Article
Multidisciplinary Sciences
Azza Ahmed, Amani Baldo, A. Sulieman, Hind Mirghani, Fouad A. Abolaban, I. I. Suliman, Isam Salih
Summary: The study showed that different shim techniques, voxel sizes, and repetition time (TR) had minimal impact on the quantification of iron in transfused dependent sickle cell patients using T2 and T2* sequences. Pixel sizes of 1x1 and 2x2 mm yielded the best results for T2 measurements, while TR variations did not significantly affect the measurements.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Ramadan A. Mahmoud, Ashraf Khodeary, Marwa S. Farhan
Summary: Beta thalassemia major patients are at risk of developing endocrine disorders early in life. High serum ferritin levels and poor patient compliance to therapy are significantly associated with increased endocrine disorders. Combined iron-chelating agents show a decreased prevalence of endocrine disorders compared to monotherapy.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Akodu Samuel Olufemi, Adekanmbi Abiodun Folashade, Ogunlesi Tinuade Adetutu
Summary: The study aimed to determine the prevalence of iron overload among non-chronically blood transfused preschool children with sickle cell anaemia. Findings showed that iron overload was prevalent in this group, with a prevalence rate of 20.6%. Iron overload was higher among older children, females, those with history of blood transfusion, and those who underwent single blood transfusion session.
AFRICAN HEALTH SCIENCES
(2021)
Article
Cell Biology
Michael A. Lopez, Sherina Bontiff, Mary Adeyeye, Aziz Shaibani, Matthew S. Alexander, Shari Wynd, Aladin M. Boriek
Summary: The MDX mouse model was used to study the role of dystrophin in skeletal muscle mechanics, finding that muscle extensibility and compliance were increased in MDX mice, as well as a higher relaxed elastic modulus in dystrophin-deficient diaphragms. Additionally, age was found to impact the passive mechanics of the diaphragm, with older MDX mice showing decreased compliance and extensibility compared to younger mice.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Peter Hekman, Johan Schefferlie, Ronette Gehring
Summary: The study investigated the impact of age-dependent pharmacokinetics (PK) on the clinical efficacy of oxytetracycline (OTC) in treating Bovine Respiratory Disease (BRD) in beef cattle. The results showed that the treatment outcomes varied in different dosing regimens and age groups.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Okan Avci, Seher Yildiz Tacar, Erdogan Selcuk Seber, Tarkan Yetisyigit
Summary: Young breast cancer patients under 40 years old exhibit aggressive disease course with low childbirth rate, requiring interdisciplinary approaches for management of this special patient population.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Akash D. Parekh, Daniel J. Indelicato, Raymond B. Mailhot Vega, Ronny L. Rotondo, Christopher G. Morris, Scott Bradfield, Julie A. Bradley
Summary: In infants with rhabdomyosarcoma undergoing proton therapy, the 5-year local control rate, progression-free survival rate, and overall survival rate were 83%, 78%, and 83% respectively. The study found that patients with nasal ala primaries had a higher rate of late recurrence, and categorizing them as unfavorable sites can improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Ayako Konishi, Shinobu Ida, Yasuko Shoji, Yuri Etani, Masanobu Kawai
Summary: In children with PWS, lower FT4 levels during infancy and normal FT3 levels suggest that routine levothyroxine replacement therapy may not be necessary.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Pediatrics
Laure Carneiro, Antoine Bouissou, Geraldine Favrais
Summary: This study aimed to assess the efficacy and tolerance of an increasing dose regimen of ibuprofen for the treatment of patent ductus arteriosus (PDA) in preterm infants. It was found that early treatment was more effective in inducing ductus arteriosus closure.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Jorge Sanz-Ros, Nekane Romero-Garcia, Cristina Mas-Bargues, Daniel Monleon, Juozas Gordevicius, Robert T. Brooke, Mar Dromant, Ana Diaz, Aksinya Derevyanko, Ana Guio-Carrion, Aurora Roman-Dominguez, Marta Ingles, Maria A. Blasco, Steve Horvath, Jose Vina, Consuelo Borras
Summary: This study found that treatment of old animals with ADSC-sEVs derived from young animals can improve various parameters associated with aging and reduce frailty. This treatment induces proregenerative effects and reduces oxidative stress, inflammation, and senescence in muscle and kidney. Additionally, tissue epigenetic age decreases and metabolome shifts to a youth-like pattern after this treatment.
