Article
Radiology, Nuclear Medicine & Medical Imaging
Wenji Xu, Xiangru Sun, Haoru Jiang, Xiaochun Wang, Bin Wang, Qiao Niu, Huaxing Meng, Jiangfeng Du, Guoqiang Yang, Bo Liu, Hui Zhang, Yan Tan
Summary: This study investigates the use of diffusion kurtosis imaging (DKI) to differentiate mild cognitive impairment (MCI) from normal controls (NC) in aluminum (Al)-exposed workers, and explores the association between DKI, cognitive performance, and plasma Al concentration. The results indicate that DKI can be a sensitive imaging biomarker for diagnosing MCI and assessing the severity of cognitive impairment. The right hippocampus shows the most significant correlation with cognitive performance. However, there is no correlation between DKI parameters and plasma Al levels.
ACADEMIC RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Yongjia Shao, Zijian Wang, Bin Ji, Hang Qi, Shangci Hao, Gang Li, Yue Zhang, Qian Xi
Summary: The olfactory ability of patients with mild cognitive impairment was found to be lower overall and positively correlated with cognitive assessment results. Fractional anisotropy changes significantly in regions such as the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe among MCI patients. Fibrous connections in certain brain regions, like the entorhinal cortex, were stronger in MCI patients, indicating a potential compensatory mechanism in the olfactory pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Ilaria Corbo, Giulia Marselli, Valerio Di Ciero, Maria Casagrande
Summary: Cognitive reserve (CR) is the ability to adapt and compensate for brain damage or disease. This systematic literature review examined the role of CR in preventing Mild Cognitive Impairment (MCI) and found that high CR is significantly associated with a reduced risk of MCI. The review also confirmed a positive relationship between CR and cognitive functioning in both MCI and healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Fangmei He, Yuchen Zhang, Xiaofeng Wu, Youjun Li, Jie Zhao, Peng Fang, Liming Fan, Chenxi Li, Tian Liu, Jue Wang
Summary: Using diffusion tensor imaging to analyze white matter microstructure changes in different trajectories of aMCI patients can predict the disease trajectory and enable early diagnosis.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Weihua Li, Zhilian Zhao, Min Liu, Shaozhen Yan, Yanhong An, Liyan Qiao, Guihong Wang, Zhigang Qi, Jie Lu
Summary: This study validates the improvement in classification performance by combining F-18-FDG PET and DTI, compared to using a single modality, for differentiating AD, aMCI, and HC.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Bahare Bigham, Seyed Amir Zamanpour, Hoda Zare
Summary: This study applied an automated method to classify patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and healthy control (HC) subjects using diffusion tensor imaging (DTI) features in the superficial white matter (SWM). Results showed that the linear kernel of support vector machines (SVM) had the highest accuracy in distinguishing AD and HC groups, followed by the quadratic kernel for MCI and HC groups, and the Gaussian kernel for AD and MCI groups. These features could be a useful tool for assisting in the diagnosis of AD and MCI.
Article
Neuroimaging
Ibrahim Shaikh, Christian Beaulieu, Myrlene Gee, Cheryl R. McCreary, Andrew E. Beaudin, Diana Valdes-Cabrera, Eric E. Smith, Richard Camicioli
Summary: Diffusion tensor imaging metrics of the fornix were compared between patients with cerebral amyloid angiopathy (CAA), Alzheimer's disease (AD), Mild Cognitive Impairment (MCI), and healthy controls. The study found significant diffusion changes in the fornix of CAA, AD, and MCI patients compared to controls, suggesting differences in the mechanisms of fornix diffusion abnormalities between CAA and AD/MCI.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qin
Summary: By mapping the region-specific nonlinear atrophic trajectory of the whole cerebrum from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), this study found that the atrophic trajectory is quadratic accelerated, especially in the superior temporal pole, caudate, and hippocampus. Furthermore, the study revealed that APOE ε4 carriers and younger patients had faster atrophic rates in specific regions. Lastly, the identified region-specific biomarkers were able to predict AD conversion within 10 years.
