Article
Gastroenterology & Hepatology
Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai
Summary: This study aimed to evaluate the efficacy and safety of vedolizumab treatment with or without concurrent immunomodulator use in Japanese patients with moderate-to-severe ulcerative colitis. The results suggested that concurrent immunomodulator use may benefit in maintaining the clinical efficacy of vedolizumab without significantly increasing the incidence of infections.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Carlos Taxonera, Maria Jesus Fernandez-Acenero, David Olivares, Marta Calvo, Begona Casis, Fernando Bermejo, Pilar Lopez Serrano, Marisa Iborra, Francisco Mesonero, Maia Bosca Watts, Cristina Diaz del Arco, Isabel Vera, Sonsoles Olivares, Alicia Algaba, Cristina Alba
Summary: This study investigated the association between golimumab trough concentrations during maintenance and outcomes such as endoscopic healing, histologic remission, and long-term persistence in UC patients. The results showed that golimumab concentrations were associated with favorable treatment outcomes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Christopher Ma, Jenny Jeyarajah, Leonardo Guizzetti, Claire E. Parker, Siddharth Singh, Parambir S. Dulai, Geert R. D'Haens, William J. Sandborn, Brian G. Feagan, Vipul Jairath
Summary: This study developed and validated a clinical decision support tool to discriminate patients with mild-to-moderate UC treated with mesalamine who have achieved endoscopic improvement. The tool showed good discriminative performance in identifying endoscopic improvement in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cristian Hernandez-Rocha, Shadi Nayeri, Williams Turpin, Mike Steel, Krzysztof Borowski, Joanne M. Stempak, James Conner, Mark S. Silverberg
Summary: This study aimed to establish the prognosis, transcriptional and microbial features of histo-endoscopic remission and activity in ulcerative colitis (UC) patients. The results showed that UC patients with histo-endoscopic remission had a lower risk of relapse and their rectosigmoid mucosa transcriptional profile resembled that of healthy controls. Host genes with antimicrobial properties were significantly associated with mucosal microbiota.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Jun Miyoshi, Ryo Ozaki, Hiromi Yonezawa, Hideaki Mori, Naohiro Kawamura, Minoru Matsuura, Tadakazu Hisamatsu
Summary: The development of a new parameter (SMI) for estimating endoscopic remission of ulcerative colitis was investigated. The SMI is a practical, quantitative parameter based on the bowel wall structure. It has the potential to be widely used in daily practice.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Keijiro Numa, Kazuki Kakimoto, Yasuyoshi Tanaka, Noboru Mizuta, Naohiko Kinoshita, Kei Nakazawa, Ryoji Koshiba, Yuki Hirata, Kazuhiro Ota, Takako Miyazaki, Shiro Nakamura, Kazuhide Higuchi, Hiroki Nishikawa
Summary: This study evaluated the efficacy of adalimumab (ADA) for maintaining remission in patients with refractory ulcerative colitis (UC). The results showed that switching to ADA after tacrolimus (TAC) therapy can effectively prevent relapse in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jun Ohara, Tetsuo Nemoto, Yasuharu Maeda, Noriyuki Ogata, Shin-Ei Kudo, Toshiko Yamochi
Summary: This study demonstrates that an automated quantitative method using a deep learning-based model is useful in predicting the prognosis of patients with ulcerative colitis by evaluating mucin depletion.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Keiichi Haga, Tomoyoshi Shibuya, Taro Osada, Shunsuke Sato, Yuka Fukuo, Osamu Kobayashi, Toshio Yamada, Daisuke Asaoka, Kentaro Ito, Kei Nomura, Mayuko Haraikawa, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Mariko Hojo, Akihito Nagahara
Summary: This study found that VDZ is effective in the majority of UC patients, with a high rate of mucosal healing even in those who have previously failed biological therapy. Early clinical remission can predict long-term remission, and week 6 can be a useful evaluation point when using VDZ for UC treatment.
