Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Manisha Bajpai, Anshuman Panda, Kristen Birudaraju, James Van Gurp, Amitabh Chak, Kiron M. Das, Parisa Javidian, Hana Aviv
Summary: Barrett's esophagus (BE) is a premalignant metaplasia in patients with chronic gastroesophageal reflux disease (GERD), which can progress to esophageal adenocarcinoma (EA). A novel chromosomal translocation t(10:16) was discovered, and a FISH-EA assay was designed to detect these chromosomal events.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Kiran H. Lagisetty, Dyke P. McEwen, Derek J. Nancarrow, Johnathon G. Schiebel, Daysha Ferrer-Torres, Dipankar Ray, Timothy L. Frankel, Jules Lin, Andrew C. Chang, Laura A. Kresty, David G. Beer
Summary: The study identified immune microenvironment changes during Barrett's esophagus progression to esophageal adenocarcinoma, characterized by increased chemokines and cytokines expression and alterations in immune cell populations. Esophageal adenocarcinoma microenvironment was found to have poor cytotoxic effector cell infiltration and increased immune inhibitory signaling, suggesting a potential immunosuppressive environment requiring further exploration for immune modulatory therapy.
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Melissa Barroux, Julia Horstmann, Lisa Fricke, Linus Schoemig, Martin Werner, Ekaterina Kraynova, Katerina Kamaradova, Jean-Francois Flejou, Bruno Maerkel, M. Priyanthi Kumarasinghe, Michael Vieth, Maria Westerhoff, Deepa T. Patil, Katja Steiger, Karl-Friedrich Becker, Wilko Weichert, Roland M. Schmid, Michael Quante, Julia Slotta-Huspenina
Summary: The dysplasia grading of Barrett's esophagus (BE) is not reliable in predicting cancer risk due to high interobserver variability. This study evaluated the suitability of PAXgene-fixed paraffin-embedded (PFPE) biopsies for histomorphological BE diagnosis. PFPE showed better preservation of nuclear details compared to FFPE, and had equal overall quality and histomorphological parameters. The interobserver reproducibility of diagnosis was higher for non-dysplastic BE and esophageal adenocarcinomas, but poor for low-grade and high-grade dysplasia.
Article
Multidisciplinary Sciences
Chengjiao Yao, Yilin Li, Lihong Luo, Qin Xiong, Xiaowu Zhong, Fengjiao Xie, Peimin Feng
Summary: The study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between EAC and BE tissue samples, performed pathway and functional enrichment analysis, and identified enriched functions and pathways. Some hub genes, such as GART and TNFSF11, as well as highly connected miRNAs like hsa-miR-143 and hsa-miR-133b were determined. This research provides insights into the development mechanism of BE and EAC.
Article
Medicine, General & Internal
Boram Choi, Yoojin Na, Min Yeop Whang, Jung Yoon Ho, Mi-Ryung Han, Seong-Woo Park, Heekyoung Song, Soo Young Hur, Youn Jin Choi
Summary: In this study, the association between MGMT methylation and persistent HPV infection was examined using cervical cytology samples and a public database. The results showed that MGMT methylation was associated with HPV infection and downregulated MGMT mRNA expression correlated with poor overall survival. MGMT methylation level could potentially serve as a prognostic indicator for the transition from atypical squamous cells/low-grade squamous intraepithelial lesion to cervical cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Yue Chen, Chenyu Sun, Yile Wu, Xin Chen, Sujatha Kailas, Zeid Karadsheh, Guangyuan Li, Zhichun Guo, Hongru Yang, Lei Hu, Qin Zhou
Summary: The use of PPI is negatively associated with the risk of progression to HGD/EAC in BE patients, and the risk of HGD/EAC can be reduced with the prolonged use of PPI. Sensitivity analysis showed the stable results of this meta-analysis, and no publication bias was detected.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Katja Lidschreiber, Lisa A. Jung, Henrik von der Emde, Kashyap Dave, Jussi Taipale, Patrick Cramer, Michael Lidschreiber
Summary: The study identified thousands of transcriptionally active enhancers in human cancer cells using transient transcriptome sequencing (TT-seq), which were associated with cell type-specific gene expression and enriched for genetic variants predisposing to cancer. Enhancer-promoter pairing analysis revealed around 40,000 putative E-P pairs enriched for transcription factors and cancer-associated genes. The cell type specificity and transcription activity of target genes increased with the number of paired putative enhancers, providing a rich resource for future gene regulation studies.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Oncology
