Article
Cell Biology
Gaia Faustini, Francesca Longhena, Alessia Musco, Federica Bono, Edoardo Parrella, Luca La Via, Alessandro Barbon, Marina Pizzi, Franco Onofri, Fabio Benfenati, Cristina Missale, Maurizio Memo, Daniela Zizioli, Arianna Bellucci
Summary: This study suggests that polymorphisms in the Synapsin III (Syn III) gene may play a role in the development of ADHD and the response to medication. It was found that Syn III is involved in the early stages of dopaminergic neuron development, and this function is conserved in vertebrates. Additionally, in mammals, Syn III regulates dendrite development stimulated by BDNF and Cdk5.
Article
Psychiatry
Judit Cabana-Dominguez, Barbara Torrico, Andreas Reif, Noelia Fernandez-Castillo, Bru Cormand
Summary: Psychiatric disorders exhibit clinical and genetic overlap, with dopaminergic and serotonergic neurotransmission playing important roles. This study assessed the genetic contribution of these systems to eight psychiatric disorders using GWAS analyses, identifying several associated genes and gene sets.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sri Jayanti, Camilla Dalla Verde, Claudio Tiribelli, Silvia Gazzin
Summary: Dopamine, a well-known neurotransmitter, plays a crucial role in Parkinson's disease and various mental and physical activities. Inflammation is recognized as a risk factor for neuronal malfunctioning and cell death in neurodegenerative diseases. Bilirubin, an endogenous defense, has been found to possess anti-inflammatory activity and prevent dopamine neuron demise. This review aims to understand the links between dopamine, inflammation (specifically TNFa), and bilirubin as an anti-inflammatory and explore strategies to preserve dopamine homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
E. M. Bruxel, C. R. Moreira-Maia, G. C. Akutagava-Martins, T. P. Quinn, M. Klein, B. Franke, M. Ribases, P. Rovira, C. Sanchez-Mora, D. B. Kappel, N. R. Mota, E. H. Grevet, C. H. D. Bau, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
Summary: This study conducted a meta-analysis to investigate the association between ADGRL3 gene variants and ADHD susceptibility in children and adults, finding significant correlation in children but not in adults. The results suggest that ADGRL3 gene is predominantly associated with childhood ADHD.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Kristine Kaalund-Brok, Tine Bodil Houmann, Marie Bang Hebsgaard, Maj-Britt Glenn Lauritsen, Louise Hyldborg Lundstrom, Helene Gronning, Lise Darling, Susanna Reinert-Petersen, Morten Aagaard Petersen, Jens Richardt Mollegaard Jepsen, Anne Katrine Pagsberg, Kerstin Jessica Plessen, Henrik Berg Rasmussen, Pia Jeppesen
Summary: Randomized placebo-controlled trials have shown the efficacy of methylphenidate (MPH) for ADHD, but selection biases may limit generalizability. A study on 207 children with ADHD found that 81.2% responded favorably to carefully titrated MPH treatment with minimal adverse effects.
Article
Neurosciences
Lin Zhong, Hongyao He, Jing Zhang, Xiaoyan Gao, Feifei Yin, Pengxiang Zuo, Ranran Song
Summary: This study found significant associations between the DRD2 and SLC6A3 genes in the dopaminergic synaptic pathway and ADHD in Chinese children. It also identified a potential interaction between the GRIN2B and DRD2 genes in increasing the susceptibility to ADHD in this population.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Erica D. Musser, Stephanie S. J. Morris, Kathleen Feeney, Rosario Pintos Lobo, Edward F. Ester
Summary: Inattention is a key symptom of ADHD, but the mechanisms underlying it are unclear. More specific approaches are needed to link disruptions in cognitive performance with ADHD behaviors. A pilot study found that even typically developing children did not maximally extract and combine information to maximize rewards in a cognitive task targeting attention selection mechanisms.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Valentina Carpentieri, Silvia Cugno, Katarina Lockic, Esterina Pascale, Walter Adriani
Summary: Epigenetic modifications, specifically changes in DNA methylation, have been found to serve as biomarkers for predicting infant/adolescent psychopathology. Methylation changes in the DAT1/SLC6A3 gene have been linked to initial severe ADHD and the response to therapy. The study also suggests that genotype and family environment may influence symptomatology. These biomarkers can be used to predict internalizing or externalizing symptoms and involve ADHD-like psycho-pathological characteristics.
