Review
Immunology
Anne K. Muehlig, Sydney Gies, Tobias B. Huber, Fabian Braun
Summary: This review summarizes the current knowledge on viral infections associated with collapsing glomerulopathy, with a special focus on the influence of systemic immune responses and potential mechanisms propagating its development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Yingchao Peng, Tao Ju, Chunlin Gao, Zhengkun Xia, Meiqiu Wang, Xiaoyi Sun, Ren Wang, Xiaojie Li, Yaqin Wei, Lili Jia, Huangyu Chen
Summary: This study aimed to investigate the clinical and prognostic relevance of C1q nephropathy in pediatric patients with primary focal segmental glomerulosclerosis. It was found that C1q nephropathy was rare in children and showed poor response to steroids. The long-term renal outcomes and remission rates were comparable between children with and without C1q nephropathy.
JOURNAL OF NEPHROLOGY
(2023)
Article
Transplantation
Francois Gougeon, Harsharan K. Singh, Volker Nickeleit
Summary: This study analyzed renal comorbidities in collapsing focal segmental glomerulosclerosis (FSGS) and found that collapsing glomerulopathy (CG) has a higher rate of comorbidities compared to tip-variant FSGS (T-FSGS). The study showed that vascular diseases, especially stenosing vasculopathies, were more prevalent in CG with comorbidities. Membranous glomerulopathies were also more common in native kidneys with accompanied CG. These findings are important for understanding the pathogenesis and possible therapeutic strategies for CG.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Oncology
Samy Hakroush, Svenja Wulf, Julia Gallwas, Bjoern Tampe
Summary: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for HER2-positive breast cancer. A study reported kidney biopsy findings of collapsing FSGS after initiation of T-DM1 therapy, highlighting the importance for nephrologists to be aware of this potentially severe complication due to T-DM1 usage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Takaya Ozeki, Michio Nagata, Takayuki Katsuno, Koji Inagaki, Kazunori Goto, Sawako Kato, Yoshinari Yasuda, Naotake Tsuboi, Shoichi Maruyama
Summary: This study analyzed the clinical implication of unclassified segmental lesions in Japanese adult patients with nephrotic syndrome compared to Columbia-classified FSGS. The results showed that unclassified segmental lesions may have equivalent clinical impact as Columbia classification of FSGS, with similar treatment responses and no significant difference in the decline of eGFR.
Article
Urology & Nephrology
Mahmut Gok, Omer Ayten, Ozkan Onur, Hakki Cetinkaya, Gulistan Gumrukcu, Gulizar Sahin
Summary: Sarcoidosis is a multisystemic granulomatous disease, and common renal involvement includes nephrocalcinosis and interstitial nephritis. A renal biopsy can help diagnose the collapsing variant of focal segmental glomerulosclerosis secondary to sarcoidosis.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tyler Tancredi, Ami DeWaters, Kathryn L. McGillen
Summary: A case study of a 38-year-old Afro-Caribbean female with COVID-19 showed renal manifestations associated with collapsing focal segmental glomerulosclerosis (FSGS), not previously reported with this disease, highlighting the potential for diverse renal complications in different populations. These renal ultrasound findings, along with duplex Doppler, may serve as useful indicators for early diagnosis and treatment in COVID-19 patients.
Article
Genetics & Heredity
David Marx, Sophie Caillard, Jerome Olagne, Bruno Moulin, Thierry Hannedouche, Guy Touchard, Arnaud Dupuis, Christian Gachet, Anne Molitor, Seiamak Bahram, Raphael Carapito
Summary: A new nonsense variant in the PODXL gene associated with kidney disease was identified, characterized by FSGS features and glomerular basement membrane duplication. This study provides important insights into the pathophysiology of the disease through light and electron microscopy.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Pediatrics
Rachel K. Cason, Anna Williams, Megan Chryst-Stangl, Guanghong Wu, Kinsie Huggins, Kaye E. Brathwaite, Brandon M. Lane, Larry A. Greenbaum, Vivette D. D'Agati, Rasheed A. Gbadegesin
Summary: This article describes a sibling pair with NUP93 mutations and collapsing FSGS. Their findings suggest that mutations in NUP93 and other nucleoporin genes may be associated with familial cFSGS.
FRONTIERS IN PEDIATRICS
(2022)
Review
Urology & Nephrology
Ke Sun, Qionghong Xie, Chuan-Ming Hao
Summary: This study focuses on the potential sources and mechanism of podocyte supplementation in FSGS. Parietal epithelial cells (PECs) have gained attention for their role in the progression of FSGS, as both influencing factors in glomerulosclerosis lesions and their repair abilities are being debated. Other resident glomerular cells are also significant in the progression of the disease.
Article
Immunology
Julie Oniszczuk, Anissa Moktefi, Aude Mausoleo, Nicolas Pallet, Stephanie Malard-Castagnet, Slim Fourati, Khalil El Karoui, Dil Sahali, Thomas Stehle, Anna Boueilh, Marie-Christine Verpont, Marie Matignon, David Buob, Philippe Grimbert, Vincent Audard
Summary: This case study reports a renal transplant recipient who developed renal complications, including nephrotic syndrome and acute kidney injury, after contracting non-severe COVID-19. The renal biopsy revealed focal and segmental glomerulosclerosis lesions. The donor had high-risk apolipoprotein L1 gene variants, which may have contributed to the acute glomerular injury observed in the patient.
Article
Chemistry, Multidisciplinary
Qiong-Dan Hu, Hong-Lian Wang, Jian Liu, Tao He, Rui-Zhi Tan, Qiong Zhang, Hong-Wei Su, Fahsai Kantawong, Hui-Yao Lan, Li Wang
Summary: Btg2 plays a pathogenic role in FSGS by promoting podocyte injury through a Smad3-dependent epithelial-mesenchymal transition pathway.
Article
Urology & Nephrology
Martina Tedesco, Federica Mescia, Isabella Pisani, Marco Allinovi, Giovanni Casazza, Lucia Del Vecchio, Marisa Santostefano, Luigi Cirillo, Francesca Ferrario, Ciro Esposito, Pasquale Esposito, Domenico Santoro, Roberta Lazzarin, Giovanni Maria Rossi, Enrico Fiaccadori, Angelo Ferrantelli, Renato Alberto Sinico, Mario Cozzolino, Maurizio Gallieni, Lino Cirami, Francesco Scolari, Augusto Vaglio, Federico Alberici
Summary: Rituximab (RTX) may be a treatment option for primary focal segmental glomerular sclerosis (FSGS), especially in steroid-dependent patients with 24-hour proteinuria <5 g and those who previously responded to RTX. The optimal long-term management for responders is unclear, with some patients experiencing sustained remission and others requiring RTX retreatment, either preemptively or after rising proteinuria.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Lorena Longaretti, Piera Trionfini, Valerio Brizi, Christodoulos Xinaris, Caterina Mele, Matteo Breno, Elena Romano, Roberta Giampietro, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Summary: A study on a patient with familial steroid-resistant FSGS identified a PAX2 mutation, suggesting a dual effect of the mutation in the onset of FSGS. Fixing the mutation improved the functionality of podocytes, providing insight into the development of proteinuria in FSGS.
Article
Immunology
Vladimir Prelevic, Ivana Juric, Marijana Coric, Zeljko Kastelan, Nikolina Basic-Jukic
Summary: This case study explores the possible link between viral infections and cFSGS in patients who underwent kidney transplantation through three case reports.
TRANSPLANTATION PROCEEDINGS
(2023)
