Review
Oncology
Ksenia S. Maslyonkina, Alexandra K. Konyukova, Darya Y. Alexeeva, Mikhail Y. Sinelnikov, Liudmila M. Mikhaleva
Summary: Barrett's esophagus is a chronic and widespread disease that can progress to neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis. Research suggests that molecular, genetic, and epigenetic alterations in the esophagus occur earlier than cancerous transformation, providing insight into potential preventative strategies.
Article
Oncology
Carlijn A. M. Roumans, Pauline A. Zellenrath, Ewout W. Steyerberg, Iris Lansdorp-Vogelaar, Michael Doukas, Katharina Biermann, Joyce Alderliesten, Gert van Ingen, Wouter B. Nagengast, Arend Karrenbeld, Frank ter Borg, Mariska Hage, Pieter C. J. ter Borg, Michael A. den Bakker, Alaa Alkhalaf, Frank C. P. Moll, Lieke Brouwer-Hol, Joop van Baarlen, Rutger Quispel, Arjan van Tilburg, Jordy P. W. Burger, Antonie J. P. van Tilburg, Ariadne H. A. G. Ooms, Thjon J. Tang, Marielle J. L. Romberg-Camps, Danny Goudkade, Marco J. Bruno, Dimitris Rizopoulos, Manon C. W. Spaander
Summary: Barrett's esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC). The cost-effectiveness of current surveillance strategies for BE is debatable. This multicenter prospective cohort study aimed to evaluate sex differences in 868 BE patients. The results showed that males had higher risk and shorter time to neoplastic progression, while females were more likely to be diagnosed with (advanced) EAC. These findings can guide the development of sex-specific guidelines and improve neoplastic risk stratification in BE surveillance.
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Gyanprakash A. Ketwaroo, Xianglin L. Du, Luis Leon Novelo, Rollin George, Daniel G. Rosen, Hashem B. El-Serag
Summary: This external validation study provides further evidence that the model including sex, LGD status, smoking status, and BE length may help to risk stratify BE patients. A simplified version excluding LGD status and/or reducing the number of risk groups has increased utility in clinical practice without loss of discriminatory ability.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mark Redston, Amy Noffsinger, Anthony Kim, Fahire G. Akarca, Marianne Rara, Diane Stapleton, Laurel Nowden, Richard Lash, Adam J. Bass, Matthew D. Stachler
Summary: This study developed a reliable criteria for grading abnormal p53 immunohistochemical expression and tested its utility as a biomarker for progression in Barrett's esophagus (BE). The findings showed that abnormal p53 expression was strongly associated with neoplastic progression in BE, regardless of histologic diagnosis and could predict progression among nondysplastic BE, indefinite for dysplasia, and low-grade dysplasia.
Article
Gastroenterology & Hepatology
Prashanthi N. Thota, Jalil Nasibli, Prabhat Kumar, Madhusudhan R. Sanaka, Amitabh Chak, Xuefeng Zhang, Xiuli Liu, Shikhar Uttam, Yang Liu
Summary: Nanoscale nuclear architecture mapping (nanoNAM) is a method for detecting structural alterations in the chromatin of epithelial cell nuclei. This study demonstrates that nanoNAM can be used to identify patients with Barrett's esophagus (BE) at risk for developing high-grade dysplasia or esophageal adenocarcinoma (EAC), and a prediction model based on nanoNAM features was developed.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Vidhi Patel, Madhusudhan R. Sanaka, Yi Qin, John McMichael, James Bena, Claire Beveridge, John Barron, Siva Raja, Jamak Modaresi Esfeh, Prashanthi N. Thota
Summary: This retrospective cohort study demonstrates that immunosuppressant use is associated with neoplastic progression in Barrett's esophagus (BE) patients, while solid organ transplantation (SOT) is not. Therefore, close surveillance of BE patients on chronic immunosuppressants needs to be considered.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Medicine, General & Internal
Francesco Maione, Alessia Chini, Rosa Maione, Michele Manigrasso, Alessandra Marello, Gianluca Cassese, Nicola Gennarelli, Marco Milone, Giovanni Domenico De Palma
Summary: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease and has a higher risk of developing esophageal adenocarcinoma. Low and high-grade dysplasia precede neoplastic transformation in this condition. The evaluation of low-grade dysplastic esophageal mucosa is still controversial, but endoscopic surveillance and minimally invasive endoscopic treatments such as endoscopic mucosal resection and radiofrequency ablation are available options. Cryotherapy ablation and argon plasma coagulation are novel endoscopic treatments with high eradication rates and fewer complications and post-procedural pain.
