Article
Critical Care Medicine
Elisa Perger, Luigi Taranto Montemurro, Debora Rosa, Stefano Vicini, Mariapaola Marconi, Lucia Zanotti, Paolo Meriggi, Ali Azarbarzin, Scott A. Sands, Andrew Wellman, Carolina Lombardi, Gianfranco Parati
Summary: The combination therapy of Reb-Oxy significantly reduces the severity of OSA and improves vigilance. These findings highlight the potential of pharmacologic treatment for OSA.
Article
Integrative & Complementary Medicine
Ali Sabbagh Gol, Amir Rezaei Ardani, Seyed Kazem Farahmand, Malihe Dadgarmoghaddam, Vahideh Ghorani, Shima Rezaei, Ali Khorsand
Summary: The study found that the additive effect of acupuncture combined with SSRIs for treating anxiety disorders was significantly better than using SSRIs alone for anti-anxiety therapy. The acupuncture group showed greater improvements in STAI score changes and cortisol level decreases compared to the other groups.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Psychiatry
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: This study aimed to evaluate the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD. The results showed that while agomelatine did not improve OCD symptoms, the combination treatment was safe and effective compared to placebo.
Article
Neurosciences
Christelle Langley, Sophia Armand, Qiang Luo, George Savulich, Tina Segerberg, Anna Sondergaard, Elisabeth B. Pedersen, Nanna Svart, Oliver Overgaard-Hansen, Annette Johansen, Camilla Borgsted, Rudolf N. Cardinal, Trevor W. Robbins, Dea S. Stenbaek, Gitte M. Knudsen, Barbara J. Sahakian
Summary: This study aimed to investigate the chronic effects of the SSRI escitalopram on cognition in healthy volunteers. The findings revealed that escitalopram decreased reinforcement sensitivity but had no significant impact on "cold" cognition and decision-making ability. These findings suggest that serotonin reuptake inhibition plays a role in reinforcement learning in healthy individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Psychology, Developmental
Lu Lu, A. Jeffrey Mills, Hailong Li, K. Heidi Schroeder, A. Sarah Mossman, T. Sara Varney, M. Kim Cecil, Xiaoqi Huang, Qiyong Gong, B. Laura Ramsey, P. Melissa DelBello, A. John Sweeney, R. Jeffrey Strawn
Summary: In adolescents with generalized anxiety disorder (GAD), escitalopram increased amygdala-prefrontal connectivity within the first 2 weeks of treatment, and the magnitude of this early change predicted subsequent clinical improvement.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: The study aimed to investigate the effectiveness of granisetron as an adjunct therapy to selective serotonin reuptake inhibitors for improving symptoms of OCD. The results showed that the addition of granisetron led to a greater reduction in obsession scores and a higher proportion of patients showing complete response compared to the placebo group.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Clara de Morais Faleiros Maranho, Vinicius Guandalini Guapo, Marcos Gonsalves de Rezende, Carolina Sales Vieira, Marcus Lira Brandao, Frederico Guilherme Graeff, Thelma Lovick, Cristina Marta Del-Ben
Summary: The study aimed to assess the potential effect of low doses of fluoxetine during the luteal phase in preventing or mitigating emotional PMS symptoms. The randomized, double-blind, placebo-controlled pilot study found that low doses of fluoxetine may have some potential in mitigating emotional PMS symptoms.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Clinical Neurology
Erfaneh Hajian Tilaki, Alireza Hasanzadeh, Mohammadreza Shalbafan, Hossein Sanjari Moghaddam, Ahmad Shamabadi, Mahsa Boroon, Shahin Akhondzadeh
Summary: This study evaluates the effectiveness and tolerability of reboxetine in combination with fluoxetine for treating OCD. The results indicate that the combination therapy effectively improves symptoms in OCD patients and is well-tolerated. However, further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.