Article
Clinical Neurology
Shiloh L. Echevarria-Cooper, Emily H. Ho, Richard C. Gershon, Sandra Weintraub, Thorsten Kahnt
Summary: Olfactory decline is associated with aging, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia. The National Institutes of Health Toolbox Odor Identification Test (NIHTB-OIT) can distinguish between these clinical categories. The scores of NIHTB-OIT decrease with age and are lower for aMCI and ADd participants compared to NC participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Biological
Emma M. Tinney, Psyche Loui, Lauren B. Raine, Lucy V. Hiscox, Peyton L. Delgorio, Mary K. Kramer, Hillary Schwarb, Christopher R. Martens, Arthur F. Kramer, Charles H. Hillman, Curtis L. Johnson
Summary: Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. This study used diffusion-weighted images to examine white matter (WM) integrity in MCI patients compared to healthy older adults. The results showed compromised WM integrity in specific brain regions of MCI patients and significant associations between cognitive status, body mass index (BMI) and WM alterations. These findings suggest that early markers of neurodegenerative diseases and modifiable lifestyle factors may affect white matter integrity.
Article
Geriatrics & Gerontology
Maurizio Bergamino, Simona Schiavi, Alessandro Daducci, Ryan R. Walsh, Ashley M. Stokes
Summary: This study utilized advanced diffusion MRI technology to investigate white matter integrity and structural connectivity in healthy controls and individuals with mild cognitive impairment (MCI). The results showed lower intracellular compartment and higher isotropic values in the MCI group compared to the healthy control group. Significant correlations were also found between intracellular compartment values and Montreal Cognitive Assessment scores in the MCI group. Network analysis revealed differences in structural connectivity between the two groups, as well as significant differences in global network efficiency.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Loretta Norton, Karnig Kazazian, Teneille Gofton, Derek B. Debicki, Davinia Fernandez-Espejo, Jonathan E. Peelle, Eyad Al Thenayan, G. Bryan Young, Adrian M. Owen
Summary: This study aimed to investigate the efficacy of functional neuroimaging in assessing cognitive function in acute disorders of consciousness. The results showed that functional neuroimaging could detect preserved auditory function and language comprehension, and even reveal covert conscious awareness in patients. Furthermore, there was a positive relationship between fMRI responsivity and the level of functional recovery.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Neurosciences
Maria Cabello-Toscano, Lidia Vaque-Alcazar, Gabriele Cattaneo, Javier Solana-Sanchez, Ivet Bayes-Marin, Kilian Abellaneda-Perez, Didac Macia-Bros, Lidia Mulet-Pons, Cristina Portellano-Ortiz, Miquel Angel Fullana, Laura Oleaga, Sofia Gonzalez, Nuria Bargallo, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study investigates the resilience to the mental health impact of the COVID-19 pandemic and identifies the demographic, psychological, and neurobiological factors associated with interindividual differences. The findings suggest that age, sex, coping strategies, and brain network status are all related to mental health. Therefore, preventive strategies should consider these factors to promote mental health during similar adverse events.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Elena Iurina, Eva Bailles, Mar Carreno, Antonio Donaire, Jordi Rumia, Teresa Boget, Nuria Bargallo, Xavier Setoain, Pedro Roldan, Estefania Conde-Blanco, Maria Centeno, Luis Pintor
Summary: The study aims to investigate the influence of personality profile in drug-resistant epilepsy patients on quality of life after surgical treatment. The results showed significant improvement in quality of life in the surgical group, which was not associated with baseline or postoperative seizure frequency at one year. The personality profile at baseline was found to be related to postoperative quality of life.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Gonzalo Forno, Jose Contador, Agnes Perez-Millan, Nuria Guillen, Neus Falgas, Jordi Sarto, Adria Tort-Merino, Magdalena Castellvi, Beatriz Bosch, Guadalupe Fernandez-Villullas, Mircea Balasa, Anna Antonell, Roser Sala-Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Llado
