Review
Endocrinology & Metabolism
Lirong Lin, Wei Tan, Xianfeng Pan, En Tian, Zhifeng Wu, Jurong Yang
Summary: Metabolic syndrome (MetS) is a disease that includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. It has a high prevalence and is an important risk factor for chronic kidney disease. This article compares different diagnostic criteria for MetS and discusses interventions and underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Wei Xiong, Xian-Fang Meng, Chun Zhang
Summary: Metabolic syndrome can lead to metabolic disorders and impair kidney structure and function, while persistent inflammation exacerbates renal damage. Inflammasomes are key in initiating inflammation, and understanding their role in kidney damage caused by metabolic disorders can provide new therapeutic perspectives for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ziyu Xu, Li Tao, Hua Su
Summary: This article discusses the issues related to metabolic syndrome and its impact on the kidneys, emphasizing the crucial role of the complement system in metabolic kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Elena G. Kornetova, Alexander N. Kornetov, Irina A. Mednova, Anastasia A. Goncharova, Valeria Gerasimova, Ivan Pozhidaev, Anastasiia S. Boiko, Arkadiy Semke, Anton J. M. Loonen, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study reveals significant variations in the prevalence of metabolic syndrome among patients with schizophrenia in different psychiatric hospitals within the same region, highlighting the importance of individualized approaches to minimize the risk of its occurrence based on the specific characteristics of each hospital.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Food Science & Technology
James Coleman Miller, Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Umesh D. Wankhade, Michael S. I. I. I. I. Robeson, Madison Nicole Putich, Jennifer Ellen Mueller, Aubrey Sarah O'Farrell, Jae Min Cho, Sree Chintapalli, Thunder Jalili, John David Symons, Pon Velayutham Anandh Babu
Summary: This study found that dietary strawberry consumption can reduce the risk of vascular complications in an animal model of MetS, and this effect is associated with changes in the composition of gut microbes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Marek Drozdzik, Maria Drozdzik, Stefan Oswald
Summary: Chronic kidney disease may affect the expression and function of membrane carriers and transporters, leading to impaired drug elimination and clinical consequences. Understanding the function of these proteins is crucial for characterizing drug pharmacokinetics, drug actions in the kidney, and defining organ pathophysiology.
Article
Biochemistry & Molecular Biology
Sheng-Wen Niu, Hugo You-Hsien Lin, I-Ching Kuo, Yen-Yi Zhen, Eddy-Essen Chang, Feng-Ching Shen, Yi-Wen Chiu, Jer-Ming Chang, Chi-Chih Hung, Shang-Jyh Hwang
Summary: The study found that uric acid (UA) is elevated in metabolic syndrome (MS) and diabetes (DM). UA is associated with obesity, inflammation markers, and renal function. High levels of UA are associated with worse renal outcomes in non-MS/DM patients, but not in MS/DM patients. Redefining MS to include hyperuricemia does not predict renal outcomes.
Article
Cell Biology
Siting Hong, Ramyar Ghandriz, Sarosh Siddiqi, Xiang-Yang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Khaled A. Ali, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Summary: Metabolic syndrome (MetS) mildly affects renal autophagy, possibly due to mitochondrial damage, and may contribute to kidney structural damage in MetS.
Article
Endocrinology & Metabolism
Benjamin C. Cossins, Inge van den Munckhof, Joost H. W. Rutten, Marinette van der Graaf, Rinke Stienstra, Leo A. B. Joosten, Mihai G. Netea, Yang Li, Niels P. Riksen
Summary: This study examined the association between adipocyte size, adipose tissue inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. The results showed that inflammation in abdominal subcutaneous adipose tissue is more related to metabolic complications than atherosclerotic complications, and there are significant sex-specific differences in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemical Research Methods
Ornuma Haonon, Zhigang Liu, Rungtiwa Dangtakot, Kitti Intuyod, Porntip Pinlaor, Anucha Puapairoj, Ubon Cha'on, Chatchawan Sengthong, Thatsanapong Pongking, Sudarat Onsurathum, Manachai Yingklang, Jutarop Phetcharaburanin, Jia Li, Somchai Pinlaor
Summary: Opisthorchis viverrini infection causes hepatobiliary diseases and is a major risk factor for cholangiocarcinoma. The infection leads to disturbances in host amino acid metabolism, TCA cycle, liver, and kidney pathologies, as well as changes in fecal microbial composition and urinary host-microbial cometabolism.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Urology & Nephrology