CLINICAL NEUROPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Jeffrey R. Strawn, Ethan A. Poweleit, Jeffrey A. Mills, Heidi K. Schroeder, Zoe A. Neptune, Ashley M. Specht, Jenni E. Farrow, Xue Zhang, Lisa J. Martin, Laura B. Ramsey
Summary: The study aims to investigate the efficacy of individualized pharmacotherapy for pediatric anxiety disorders based on CYP2C19 phenotypes, and whether it can improve treatment response and reduce side effect burden.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Urology & Nephrology
Satoru Takahashi, Kumiko Kato, Mineo Takei, Osamu Yokoyama, Momokazu Gotoh
Summary: The study demonstrated that TAS-303 effectively reduced incontinence episode frequency in some patients with stress urinary incontinence and showed improvement in some secondary end-points. TAS-303 was well tolerated and had a favorable safety profile.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Paraskevas Gkolfakis, Daryl Ramai, Georgios Tziatzios, Janice Lester, Stefano Francesco Crino, Leonardo Frazzoni, Ioannis S. Papanikolaou, Marianna Arvanitakis, Daniel Blero, Arnaud Lemmers, Pierre Eisendrath, Lorenzo Fuccio, Konstantinos Triantafyllou, Armando Gabbrielli, Jacques Deviere
Summary: All treatments except mechanical lithotripsy were more effective than sphincterotomy in terms of stone removal rate. Cholangioscopy ranked the highest in increasing the success rate of stone removal, followed by S+EPLBD. None of the interventions showed significant differences in adverse event rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Microbiology
Evripidis Rizos, Emmanouel Pyleris, Mark Pimentel, Konstantinos Triantafyllou, Evangelos J. Giamarellos-Bourboulis
Summary: Small intestinal bacterial overgrowth (SIBO) is associated with an inflammatory environment, leading to elevated levels of cytokines. Elevated IL-1β levels have a significant association with SIBO, while elevated IL-6 and TNF-α levels have no significant association with SIBO. Methanobevibacter smithii is positively related to elevated IL-1β levels, while Klebsiella pneumoniae is positively related to elevated IL-6 and TNF-α levels.
Review
Microbiology
Konstantinos Tsamakis, Sofia Galinaki, Evangelos Alevyzakis, Ioannis Hortis, Dimitrios Tsiptsios, Evangelia Kollintza, Stylianos Kympouropoulos, Konstantinos Triantafyllou, Nikolaos Smyrnis, Emmanouil Rizos
Summary: There is an increasing body of evidence suggesting that gut microbiota plays a role in psychiatric disorders. The existing literature indicates a link between alterations in the gut microbiome and conditions such as autism, depression, bipolar disorder, and psychosis. This review aims to summarize recent findings on the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis.
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Liboria Laterza, Marina La Marca, Rocco Maurizio Zagari, Franco Radaelli, Cesare Hassan, Alessandro Repici, Antonio Facciorusso, Paraskevas Gkolfakis, Cristiano Spada, Konstantinos Triantafyllou, Franco Bazzoli, Mario Dinis-Ribeiro, Lorenzo Fuccio
Summary: This study assessed the diagnostic performance of alarm features (rectal bleeding, anemia, change in bowel habit, and weight loss) for colorectal cancer (CRC) diagnosis through a systematic review and meta-analysis. The results showed variable accuracy for each alarm feature, and rectal bleeding and anemia were identified as the most practical features for selecting patients for colonoscopy.
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Review
Gastroenterology & Hepatology
Apostolis Papaefthymiou, Daryl Ramai, Marcello Maida, Georgios Tziatzios, Michael Fernandez Y. Viesca, Ioannis Papanikolaou, Konstantina Paraskeva, Konstantinos Triantafyllou, Alessandro Repici, Cesare Hassan, Cecilia Binda, Torsten Beyna, Antonio Facciorusso, Marianna Arvanitakis, Paraskevas Gkolfakis
Summary: This systematic review and meta-analysis found that motorized spiral enteroscopy (mSE) has high rates of diagnostic and therapeutic success with a low prevalence of severe adverse events.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Microbiology
Georgios Tziatzios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J. J. Giamarellos-Bourboulis, Konstantinos Triantafyllou
Summary: Functional dyspepsia (FD) is a common disorder with no definitive, universal treatment. Probiotics have been suggested as a potential therapeutic option for FD due to their effects on gastrointestinal symptoms in patients with Irritable Bowel Syndrome (IBS). However, the evidence for the efficacy of probiotics in FD remains unclear. This review aims to summarize the available evidence for the use of probiotics in FD.
Article
Gastroenterology & Hepatology
Peter J. Lee, Ali Lahooti, Stacey Culp, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Ila Lahooti, Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin Traian Babu, Haq Nawaz, Silvia Cristina Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Luis Lara, Samuel Han, Georgios I. Papachristou
Summary: This study aimed to determine the adjusted effects of body mass index (BMI) and alcoholic etiology on the risk of multisystem organ failure (MSOF) in patients with acute pancreatitis (AP). The results showed that alcoholic etiology was independently associated with increased risk of MSOF compared to non-alcohol etiologies, and obese men (but not women) were more susceptible to MSOF.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Simon M. Everett, Konstantinos Triantafyllou, Cesare Hassan, Klaus Mergener, Tony C. Tham, Nuno Almeida, Giulio Antonelli, Andrew Axon, Raf Bisschops, Michael Bretthauer, Vianna Costil, Farid Foroutan, James Gauci, Istvan Hritz, Helmut Messmann, Maria Pellise, Philip Roelandt, Andrada Seicean, Georgios Tziatzios, Andrei Voiosu, Ian M. Gralnek
Summary: All endoscopic procedures carry risks, so endoscopists should involve patients in the decision-making process and respect their right to self-determination. The European Society of Gastrointestinal Endoscopy has established a series of statements as a minimum standard of practice for informed consent, but there is a lack of guidance in many countries, leading to variations in care and potential legal risks.
