Article
Peripheral Vascular Disease
Xiao-Fei Ye, Qi-Fang Huang, Yan Li, Ji-Guang Wang
Summary: There is a seasonal variation in the antihypertensive treatment effect, with greater blood pressure reduction in patients who commenced treatment in the cold seasons.
HYPERTENSION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Andrea Mariela Araya-Sibaja, Cinira Fandaru, Ana Maria Guevara-Camargo, Felipe Vargas-Huertas, William J. Zamora, Jose Roberto Vega-Baudrit, Teodolito Guillen-Giron, Mirtha Navarro-Hoyos, Paola Paoli, Patrizia Rossi, William Jones
Summary: This study investigates the effect of solvents on the crystal forms of irbesartan. Different salts of irbesartan were obtained using different solvents, and their structures and properties were characterized using various techniques. The findings provide insights into the role of solvents in the formation of pharmaceutical solids.
Article
Physiology
K. Melissa Hallow, Charles H. Van Brackle, Sommer Anjum, Sergey Ermakov
Summary: Cardiac and renal function are interconnected through various mechanisms, influencing each other. Insufficient understanding of the integrative function of these physiological systems has led to unexpected clinical trial results. Mathematical models have been used to better understand organ functions, but there is currently no integrated model of cardiac and renal functions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lijuan Chen, Peng Fang
Summary: This study aimed to examine the antihypertensive effect of rhynchophylline on spontaneously hypertensive rats and its alleviation of myocardial hypertrophy. The results showed that rhynchophylline can lower blood pressure in rats, improve their overall condition, decrease left ventricular mass index and heart mass index, increase serum nitric oxide and nitric oxide synthase levels, and decrease myocardial angiotensin II and atrial natriuretic peptide levels.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Review
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: This review article focuses on the immunomodulatory properties of angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in hypertensive patients. ACEI and ARB can inhibit proinflammatory cytokine secretion, decrease expression of adhesion molecules, and normalize CRP concentration, thus exerting immune regulatory effects. This has significant importance in the treatment of patients with underlying chronic inflammatory responses and may also benefit those with comorbidities like metabolic syndrome, allergies, or autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jose A. Carlos-Escalante, Marcela de Jesus-Sanchez, Alejandro Rivas-Castro, Pavel S. Pichardo-Rojas, Claudia Arce, Talia Wegman-Ostrosky
Summary: Cancer is a complex group of diseases that ranks as the second largest cause of mortality worldwide. Repurposing existing drugs is seen as a cheaper and quicker alternative to developing new drugs for treating cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Chemistry, Medicinal
Chang-Keun Cho, Pureum Kang, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi
Summary: A physiologically based pharmacokinetic (PBPK) model was established to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes, providing a tool for personalized pharmacotherapy.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Clinical Neurology
Benjamin Maier, Benjamin Gory, Bertrand Lapergue, Igor Sibon, Sebastien Richard, Maeva Kyheng, Julien Labreuche, Jean-Philippe Desilles, Raphael Blanc, Michel Piotin, Mikael Mazighi, Jean-Michel Halimi
Summary: This study investigates the impact of prestroke antihypertensive treatments (AHT) on baseline stroke severity and neurological outcomes in acute ischemic stroke (AIS) patients. The results suggest that AIS patients treated with RAS inhibitor agents before stroke exhibited less severe stroke, had fewer occurrences of intracranial hemorrhage, and showed a trend towards better NIHSS scores at 24 hours compared to those under non-RAS inhibitor treatments.
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jihei Sara Lee, Hye Ryeong Cha, Hyoung Won Bae, Sang Yeop Lee, Wungrak Choi, Seung Won Lee, Chan Yun Kim
Summary: The purpose of this study was to investigate the effect of antihypertensive medication on the risk of open-angle glaucoma (OAG) in patients diagnosed with hypertension. The study found that certain antihypertensive medications slightly increased the risk of OAG, but the effects were small. Further research is needed to understand the associations between hypertension, medication, therapeutic effect, and OAG.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Koji Kawabeta, Masahiro Yuasa, Michihiro Sugano, Kazunori Koba
Summary: Dietary beta-conglycinin has been shown to lower blood pressure in spontaneously hypertensive rats by increasing plasma adiponectin concentration and possibly regulating the renin-angiotensin system.
