Article
Psychiatry
Catarina Raposo-Lima, Ines Miguel Pereira, Fernanda Marques, Pedro Morgado
Summary: This exploratory study found significantly higher levels of NGAL in OCD patients compared to healthy controls, providing evidence for a potential role of immune dysregulation in the pathophysiology of OCD.
Article
Medicine, General & Internal
David Zahler, Ilan Merdler, Ariel Banai, Eden Shusterman, Omri Feder, Tamar Itach, Leemor Robb, Shmuel Banai, Yacov Shacham
Summary: Elevated NGAL levels have prognostic utility for renal and clinical outcomes among STEMI patients undergoing primary PCI, independent of traditional inflammatory markers. High NGAL is associated with increased short-term adverse outcomes, such as acute kidney injury, lower left ventricular ejection fraction, higher 30-day mortality, and higher incidence of MACE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Medicine, General & Internal
Izabela Duda, Lukasz Krzych
Summary: The study demonstrated that plasma NGAL, combined with indices of critical illness, is a useful biomarker for predicting mortality in heterogeneous population of ICU patients. pNGAL on D3 was found to be the most suitable for predicting in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Stine Jacobsen, Camilla Drejer Mortensen, Elisabeth Alkaersig Hoj, Anne Mette Vinther, Lise Charlotte Berg, Ditte Marie Top Adler, Denis Verwilghen, Gaby van Galen
Summary: Early detection of joint infection in horses is crucial for preventing further damage and ensuring proper treatment. The biomarker NGAL has proven to be highly accurate in diagnosing joint infection in horses and monitoring treatment response. NGAL measurements may enable early detection and prompt therapy initiation, improving prognosis for horses with joint infection.
Article
Urology & Nephrology
Anthony Batte, Sahit Menon, John M. Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Zachary Berrens, Edrisa Ibrahim Mutebi, Rodney Ogwang, Robert O. Opoka, Chandy C. John, Andrea L. Conroy
Summary: This study investigated the diagnosis of acute kidney injury in low- and middle-income countries. By measuring urine NGAL levels using a dipstick test, it was found that children with sickle cell anemia were at a higher risk of acute kidney injury, and urine NGAL levels may be associated with mortality.
KIDNEY INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Zhimin Huang, Lin Wu, Ming Zeng, Buyun Wu, Xueqiang Xu, Huijuan Mao, Yanggang Yuan, Changying Xing
Summary: This study aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). The results showed that urinary NGAL (uNGAL) levels were significantly higher in the AKI group compared to the CKD group, while serum NGAL (sNGAL) levels were not significantly different. Furthermore, the u/s NGAL ratio and fractional excretion of NGAL (Fe NGAL) were able to effectively distinguish AKI from CKD. Further confirmatory studies are still necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Hsin-Yin Chuang, Wen-Yih Jeng, Ellian Wang, Si-Tse Jiang, Chen-Ming Hsu, Hsiu Mei Hsieh-Li, Yuan-Yow Chiou
Summary: PKD is a common inherited disease characterized by fluid-filled cysts, and studying the mechanisms of NGAL on cysts can provide insights for future clinical treatments.
Article
Medicine, General & Internal
Dina Midan, Fady El-Gendy, Dalia Abo ELAlla, Mayada Kotb
Summary: Sepsis is a life-threatening condition in neonates, and its diagnosis is challenging. This study evaluated the diagnostic performance of NGAL as a biomarker for early detection of neonatal sepsis. NGAL levels showed significant differences between sepsis cases and controls, and were significantly higher in non-survivors. NGAL demonstrated strong discriminatory power and could potentially serve as a promising diagnostic marker for neonatal sepsis.
ANNALS OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Benjamin Bonnard, Ernesto Martinez-Martinez, Amaya Fernandez-Celis, Marie Pieronne-Deperrois, Quoc-Tuan Do, Isbaal Ramos, Patrick Rossignol, Faiez Zannad, Paul Mulder, Antoine Ouvrard-Pascaud, Natalia Lopez-Andres, Frederic Jaisser
Summary: New compounds with potent inhibitory activity on NGAL-induced fibrosis and inflammation have been identified. These inhibitors showed promising effects in improving cardiac function in myocardial infarction models and preventing renal fibrosis in chronic kidney disease models. They may be potential therapeutic options for diseases involving NGAL.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Huogen Liu, Xin Wan, Yundi Shi, Hailin Shu, Rijin Huang, Ling Gu
Summary: The study showed that elevated serum NGAL levels in elderly patients with coronary heart disease were associated with a higher prevalence of cardiovascular disease history and an increased risk of cardiovascular death. Serum NGAL can independently predict cardiovascular death in these patients, highlighting its potential clinical application.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Junichiro Kawagoe, Yuta Kono, Yuki Togashi, Mayuko Ishiwari, Kazutoshi Toriyama, Chika Yajima, Hideaki Nakayama, Satoshi Kasagi, Shinji Abe, Yasuhiro Setoguchi
Summary: Serum NGAL levels were associated with clinical parameters in patients with asthma, especially with obstructive ventilatory defect. NGAL may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma.
CURRENT MEDICAL SCIENCE
(2021)
Article
Clinical Neurology
Peter Hermann, Anna Villar-Pique, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Ines Baldeiras, Joachim Riggert, Inga Zerr, Franc Llorens
Summary: In this study, we found that plasma Lipocalin-2 was significantly lower in patients with Alzheimer's disease and has the potential to be a diagnostic biomarker. Furthermore, Lipocalin-2 seems to be independent from other currently employed biomarkers.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medical Laboratory Technology
Ze-Liang Qiu, Bi-Qing Yan, Rui Zhao, Dong-Wei Xu, Kan Shen, Xing-Qi Deng, Shi-Qi Lu
Summary: This study aimed to assess the early predictive values of hepcidin, NGAL, and their combination for secondary AKI in patients with sepsis. Results indicated that higher serum hepcidin and urine NGAL levels at admission were independent predictors of AKI development in critically septic patients. Serum hepcidin and urine NGAL were comparable predictive indicators of AKI occurrence, with their combination showing improved accuracy in prediction.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Ching-Ting Wei, I-Ting Tsai, Cheng-Ching Wu, Wei-Chin Hung, Chin-Feng Hsuan, Teng-Hung Yu, Chia-Chang Hsu, Jer-Yiing Houng, Fu-Mei Chung, Yau-Jiunn Lee, Yung-Chuan Lu
Summary: Plasma NGAL levels were found to be significantly elevated in patients with breast cancer, independently associated with the disease even after adjusting for known biomarkers. The levels were also correlated with disease severity and inflammatory biomarkers, suggesting a potential role of NGAL in breast cancer pathogenesis through inflammatory reactions.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)