Article
Oncology
Liat Hammer, David Hausner, Maoz Ben-Ayun, Einat Shacham-Shmueli, Ofir Morag, Ofer Margalit, Ben Boursi, Nirit Yarom, Galia Jacobson, Tamar Katzman, Ross Abrams, Adam Dicker, Talia Golan, Zvi Symon, Yaacov R. Lawrence
Summary: The study suggests that celiac plexus radiosurgery could alleviate cancer-related pain.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Till Tobias Boehlen, Jean-Francois Germond, Jean Bourhis, Marie-Catherine Vozenin, Esat Mahmut Ozsahin, Francois Bochud, Claude Bailat, Raphael Moeckli
Summary: This study evaluated the magnitude of normal tissue sparing provided by the FLASH effect and parameterized its relationship with dose. The results showed that the magnitude of tissue sparing decreases as the dose increases and is dependent on the irradiated tissue.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Michael T. Milano, Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tome, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D. Solberg, John P. Kirkpatrick, Louis S. Constine, John C. Flickinger, Lawrence B. Marks, Issam El Naqa
Summary: This study analyzed dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy after single-fraction stereotactic radiosurgery or hypofractionated radiosurgery. The results showed that the maximum point dose to the optic apparatus was related to RION risk, providing insight into NTCP risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taki Eddine Addala, Aymeric Hamard, Fehmi Snene, Xavier Bobbia, Sophie Bastide, Asmaa Belaouni, Ahmed Larbi, Jean-Emmanuel De La Coussaye, Jean-Paul Beregi, Julien Frandon, Joel Greffier, Helene de Forges, Pierre-Geraud Claret
Summary: This study assessed the diagnostic sensitivity and specificity of ULD-CT versus digital radiographs in patients with extremity traumas. The results showed that ULD-CT had better detection performance for extremity fractures compared to digital radiographs, with a similar effective dose level.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Hematology
Yunfan Yang, Hongmei Luo, Yuhuan Zheng, Zhongqing Zou, Ting Niu, Yongqian Jia, Huanling Zhu, Ting Liu, Yu Wu, Hong Chang, Jie Ji, Jian Li, Ling Pan
Summary: The study aimed to investigate the effect of low-dose ruxolitinib treatment on myelofibrosis (MF), revealing that low-dose treatment resulted in gradual spleen response and significant improvement in bone marrow fibrosis.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Michal Staruch, Silvia Gomez, Susanne Rogers, Istvan Takacs, Thomas Kern, Sabine Adler, Dieter Cadosch, Oliver Riesterer
Summary: The administration of two series of low-dose radiotherapy (LDRT), prior response to steroid injection (SI), and the absence of structural abnormalities can predict better treatment outcomes in patients with greater trochanteric pain syndrome (GTPS).
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Orthopedics
Rui Xu, Yinan Jin, Suhong Tang, Wenwen Wang, Yu-E Sun, Yue Liu, Wei Zhang, Bailing Hou, Yulin Huang, Zhengliang Ma
Summary: This study investigates the genetic factors associated with severe chronic pain in older adult patients after lower extremity arthroplasty and identifies several gene variants related to the development of chronic postsurgical pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Medicine, General & Internal
Alessandro Riccardi, Mario Guarino, Sossio Serra, Michele Domenico Spampinato, Simone Vanni, Dana Shiffer, Antonio Voza, Andrea Fabbri, Fabio De Iaco
Summary: Pain is a common reason for medical consultations and emergency department visits. Ketamine, a drug initially used for sedation and anesthesia, has emerged as a versatile tool for pain management. However, its psychomimetic effects have limited its use in emergency departments. This narrative review discusses ketamine's role as an analgesic, its strengths and weaknesses, and the use of additional drugs for improving analgesia and treating side effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Na Kim, Hee Jin Park, Myung Sub Kim, Shin Ho Kook, Soo Youn Ham, Eugene Kim, Se Jin Park