Letter
Medicine, General & Internal
Beth L. Pineles, Anthony D. Harris, Katherine E. Goodman
Summary: This study compares morbidity and delivery outcomes among pregnant 10- to 13-year-olds, 14- to 17-year-olds, and 18- to 19-year-olds using a US claims database.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Michael J. MacDonald, Israr-ul H. Ansari, Amy S. Riedemann, Scott W. Stoker, Jens C. Eickhoff, Peter J. Chlebeck, Luis A. Fernandez, Melissa J. Longacre
Summary: Net synthesis of pancreatic beta-cells peaks before 2 years of age and beta-cell mass is set within the first 5 years of life. In-frame translational readthrough of the NRP1 gene generates a truncated neuropilin-1 protein, which lacks downstream sequence necessary for binding VEGF and stimulates beta-cell replication. Decreased insulin cells and a genetic marker in NRP1 intron 9 are associated with early onset of type 1 diabetes.
Article
Astronomy & Astrophysics
Zhiqiang Yan, Tereza Jerabkova, Pavel Kroupa
Summary: The stellar initial mass function (IMF) is a scale-invariant probability density distribution function (PDF), but observations challenge this interpretation. We study the relation between the most massive star in a star cluster and its parental cluster mass to understand star formation. By comparing observed data with synthetic clusters, we reject the hypothesis that the IMF is a PDF. We propose a deterministic stellar mass sampling tool and find a flattening in the relation near a certain mass, suggesting important physical processes in cluster formation.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Geriatrics & Gerontology
Navneet N. Lal, Jon Cornwall, Philip W. Sheard
Summary: Age-related loss of skeletal muscle mass in mice is mainly due to fiber shortening rather than fiber loss, with alterations in muscle morphology playing a significant role in muscle wasting. Tendon length and pennation angle remain consistent across the lifespan, while changes in connective tissue selectively impact muscle structure.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Psychology, Developmental
Laura Cabral, Finnegan J. Calabro, Jerod Rasmussen, Will Foran, Lucille A. Moore, Alice Graham, Thomas G. O'Connor, Pathik D. Wadhwa, Sonja Entringer, Damien Fair, Claudia Buss, Ashok Panigrahy, Beatriz Luna
Summary: Understanding the development of the striatum is crucial for motor, cognitive, and reward behavior later in life, but little is known about age-related changes in striatal physiology during the neonatal period. Using MRI-based measurement of tissue iron deposition, researchers found that iron increased with postnatal age in the pallidum and putamen but not the caudate. The findings suggest distinct changes in striatal subregions and provide insight into the differentiation between motor and cognitive systems.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Neuroimaging
Ravi R. Bhatt, Lonnie K. Zeltzer, Julie Coloigner, John C. Wood, Tom D. Coates, Jennifer S. Labus
NEUROIMAGE-CLINICAL
(2019)
Article
Hematology
Yaqiong Chai, Adam M. Bush, Julie Coloigner, Aart J. Nederveen, Benita Tamrazi, Chau Vu, Soyoung Choi, Thomas D. Coates, Natasha Lepore, John C. Wood
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Hematology
