The JAK2 exon 12 mutations: A comprehensive review

Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations

(2011) F. Passamonti et al.   BLOOD

Bone Marrow Morphologic Features in Polycythemia Vera WithJAK2Exon 12 Mutations

(2010) Meredith A. Lakey et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

High Percentage ofJAK2Exon 12 Mutation in Asian Patients With Polycythemia Vera

(2010) Yu-Min Yeh et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms

(2010) A. V. Jones et al.   BLOOD

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

(2010) F. X. Schaub et al.   BLOOD

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

Detection of Exon 12 Mutations in the JAK2 Gene

(2010) Todd S. Laughlin et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations

(2010) A Pardanani et al.   LEUKEMIA

A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications

(2010) F Passamonti et al.   LEUKEMIA

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interlaboratory Development and Validation of a HRM Method Applied to the Detection of JAK2 Exon 12 Mutations in Polycythemia Vera Patients

(2010) Valerie Ugo et al.   PLoS One

Isolated erythrocytosis in V617F negative patients with JAK2 exon 12 mutations: Report of a new mutation

(2009) Martina Bernardi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis

(2009) L. Malcovati et al.   BLOOD

Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms

(2009) Lizz F. Grimwade et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

(2009) Philip A. Beer et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Novel JAK2 Exon 12 Mutation Identified in the Retrospective Analysis of Paraffin-embedded Tissues of Polycythemia Vera Patients

(2009) Tatiana Burjanivova et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

No Evidence for the JAK2 (V617F) or JAK2 Exon 12 Mutations in Primary Mediastinal Large B-cell Lymphoma

(2009) David Wu et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Fast and reliable mutation detection of the complete exon 11-15JAK2coding region using non-isotopic RNase cleavage assay (NIRCA)

(2009) Konstantinos Kambas et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

(2009) J. Elliott et al.   HAEMATOLOGICA

Detection of JAK2 exon 12 mutations in 15 patients with JAK2V617F negative polycythemia vera

(2009) S. Schnittger et al.   HAEMATOLOGICA

Detection of Low Allele Burden of JAK2 Exon 12 Mutations Using TA-cloning in Patients with Erythrocytosis

(2009) J. H. Ohyashiki et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

A JAK2 Interdomain Linker Relays Epo Receptor Engagement Signals to Kinase Activation

(2009) Lequn Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Resolution Melting Analysis for JAK2 Exon 14 and Exon 12 Mutations

(2009) Inmaculada Rapado et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The ‘GGCC’ haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera

(2009) D Olcaydu et al.   LEUKEMIA

Mutations of ASXL1 gene in myeloproliferative neoplasms

(2009) N Carbuccia et al.   LEUKEMIA

JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms

(2009) Anna Siemiątkowska et al.   LEUKEMIA RESEARCH

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

(2009) Damla Olcaydu et al.   NATURE GENETICS

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

(2009) Amy V Jones et al.   NATURE GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK mutations in high-risk childhood acute lymphoblastic leukemia

(2009) C. G. Mullighan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations

(2009) Tai-Sung Lee et al.   BMC STRUCTURAL BIOLOGY

Absence of JAK2 Exon 12 Mutation in Acute Leukemias

(2008) Eun Goo Jeong et al.   ACTA HAEMATOLOGICA

Absence of the JAK2 exon 12 mutations in patients with splanchnic venous thrombosis and without overt myeloproliferative neoplasms

(2008) Alessia Fiorini et al.   AMERICAN JOURNAL OF HEMATOLOGY

Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations

(2008) S. Li et al.   BLOOD

MPL and JAK2 exon 12 mutations in patients with the Budd-Chiari syndrome or extrahepatic portal vein obstruction

(2008) G. M. Bergamaschi et al.   BLOOD

The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases

(2008) J.-J. Kiladjian et al.   BLOOD

Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera

(2008) Holger Cario et al.   BRITISH JOURNAL OF HAEMATOLOGY

Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modelling of a novel exon 12 insertion mutation in a case of idiopathic erythrocytosis

(2008) Elena Albiero et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients

(2008) Eirini Kouroupi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Is refractory anaemia with ring sideroblasts and thrombocytosis (RARS-T) a necessary or useful diagnostic category?

(2008) Douglas Wardrop et al.   BRITISH JOURNAL OF HAEMATOLOGY

Rapid identification of JAK2 exon 12 mutations using high resolution melting analysis

(2008) A. V. Jones et al.   HAEMATOLOGICA

The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders

(2008) A. Theocharides et al.   HAEMATOLOGICA

Mutation Profile of JAK2 Transcripts in Patients with Chronic Myeloproliferative Neoplasias

(2008) Wanlong Ma et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

(2008) Dani Bercovich et al.   LANCET

JAK2exon 12 mutation inJAK2V617F-negative polycythemia vera

(2008) Benno Röthlisberger et al.   LEUKEMIA & LYMPHOMA

Low frequency of JAK2 exon 12 mutations in classic and atypical CMPDs

(2008) C. Ormazábal et al.   LEUKEMIA RESEARCH

Inhibition of the Bcl-xLDeamidation Pathway in Myeloproliferative Disorders

(2008) Rui Zhao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

(2007) R. Tiedt et al.   BLOOD