Review
Microbiology
Maroulla D. Nikolaki, Arezina N. Kasti, Konstantinos Katsas, Konstantinos Petsis, Sophia Lambrinou, Vasiliki Patsalidou, Sophia Stamatopoulou, Katerina Karlatira, John Kapolos, Konstantinos Papadimitriou, Konstantinos Triantafyllou
Summary: This review explores the role of branched short-chain fatty acids (BCFAs) on gut inflammation in patients with irritable bowel syndrome (IBS) and the impact of low-FODMAP diet (LFD) on BCFAs production. The included studies have contradictory findings about the effects of BCFAs on intestinal health in IBS patients.
Review
Medicine, General & Internal
Thomas Vasilakis, Dimitrios Ziogas, Georgios Tziatzios, Paraskevas Gkolfakis, Eleni Koukoulioti, Christina Kapizioni, Konstantinos Triantafyllou, Antonio Facciorusso, Ioannis S. Papanikolaou
Summary: Gastric subepithelial lesions (SELs) are intramural lesions beneath the gastric mucosa. Accurate diagnosis is crucial as SELs can be benign, malignant, or have malignant potential. Endosonography is the gold standard for diagnosis, but histological examination may be necessary for certain lesions, particularly smaller ones. New methods such as contrast enhanced endosonography, EUS elastography, and artificial intelligence systems have been developed to assist decision making. This review provides a comprehensive overview and summarizes the latest diagnostic advances in endosonography for gastric SELs in the past decade.
Review
Gastroenterology & Hepatology
Magdalini Manti, Georgios Tziatzios, Antonio Facciorusso, Apostolis Papaefthymiou, Daryl Ramai, Ioannis Papanikolaou, Cesare Hassan, Konstantinos Triantafyllou, Konstantina Paraskeva, Paraskevas Gkolfakis
Summary: Add-on devices with projections placed on the distal tip of the colonoscope improve the detection of precancerous lesions during colonoscopy for screening purposes. Meta-analysis results indicate that the use of these devices results in a higher adenoma detection rate compared to standard colonoscopy.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Eleni Manthopoulo, Daryl Ramai, Alexandros Ioannou, Paraskevas Gkolfakis, Ioannis S. Papanikolaou, Benedetto Mangiavillano, Konstantinos Triantafyllou, Stefano Francesco Crino, Antonio Facciorusso
Summary: Endoscopic ultrasound (EUS) is a technique that allows for the collection of tissue samples via a fine needle while visualizing the area. This study focuses on EUS tissue acquisition in organs other than the pancreas, including the liver, biliary tree, lymph nodes, and gastrointestinal tracts. The review discusses the evolving techniques used for tissue sampling under EUS guidance, as well as the importance of needle type and size in sample quality.
ANNALS OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Paraskevas Gkolfakis, Christina Kapizioni, Georgios Tziatzios, Antonio Facciorusso, Leonardo Frazzoni, Konstantinos Thomopoulos, Spyros Potamianos, Dimitrios Christodoulou, Vasilios Papadopoulos, Lorenzo Fuccio, Cesare Hassan, Konstantinos Triantafyllou
Summary: This study evaluated the comparative efficacy of predictive scores in predicting inadequate bowel cleansing among hospitalized patients undergoing colonoscopy. The results showed that Model B outperformed its comparators in predicting inadequate bowel preparation, particularly in mobilized inpatients.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Paraskevas Gkolfakis, Georgios Tziatzios, Daryl Ramai, Ioannis S. Papanikolaou, Konstantinos Triantafyllou, Andrea Lisotti, Pietro Fusaroli, Benedetto Mangiavillano, Saurabh Chandan, Babu P. Mohan, Stefano Francesco Crino
Summary: This meta-analysis compares the diagnostic accuracy of rapid on-site evaluation (ROSE) in EUS-guided fine-needle biopsy (EUS-FNB) for pancreatic masses. The results show that the sample adequacy and diagnostic accuracy are higher in the EUS-FNB + ROSE group compared to the EUS-FNB group, especially when a reverse bevel needle is used. However, there is no significant difference between the two groups when newer end-cutting needles are used. There is also no significant difference in diagnostic sensitivity, specificity, and the number of needle passes needed.
ENDOSCOPIC ULTRASOUND
(2022)