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Review
Multidisciplinary Sciences
Jung Tae Kim, Kibong Kim, Lin Ang, Hye Won Lee, Jun-Yong Choi, Myeong Soo Lee
Summary: This article describes a systematic review that aims to evaluate the effectiveness of acupuncture as a treatment for ADHD. The study will conduct literature searches in multiple databases and analyze the selected studies using the Cochrane Risk of Bias Assessment Tool. The findings of this review will be used to support relevant health policies and practices.
Article
Medicine, General & Internal
Johannes Lieslehto, Jari Tiihonen, Markku Laehteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
Summary: This study investigated the impact of pharmacotherapy on suicide risk in patients with borderline personality disorder (BPD). The results indicated that ADHD medication may reduce the risk of suicide, while mood stabilizers and antidepressants may increase the risk. The findings suggest that benzodiazepines should be used with caution due to their association with increased suicide risk in patients with BPD.
Review
Psychiatry
Shufang Mei, Wencai Chen, Sijing Chen, Yani Hu, Xiaoyan Dai, Xiujun Liu
Summary: This study found no association between the Val66Met polymorphism of the BDNF gene and susceptibility to ADHD through a meta-analysis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Developmental
Thaira J. C. Openneer, Zsanett Tarnok, Emese Bognar, Noa Benaroya-Milshtein, Blanca Garcia-Delgar, Astrid Morer, Tamar Steinberg, Pieter J. Hoekstra, Andrea Dietrich, Alan Apter, Valentina Baglioni, Juliane Ball, Noa Benaroya-Milshtein, Benjamin Bodmer, Emese Bognar, Bianka Burger, Judith Buse, Francesco Cardona, Marta Correa Vela, Nanette M. Debes, Andrea Dietrich, Maria Cristina Ferro, Carolin Fremer, Blanca Garcia-Delgar, Mariangela Gulisano, Annelieke Hagen, Julie Hagstrom, Tammy J. Hedderly, Isobel Heyman, Pieter J. Hoekstra, Chaim Huyser, Marcos Madruga-Garrido, Anna Marotta, Pablo Mir, Astrid Morer, Norbert Mueller, Kirsten Mueller-Vahl, Alexander Muenchau, Peter Nagy, Valeria Neri, Thaira J. C. Openneer, Alessandra Pellico, Kerstin J. Plessen, Cesare Porcelli, Marina Redondo, Renata Rizzo, Veit Roessner, Daphna Ruhrman, Jaana M. L. Schnell, Paola Rosaria Silvestri, Liselotte Skov, Tamar Steinberg, Friederike Tagwerker Gloor, Zsanett Tarnok, Jennifer Tubing, Victoria L. Turner, Frank Visscher
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Gabriella Eordegh, Akos Pertich, Zsanett Tarnok, Peter Nagy, Balazs Bodosi, Zsofia Giricz, Orsolya Hegedus, Dora Merkl, Diana Nyujto, Szabina Olah, Attila Oze, Reka Vidomusz, Attila Nagy
Article
Behavioral Sciences
Fanni Lehoczki, Peter Szenczi, Oxana Banszegi, Krisztina Lakatos, Tamas Farago
Article
Clinical Neurology
Luca Pagliaroli, Andrea Vereczkei, Shanmukha Sampath Padmanabhuni, Zsanett Tarnok, Luca Farkas, Peter Nagy, Renata Rizzo, Tomasz Wolanczyk, Urszula Szymanska, Mira Kapisyzi, Entela Basha, Anastasia Koumoula, Christos Androutsos, Vaia Tsironi, Iordanis Karagiannidis, Peristera Paschou, Csaba Barta
FRONTIERS IN NEUROLOGY
(2020)
Article
Psychiatry
Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten R. Muller-Vahl, Manfred Stuhrmann, Yves Dion, Guy A. Rouleau, Harald Aschauer, Mara Stamenkovic, Monika Schloegelhofer, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Noethen, Johannes Hebebrand, Anke Hinney, Robert A. King, Thomas V. Fernandez, Csaba Barta, Zsanett Tarnok, Peter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L. Budman, Renata Rizzo, Gholson J. Lyon, William M. McMahon, James R. Batterson, Danielle C. Cath, Irene A. Malaty, Michael S. Okun, Cheston Berlin, Douglas W. Woods, Paul C. Lee, Joseph Jankovic, Mary M. Robertson, Donald L. Gilbert, Lawrence W. Brown, Barbara J. Coffey, Andrea Dietrich, Pieter J. Hoekstra, Samuel Kuperman, Samuel H. Zinner, Michael Wagner, James A. Knowles, A. Jeremy Willsey, Jay A. Tischfield, Gary A. Heiman, Nancy J. Cox, Nelson B. Freimer, Benjamin M. Neale, Lea K. Davis, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Peristera Paschou, Roger Kurlan, James F. Leckman, Jan H. Smit, Anastasios Konstantinidis, Tomasz Wolanczyk, Lawrence Brown, Keun-Ah Cheon, Blanca Garcia-Delgar, Dorothy E. Grice, Julie Hagstrom, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Bennett L. Leventhal, Marcos Madruga-Garrido, Pablo Mir, Astrid Morer, Alexander Muenchau, Kerstin J. Plessen, Veit Roessner, Eun-Young Shin, Dong-Ho Song, Jungeun Song
