Review
Medicine, General & Internal
Lauren Lacey, Sibte Hassan, Sebastian Franik, Mourad W. Seif, M. Ahsan Akhtar
Summary: The effects of assisted hatching (AH) on live birth rates are uncertain and may increase the risk of multiple pregnancies. Although AH may offer a slightly increased chance of achieving a clinical pregnancy, the quality of data is low, and it is uncertain whether it influences miscarriage rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
Huixiao Chen, Ping Sun, Na Zhang, Shangge Lv, Yongzhi Cao, Lei Yan
Summary: This study assessed the effect of uterine septum resection on reproductive outcomes in patients with secondary infertility undergoing in vitro fertilization/intracytoplasmic sperm injection. The results showed that uterine septum resection improved the pregnancy rates and live birth rates in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Veterinary Sciences
Effrosyni Fatira, Milos Havelka, Taiju Saito, Jose Landeira, Marek Rodina, David Gela, Martin Psenicka
Summary: In this study, the researchers applied intracytoplasmic sperm injection (ICSI) technology to endangered sturgeons and found that it successfully produced embryos and larvae. Furthermore, molecular analysis showed genome integration of both egg and sperm donor species, demonstrating the potential of ICSI for assisted reproduction in sturgeons.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yubin Li, Qiyuan Chang, Qingyun Mai
Summary: This retrospective cohort study investigated the incidence, pregnancy and neonatal outcomes of monozygotic twins (MZTs) following assisted reproductive technology (ART) treatments, including IVF, ICSI, PGT, and TESA. The study found that the rate of MZTs was similar among the four ART groups, but the IVF group had a higher risk of pregnancy loss and early miscarriage, while the TESA group had a higher risk of twin-to-twin transfusion syndrome (TTTS).
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Luisa Ramirez-Agamez, Camilo Hernandez-Aviles, Dickson D. Varner, Charles C. Love
Summary: This study explores stallion-associated factors in intracytoplasmic sperm injection (ICSI) using frozen/thawed sperm. The results indicate that the composition of freezing extender affects the developmental competence of sperm and in vitro-matured equine oocytes after ICSI. Furthermore, there were no significant differences observed when using ejaculated or epididymal sperm, or sperm with different morphological features in ICSI outcomes.
Review
Obstetrics & Gynecology
Nami Morishita, Masanori Ochi, Toshitaka Horiuchi
Summary: This study discussed the advantages of using Syrian hamsters in reproductive biology and developmental biology research, as well as the challenges of in vitro embryo manipulations due to their sensitivity to environmental factors. The authors summarized key points for hamster ICSI, highlighting the importance of controlled environmental conditions, timing of sperm injection, and optimal culture conditions. Despite low success rates, further research is needed to improve manipulation techniques for hamster ICSI and to address experimental challenges.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Meijuan Peng, Mingyang Wen, Tao Jiang, Yangqian Jiang, Hong Lv, Ting Chen, Xiufeng Ling, Hong Li, Qingxia Meng, Boxian Huang, Shiyao Tao, Lei Huang, Cong Liu, Xin Xu, Qun Lu, Xiaoyu Liu, Bo Xu, Xiumei Han, Kun Zhou, Jiaping Chen, Yuan Lin, Hongxia Ma, Yankai Xia, Hongbing Shen, Zhibin Hu, Feng Chen, Jiangbo Du, Guangfu Jin
Summary: This study aimed to investigate the association of pre-treatment psychological distress with clinical pregnancy rate among infertility couples undergoing IVF/ICSI treatment. The findings indicated that psychological distress experienced prior to treatment was not associated with clinical pregnancy outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Yuqing Jiang, Zhaoyang Shen, Jianmin Xu, Jing Zhu, Huan Wang, Wenhui Chen, Yingpu Sun, Qingling Yang
Summary: High sperm DNA fragmentation index (DFI) in overweight/obese women during ICSI cycles leads to decreased fertilization, cleavage, and high-quality embryo rates. The diminished capacity of oocytes to repair sperm DNA damage may be the cause of the decreased early developmental potential in embryos from overweight/obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li
Summary: This review summarizes and discusses the mutations of nine important genes associated with fertilization failure in infertile patients. The review highlights their roles in the fertilization process and suggests these mutations as potential targets for precision treatments in reproductive medicine. Furthermore, the review provides helpful clues for genetic counseling and optimizing clinical treatments for human infertility by supplying timely information on the genetic causes of fertilization failure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Domenico Baldini, Daniele Ferri, Giorgio Maria Baldini, Dario Lot, Assunta Catino, Damiano Vizziello, Giovanni Vizziello
Summary: In assisted reproductive technology (ART), the selection of sperm cells is crucial for fertilization potential, with intracytoplasmic sperm injection (ICSI) being the most widely used technique. Various methods have been developed to mimic natural selection processes, but doubts and disagreements on the most effective technique remain.
Article
Endocrinology & Metabolism
Jing Ling Ruan, Shan Shan Liang, Jia Ping Pan, Zhi Qin Chen, Xiao Ming Teng
Summary: This retrospective study found that artificial oocyte activation (AOA) with calcium ionophore ionomycin can significantly improve the reproductive outcomes of patients with previous fertilization failure and poor embryo development after intracytoplasmic sperm injection (ICSI). AOA can increase fertilization rate, embryo quality, implantation rate, clinical pregnancy rate, and live birth rate, while decreasing miscarriage rate. The study suggests that AOA is an effective and safe treatment option for some infertility patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Zhiqi Liao, Lei Cai, Chang Liu, Jie Li, Xinyao Hu, Youhua Lai, Lin Shen, Cong Sui, Hanwang Zhang, Kun Qian
Summary: A predictive nomogram model was constructed based on 11513 IVF/ICSI singleton live births, identifying 14 risk factors associated with preterm delivery. The model exhibited good performance and calibration, suggesting its potential clinical value.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Carol Sukhn, Ghazi Zaatari, Akram Ghantous, Nour Assaf, Najwa Hammoud, Daad Farhat, Johnny Awwad
Summary: This study found that paternal exposure to trace heavy metals can influence intermediate reproductive endpoints in ICSI cycles. Blood concentrations of Cd, As, and U were inversely associated with embryo cell cleavage on day 3, while blood and semen levels of Pb, as well as semen U levels, were positively associated with the proportion of implanted embryos. However, there were no significant associations observed for clinical pregnancy and live birth rates with any paternal heavy metal concentrations in semen and blood.
REPRODUCTIVE SCIENCES
(2021)
Review
Medicine, General & Internal
Romualdo Sciorio, Sandro C. Esteves
Summary: This review discusses the use of intracytoplasmic sperm injection (ICSI) in assisted reproductive technology (ART) and the potential risks associated with it. While ICSI has been successful in helping individuals with infertility, there is growing evidence that it may lead to adverse health outcomes in offspring, including epigenetic disorders and other abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