Yuhan Hao, Ulas Karaoz, Liying Yang, Patrick S. Yachimski, Wenzhi Tseng, Carlos W. Nossa, Weimin Ye, Mengkao Tseng, Michael Poles, Fritz Francois, Morris Traube, Stuart M. Brown, Yu Chen, Manolito Torralba, Richard M. Peek, Eoin L. Brodie, Zhiheng Pei
Summary: The incidence of esophageal adenocarcinoma (EA) in the United States has increased significantly since the 1970s, and the reasons for this are still unclear. This study suggests that the widespread use of antibiotics may have increased the procarcinogenic potential of the orodigestive microbiota, leading to the development of gastroesophageal reflux (GR), Barrett's esophagus (BE), and EA. By analyzing the microbiota in the mouth, esophagus, stomach, and rectum, the researchers discovered significant differences in the abundance of microbial taxa between normal controls (NC) and the three disease phenotypes. They also found that the oral and esophageal microbiota became more diverse along the sequence of GR -> BE -> EA, with certain genera progressively depleted or enriched. In addition, gene functional content analysis revealed an enrichment of genes related to antibiotic resistance, immune response, nitrate-nitrite-nitric oxide pathway, and acetaldehyde metabolism throughout the stages of EA development. These findings suggest that the orodigestive microbiota undergoes dysbiosis and microbial gene changes during the development of EA, and further research is needed to understand their roles in EA pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Vittoria Guarda, Lea Schroeder, Michael Pawlita, Kristian Ikenberg, Niels J. Rupp, Wolfram Jochum, Sandro J. Stoeckli, Dana Holzinger, Martina A. Broglie
Summary: This study found that HPV infection can be detected in normal oropharyngeal tissue, but without transcriptional activity. This suggests that a multifocal virus-induced cancerization may not be associated with HPV-related OPSCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Editorial Material
Surgery
Sam Alhayo, Rafael Gaszynski, Neil Merrett
ANZ JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
James C. Glasbey, Tom E. F. Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P. Arnaud, Brittany Bankhead-Kendall, M. K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas-Chavarri, Miguel F. Cunha, Justine I. Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J. Edward Fitzgerald, Maria Fourtounas, Alex James Fowler, Kay Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R. Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter Hutchinson, Gabriella Hyman, Arda Isik, Umesh Jayarajah, Haytham M. A. Kaafarani, Bryar Kadir, Ismail Lawani, Hans Lederhuber, Elizabeth Li, Markus W. Loffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D. McClain, Kenneth A. McLean, John G. Meara, Antonio Ramos-De La Medina, Mengistu Mengesha, Ana Minaya, Maria Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabrielle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana Filipa Ferreira Simoes, Neil Smart, Richard Sulliva, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H. Taylor, Mary L. Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu
Summary: This study developed and validated a novel index (SPI) to support the strengthening of local elective surgical systems and address growing backlogs. The findings showed that hospitals with a higher SPI were associated with an increased planned surgical volume ratio, independent of income status, COVID-19 burden, and hospital type. Annual self-assessment of surgical preparedness is recommended to identify areas for improvement and enhance the resilience of local surgical systems.
Editorial Material
Surgery
Diane E. Watson, Payal Mukherjee, Jean-Frederic Levesque, Joe Portelli, Arthur Richardson, Mohamed Khadra, Neil Merrett
ANZ JOURNAL OF SURGERY
(2022)
Article
Oncology
Sander Ubels, Eric Matthee, Moniek Verstegen, Bastiaan Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Jan Willem T. Dekker, Marc J. van Det, Stijn van Esser, Ewen A. Griffiths, Jan Willem Haveman, Grard Nieuwenhuijzen, Peter D. Siersema, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman, Joos Heisterkamp, Fatih Polat, Jeroen Schouten, Pritam Singh
Summary: This study aimed to assess the differences in failure to rescue (FTR) after anastomotic leak (AL) between different centers. The results showed that high-volume centers had lower FTR, which could be explained by lower leak severity, lower secondary ICU readmission rate, and higher availability of therapeutic modalities.
Article
Surgery
D. Frankcombe, N. Gauri, V Satchithanandha, Y. Liang, S. Bak, T. Suri, D. Loxley, N. Merrett, D. Kaushal
Summary: This study found that during the COVID-19 pandemic, patients with acute appendicitis in South Western Sydney Local Health District were more likely to undergo CT scans, have complicated appendicitis, and require caecectomy.