Jon A. Detterich, Roberta Kato, Adam Bush, Patjanaporn Chalacheva, Derek Ponce, Madushka De Zoysa, Payal Shah, Michael C. Khoo, Herbert J. Meiselman, Thomas D. Coates, John C. Wood
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Hematology
Payal Shah, Maha Khaleel, Wanwara Thuptimdang, John Sunwoo, Saranya Veluswamy, Patjanaporn Chalacheva, Roberta M. Kato, Jon Detterich, John C. Wood, Lonnie Zeltzer, Richard Sposto, Michael C. K. Khoo, Thomas D. Coates
Article
Physiology
Patjanaporn Chalacheva, Roberta M. Kato, Payal Shah, Saranya Veluswamy, Christopher C. Denton, John Sunwoo, Wanwara Thuptimdang, John C. Wood, Jon A. Detterich, Thomas D. Coates, Michael C. K. Khoo
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Hematology
Soyoung Choi, Sharon H. O'Neil, Anand A. Joshi, Jian Li, Adam M. Bush, Thomas D. Coates, Richard M. Leahy, John C. Wood
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Clinical Neurology
Aravind Thavamani, Krishna Kishore Umapathi, Mammen Puliyel, Dennis Super, Veerajalandhar Allareddy, Abdulla Ghori
PEDIATRIC NEUROLOGY
(2020)
Letter
Hematology
Juan Espinoza, Payal Shah, Saranya Veluswamy, Lonnie Zeltzer, Michael C. K. Khoo, Thomas D. Coates, Jacquelyn Baskin
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Letter
Hematology
Eamon Doyle, Nilesh Ghugre, Thomas D. Coates, John C. Wood
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Meeting Abstract
Hematology
Patjanaporn Chalacheva, Yunhua Ji, Carol L. Rosen, Michael R. DeBaun, Michael C. K. Khoo, Thomas Coates
Article
Integrative & Complementary Medicine
Sarah R. Martin, Payal Shah, Christopher Denton, Lonnie K. Zeltzer, Saranya Veluswamy, Michael C. K. Khoo, Thomas D. Coates
COMPLEMENTARY THERAPIES IN MEDICINE
(2020)
Article
Oncology
Krishna Kishore Umapathi, Aravind Thavamani, Mammen Puliyel
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2020)
Article
Medicine, General & Internal
M. D. Cappellini, V. Viprakasit, A. T. Taher, P. Georgiev, K. H. M. Kuo, T. Coates, E. Voskaridou, H. -K. Liew, I. Pazgal-Kobrowski, G. L. Forni, S. Perrotta, A. Khelif, A. Lal, A. Kattamis, E. Vlachaki, R. Origa, Y. Aydinok, M. Bejaoui, P. J. Ho, L. -P. Chew, P. -C. Bee, S. -M. Lim, M. -Y. Lu, A. Tantiworawit, P. Ganeva, L. Gercheva, F. Shah, E. J. Neufeld, A. Thompson, A. Laadem, J. K. Shetty, J. Zou, J. Zhang, D. Miteva, T. Zinger, P. G. Linde, M. L. Sherman, O. Hermine, J. Porter, A. Piga
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Oncology
Monica L. Hulbert, Deepa Manwani, Emily Riehm Meier, Ofelia A. Alvarez, R. Clark Brown, Michael U. Callaghan, Andrew D. Campbell, Thomas D. Coates, Melissa J. Frei-Jones, Jane S. Hankins, Matthew M. Heeney, Lewis L. Hsu, Jeffrey D. Lebensburger, Charles T. Quinn, Nirmish Shah, Kim Smith-Whitley, Courtney Thornburg, Julie Kanter
Summary: This article describes a modified Delphi consensus-seeking process to determine the essential elements of a comprehensive pediatric SCD center. Through the participation of specialists, consensus was reached on the essential, optimal, and suggested elements, laying the foundation for the formal recognition process of pediatric comprehensive SCD centers.
PEDIATRIC BLOOD & CANCER
(2023)
Meeting Abstract
Oncology
Nikki Agarwal, Mammen Puliyel, Dora Cobrinik, Aparna Roy
PEDIATRIC BLOOD & CANCER
(2019)