Summary: Through genome-wide analysis, pathways underlying the neurobiology of Tourette syndrome have been elucidated, revealing associations with gene sets related to neuronal and glial functions. The study reinforces previous findings while also providing new insights into the neurobiology of TS.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Eszter Toth-Faber, Zsanett Tarnok, Karolina Janacsek, Andrea Kobor, Peter Nagy, Bence Cs Farkas, Szabina Olan, Dora Merkl, Orsolya Hegedus, Derso Nemeth, Adam Takacs
Summary: Children with TS showed enhanced sensitivity to statistical information but impaired sequence learning compared to typically developing children. These results can provide a potential path for improving therapy methods and skill-oriented educational programs for TS.
CHILD NEUROPSYCHOLOGY
(2021)
Review
Psychology, Developmental
Per Andren, Ewgeni Jakubovski, Tara L. Murphy, Katrin Woitecki, Zsanett Tarnok, Sharon Zimmerman-Brenner, Jolande van de Griendt, Nanette Mol Debes, Paula Viefhaus, Sally Robinson, Veit Roessner, Christos Ganos, Natalia Szejko, Kirsten R. Mueller-Vahl, Danielle Cath, Andreas Hartmann, Cara Verdellen
Summary: Part II of the European clinical guidelines for Tourette syndrome and other tic disorders provides updated information and recommendations for psychological interventions, recommending Habit Reversal Training (HRT) and Exposure and Response Prevention (ERP) as first-line interventions for tic disorders. Cognitive interventions and third-wave interventions are currently not recommended as stand-alone treatments for tic disorders.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Neurosciences
Eszter Toth-Faber, Zsanett Tarnok, Adam Takacs, Karolina Janacsek, Dezso Nemeth
Summary: Tourette syndrome is a childhood-onset neurodevelopmental disorder characterized by motor and vocal tics. This study investigated the acquisition and retention of procedural memory in children with TS, finding evidence for short-term and long-term retention of probability-based information, but potential impairment in learning of serial-order information.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Psychology, Developmental
Natalia Szejko, Sally Robinson, Andreas Hartmann, Christos Ganos, Nanette M. Debes, Liselotte Skov, Martina Haas, Renata Rizzo, Jeremy Stern, Alexander Munchau, Virginie Czernecki, Andrea Dietrich, Tara L. Murphy, Davide Martino, Zsanett Tarnok, Tammy Hedderly, Kirsten R. Muller-Vahl, Danielle C. Cath
Summary: This article presents an updated version 2.0 of European clinical guidelines for Tourette syndrome and other tic disorders, focusing on assessment. The guidelines were developed through thorough literature screening, national guidelines supplementation, and expert discussions within ESSTS. Diagnostic changes between DSM-IV and DSM-5 classifications, recommendations for rating scales, and new information on differential diagnoses are highlighted. Additionally, a recent survey among ESSTS members on assessment in TS is discussed.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Anette-Eleonore Schrag, Davide Martino, Hanyuying Wang, Gareth Ambler, Noa Benaroya-Milstein, Maura Buttiglione, Francesco Cardona, Roberta Creti, Androulla Efstratiou, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Pablo Mir, Astrid Morer, Natalie Moll, Norbert E. Muller, Kirsten R. Muller-Vahl, Kerstin J. Plessen, Cesare Porcelli, Renata Rizzo, Veit Roessner, Markus Schwarz, Zsanett Tarnok, Susanne Walitza, Andrea Dietrich, Pieter J. Hoekstra
Summary: This study aimed to investigate the association between group A streptococcal (GAS) infections and tic incidence among unaffected children with a family history of chronic tic disorders (CTDs). Findings showed a strong association between sex and tic onset, with girls having a lower risk of developing tics compared to boys. However, there was no statistical evidence to suggest an association between GAS exposure and tic onset.