Summary: This study assessed how the APOE genotype differentially affects cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease patients. The results showed that the APOE genotype has a significant effect on grey matter volume, with LOAD APOE4 genotype mostly associated with cortical and temporal atrophy, while EOAD APOE4 genotype might have a more specific effect on subcortical structures (mammillary body). Therefore, the APOE genotype needs to be taken into account when classifying patients by age at onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Anna Campabadal, Javier Oltra, Carme Junque, Nuria Guillen, Maria Angeles Boti, Roser Sala-Llonch, Gemma C. Monte-Rubio, Gema Lledo, Nuria Bargallo, Lorena Rami, Raquel Sanchez-Valle, Barbara Segura
Summary: This study investigates structural brain changes in patients with persistent olfactory dysfunctions after COVID-19. It found differences in gray matter volume and diffusion in the olfactory system among COVID-19 patients, which can explain the prolonged olfactory deficits in these patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Isabelle Budin-Ljosne, Barbara B. Friedman, William F. C. Baare, David Bartres-Faz, Rebecca B. Carver, Christian A. Drevon, Klaus P. Ebmeier, Anders M. Fjell, Paolo Ghisletta, Richard N. Henson, Rogier Kievit, Kathrine S. Madsen, Laura Nawijn, Sana Suri, Cristina Sole-Padulles, Kristine B. Walhovd, Eniko Zsoldos
Summary: The involvement of stakeholders in the "Lifebrain" project was seen as meaningful and relevant, benefiting both researchers and stakeholders. However, there were barriers such as lack of time, difficulties in identifying relevant stakeholders, and challenges in communicating scientific issues. Stakeholder engagement in basic brain research requires dedicated resources, clear communication, and defined roles and responsibilities.
HEALTH EXPECTATIONS
(2023)
Article
Neurosciences
Sara Calzolari, Roya Jalali, Davinia Fernandez-Espejo
Summary: This study explored the effects of tDCS on the motor network in the brain and found that it has widespread effects on connectivity, extending beyond the targeted area and modulating connectivity between cortex, thalamus, and cerebellum. The changes have unique nonlinear temporal patterns. This research provides insights into the network-level effects of tDCS and may guide future optimization of its cognitive and clinical applications.
Article
Critical Care Medicine
Brian L. Edlow, Varina L. Boerwinkle, Jitka Annen, Melanie Boly, Olivia Gosseries, Steven Laureys, Pratik Mukherjee, Louis Puybasset, Robert D. Stevens, Zachary D. Threlkeld, Virginia F. J. Newcombe, Davinia Fernandez-Espejo, Curing Coma Campaign
Summary: Advances in neuroimaging have provided insights into the mechanisms causing disorders of consciousness in patients with severe brain injuries. Neuroimaging techniques have improved diagnosis and prognosis, leading to endorsement of fMRI for clinical evaluation. However, standardized reporting is needed for research and collaboration.
NEUROCRITICAL CARE
(2023)
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Multidisciplinary Sciences
E. Monteagudo-Gimeno, R. Sanchez-Gonzalez, J. Radua-Castano, L. Fortea-Gonzalez, T. Boget-Llucia, M. Carreno-Martinez, A. Donaire-Pedraza, N. Bargallo-Alabart, X. Setoain-Perego, J. Rumia-Arboix, A. Bulbena-Vilarrasaa, L. Pintor-Perez
Article
Psychiatry
I. Bayes-Marin, M. Cabello-Toscano, G. Cattaneo, J. Solana-Sanchez, D. Fernandez, C. Portellano-Ortiz, J. M. Tormos, A. Pascual-Leone, D. Bartres-Faz
Summary: The study aimed to identify trajectories of mental health during a two-year follow-up of the COVID-19 pandemic and investigate the associations between these trajectories and various factors. They found that most participants belonged to the "resilient" trajectory, while a smaller proportion belonged to the "chronic-worsening" trajectory. Protective factors and risk factors played different roles in different mental health outcomes.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