Article
Multidisciplinary Sciences
Thomas G. Paulson, Patricia C. Galipeau, Kenji M. Oman, Carissa A. Sanchez, Mary K. Kuhner, Lucian P. Smith, Kevin Hadi, Minita Shah, Kanika Arora, Jennifer Shelton, Molly Johnson, Andre Corvelo, Carlo C. Maley, Xiaotong Yao, Rashesh Sanghvi, Elisa Venturini, Anne-Katrin Emde, Benjamin Hubert, Marcin Imielinski, Nicolas Robine, Brian J. Reid, Xiaohong Li
Summary: Using whole genome sequencing, this study compared genomic alterations in patients with stable Barrett's esophagus and those who progressed to esophageal adenocarcinoma. The findings reveal common somatic genome dynamics in Barrett's esophagus regardless of outcome, but also define specific genomic features associated with progression to cancer.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Dennis Yang, William King, Hiroyuki Aihara, Michael S. Karasik, Saowanee Ngamruengphong, Abdul Aziz Aadam, Mohamed O. Othman, Neil Sharma, Ian S. Grimm, Alaa Rostom, B. Joseph Elmunzer, Salmaan A. Jawaid, Yaseen B. Perbtani, Brenda J. Hoffman, Ashwin S. Akki, Alexander Schlachterman, Roxana M. Coman, Andrew Y. Wang, Peter V. Draganov
Summary: This study found that ESD can change the diagnosis in patients with BE visible neoplasia, particularly in those with suspected invasive disease. Lesions in the distal esophagus and gastroesophageal junction, as well as prior radiofrequency ablation, were predictors of change in histologic diagnosis.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mate Knabe, Torsten Beyna, Thomas Roesch, Jacques Bergman, Hendrik Manner, Andrea May, Guido Schachschal, Horst Neuhaus, Jennis Kandler, Bas Weusten, Oliver Pech, Siegbert Faiss, Mario Anders, Michael Vieth, Susanne Sehner, Raf Bisschops, Pradeep Bhandari, Christian Ell, Hanno Ehlken
Summary: This study evaluated a potential alternative treatment for neoplastic Barrett's esophagus, called hybrid argon plasma ablation. The results showed that this technique achieved the expected eradication and recurrence rates of Barrett's intestinal metaplasia and neoplasia within 2 years. However, a randomized comparative trial is needed to provide final evidence compared to radiofrequency ablation.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Chanakyaram A. Reddy, Anna Tavakkoli, Vincent L. Chen, Sheryl Korsnes, Aarti Oza Bedi, Philip W. Carrott, Andrew C. Chang, Kiran H. Lagisetty, Richard S. Kwon, B. Joseph Elmunzer, Mark B. Orringer, Cyrus Piraka, Anoop Prabhul, Rishindra M. Reddy, Erik Wamsteker, Joel H. Rubenstein
Summary: This study compared long-term quality of life between patients undergoing endoscopic therapy and esophagectomy for Barrett's esophagus with high-grade dysplasia or T1a esophageal adenocarcinoma. While patients who underwent endoscopic therapy had worse physical and role functioning, they had significantly lower odds of experiencing symptoms such as diarrhea, trouble eating, choking, coughing, and speech difficulty compared to esophagectomy patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Noam Peleg, Hemda Schmilovitz-Weiss, Steven Shamah, Ariel Schwartz, Iris Dotan, Boris Sapoznikov
Summary: NLR can serve as a predictor for histologic progression in patients with BE, with a high discriminatory capacity for progression to HGD and EAC, especially effective in patients with NDBE.