Summary: This study aimed to compare the image quality of extremities CT scans with low-dose and standard-dose radiation, finding that objective image noise was higher in low-dose CT images of the shoulder and pelvis, leading to decreased subjective image quality. However, in the wrist, both objective image noise and subjective image quality remained similar between low-dose and standard CT scans, and in the ankle, some measurements of image quality were comparable between the two dose regimens.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karin N. Westlund, Marena A. Montera, Aleyah E. Goins, Sascha R. A. Alles, Nikita Suri, Sabrina L. McIlwrath, Robyn Bartel, Ravi V. Durvasula, Adinarayana Kunamneni
Summary: Non-opioid engineered scFv antibodies targeting the P2X4R receptor show potential as biotherapeutic interventions for chronic pain, with enhanced binding affinity and tissue penetrability leading to persistent pain relief in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jens Tijtgat, Evan Calliauw, Iris Dirven, Manon Vounckx, Randa Kamel, Anne Marie Vanbinst, Hendrik Everaert, Laura Seynaeve, Dirk Van Den Berge, Johnny Duerinck, Bart Neyns
Summary: Focal radiation necrosis of the brain (fRNB) is a potential adverse event following stereotactic radiation therapy (SRT) or stereotactic radiosurgery (SRS), with higher incidence in cancer patients treated with immune checkpoint inhibitors. A low-dose regimen of bevacizumab (BEV) was found to be effective in improving clinical symptoms and reducing edema volume in fRNB patients, without significant adverse effects. This fixed low-dose BEV regimen may serve as a well-tolerated and cost-effective alternative treatment option for fRNB, warranting further investigation.
Article
Oncology
Shankar Siva, Mathias Bressel, Tao Mai, Hien Le, Shalini Vinod, Harini de Silva, Sean Macdonald, Marketa Skala, Nicholas Hardcastle, Angela Rezo, David Pryor, Suki Gill, Braden Higgs, Kassandra Wagenfuehr, Rebecca Montgomery, Raef Awad, Brent Chesson, Thomas Eade, Wenchang Wong, Giuseppe Sasso, Richard De Abreu Lourenco, Tomas Kron, David Ball, Paul Neeson
Summary: This study aimed to compare the treatment efficacy of single-fraction and multifraction SABR for pulmonary oligometastases, and the results showed no significant differences in safety, efficacy, or symptom burden between the two approaches, with single-fraction SABR being more efficient for delivery.
Article
Oncology
Asal Rahimi, Ambrosia Simmons, D. Nathan Kim, Marilyn Leitch, Jonathan Haas, Xuejun Gu, Chul Ahn, Ang Gao, Ann Spangler, Howard E. Morgan, Sally Goudreau, Stephen Seiler, Deborah Farr, Rachel Wooldridge, Barbara Haley, Shohreh Bahrami, Sarah Neufeld, Christopher Mendez, Prasanna Alluri, Roshni Rao, Robert D. Timmerman
Summary: The study on single-fraction stereotactic partial breast irradiation (S-PBI) for early stage breast cancer after partial mastectomy using a robotic stereotactic radiation system demonstrates the feasibility of safely escalating the dose to 30 Gy in a single fraction with low toxicity and minimal impact on cosmesis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Chemistry, Physical
Shujie Tie, Xiaojun Wu, Yazhou Wei, Ning Yang, Lixu Xie, Jianguo Zhu, Xiaojia Zheng
Summary: Ferroelectric perovskite oxides are suitable for low-dose X-ray detection, with a low detection limit and good operational stability. This study will promote the exploration of new strategies using ferroelectric oxides for low-dose and stable X-ray detectors.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Oncology
Michael R. Folkert, Jeffrey J. Meyer, Todd A. Aguilera, Takeshi Yokoo, Nina N. Sanford, William G. Rule, John Mansour, Adam Yopp, Patricio Polanco, Raquibul Hannan, Lucien A. Nedzi, Robert D. Timmerman
Summary: This study reported long-term outcomes of patients with liver metastases treated with single-fraction liver SABR. The results showed that single-fraction SABR at doses of 35 and 40 Gy was safe, well-tolerated, and demonstrated excellent local control in selected patients with liver metastases. Follow-up results confirmed the efficacy of single-fraction SABR doses of 40 Gy in subsequent patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)