Rebecca I. Spain, Nicole K. Andeen, Pamela C. Gibson, Mary H. Samuels, Cynthia D. Morris, Andrew J. Solomon, Richard Solomon, Carin Waslo, Rupali S. Avasare
Summary: Lipoic acid, a popular antioxidant and insulin-mimetic supplement, was found to cause high-grade proteinuria in multiple sclerosis patients in a clinical trial. This led to the discovery of NELL1-associated membranous nephropathy cases related to lipoic acid supplementation, which improved with discontinuation of the supplement and supportive therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Emanuela Marchese, Marianna Caterino, Roberta Fedele, Francesca Pirozzi, Armando Cevenini, Neha Gupta, Diego Ingrosso, Alessandra Perna, Giovambattista Capasso, Margherita Ruoppolo, Miriam Zacchia
Summary: This study provides insights into the mechanisms underlying renal disease in Bardet-Biedl syndrome (BBS) through urine metabolomic and proteomic analyses. The increased urinary excretion of lactate suggests a possible renal-specific defective handling. The BBS10 gene may play a role in renal metabolism, RNA processing, and cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Robert M. Geraghty, Paul Cook, Paul Roderick, Bhaskar Somani
Summary: The study suggests that kidney stone formers are at an increased risk of developing metabolic syndrome compared to non-formers, potentially indicating an underlying metabolic abnormality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ali Arab, Sara Mostafalou
Summary: The use of pesticides has greatly benefited humankind in improving crop yield and general hygiene, but there is substantial evidence on their toxic effects on living systems. Numerous studies have evaluated the link between pesticide exposure and various chronic diseases such as cancer, neurotoxicity, and developmental toxicity. There is also evidence linking pesticide exposure to a higher incidence of metabolic diseases associated with insulin resistance, including diabetes, obesity, metabolic syndrome, hypertension, polycystic ovary syndrome, and chronic kidney diseases. This review will systematically examine the metabolic toxicity of pesticides in relation to these diseases, with a focus on their effects on insulin signaling pathway and the development of insulin resistance.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Florian G. Scurt, Maximilian J. Ganz, Carolin Herzog, Katrin Bose, Peter R. Mertens, Christos Chatzikyrkou
Summary: The prevalence of kidney disease is increasing rapidly worldwide due to rising rates of obesity, diabetes, and metabolic syndrome. These conditions place a significant financial burden on healthcare systems. Despite treatment options, there is still a significant risk of progression to end-stage renal disease in high-risk obese and diabetic populations. The metabolic syndrome adversely affects the development and progression of chronic kidney failure. Understanding the underlying mechanisms of metabolic syndrome-associated kidney disease is important in developing strategies for prevention and slowing disease progression.
Letter
Pathology
Youssef M. K. Farag
ADVANCES IN ANATOMIC PATHOLOGY
(2011)
Article
Hematology
Youssef M. K. Farag, Sai Ram Keithy-Reddy, Bharati V. Mittal, Vinod Bansal, Jaweed Fareed, Ajay K. Singh
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2012)
Article
Urology & Nephrology
Y. M. K. Farag, S. R. Keithi-Reddy, B. V. Mittal, S. P. Surana, F. Addabbo, M. S. Goligorsky, A. K. Singh
CLINICAL NEPHROLOGY
(2011)
Editorial Material
Urology & Nephrology
Y. M. K. Farag, G. P. Bayliss, A. K. Singh
KIDNEY INTERNATIONAL
(2008)
Article
Urology & Nephrology
M. P. Alexander, Y. M. K. Farag, B. V. Mittal, H. G. Rennke, A. K. Singh
KIDNEY INTERNATIONAL
(2008)
Article
Urology & Nephrology
Mariam P. Alexander, Youssef M. K. Farag, Bharati V. Mittal, Helmut G. Rennke, Stefan G. Tullius, Ajay K. Singh
KIDNEY INTERNATIONAL
(2009)
Review
Transplantation
Youssef M. K. Farag, Mahmoud R. Gaballa
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2011)
Review
Urology & Nephrology
Youssef M. K. Farag, Jamal S. Al Wakeel
NEPHRON CLINICAL PRACTICE
(2011)
Article
Pediatrics
Jameela Abdulaziz Kari, Sherif El-Desoky, Youssef Farag, Hisham Mosli, Abdul-Malik Altyieb, Ahmad Al Sayad, Othman Radawi, Hosam Ghabra, Faten Basnawi, Ohood Bahrawi, Ajay Singh, Hassan Farsi
PEDIATRIC NEPHROLOGY
(2013)
Review
Medicine, General & Internal
Mahmoud R. Gaballa, Youssef M. K. Farag
CENTRAL EUROPEAN JOURNAL OF MEDICINE
(2013)
Review
Urology & Nephrology
Youssef M. K. Farag, Jameela A. Kari, Ajay K. Singh
NEPHRON CLINICAL PRACTICE
(2012)
Meeting Abstract
Urology & Nephrology
Jamal Al Wakeel, Durdana Hammad, Youssef M. K. Farag
AMERICAN JOURNAL OF KIDNEY DISEASES
(2011)