Article
Gastroenterology & Hepatology
Henry E. Badgery, Tjuntu Muhlen-Schulte, John R. Zalcberg, Bianka D'souza, Jan F. Gerstenmaier, Craig Pickett, Jaswinder Samra, Daniel Croagh
Summary: In this multicentre observational study, a high degree of interobserver variability was found among clinicians and radiologists in assessing resectability of pancreatic cancer, with higher agreement among radiologists. This highlights the importance of central review and quality control initiatives to ensure consistent clinical decision making for patients with PDAC.
Article
Oncology
Jessica L. Chitty, Michelle Yam, Lara Perryman, Amelia L. Parker, Joanna N. Skhinas, Yordanos F. I. Setargew, Ellie T. Y. Mok, Emmi Tran, Rhiannon D. Grant, Sharissa L. Latham, Brooke A. Pereira, Shona C. Ritchie, Kendelle J. Murphy, Michael Trpceski, Alison D. Findlay, Pauline Melenec, Elysse C. Filipe, Audrey Nadalini, Sipiththa Velayuthar, Gretel Major, Kaitlin Wyllie, Michael Papanicolaou, Shivanjali Ratnaseelan, Phoebe A. Phillips, George Sharbeen, Janet Youkhana, Alice Russo, Antonia Blackwell, Jordan F. Hastings, Morghan C. Lucas, Cecilia R. Chambers, Daniel A. Reed, Janett Stoehr, Claire Vennin, Ruth Pidsley, Anaiis Zaratzian, Andrew M. Da Silva, Michael Tayao, Brett Charlton, David Herrmann, Max Nobis, Susan J. Clark, Andrew V. Biankin, Amber L. Johns, David R. Croucher, Adnan Nagrial, Anthony J. Gill, Sean M. Grimmond, Marina Pajic, Paul Timpson, Wolfgang Jarolimek, Thomas R. Cox
Summary: By inhibiting the activity of pan-lysyl oxidase, PXS-5505 can reduce fibrosis and stiffness in pancreatic tumors, decrease cancer cell invasion and metastasis, and enhance the efficacy of chemotherapy.
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Neesa Fadaee, Rafael Gaszynski, Neil Merrett, Andrew Gray
Summary: Background: Laparoscopic fundoplication (LF) is a well-established surgical intervention for gastro-esophageal reflux disease. This review aimed to examine patient-reported outcomes of LF in non-metropolitan centers. Results: Seven observational cohort studies showed favorable patient-reported outcomes for LF in community settings, with high patient satisfaction and low post-operative prevalence of reflux and dysphagia. Further research is needed to ensure the safety of LF in non-metropolitan hospitals. Conclusion: LF in community hospitals yields positive patient-reported outcomes comparable to those in tertiary-level centers.
Article
Oncology
Thi N. T. Huynh, Gunter Hartel, Monika Janda, David Wyld, Neil Merrett, Helen Gooden, Rachel E. Neale, Vanessa L. Beesley
Summary: This study is the first to quantitatively assess the supportive care needs of pancreatic cancer patients' carers and their associations with psychological outcomes, finding that carers have exceptionally high levels of unmet needs, particularly in healthcare and information domains, which are strongly associated with anxiety and depression among both carers and patients. The results suggest the importance of implementing optimal care guidelines to address these needs.
Article
Oncology
Jessica L. Chitty, Michelle Yam, Lara Perryman, Amelia L. Parker, Joanna N. Skhinas, Yordanos F. I. Setargew, Ellie T. Y. Mok, Emmi Tran, Rhiannon D. Grant, Sharissa L. Latham, Brooke A. Pereira, Shona C. Ritchie, Kendelle J. Murphy, Michael Trpceski, Alison D. Findlay, Pauline Melenec, Elysse C. Filipe, Audrey Nadalini, Sipiththa Velayuthar, Gretel Major, Kaitlin Wyllie, Michael Papanicolaou, Shivanjali Ratnaseelan, Phoebe A. Phillips, George Sharbeen, Janet Youkhana, Alice Russo, Antonia Blackwell, Jordan F. Hastings, Morghan C. Lucas, Cecilia R. Chambers, Daniel A. Reed, Janett Stoehr, Claire Vennin, Ruth Pidsley, Anaiis Zaratzian, Andrew M. Da Silva, Michael Tayao, Brett Charlton, David Herrmann, Max Nobis, Susan J. Clark, Andrew V. Biankin, Amber L. Johns, David R. Croucher, Adnan Nagrial, Anthony J. Gill, Sean M. Grimmond, Amber L. Johns, Anthony J. Gill, Lorraine A. Chantrill, Paul Timpson, Angela Chou, Marina Pajic, Tanya Dwarte, David Herrmann, Claire Vennin, Thomas R. Cox, Brooke A. Pereira, Shona