Article
Infectious Diseases
G. Dimopoulos, M. P. Almyroudi, I Kapralos, O. Apostolopoulou, A. Flevari, D. P. Nicolau, A. Dokoumetzidis
Summary: This study aimed to evaluate the pharmacokinetics of off-label high-dose tigecycline in patients with ventilator-associated pneumonia (VAP). The results showed that a daily dose of 200 mg tigecycline can increase drug concentrations in plasma and epithelial lining fluid (ELF), and the high ELF penetration supports the effectiveness of tigecycline in VAP.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Infectious Diseases
Maria Mastrogianni, Theodoros Katsoulas, Petros Galanis, Anna Korompeli, Pavlos Myrianthefs
Summary: Ventilator-associated pneumonia (VAP) remains a common risk in mechanically ventilated patients. Different care bundles have been proposed to reduce VAP, and this study aimed to identify the combined interventions used by ICUs worldwide. A total of 38 studies meeting the inclusion criteria were analyzed, and the most common interventions in the care bundles were identified. The studies with the highest VAP reduction utilized the IHI Ventilator Bundle combined with adequate endotracheal tube cuff pressure and subglottic suctioning.
Article
Nursing
Vicent Bankanie, Anne H. Outwater, Li Wan, Li Yinglan
Summary: This study assesses ICU nurses' knowledge, compliance, and barriers towards evidence-based guidelines for the prevention of VAP in Tanzania. Findings show that nurses have low knowledge and compliance levels, with main barriers being lack of skills, inadequate staff, and knowledge deficiency.
Review
Nutrition & Dietetics
Huzaifa Ahmad Cheema, Abia Shahid, Muhammad Ayyan, Biah Mustafa, Afra Zahid, Maurish Fatima, Muhammad Ehsan, Farwa Athar, Natalie Duric, Tamas Szakmany
Summary: This meta-analysis found that probiotics may reduce the incidence of VAP and shorten ICU stay and duration of antibiotic use. However, caution should be exercised in using probiotics due to the low quality of evidence.
Article
Nursing
Eman Arafa Hassan, Suad Elsayed Abdelmotalb Elsaman
Summary: Compliance with the ventilator bundle was found to be associated with a decreased risk of ventilator-associated events (VAEs) occurrence. Mechanically ventilated patients had a lower likelihood of experiencing VAEs when receiving the ventilator bundle.
Review
Critical Care Medicine
Lewis Winning, Fionnuala T. Lundy, Bronagh Blackwood, Daniel F. McAuley, Ikhlas El Karim
Summary: The link between oral health and respiratory infections, especially in intubated patients, is crucial. There is currently a lack of consensus on the best oral care practices, highlighting the need for standardized research to provide personalized oral care.
Article
Public, Environmental & Occupational Health
Gregorczyk-Maga Iwona, Palka Anna, Fiema Mateusz, Kania Michal, Kujawska Anna, Maga Pawel, Jachowicz-Matczak Estera, Romaniszyn Dorota, Chmielarczyk Agnieszka, Zoltowska Barbara, Wojkowska-Mach Jadwiga
Summary: This study observed the impact of tooth brushing on oral hygiene in COVID-19 patients in an ICU setting. It was found that tooth brushing reduced dysbiosis of oral bacteriota but did not decrease the risk of hospital-acquired infections (HAIs).
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Infectious Diseases
Eman E. Hegazy, Marwa Gamal Bahey, Alaa Mohammed Abo Hagar, Amira Abdelgalil Elkholy, Esraa A. Mohamed
Summary: This study revealed that VAP caused by carbapenem-resistant gram-negative bacteria is a significant public health challenge in Egypt with high mortality rates and healthcare costs. The use of MASTDISCS combi Carba plus disc system is an efficient method for identifying different carbapenemases among enterobacterales.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Chemistry, Medicinal
Mojtaba Mojtahedzadeh, Mahdi Mashhadi Akbar Boojar, Solomon Habtemariam, Seyed Mohammad Nabavi, Atabak Najafi, Amirhosein Ghahremanian, Mohammad Baktash, Safieh Aghaabdollahian, Antoni Sureda, Mahdi Bagheri
Summary: This study systematically reviewed the efficacy of oral products in controlling and reducing VAP, selecting 18 relevant articles and finding that chlorhexidine and some oral herbal medications are beneficial in preventing VAP.
PHYTOTHERAPY RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Sharare Karimi, Ensi Kolyaei, Pooya Karimi, Khaled Rahmani
Summary: This study conducted a randomized controlled trial in three hospitals, finding that the use of an oral health care guideline was more effective than routine care in preventing ventilator-associated pneumonia. The incidence of VAP was 5% in the intervention group and 64% in the control group.
INFECTION PREVENTION IN PRACTICE
(2023)
Article
Environmental Sciences
Zhaomei Cui, Yingying Ma, Yuanyuan Yu, Na Li, Jun Wang, Anbiao Wang, Qi Tan
Summary: This study analyzed the relationship between ambient air pollutant exposure during intensive care unit (ICU) stays and the development of ventilator-associated pneumonia (VAP) in pediatric cardiac surgery patients. The results showed that exposure to increased levels of PM2.5 was significantly associated with an enhanced risk for VAP development, even with PM2.5 levels below the National Ambient Air Quality standard (NAAQS). Therefore, ambient PM2.5 may represent a previously unrecognized risk factor for pneumonia, and current environmental pollution standards need to be reevaluated to consider susceptible populations.
ENVIRONMENTAL HEALTH
(2023)
Review
Critical Care Medicine
Mackenzie Howatt, Michael Klompas, Andre C. Kalil, Mark L. Metersky, John Muscedere
Summary: Carbapenem-based empiric regimens showed lower mortality rates compared with non-carbapenems, but had a trend toward developing resistance. The mortality benefit was more prominent in trials with lower disease severity and was not associated with the presence of Pseudomonas.
Article
Computer Science, Artificial Intelligence
Ali Samadani, Taiyao Wang, Kees van Zon, Leo Anthony Celi
Summary: This study developed a personalized risk assessment predictive model using machine learning to identify patients at risk of developing ventilator-associated pneumonia (VAP). By creating a set of criteria to mark suspected infection events, an ensemble of decision trees was built to predict the risk of VAP in the next 24 hours. The model provides an early prediction of VAP and characterizes the VAP prediction for different hospital types. The model allows for early intervention and confirmatory diagnostic actions.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ting Ji, Xingxing Zhu, Futai Shang, Xiangcheng Zhang
Summary: This study indicates that probiotics can reduce the incidence of VAP, as well as reduce bacterial colonization in the oropharynx and stomach. Additionally, the results suggest that probiotics do not have adverse effects.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Xiaomeng Yi, Xuxia Wei, Mi Zhou, Yingying Ma, Jinfeng Zhuo, Xin Sui, Yuling An, Haijin Lv, Yang Yang, Huimin Yi
Summary: In two intensive care unit settings in China, the implementation of a comprehensive unit-based safety program (CUSP) effectively reduced the incidence of ventilator-associated pneumonia (VAP) and other infections in patients receiving mechanical ventilation. It also prolonged the time until VAP occurrence, reduced the days of antibiotic use for VAP, shortened the length of stay in the ICU and hospital, and enhanced safety culture awareness.
FRONTIERS IN PUBLIC HEALTH
(2022)