The AKT genes and their roles in various disorders

Megalencephaly-capillary malformation (MCAP) and megalencephaly-polydactyly-polymicrogyria-hydrocephalus (MPPH) syndromes: Two closely related disorders of brain overgrowth and abnormal brain and body morphogenesis

(2012) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

(2012) C. Parikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT/GSK3 signaling pathway and schizophrenia

(2012) Effat S. Emamian   Frontiers in Molecular Neuroscience

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

High-resolution array CGH defines critical regions and candidate genes for microcephaly, abnormalities of the corpus callosum, and seizure phenotypes in patients with microdeletions of 1q43q44

(2011) Blake C. Ballif et al.   HUMAN GENETICS

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Activating Mutation of AKT2 and Human Hypoglycemia

(2011) K. Hussain et al.   SCIENCE

Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions

(2011) Sean G Jackson et al.   BMC STRUCTURAL BIOLOGY

The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: an updated review

(2010) Kota J Reddy et al.   Journal of Cardiovascular Medicine

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis

(2009) L. Lian et al.   BLOOD

A novel AKT3 mutation in melanoma tumours and cell lines

(2008) M A Davies et al.   BRITISH JOURNAL OF CANCER

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

(2008) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH