Editorial Material
Immunology
Andrea K. Thet, Paul J. Kelly, Sabirah N. Kasule, Anish K. Shah, Arpan Chawala, Amber Latif, Sridhar S. Chilimuri, Cosmina B. Zeana
Summary: We present a case of progressive, severe monkeypox virus infection in an AIDS patient, who showed significant improvement after receiving vaccinia immune globulin intravenous. This highlights the use of vaccinia immune globulin intravenous as an adjunct therapy for severe disease in immunocompromised hosts.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Bar Goldberg, Dana Danino, Yoel Levinsky, Itzhak Levy, Rachel Straussberg, Halima Dabaja-Younis, Alex Guri, Yotam Almagor, Diana Tasher, Daniel Elad, Zina Baider, Shlomo Blum, Oded Scheuerman
Summary: This is a study on infant botulism infection, which presents with descending paralysis, constipation, and respiratory failure. Laboratory-confirmed cases are rare in Israel, but there was a cluster of 5 cases reported between 2019 and 2021, suggesting a possible increase in incidence. The median age of diagnosis was 6.5 months, older than previously reported, and most cases occurred between March and July. One case reported honey consumption, and possible environmental risk factors were reported in 6 cases. Although infant botulism is rare, its incidence in Israel may have increased in recent years, with different epidemiology and risk factors compared to previous cases reported in the country.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Immunology
Elena E. Perez, Jacques Hebert, Anne K. Ellis, Oral Alpan, William R. Lumry, Ralph Shapiro, Daniel Suez, J. Fernando Mandujano, Richard L. Wasserman
Summary: The study demonstrated that GC5107 is an effective, safe, and well-tolerated treatment for patients with primary immunodeficiency in preventing serious bacterial infections. One acute serious bacterial infection occurred during the 12-month study period, with low incidence rates of other infections and hospitalizations. The medication was well-tolerated with few adverse events reported.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Roger H. Kobayashi, Michael T. Rigas
Summary: The report highlights the potential risks of using immune globulin on kidney function, and provides recommendations for kidney disease screening, monitoring, and management. Using high doses of IG on patients with impaired kidney function may pose risks.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Virology
Joanna J. Song, Andrea Chobrutskiy, Boris I. Chobrutskiy, Konrad J. Cios, Taha I. Huda, Rachel A. Eakins, Michael J. Diaz, George Blanck
Summary: The liver shows immune privilege compared to other organs, and hepatocellular carcinoma (HCC) exhibits attenuated immune response. HCC has the lowest numbers of adaptive immune receptor (IR) recombination reads and a higher number of immunoglobulin rather than T-cell receptor recombination reads compared to other cancers. The high chemical complementarity between HCC-resident complementarity determining region-3 (CDR3) amino acid sequences and hepatitis B virus (HBV) epitopes is correlated with increased survival probabilities, suggesting the potential of CDR3 AA sequences as biomarkers and therapeutic targets for HCC patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Clinical Neurology
Yi Xiao, Qianqian Wei, Ruwei Ou, Tianmi Yang, Qirui Jiang, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Shichan Wang, Junyu Lin, Bi Zhao, Wei Song, Xueping Chen, Ying Wu, Chunyu Li, Huifang Shang
Summary: This study explores the relationship between peripheral adaptive immune indicators and the rate of disease progression in early Parkinson's disease. It found that the subset of peripheral T lymphocytes is associated with cognitive decline in early PD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Yongmei Ma, Jingjing Zhang, Rong Fan
Summary: This study analyzes the clinical effect of glucocorticoid plus intravenous immunoglobulin in treating children with immunoglobulin-insensitive Kawasaki disease. The results show that glucocorticoid plus intravenous immunoglobulin can significantly promote symptom resolution, alleviate inflammatory response, and improve immune function, with good safety.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Brittany N. Bates, Mark E. Olah
Summary: The study evaluated the clinical use of a new IV immune globulin product, human-slra, for treating PIDD. The results demonstrated good efficacy and a low rate of adverse events compared to other immune globulin products. Therefore, this new immune globulin product may provide a new treatment option for patients with PIDD.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Luigi Brunetti, Helene Chapy, Ronald G. G. Nahass, Rebecca Moore, Andrew Wassef, Derek Adler, Edward Yurkow, Leonid Kagan
Summary: The effect of obesity on IgG pharmacokinetics was investigated in a rat model and clinical evidence for an association between body composition and IVIG pharmacokinetic parameters in humans was collected. The pharmacokinetics of human IgG was significantly different between obese and lean rats. In the clinical study, total serum IgG concentration and subtype half-life negatively correlated with BMI and fat mass.
Editorial Material
Biotechnology & Applied Microbiology
Jerry Siegel, Karl Kappeler
Summary: The FDA strongly encourages safety and efficacy studies in all age groups for vaccines and treatments for severe diseases. A recent study on pediatric patients using rabies immunoglobulin showed that most patients achieved the desired immune response without any serious adverse events or deaths.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yingying Liang, Sevin Turcan
Summary: Epigenetic drugs have been used in the treatment of hematologic malignancies, and their potential in solid tumors is still being investigated. Current evidence suggests that these drugs may enhance antitumor immunity by increasing antigen presentation and improving the therapeutic effect of immune checkpoint inhibitors.
Article
Obstetrics & Gynecology
Tal Henry Lesser, Michael O'Malley, Robert M. Ehsanipoor
Summary: This study suggests that prenatal RHD genotyping for partial D antigen in pregnant women can prevent mischaracterization as RhD-positive during transfusion.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Priya Patel, Rohit Pal, Krishna Butani, Sudarshan Singh, Bhupendra G. Prajapati
Summary: Nanotechnology has significant potential in the field of cosmetics, offering improved efficacy and addressing issues with traditional cosmetics. The use of nanocarriers such as vesicles and solid lipid nanoparticles enhances product effectiveness, particularly in treating common skin diseases.
Article
Pharmacology & Pharmacy
Sarah Perreault, Molly Schiffer, Virginia Clinchy-Jarmoszko, Nicole Bocchetta, Lisa Barbarotta, Osama Abdelghany, Francine Foss, Scott Huntington, Stuart Seropian, Iris Isufi
Summary: Transitioning from clinic-based to home-based IVIG/SCIG infusion can effectively reduce the risk of potential exposure in high-risk immunosuppressed population during a pandemic, with no impact on patient satisfaction, adherence, or efficacy. The initiative resulted in cost savings for patients and increased available chair time in the infusion clinic.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2021)
Article
Virology
Kacy A. Ramirez, James Mond, Jesse Papenburg, Guy Boivin, Brian E. Gilbert, Ann R. Falsey, Bindiya Bagga, John P. Devincenzo
Summary: RSV-IG may be beneficial in treating RSV infection in immunocompromised patients. Experimental studies on infected children and rats showed that the use of RSV-IG can reduce lung viral load and provide protective neutralizing antibodies.