Review
Gastroenterology & Hepatology
Rocio Sedano, Malcolm Hogan, Tran M. Nguyen, Joshua Chang, G. Y. Zou, John K. Macdonald, Niels Vande Casteele, Jurij Hanzel, Eileen Crowley, Robert Battat, Parambir S. Dulai, Siddharth Singh, Geert D'Haens, William Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study provides a summary of placebo rates in induction and maintenance clinical trials of ulcerative colitis, as well as identifying the factors influencing these rates. The results show that placebo rates vary depending on the endpoint assessed, trial purpose, and drug class.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Health Care Sciences & Services
Mimari Kanazawa, Keiichi Tominaga, Akira Yamamiya, Takanao Tanaka, Shoko Watanabe, Takeshi Sugaya, Keiichiro Abe, Akira Kanamori, Takahiro Arisaka, Koki Hoshi, Makoto Iijima, Kenichi Goda, Yasuo Haruyama, Atsushi Irisawa
Summary: The study revealed low interobserver reliability among endoscopic observers when evaluating MES parameters in UC patients in histological remission, with even UC practice experts showing low reliability for certain parameters such as Erythema and Decreased vascular pattern.
Article
Health Care Sciences & Services
Chang Kyo Oh, Han Hee Lee, Jin Su Kim, Bo-In Lee, Young-Seok Cho
Summary: This study aimed to evaluate the clinical features and long-term outcomes of appendiceal orifice inflammation (AOI) in patients with ulcerative colitis (UC). The study found that UC patients with AOI had a lower risk of achieving complete endoscopic remission (ER), suggesting the need for careful treatment strategies in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Floris de Voogd, Elsa A. van Wassenaer, Aart Mookhoek, Steven Bots, Sara van Gennep, Mark Lowenberg, Geert R. D'Haens, Krisztina B. Gecse
Summary: This study evaluated the use of intestinal ultrasound (IUS) in the treatment response of ulcerative colitis (UC). The results showed that bowel wall thickness (BWT) is the most accurate parameter for determining endoscopic improvement and treatment response.
Article
Gastroenterology & Hepatology
Chikako Watanabe, Masakazu Nagahori, Toshimitsu Fujii, Kaoru Yokoyama, Naoki Yoshimura, Taku Kobayashi, Hirokazu Yamagami, Kazuya Kitamura, Kagaya Takashi, Shiro Nakamura, Makoto Naganuma, Shunji Ishihara, Motohiro Esaki, Maria Yonezawa, Reiko Kunisaki, Atsushi Sakuraba, Naoaki Kuji, Soichiro Miura, Toshifumi Hibi, Yasuo Suzuki, Ryota Hokari
Summary: This study found that non-adherence to mesalamine was underestimated by physicians in pregnant UC patients, leading to disease relapse and potentially adverse pregnancy outcomes. Non-adherence was identified as an independent risk factor for relapse and could impact pregnancy outcomes. Preconceptional education on medication safety and avoiding self-discontinuation is necessary for these patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Kousaku Kawashima, Naoki Oshima, Kenichi Kishimoto, Masatoshi Kataoka, Mai Fukunaga, Satoshi Kotani, Hiroki Sonoyama, Akihiko Oka, Yoshiyuki Mishima, Hideaki Kazumori, Noriyoshi Ishikawa, Asuka Araki, Shunji Ishihara
Summary: This study aimed to determine the optimal FC cutoff value for predicting HH in UC patients and investigate FC's predictability for prolonged CR. The results showed that FC levels < 82 μg/g can predict HH in UC patients with clinical and endoscopic remission, and low FC also leads to prolonged CR.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Hunter Wang, Ingrid Fewings, Lee Bornman, Bruce Shadbolt, Mitali Fadia, Kavitha Subramaniam
Summary: Histologic activity is important in predicting future relapse in UC patients. This study found that histologic remission using the NHI score independently predicts longer relapse-free survival and may be a superior therapeutic target than endoscopic remission.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)