C. Ritchie, Daniel A. Reed, Cecilia R. Chambers, Xanthe L. Metcalf, Max Nobis, Gloria Jeong, Lara Kenyon, Nicola Waddell, John V. Pearson, Ann-Marie Patch, Katia Nones, Felicity Newell, Pamela Mukhopadhyay, Venkateswar Addala, Stephen Kazakoff, Oliver Holmes, Conrad Leonard, Scott Wood, Sean M. Grimmond, Oliver Hofmann, Jaswinder S. Samra, Nick Pavlakis, Jennifer Arena, Hilda A. High, Ray Asghari, Neil D. Merrett, Amitabha Das, Peter H. Cosman, Kasim Ismail, Alina Stoita, David Williams, Allan Spigellman, Duncan Mcleo, Judy Kirk, James G. Kench, Peter Grimison, Charbel Sandroussi, Annabel Goodwin, R. Scott Mead, Katherine Tucker, Lesley Andrews, Michael Texler, Cindy Forrest, Mo Ballal, David Fletcher, Maria Beilin, Kynan Feeney, Krishna Epari, Sanjay Mukhedkar, Nikolajs Zeps, Nan Q. Nguyen, Andrew R. Ruszkiewicz, Chris Worthley, John Chen, Mark E. Brooke-Smith, Virginia Papangelis, Andrew D. Clouston, Andrew P. Barbour, Thomas J. O'Rourke, Jonathan W. Fawcett, Kellee Slater, Michael Hatzifotis, Peter Hodgkinson, Mehrdad Nikfarjam, James R. Eshleman, Ralph H. Hruban, Christopher L. Wolfgang, Aldo Scarpa, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Andrew V. Biankin, Nigel B. Jamieson, David K. Chang, Stephan B. Dreyer, Paul Timpson, Thomas R. Cox, Marina Pajic, Anthony J. Gill, Jaswinder S. Samra, Brooke A. Pereira, David Herrmann, Amber L. Johns, Gloria Jeong, Shona C. Ritchie, Daniel A. Reed, Cecilia R. Chambers, Janett Stoehr, Morghan C. Lucas, Joanna N. Skhinas, Lea Abdulkhalek, Max Nobis, Tatjana Schmitz, Victoria Lee, Xanthe L. Metcalf, Sean M. Grimmond, Kym Pham Stewart, Mehreen Arshi, Angela M. Steinmann, Lara Kenyon, Marina Pajic, Paul Timpson, Wolfgang Jarolimek, Thomas R. Cox
Summary: The pan-lysyl oxidase inhibitor PXS-5505 reduces chemotherapy-induced desmoplasia and stiffness, improving chemotherapy response and survival in pancreatic cancer models.
Letter
Surgery
Aldenb Lorenzo, David Goltsman, Xin L. Wong, Kevin Jia, Neil Merrett
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Rafael Gaszynski, Pearl Wong, Andrew Gray, Jason Diab, Amitabha Das, Christos Apostolou, Neil Merrett
Summary: Advancements in operative techniques to prevent surgical site infections are important for improving patient outcomes. This study compared the effectiveness of the 'loop and drain technique' in patients undergoing upper gastrointestinal surgery and found that it significantly reduced the rate of surgical site infections compared to traditional methods. The LDT method may offer a cost-effective approach to improving patient outcomes after upper gastrointestinal surgery.
ANZ JOURNAL OF SURGERY
(2022)
Article
Surgery
Sander Ubels, Moniek Verstegen, Bastiaan Klarenbeek, Stefan Bouwense, Mark van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan W. Haveman, Joos Heisterkamp, Renol Koshy, Grard Nieuwenhuijzen, Fatih Polat, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: The Severity of oEsophageal Anastomotic Leak (SEAL) score was developed using data from the TENTACLE-Esophagus study, an international, multicentre retrospective cohort study including 1509 patients with anastomotic leak after oesophagectomy. The SEAL score was developed to determine anastomotic leak severity at diagnosis, and combines 12 leak-related parameters at diagnosis. The score may be useful in clinical practice and could improve future research.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Aldenb Lorenzo, David Goltsman, Christos Apostolou, Amitabha Das, Neil Merrett
Summary: This study aims to investigate the impact of diabetes on postoperative complications after oesophagectomy. The results showed that diabetic patients had higher rates of medical and surgical complications, wound complications, and anastomotic leaks compared to non-diabetic patients. Subgroup analysis of hybrid procedures revealed a significant increase in the risk of surgical complications, medical complications, and anastomotic leaks in insulin-dependent diabetic patients compared to non-insulin-dependent diabetic patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)