Article
Gastroenterology & Hepatology
Linda S. Yang, Bronte A. Holt, Richard Williams, Richard Norris, Edward Tsoi, Georgina Cameron, Paul Desmond, Andrew C. F. Taylor
Summary: This study retrospectively analyzed patients with dysplastic Barrett's esophagus and found that buried Barrett's mucosa was identified in 7% of cases, even in treatment-naive patients. The proposed endoscopic features showed a diagnostic accuracy of 79% in patients with histologically confirmed disease. These features may predict the presence of buried Barrett's mucosa, which could contain dysplasia or neoplasia.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Esther Klaver, Angela Bureo Gonzalez, Nahid Mostafavi, Rosalie Mallant-Hent, Lucas C. Duits, Bert Baak, Clarisse J. M. Bohmer, Arnoud H. A. M. van Oijen, Ton Naber, Pieter Scholten, Sybren L. Meijer, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: This study utilized a large, prospective community-based Barrett's cohort and found that Barrett's length, low-grade dysplasia, and age were important risk factors for progression to HGD/EAC.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Nutrition & Dietetics
Andrew T. Kunzmann, Helen G. Coleman, Wen-Yi Huang, Cari M. Kitahara, Marie M. Cantwell, Sonja I. Berndt
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2015)
Article
Oncology
Helen G. Coleman, Reid M. Ness, Walter E. Smalley, Wei Zheng, Martha J. Shrubsole
CANCER CAUSES & CONTROL
(2015)
Review
Oncology
Caoimhe M. Bennett, Helen G. Coleman, Philip G. Veal, Marie M. Cantwell, Charlotte C. L. Lau, Liam J. Murray
CANCER EPIDEMIOLOGY
(2015)
Article
Oncology
Helen G. Coleman, Maurice B. Loughrey, Liam J. Murray, Brian T. Johnston, Anna T. Gavin, Martha J. Shrubsole, Shivaram K. Bhat, Patrick B. Allen, Vivienne McConnell, Marie M. Cantwell
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2015)
Article
Gastroenterology & Hepatology
R. T. Gray, H. G. Coleman, K. W. Lau, C. McCaughey, P. V. Coyle, L. J. Murray, B. T. Johnston
DISEASES OF THE ESOPHAGUS
(2017)
Article
Medicine, Research & Experimental
Yinhai Wang, Damian T. McManus, Kenneth Arthur, Brian T. Johnston, Andrew J. Kennedy, Helen G. Coleman, Liam J. Murray, Peter W. Hamilton
LABORATORY INVESTIGATION
(2015)
Article
Pathology
Maurice B. Loughrey, Paul J. Kelly, Oisin P. Houghton, Helen G. Coleman, Joseph P. Houghton, Anne Carson, Manuel Salto-Tellez, Peter W. Hamilton
Article
Public, Environmental & Occupational Health
Helen G. Coleman, Cari M. Kitahara, Liam J. Murray, Kevin W. Dodd, Amanda Black, Rachael Z. Stolzenberg-Solomon, Marie M. Cantwell
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2014)
Article
Dermatology
C. McCourt, H. G. Coleman, L. J. Murray, M. M. Cantwell, O. Dolan, D. G. Powe, C. R. Cardwell
BRITISH JOURNAL OF DERMATOLOGY
(2014)
Article
Oncology
Chris R. Cardwell, Evelyn M. Flahavan, Carmel M. Hughes, Helen G. Coleman, Joe M. O'Sullivan, Des G. Powe, Liam J. Murray
CANCER CAUSES & CONTROL
(2014)
Article
Oncology
Chris R. Cardwell, Helen G. Coleman, Liam J. Murray, Joe M. O'Sullivan, Des G. Powe
CANCER EPIDEMIOLOGY
(2014)
Article
Gastroenterology & Hepatology
Shivaram K. Bhat, Damian T. McManus, Helen G. Coleman, Brian T. Johnston, Christopher R. Cardwell, Una McMenamin, Finian Bannon, Blanaid Hicks, Grace Kennedy, Anna T. Gavin, Liam J. Murray
Article
Public, Environmental & Occupational Health
Chris R. Cardwell, Helen G. Coleman, Liam J. Murray, Frank Entschladen, Des G. Powe
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2013)
Review
Oncology
Ashleigh C. Hamilton, David W. Donnelly, Deirdre Fitzpatrick, Helen G. Coleman
Summary: The incidence of specific types of early-onset cancers in adults aged 18-49 years is increasing in high-income countries. This review summarizes the epidemiology of early-onset cancers using exemplar data from a high-income UK region, discusses the supportive care needs for young patients, and outlines future research directions.