Background: Retinal ischaemia is a common feature in eyes with diabetic retinopathy (DR), but the understanding of its mechanisms, risk factors, and other characteristics is limited. There is currently no treatment available for revascularization of the ischemic retina. Therefore, research on retinal ischemia is of great importance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Sonia Missiroli, Mariasole Perrone, Caterina Boncompagni, Chiara Borghi, Alberto Campagnaro, Francesco Marchetti, Gabriele Anania, Pantaleo Greco, Francesco Fiorica, Paolo Pinton, Carlotta Giorgi
Summary: The NLRP3 inflammasome is a key player in cancer development, with inhibitors, antagonists, and monoclonal antibodies being considered as potential therapeutic approaches. Understanding NLRP3 inflammasome-dependent mechanisms in cancer may lead to the development of new drugs targeting tumor-associated inflammatory responses.
Review
Nutrition & Dietetics
Dimitra Vasdeki, Theocharis Koufakis, Georgios Tsamos, Luca Busetto, Pantelis Zebekakis, Kalliopi Kotsa
Summary: Type 2 diabetes mellitus is a progressive disease that can potentially be managed through lifestyle changes, obesity surgery, and glucose-lowering therapy, but there are still some unknowns regarding its long-term effects on diabetic complications.