Editorial Material
Neurosciences
Karolina Janacsek, Adam Takacs, Zsanett Tarnok
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Psychology, Developmental
Charlotte Sanderson, Cara Verdellen, Nanette Debes, Zsanett Tarnok, Jolande van de Griendt, Sharon Zimmerman-Brenner, Tara Murphy
Summary: Co-occurring psychiatric conditions are common in tic disorders and Tourette syndrome, impacting the implementation and efficacy of behavioural therapies. This article provides guidelines for implementing behavioural and psychosocial interventions for common comorbidities such as ADHD, OCD, anxiety, disruptive behaviour, ASD, and depression, and suggests future research directions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Pritesh Jain, Tyne Miller-Fleming, Apostolia R. Topaloudi, Dongmei K. Yu, Petros Drineas, Marianthi Georgitsi, Zhiyu Yang, Renata Rizzo, Kirsten R. Mueller-Vahl, Zeynep A. Tumer, Nanette Mol Debes, Andreas S. Hartmann, Christel E. Depienne, Yulia S. Worbe, Pablo Mir, Danielle C. Cath, Dorret Boomsma, Veit Roessner, Tomasz Wolanczyk, Piotr Janik, Natalia Szejko, Cezary Zekanowski, Csaba Barta, Zsofia Nemoda, Zsanett Tarnok, Joseph D. Buxbaum, Dorothy Grice, Jeffrey Glennon, Hreinn Stefansson, Bastian Hengerer, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Astrid Morer, Norbert Mueller, Alexander Munchau, Kerstin J. Plessen, Cesare Porcelli, Susanne Walitza, Anette Schrag, Davide Martino, Andrea Dietrich, Carol A. Mathews, Jeremiah M. Scharf, Pieter J. Hoekstra, Lea K. Davis, Peristera Paschou
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Nico Adelhoefer, Theresa Paulus, Moritz Mueckschel, Tobias Baeumer, Annet Bluschke, Adam Takacs, Eszter Toth-Faber, Zsanett Tarnok, Veit Roessner, Anne Weissbach, Alexander Muenchau, Christian Beste
Summary: Adelhofer et al. found that 1/f noise and aperiodic activity are increased in patients with Tourette syndrome, but are not directly related to tics, suggesting a novel facet of the disorder. This supports the 'neural noise account' of Tourette syndrome, which proposes that abnormalities in neural noise may be relevant for understanding the disorder. The study also showed that these neural activity patterns in Tourette syndrome are not correlated with clinical measures of tics, indicating a potential new direction for research in this field.
BRAIN COMMUNICATIONS
(2021)
Article
Clinical Neurology
Davide Martino, Anette Schrag, Zacharias Anastasiou, Alan Apter, Noa Benaroya-Milstein, Maura Buttiglione, Francesco Cardona, Roberta Creti, Androulla Efstratiou, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Marcos Madruga, Pablo Mir, Astrid Morer, Nanette Mol Debes, Natalie Moll, Norbert Muller, Kirsten Muller-Vahl, Alexander Munchau, Peter Nagy, Kerstin Jessica Plessen, Cesare Porcelli, Renata Rizzo, Veit Roessner, Jaana Schnell, Markus Schwarz, Liselotte Skov, Tamar Steinberg, Zsanett Tarnok, Susanne Walitza, Andrea Dietrich, Pieter J. Hoekstra
Summary: This study examined the association between GAS pharyngeal exposures and tic exacerbations in children with CTD across Europe. The results did not support GAS exposures as contributing factors for tic exacerbations and suggested that specific workup or active management of GAS infections is unlikely to modify the course of tics in CTD.