Narrow Band Imaging for Detection of Dysplasia in Colitis: A Randomized Controlled Trial

OBJECTIVES: In ulcerative colitis surveillance, chromoendoscopy improves dysplasia detection 3-5-fold compared with white light endoscopy (WLE). The aim of this study was to investigate whether narrow band imaging (NBI) can improve dysplasia detection compared with WLE. METHODS: This was a randomized, parallel-group trial. A total of 220 patients were needed to be recruited to detect a threefold increase in dysplasia detection. In all, 112 patients with long-standing ulcerative colitis were randomized to colonoscopic extubation with NBI (56) or WLE (56) (1:1 ratio) at two tertiary endoscopy units in the United Kingdom. Targeted biopsies of suspicious areas and quadrantic random biopsies every 10 cm were taken in both groups. The primary outcome measure was the proportion of patients with at least one area of dysplasia detected. In a prespecified mid-point analysis, the criteria for trial discontinuation were met and the trial was stopped and analyzed at this point. RESULTS: There was no difference in the primary outcome between the two groups, with 5 patients having at least one dysplastic lesion in each group (odds ratio (OR) 1.00, 95% confidence interval (95% CI) 0.27-3.67, P = 1.00). This remained unchanged when adjusted for other variables (OR 0.69, 95% CI 0.16-2.96, P = 0.62). Overall, dysplasia detection was 9% in each arm. Yield of dysplasia from random nontargeted biopsies was 1/2,707 (0.04%). CONCLUSIONS: Overall, in this multicenter parallel-group trial, there was no difference in dysplasia detection when using NBI compared with high-definition WLE colonoscopy. Random background biopsies were ineffective in detecting dysplasia.