Review
Peripheral Vascular Disease
Takeshi Takami, Satoshi Hoshide, Kazuomi Kario
Summary: Heart failure is a significant global health problem with stages classified from A to D, as well as into HFpEF and HFrEF categories. Hypertension and arterial stiffness are major factors in the progression of HF, particularly in HFpEF patients. Early intervention targeting arterial stiffness and hypertension is crucial for optimal treatment of HFpEF.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jingsi Zhang, Lina Yang, Yanchun Ding
Summary: In this study, alterations in the monocyte phenotype and inflammatory state of hypertensive patients with left ventricular hypertrophy (LVH) were observed. Irbesartan was found to upregulate CD163 and CD206 expression in a concentration-dependent manner, as well as increase IL-10 expression and inhibit TNF-alpha expression, suggesting a potential novel mechanism for how irbesartan alleviates LVH in hypertensive patients.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Paola Nicoletti, Guruprasad P. Aithal, Thomas C. Chamberlain, Sally Coulthard, Mohammad Alshabeeb, Jane Grove, Raul J. Andrade, Einar Bjornsson, John F. Dillon, Par Hallberg, M. Isabel Lucena, Anke H. Maitland-van der Zee, Jennifer H. Martin, Mariam Molokhia, Munir Pirmohamed, Mia Wadelius, Yufeng Shen, Matthew R. Nelson, Ann K. Daly
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Elizabeth T. Cirulli, Paola Nicoletti, Karen Abramson, Raul J. Andrade, Einar S. Bjornsson, Naga Chalasani, Robert J. Fontana, Par Hallberg, Yi Ju Li, M. Isabel Lucena, Nanye Long, Mariam Molokhia, Matthew R. Nelson, Joseph A. Odin, Munir Pirmohamed, Thorunn Rafnar, Jose Serrano, Kari Stefansson, Andrew Stolz, Ann K. Daly, Guruprasad P. Aithal, Paul B. Watkins, Fernando Bessone, Einar Bjornsson, Ingolf Cascorbi, John F. Dillon, Christopher P. Day, Nelia Hernandez, Luisa Ibanez, Gerd A. Kullak-Ublic, Tarja Laitinen, Dominique Larrey, Anke Maitland-van der Zee, Jennifer H. Martin, Dick Menzies, Shengying Qin, Mia Wadelius
Article
Medicine, General & Internal
Par Hallberg, Hans Smedje, Niclas Eriksson, Hugo Kohnke, Makrina Daniilidou, Inger Ohman, Qun-Ying Yue, Marco Cavalli, Claes Wadelius, Patrik K. E. Magnusson, Anne-Marie Landtblom, Mia Wadelius
Article
Endocrinology & Metabolism
Mohammad Kharazmi, Karl Michaelsson, Jorg Schilcher, Niclas Eriksson, Hakan Melhus, Mia Wadelius, Par Hallberg
CALCIFIED TISSUE INTERNATIONAL
(2019)
Article
Pharmacology & Pharmacy
Paola Nicoletti, Sarah Barrett, Laurence McEvoy, Ann K. Daly, Guruprasad Aithal, M. Isabel Lucena, Raul J. Andrade, Mia Wadelius, Par Hallberg, Camilla Stephens, Einar S. Bjornsson, Peter Friedmann, Kati Kainu, Tarja Laitinen, Anthony Marson, Mariam Molokhia, Elizabeth Phillips, Werner Pichler, Antonino Romano, Neil Shear, Graeme Sills, Luciana K. Tanno, Ashley Swale, Aris Floratos, Yufeng Shen, Matthew R. Nelson, Paul B. Watkins, Mark J. Daly, Andrew P. Morris, Ana Alfirevic, Munir Pirmohamed
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Rheumatology
Johanna Karlsson Sundbaum, Niclas Eriksson, Par Hallberg, Niklas Lehto, Mia Wadelius, Eva Baecklund
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2019)
Article
Genetics & Heredity
Par Hallberg, Qun-Ying Yue, Erik Eliasson, Hakan Melhus, Joel As, Mia Wadelius
PHARMACOGENOMICS JOURNAL
(2020)
Article
Medicine, General & Internal
