Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 74, Issue 6, Pages 480-486Publisher
WILEY
DOI: 10.1111/aji.12426
Keywords
Endometrium; proportion; regulatory T cells; Th1; Th17; Th2
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Funding
- Ministry of Health, Labor and Welfare
- Ministry of Education, Culture, Sports, Science and Technology
- Grants-in-Aid for Scientific Research [26462476] Funding Source: KAKEN
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Problem The proportion of CD4+ T lymphocytes, Th1, Th2, Th17, and regulatory T cells in endometriosis lesions and peripheral blood are not known. Method of study Lymphocytes were isolated from endometriosis lesions (n = 10) and endometrium (n = 10). Lymphocytes in peripheral blood were isolated from patients with and without endometriosis (n = 10, 10). The CD4+ T-lymphocyte profile was analyzed by flow cytometry. Results The proportion of Th1 lymphocytes was significantly lower in endometriosis tissue (59.64 +/- 9.2%) in comparison with endometrial tissue (79.07 +/- 8.97%), whereas the Th17 lymphocyte fraction was significantly higher in endometriosis tissue (6.66 +/- 2.53%) in comparison with endometrial tissue (2.27 +/- 1.51%). Analysis of peripheral blood indicated that the Th1 proportion was significantly higher in women with endometriosis (10.25 +/- 2.82%) in comparison with controls (6.96 +/- 4.13%). Conclusion The CD4+ T-lymphocyte profile in lesions and peripheral blood is altered in women with endometriosis. These findings may help better understanding of T-lymphocyte involvement in the pathophysiology of endometriosis.
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