Helge Brandberg, Thomas Kahan, Jonas Spaak, Kay Sundberg, Sabine Koch, Athena Adeli, Carl Johan Sundberg, David Zakim
Article
Health Care Sciences & Services
Helge Brandberg, Carl Johan Sundberg, Jonas Spaak, Sabine Koch, David Zakim, Thomas Kahan
Summary: This study aimed to evaluate the effectiveness of self-reported medical histories collected via a computerized history taking (CHT) program on a tablet among patients with acute chest pain in the emergency department. Results showed that a majority of patients were able to effectively interact with CHT to provide sufficient data for cardiovascular risk stratification. However, utility was somewhat lower in certain patient subgroups, indicating the need for further studies to assess the potential benefits of CHT in improving management and prognosis for this large patient population.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Peripheral Vascular Disease
Piotr Sobieraj, Peter M. Nilsson, Thomas Kahan
Summary: The SPRINT study demonstrated that intensive blood pressure lowering not only reduced heart failure events, but also significantly decreased the risk of cardiovascular events, supporting the use of a more intensive treatment strategy for high-risk hypertensive patients.
Editorial Material
Medicine, General & Internal
Thomas Kahan
Article
Multidisciplinary Sciences
David Zakim, Helge Brandberg, Sami El Amrani, Andreas Hultgren, Natalia Stathakarou, Sokratis Nifakos, Thomas Kahan, Jonas Spaak, Sabine Koch, Carl Johan Sundberg, Amit Bahl, Amit Bahl, Amit Bahl, Amit Bahl
Summary: This study compares the completeness and accuracy of medical history data collected by physicians in the emergency room with data collected by computerized history-taking (CHT). The findings show that CHT is more complete and accurate than physician history-taking, but there are frequent factual inconsistencies between the two methods.
Article
Cardiac & Cardiovascular Systems
Eva Gerdts, Isabella Sudano, Sofie Brouwers, Claudio Borghi, Rosa Maria Bruno, Claudio Ceconi, Veronique Cornelissen, Francois Dievart, Marc Ferrini, Thomas Kahan, Maja Lisa Lochen, Angela H. E. M. Maas, Felix Mahfoud, Anastasia S. Mihailidou, Trine Moholdt, Gianfranco Parati, Giovanni de Simone
Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.
EUROPEAN HEART JOURNAL
(2022)
Article
Health Care Sciences & Services
Kay Sundberg, Athena Adeli, Helge Brandberg, Jonas Spaak, Sabine Koch, Carl J. Sundberg, David Zakim, Thomas Kahan, Kaisa Fritzell
Summary: Most patients had a positive experience with the CLEOS program in the ED setting, although some found it to be extensive. Adjustments to the extent of the interview for better adaptation to the clinical setting should be the future development of the program.
HEALTH EXPECTATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan S. M. Johansson, Per Hjerpe, Georgios Mourtzinis, Thomas Kahan, Charlotta Ljungman
Summary: According to this retrospective cohort study, prediabetes in hypertensive patients is not independently associated with incident heart failure, but is associated with all-cause mortality when fasting plasma glucose levels are in the range of 6.1-6.9 mmol/L. Prediabetic patients had lower time in therapeutic blood pressure range, suggesting the potential for improving blood pressure control to reduce the occurrence of heart failure in prediabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)